Protein: IMA7
Importin subunit alpha-7 (Karyopherin subunit alpha-6)

Gene: IMA7, KPNA6
Organism: Homo sapiens
Interactions: 147
UniProt ID: O60684

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006366 - transcription by RNA polymerase II
GO:0006606 - protein import into nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

238747

NUP50
Nuclear pore complex protein Nup50

7

20

High-throughput

0.971

High

238680

IMB1
Importin subunit beta-1

3

20

Small-scale

0.871

High

238650

IMA5
Importin subunit alpha-5

3

7

High-throughput

0.861

High

238622

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

6

12

High-throughput

0.730

High

195612

MCES
mRNA cap guanine-N7 methyltransferase

5

5

High-throughput

0.721

High

238654

RAC1
Ras-related C3 botulinum toxin substrate 1

1

8

High-throughput

0.698

High

238687

TAF9
Transcription initiation factor TFIID subunit 9

3

3

High-throughput

0.667

High

238630

LMNB1
Lamin-B1

3

12

High-throughput

0.665

High

238714

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

3

10

High-throughput

0.665

High

238629

PTN2
Tyrosine-protein phosphatase non-receptor type 2

3

2

High-throughput

0.656

High

238649

NU153
Nuclear pore complex protein Nup153

2

20

High-throughput

0.628

High

238671

HDAC1
Histone deacetylase 1

2

11

High-throughput

0.628

High

238731

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

2

11

High-throughput

0.628

High

238743

CHD8
Chromodomain-helicase-DNA-binding protein 8

2

20

High-throughput

0.628

High

238637

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

2

11

High-throughput

0.625

High

238669

SKP2
S-phase kinase-associated protein 2

2

3

Small-scale

0.624

High

238631

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

9

Small-scale

0.618

High

238644

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.618

High

238705

ARMC8
Armadillo repeat-containing protein 8

1

9

High-throughput

0.618

High

238668

G3BP1
Ras GTPase-activating protein-binding protein 1

2

5

High-throughput

0.611

High

238673

CUL3
Cullin-3

2

13

High-throughput

0.611

High

238736

XRN2
5'-3' exoribonuclease 2

2

1

High-throughput

0.611

High

238745

LYAR
Cell growth-regulating nucleolar protein

2

4

High-throughput

0.611

High

238744

KBTB4
Kelch repeat and BTB domain-containing protein 4

3

6

Small-scale

0.609

High

238656

PO6F2
POU domain, class 6, transcription factor 2

2

11

High-throughput

0.606

High

238718

KAT5
Histone acetyltransferase KAT5

2

7

High-throughput

0.606

High

238720

DCPS
m7GpppX diphosphatase

2

2

High-throughput

0.606

High

238723

P121A
Nuclear envelope pore membrane protein POM 121

2

16

High-throughput

0.606

High

238732

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

5

High-throughput

0.606

High

238741

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

2

7

High-throughput

0.606

High

238750

MAGD1
Melanoma-associated antigen D1

2

2

High-throughput

0.606

High

238688

HIF1A
Hypoxia-inducible factor 1-alpha

2

13

Small-scale

0.602

High

213990

SPOP
Speckle-type POZ protein

2

8

High-throughput

0.601

High

238651

NCBP2
Nuclear cap-binding protein subunit 2

2

5

High-throughput

0.601

High

238659

RELB
Transcription factor RelB

2

9

High-throughput

0.601

High

238663

NCBP1
Nuclear cap-binding protein subunit 1

2

5

High-throughput

0.601

High

238684

SURF2
Surfeit locus protein 2

2

0

High-throughput

0.585

High

226007

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

238638

CCNF
Cyclin-F

2

5

High-throughput

0.584

High

238679

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

20

Small-scale

0.584

High

238698

MEPCE
7SK snRNA methylphosphate capping enzyme

2

6

High-throughput

0.584

High

157692

GEMI2
Gem-associated protein 2

2

0

High-throughput

0.580

High

238708

SR1IP
Protein SREK1IP1

2

3

High-throughput

0.574

High

238642

NOP2
Probable 28S rRNA

1

1

High-throughput

0.573

High

238690

LARP7
La-related protein 7

2

7

Small-scale

0.571

High

238643

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

8

Small-scale

0.561

High

238658

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

Small-scale

0.561

High

238676

KEAP1
Kelch-like ECH-associated protein 1

1

3

Small-scale

0.561

High

238704

F90A1
Protein FAM90A1

2

2

High-throughput

0.553

High

238621

IL1A
Interleukin-1 alpha

1

0

High-throughput

0.549

High

238664

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

2

High-throughput

0.541

High

238674

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.541

High

133254

NOP56
Nucleolar protein 56

1

12

High-throughput

0.536

High

146776

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

2

High-throughput

0.536

High

175358

PPM1D
Protein phosphatase 1D

1

2

High-throughput

0.536

High

238628

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

238648

CLK3
Dual specificity protein kinase CLK3

1

9

High-throughput

0.536

High

238657

CBX1
Chromobox protein homolog 1

1

16

High-throughput

0.536

High

238662

RBBP4
Histone-binding protein RBBP4

1

10

High-throughput

0.536

High

238665

ILF3
Interleukin enhancer-binding factor 3

1

4

High-throughput

0.536

High

238666

CBX3
Chromobox protein homolog 3

1

16

High-throughput

0.536

High

238678

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

13

High-throughput

0.536

High

238683

NONO
Non-POU domain-containing octamer-binding protein

1

1

High-throughput

0.536

High

238686

RBBP7
Histone-binding protein RBBP7

1

10

High-throughput

0.536

High

238692

ALKB5
RNA demethylase ALKBH5

1

1

High-throughput

0.536

High

238700

TAD2B
Transcriptional adapter 2-beta

1

5

High-throughput

0.536

High

238706

KLHL7
Kelch-like protein 7

1

3

High-throughput

0.536

High

238712

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

238715

HDAC2
Histone deacetylase 2

1

12

High-throughput

0.536

High

238724

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.536

High

238730

RAMAC
RNA guanine-N7 methyltransferase activating subunit

1

1

High-throughput

0.536

High

238735

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

3

High-throughput

0.536

High

238737

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.536

High

238740

EAF6
Chromatin modification-related protein MEAF6

1

2

High-throughput

0.536

High

238742

SP110
Sp110 nuclear body protein

1

15

High-throughput

0.536

High

238749

NOP58
Nucleolar protein 58

1

12

High-throughput

0.536

High

238677

IRF3
Interferon regulatory factor 3

1

5

Small-scale

0.534

High

238617

JERKY
Jerky protein homolog

1

3

High-throughput

0.515

High

238697

CENPU
Centromere protein U

1

0

High-throughput

0.513

High

238711

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.513

High

174476

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

238633

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

14

Small-scale

0.501

High

238652

ZN131
Zinc finger protein 131

1

9

Small-scale

0.501

High

238716

CBP
CREB-binding protein

1

12

Small-scale

0.501

High

238729

EPAS1
Endothelial PAS domain-containing protein 1

1

13

Small-scale

0.501

High

238703

CACL1
CDK2-associated and cullin domain-containing protein 1

1

14

High-throughput

0.489

High

238693

ANR11
Ankyrin repeat domain-containing protein 11

1

9

High-throughput

0.481

High

126416

FOXE1
Forkhead box protein E1

1

5

High-throughput

0.479

High

176075

PPM1G
Protein phosphatase 1G

1

5

High-throughput

0.479

High

233092

NUPR1
Nuclear protein 1

1

4

High-throughput

0.479

High

238618

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

2

Small-scale

0.479

High

238619

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

238620

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

1

High-throughput

0.479

High

238623

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

238625

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

238626

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.479

High

238632

TNR6
Tumor necrosis factor receptor superfamily member 6

1

4

High-throughput

0.479

High

238634

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

238635

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

238636

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

4

High-throughput

0.479

High

238641

GATA4
Transcription factor GATA-4

1

3

High-throughput

0.479

High

238645

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

238646

CENPA
Histone H3-like centromeric protein A

1

7

High-throughput

0.479

High

238647

MCM2
DNA replication licensing factor MCM2

1

5

High-throughput

0.479

High

238653

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.479

High

238655

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.479

High

238660

TF65
Transcription factor p65

1

9

High-throughput

0.479

High

238661

CTSL2
CTD small phosphatase-like protein 2

1

4

Small-scale

0.479

High

238667

TIF1B
Transcription intermediary factor 1-beta

1

6

High-throughput

0.479

High

238670

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

238672

IRF5
Interferon regulatory factor 5

1

5

Small-scale

0.479

High

238681

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.479

High

238682

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

238689

CL16A
Protein CLEC16A

1

3

High-throughput

0.479

High

238695

BCOR
BCL-6 corepressor

1

9

Small-scale

0.479

High

238699

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

238702

NLRC5
Protein NLRC5

1

2

Small-scale

0.479

High

238707

SIR6
NAD-dependent protein deacylase sirtuin-6

1

7

High-throughput

0.479

High

238710

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

238713

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

238717

CSN5
COP9 signalosome complex subunit 5

1

5

High-throughput

0.479

High

238721

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

4

High-throughput

0.479

High

238722

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

7

High-throughput

0.479

High

238728

PHB2
Prohibitin-2

1

5

Small-scale

0.479

High

238733

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

238734

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

3

High-throughput

0.479

High

238746

ZRAN1
Ubiquitin thioesterase ZRANB1

1

15

High-throughput

0.479

High

238748

TRI33
E3 ubiquitin-protein ligase TRIM33

1

9

High-throughput

0.479

High

238751

NEMO
NF-kappa-B essential modulator

1

3

Small-scale

0.479

High

238752

X5D778
Ankyrin repeat domain 11 isoform A

1

9

High-throughput

0.470

High

238640

MTHR
Methylenetetrahydrofolate reductase

1

0

High-throughput

0.458

High

238701

MET16
RNA N6-adenosine-methyltransferase METTL16

1

0

High-throughput

0.458

High

238719

ARK2N
Protein ARK2N

1

0

High-throughput

0.458

High

238725

CAR19
Caspase recruitment domain-containing protein 19

1

0

Small-scale

0.458

High

238685

SF01
Splicing factor 1

1

5

High-throughput

0.457

High

238627

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

238639

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

3

Small-scale

0.445

High

238675

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

238691

NCBP3
Nuclear cap-binding protein subunit 3

1

2

High-throughput

0.445

High

238709

ZBT34
Zinc finger and BTB domain-containing protein 34

1

18

Small-scale

0.445

High

238726

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

1

High-throughput

0.445

High

238739

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

238624

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

238694

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

238696

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

238738

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

238727

VPS35
Vacuolar protein sorting-associated protein 35

1

0

Small-scale

0.426

High


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Last updated: 15 Jul 2024