Protein: HDAC1
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)

Gene: HDAC1
Organism: Mus musculus
Interactions: 131
UniProt ID: O09106

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000792 - heterochromatin
GO:0000976 - transcription cis-regulatory region binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

140250

HDAC2
Histone deacetylase 2

5

16

Small-scale

0.914

High

140317

MTA2
Metastasis-associated protein MTA2

5

20

Small-scale

0.909

High

140301

RCOR1
REST corepressor 1

2

20

Small-scale

0.754

High

140322

MECP2
Methyl-CpG-binding protein 2

2

15

Small-scale

0.754

High

140270

SIN3A
Paired amphipathic helix protein Sin3a

10

18

Small-scale

0.751

High

140287

KDM1A
Lysine-specific histone demethylase 1A

5

10

Small-scale

0.706

High

140241

SOX2
Transcription factor SOX-2

4

20

Small-scale

0.694

High

140278

SIN3B
Paired amphipathic helix protein Sin3b

4

18

Small-scale

0.676

High

140226

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

3

8

Small-scale

0.674

High

140225

PO5F1
POU domain, class 5, transcription factor 1

3

3

High-throughput

0.667

High

140230

NFKB1
Nuclear factor NF-kappa-B p105 subunit

3

20

Small-scale

0.650

High

140234

CEBPB
CCAAT/enhancer-binding protein beta

3

17

Small-scale

0.646

High

140217

MYOD1
Myoblast determination protein 1

3

1

Small-scale

0.640

High

140212

SP1
Transcription factor Sp1

2

20

Small-scale

0.624

High

140198

HDAC1
Histone deacetylase 1

1

15

Small-scale

0.618

High

140210

HDAC3
Histone deacetylase 3

1

14

Small-scale

0.618

High

140291

RERE
Arginine-glutamic acid dipeptide repeats protein

1

20

Small-scale

0.618

High

140302

MTA1
Metastasis-associated protein MTA1

1

20

Small-scale

0.618

High

140211

ZBT7A
Zinc finger and BTB domain-containing protein 7A

2

20

Small-scale

0.611

High

140274

EZH2
Histone-lysine N-methyltransferase EZH2

2

20

Small-scale

0.601

High

140244

CEBPA
CCAAT/enhancer-binding protein alpha

2

10

Small-scale

0.594

High

140306

SATB2
DNA-binding protein SATB2

2

3

Small-scale

0.588

High

140276

E2F1
Transcription factor E2F1

2

6

Small-scale

0.586

High

140307

EED
Polycomb protein EED

2

19

High-throughput

0.586

High

140218

RB
Retinoblastoma-associated protein

2

12

Small-scale

0.584

High

140256

TYY1
Transcriptional repressor protein YY1

2

10

Small-scale

0.584

High

140266

Q3UQ17
Zinc finger and BTB domain containing 16

2

9

Small-scale

0.584

High

140294

NANOG
Homeobox protein NANOG

2

12

Small-scale

0.584

High

140310

FOXP3
Forkhead box protein P3

2

16

Small-scale

0.571

High

57643

A2AWT7
Upstream binding transcription factor, RNA polymerase I

1

20

Small-scale

0.561

High

140201

TCF21
Transcription factor 21

1

8

Small-scale

0.561

High

140233

HNF1B
Hepatocyte nuclear factor 1-beta

1

2

Small-scale

0.561

High

140243

PDX1
Pancreas/duodenum homeobox protein 1

1

5

Small-scale

0.561

High

140254

CRY1
Cryptochrome-1

1

1

Small-scale

0.561

High

140283

RBL2
Retinoblastoma-like protein 2

1

12

Small-scale

0.561

High

140308

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

9

Small-scale

0.561

High

140296

NSD2
Histone-lysine N-methyltransferase NSD2

1

20

Small-scale

0.554

High

140199

PHB2
Prohibitin-2

1

8

Small-scale

0.552

High

140203

FOG1
Zinc finger protein ZFPM1

1

14

Small-scale

0.536

High

140259

TF65
Transcription factor p65

1

20

Small-scale

0.536

High

140265

TF2L1
Transcription factor CP2-like protein 1

1

3

High-throughput

0.536

High

140277

ERR2
Steroid hormone receptor ERR2

1

20

High-throughput

0.536

High

140280

TLE1
Transducin-like enhancer protein 1

1

20

Small-scale

0.536

High

140290

MBB1A
Myb-binding protein 1A

1

2

Small-scale

0.536

High

140293

KDM5B
Lysine-specific demethylase 5B

1

14

Small-scale

0.536

High

140297

SALL4
Sal-like protein 4

1

7

High-throughput

0.536

High

93752

ZN431
Zinc finger protein 431

1

1

Small-scale

0.534

High

140257

GSC
Homeobox protein goosecoid

1

5

Small-scale

0.534

High

140207

GFI1B
Zinc finger protein Gfi-1b

1

8

Small-scale

0.516

High

57753

ARI1A
AT-rich interactive domain-containing protein 1A

1

9

Small-scale

0.515

High

140219

DNMT1
DNA

1

8

Small-scale

0.515

High

140298

SKOR1
SKI family transcriptional corepressor 1

1

7

Small-scale

0.515

High

140232

CREM
cAMP-responsive element modulator

1

7

Small-scale

0.501

High

140249

H4
Histone H4

1

12

Small-scale

0.501

High

140258

MSX2
Homeobox protein MSX-2

1

6

Small-scale

0.501

High

140284

Q6P5E3
Sal-like 1

1

8

Small-scale

0.501

High

140314

KLF13
Krueppel-like factor 13

1

20

Small-scale

0.501

High

140206

PER2
Period circadian protein homolog 2

1

10

Small-scale

0.500

High

140213

P53
Cellular tumor antigen p53

1

7

Small-scale

0.500

High

140251

BACH1
Transcription regulator protein BACH1

1

20

Small-scale

0.500

High

140286

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

18

Small-scale

0.500

High

140304

HOP
Homeodomain-only protein

1

2

Small-scale

0.500

High

140205

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

12

Small-scale

0.484

High

140273

Q60I23
SRY

1

20

High-throughput

0.484

High

140272

RBBP7
Histone-binding protein RBBP7

1

20

High-throughput

0.481

High

56897

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

19

Small-scale

0.479

High

139901

MNT
Max-binding protein MNT

1

20

Small-scale

0.479

High

140200

BHE40
Class E basic helix-loop-helix protein 40

1

6

Small-scale

0.479

High

140202

DAXX
Death domain-associated protein 6

1

4

Small-scale

0.479

High

140204

CFLAR
CASP8 and FADD-like apoptosis regulator

1

6

Small-scale

0.479

High

140208

SP3
Transcription factor Sp3

1

20

Small-scale

0.479

High

140209

SAP30
Histone deacetylase complex subunit SAP30

1

7

Small-scale

0.479

High

140215

IL6
Interleukin-6

1

1

Small-scale

0.479

High

140216

JUNB
Transcription factor JunB

1

13

Small-scale

0.479

High

140220

IRF1
Interferon regulatory factor 1

1

5

Small-scale

0.479

High

140221

ASSY
Argininosuccinate synthase

1

2

Small-scale

0.479

High

140222

GATA1
Erythroid transcription factor

1

15

Small-scale

0.479

High

140223

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

6

Small-scale

0.479

High

140224

IFRD1
Interferon-related developmental regulator 1

1

2

Small-scale

0.479

High

140227

CXA1
Gap junction alpha-1 protein

1

2

Small-scale

0.479

High

140228

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.479

High

140229

CCND1
G1/S-specific cyclin-D1

1

6

Small-scale

0.479

High

140231

ETS1
Protein C-ets-1

1

7

Small-scale

0.479

High

140235

APEX1
DNA repair nuclease/redox regulator APEX1

1

4

Small-scale

0.479

High

140236

RXRA
Retinoic acid receptor RXR-alpha

1

20

Small-scale

0.479

High

140238

HES1
Transcription factor HES-1

1

6

Small-scale

0.479

High

140239

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.479

High

140240

STA5A
Signal transducer and activator of transcription 5A

1

10

Small-scale

0.479

High

140245

ATX1
Ataxin-1

1

1

High-throughput

0.479

High

140246

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

10

Small-scale

0.479

High

140247

MO4L1
Mortality factor 4-like protein 1

1

6

Small-scale

0.479

High

140248

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

9

High-throughput

0.479

High

140252

SMYD1
Histone-lysine N-methyltransferase Smyd1

1

4

Small-scale

0.479

High

140253

SMAD4
Mothers against decapentaplegic homolog 4

1

12

Small-scale

0.479

High

140255

JDP2
Jun dimerization protein 2

1

17

Small-scale

0.479

High

140260

RELB
Transcription factor RelB

1

20

Small-scale

0.479

High

140261

SMCA4
Transcription activator BRG1

1

20

Small-scale

0.479

High

140263

DDB1
DNA damage-binding protein 1

1

9

Small-scale

0.479

High

140264

Q3UM65
Runt-related transcription factor

1

10

Small-scale

0.479

High

140267

TET1
Methylcytosine dioxygenase TET1

1

4

Small-scale

0.479

High

140268

TET2
Methylcytosine dioxygenase TET2

1

4

Small-scale

0.479

High

140269

PHF12
PHD finger protein 12

1

20

Small-scale

0.479

High

140271

RBBP4
Histone-binding protein RBBP4

1

20

Small-scale

0.479

High

140275

CCNE1
G1/S-specific cyclin-E1

1

2

Small-scale

0.479

High

140279

SSXT
Protein SSXT

1

16

Small-scale

0.479

High

140281

TFE3
Transcription factor E3

1

10

High-throughput

0.479

High

140282

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

20

High-throughput

0.479

High

140285

XPO1
Exportin-1

1

7

Small-scale

0.479

High

140288

DACT2
Dapper homolog 2

1

4

Small-scale

0.479

High

140289

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

11

Small-scale

0.479

High

140292

FACD2
Fanconi anemia group D2 protein homolog

1

1

High-throughput

0.479

High

140295

Q8BPQ2
Kruppel-like transcription factor 6

1

20

Small-scale

0.479

High

140299

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.479

High

140305

DACT1
Dapper homolog 1

1

4

Small-scale

0.479

High

140309

TF7L2
Transcription factor 7-like 2

1

20

Small-scale

0.479

High

140311

HDAC9
Histone deacetylase 9

1

18

Small-scale

0.479

High

140312

BRMS1
Breast cancer metastasis-suppressor 1 homolog

1

9

Small-scale

0.479

High

140315

CUL3
Cullin-3

1

11

Small-scale

0.479

High

140316

CAF1A
Chromatin assembly factor 1 subunit A

1

7

High-throughput

0.479

High

140318

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

1

20

Small-scale

0.479

High

140320

KLF5
Krueppel-like factor 5

1

20

Small-scale

0.479

High

140321

TF7L1
Transcription factor 7-like 1

1

20

Small-scale

0.479

High

140262

CIART
Circadian-associated transcriptional repressor

1

0

Small-scale

0.458

High

140313

GON4L
GON-4-like protein

1

0

Small-scale

0.458

High

140319

GBP2
Guanylate-binding protein 2

1

0

Small-scale

0.458

High

140242

CENPC
Centromere protein C

1

6

High-throughput

0.445

High

140214

CFAD
Complement factor D

1

1

High-throughput

0.437

High

140237

KIF2A
Kinesin-like protein KIF2A

1

3

Small-scale

0.437

High

140300

Q8C5P6
C2H2-type domain-containing protein

1

14

Small-scale

0.437

High

140303

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.437

High


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Last updated: 15 Jul 2024