Protein: NSUN2
RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4)

Gene: NSUN2
Organism: Homo sapiens
Interactions: 193
UniProt ID: Q08J23

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0001701 - in utero embryonic development
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

346627

MYC
Myc proto-oncogene protein

4

5

High-throughput

0.676

High

983108

UBE3A
Ubiquitin-protein ligase E3A

3

2

High-throughput

0.667

High

158276

LIN7A
Protein lin-7 homolog A

2

1

High-throughput

0.628

High

584589

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

2

4

High-throughput

0.628

High

997573

MTA70
N6-adenosine-methyltransferase catalytic subunit

2

2

High-throughput

0.628

High

997616

LIN7C
Protein lin-7 homolog C

2

1

High-throughput

0.628

High

418208

NPM
Nucleophosmin

2

3

Small-scale

0.611

High

997554

CUL3
Cullin-3

2

4

High-throughput

0.611

High

997562

IF16
Gamma-interferon-inducible protein 16

2

3

High-throughput

0.611

High

997564

IFIX
Pyrin and HIN domain-containing protein 1

2

3

High-throughput

0.611

High

997593

CNDP2
Cytosolic non-specific dipeptidase

2

0

High-throughput

0.602

High

997620

PALS2
Protein PALS2

2

0

High-throughput

0.602

High

227277

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

244344

BRD4
Bromodomain-containing protein 4

2

2

High-throughput

0.584

High

779303

CCNF
Cyclin-F

2

2

High-throughput

0.584

High

997614

ANLN
Anillin

2

3

High-throughput

0.584

High

529035

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.576

High

374117

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

1

High-throughput

0.571

High

581698

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.547

High

997555

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

0

High-throughput

0.547

High

257993

DNJB6
DnaJ homolog subfamily B member 6

1

2

High-throughput

0.536

High

319178

BRD1
Bromodomain-containing protein 1

1

3

Small-scale

0.536

High

403202

LA
Lupus La protein

1

1

High-throughput

0.536

High

496922

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

649479

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.536

High

805977

RL5
Large ribosomal subunit protein uL18

1

3

High-throughput

0.536

High

907869

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

922984

RL11
Large ribosomal subunit protein uL5

1

3

High-throughput

0.536

High

933415

TBA4A
Tubulin alpha-4A chain

1

4

High-throughput

0.536

High

972321

TIE2
Angiopoietin-1 receptor

1

8

High-throughput

0.536

High

997553

CUL1
Cullin-1

1

4

High-throughput

0.536

High

997575

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

997582

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.536

High

997585

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.536

High

997586

CUL5
Cullin-5

1

4

High-throughput

0.536

High

997592

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.536

High

384725

NTRK1
High affinity nerve growth factor receptor

2

7

High-throughput

0.533

High

997576

LCA5
Lebercilin

2

2

High-throughput

0.521

High

819619

NRIP1
Nuclear receptor-interacting protein 1

1

0

High-throughput

0.518

High

176176

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.513

High

336478

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

380771

S100B
Protein S100-B

1

0

High-throughput

0.513

High

537636

NCF1
Neutrophil cytosol factor 1

1

0

High-throughput

0.513

High

685924

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

828749

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

911355

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.513

High

997560

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

997594

PHAR3
Phosphatase and actin regulator 3

1

0

High-throughput

0.513

High

997631

NGN3
Neurogenin-3

1

0

High-throughput

0.513

High

997632

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

997633

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

902546

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

997590

AURKB
Aurora kinase B

1

1

Small-scale

0.501

High

316866

KLF8
Krueppel-like factor 8

1

10

High-throughput

0.500

High

997601

KLF16
Krueppel-like factor 16

1

6

High-throughput

0.500

High

997624

KLF15
Krueppel-like factor 15

1

7

High-throughput

0.500

High

997623

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

666586

LTK
Leukocyte tyrosine kinase receptor

1

11

High-throughput

0.489

High

975644

LMNB2
Lamin-B2

1

3

High-throughput

0.489

High

984567

CALD1
Caldesmon

1

3

High-throughput

0.489

High

997600

URM1
Ubiquitin-related modifier 1

1

0

Small-scale

0.479

High

125411

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.479

High

130865

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

High-throughput

0.479

High

182719

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

209927

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

233399

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

294755

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

298461

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

308646

KI20A
Kinesin-like protein KIF20A

1

4

High-throughput

0.479

High

312589

ARI2
E3 ubiquitin-protein ligase ARIH2

1

6

High-throughput

0.479

High

322526

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

6

High-throughput

0.479

High

338334

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

379331

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.479

High

440485

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

442101

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

487374

ANDR
Androgen receptor

1

5

High-throughput

0.479

High

503970

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

507965

FGFR1
Fibroblast growth factor receptor 1

1

10

High-throughput

0.479

High

552576

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

569649

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

582251

NUCL
Nucleolin

1

1

Small-scale

0.479

High

603469

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

3

High-throughput

0.479

High

651048

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

655341

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

High-throughput

0.479

High

665587

EPHB2
Ephrin type-B receptor 2

1

4

High-throughput

0.479

High

674407

UFO
Tyrosine-protein kinase receptor UFO

1

11

High-throughput

0.479

High

718794

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

720315

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

729269

VGFR3
Vascular endothelial growth factor receptor 3

1

6

High-throughput

0.479

High

729646

VGFR2
Vascular endothelial growth factor receptor 2

1

5

High-throughput

0.479

High

823930

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

835703

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.479

High

841680

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.479

High

850017

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.479

High

869868

PMS2
Mismatch repair endonuclease PMS2

1

2

High-throughput

0.479

High

877709

FOXA1
Hepatocyte nuclear factor 3-alpha

1

3

High-throughput

0.479

High

880699

HDAC4
Histone deacetylase 4

1

7

High-throughput

0.479

High

903170

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.479

High

908443

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

914033

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

916540

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.479

High

921538

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.479

High

923337

RL8
Large ribosomal subunit protein uL2

1

3

High-throughput

0.479

High

940825

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

Small-scale

0.479

High

968297

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

13

High-throughput

0.479

High

997549

MERTK
Tyrosine-protein kinase Mer

1

10

High-throughput

0.479

High

997550

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

997551

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.479

High

997552

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

2

High-throughput

0.479

High

997557

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.479

High

997558

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

997559

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

997561

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

997565

ZN746
Zinc finger protein 746

1

9

High-throughput

0.479

High

997570

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

997572

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

997574

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

997578

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.479

High

997579

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

997583

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

997584

HDAC2
Histone deacetylase 2

1

4

High-throughput

0.479

High

997587

ARMC5
Armadillo repeat-containing protein 5

1

4

High-throughput

0.479

High

997588

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

997591

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

997596

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

997598

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

5

High-throughput

0.479

High

997602

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

997604

TRI31
E3 ubiquitin-protein ligase TRIM31

1

2

High-throughput

0.479

High

997606

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

997607

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

997608

SENP3
Sentrin-specific protease 3

1

2

Small-scale

0.479

High

997609

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

997610

ECT2
Protein ECT2

1

1

High-throughput

0.479

High

997611

RHOF
Rho-related GTP-binding protein RhoF

1

1

High-throughput

0.479

High

997612

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

2

High-throughput

0.479

High

997613

BRD7
Bromodomain-containing protein 7

1

4

High-throughput

0.479

High

997615

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.479

High

997617

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

997621

HDAC6
Histone deacetylase 6

1

7

High-throughput

0.479

High

997622

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

997626

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

997627

ALK
ALK tyrosine kinase receptor

1

9

High-throughput

0.479

High

997628

CE164
Centrosomal protein of 164 kDa

1

2

High-throughput

0.479

High

997630

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

205319

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

450857

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

530636

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

615706

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

813410

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

997566

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

997571

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

997580

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

997581

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

997599

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

997605

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

997618

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

997619

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

401899

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

931113

YBOX1
Y-box-binding protein 1

1

2

High-throughput

0.445

High

997556

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

4

High-throughput

0.445

High

997563

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

148727

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.437

High

435624

IGF1R
Insulin-like growth factor 1 receptor

1

9

High-throughput

0.437

High

445847

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

9

High-throughput

0.437

High

572626

VGFR1
Vascular endothelial growth factor receptor 1

1

5

High-throughput

0.437

High

600561

EPHA1
Ephrin type-A receptor 1

1

5

High-throughput

0.437

High

609265

FGFR3
Fibroblast growth factor receptor 3

1

9

High-throughput

0.437

High

738198

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

5

High-throughput

0.437

High

953071

PR20A
Proline-rich protein 20A

1

1

High-throughput

0.437

High

981865

RON
Macrophage-stimulating protein receptor

1

9

High-throughput

0.437

High

997567

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.437

High

997577

LMTK2
Serine/threonine-protein kinase LMTK2

1

8

High-throughput

0.437

High

997595

LMTK3
Serine/threonine-protein kinase LMTK3

1

10

High-throughput

0.437

High

997625

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.437

High

587546

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

997589

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

831263

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

952969

PR20E
Proline-rich protein 20E

1

1

High-throughput

0.407

High

155339

NRP1
Neuropilin-1

3

0

High-throughput

0.347

High

996474

FGL1
Fibrinogen-like protein 1

3

0

High-throughput

0.347

High

849624

CCR4
C-C chemokine receptor type 4

1

0

High-throughput

0.282

High

997603

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.279

Low

329679

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.269

Low

169444

BET1
BET1 homolog

1

0

High-throughput

0.249

Low

225618

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

352084

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

352594

TNFA
Tumor necrosis factor

1

0

High-throughput

0.249

Low

807700

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.249

Low

832839

TSP3
Thrombospondin-3

1

0

High-throughput

0.249

Low

997568

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

997597

ZFY21
Zinc finger FYVE domain-containing protein 21

1

0

Small-scale

0.249

Low

997629

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

997569

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024