Protein: NCOA2
Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2)

Gene: NCOA2
Organism: Homo sapiens
Interactions: 115
UniProt ID: Q15596

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001162 - RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369673

ESR1
Estrogen receptor

19

20

Small-scale

0.987

High

487467

ANDR
Androgen receptor

11

20

Small-scale

0.970

High

377346

GCR
Glucocorticoid receptor

7

20

Small-scale

0.953

High

587173

RXRA
Retinoic acid receptor RXR-alpha

5

20

Small-scale

0.922

High

487974

RARA
Retinoic acid receptor alpha

5

20

Small-scale

0.921

High

1075383

ESR2
Estrogen receptor beta

5

20

Small-scale

0.914

High

509955

VDR
Vitamin D3 receptor

5

20

Small-scale

0.911

High

740529

PPARG
Peroxisome proliferator-activated receptor gamma

6

20

Small-scale

0.906

High

1075384

CBP
CREB-binding protein

4

20

Small-scale

0.891

High

1075370

NCOA1
Nuclear receptor coactivator 1

4

20

Small-scale

0.867

High

1061324

NR1I3
Nuclear receptor subfamily 1 group I member 3

3

20

High-throughput

0.861

High

500487

THB
Thyroid hormone receptor beta

3

20

Small-scale

0.840

High

998745

EP300
Histone acetyltransferase p300

3

20

Small-scale

0.835

High

649117

ARNT
Aryl hydrocarbon receptor nuclear translocator

2

20

Small-scale

0.800

High

975430

PPARD
Peroxisome proliferator-activated receptor delta

2

20

Small-scale

0.778

High

992420

PPARA
Peroxisome proliferator-activated receptor alpha

2

20

Small-scale

0.778

High

500428

THA
Thyroid hormone receptor alpha

2

20

Small-scale

0.768

High

728922

AHR
Aryl hydrocarbon receptor

2

20

Small-scale

0.768

High

414507

PRGR
Progesterone receptor

2

20

Small-scale

0.754

High

1075403

NCOA3
Nuclear receptor coactivator 3

2

20

Small-scale

0.754

High

796225

MAGAA
Melanoma-associated antigen 10

4

12

High-throughput

0.699

High

130327

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

20

Small-scale

0.692

High

320207

ERR2
Steroid hormone receptor ERR2

1

20

Small-scale

0.647

High

510020

ERR1
Steroid hormone receptor ERR1

1

20

Small-scale

0.647

High

786485

STAT6
Signal transducer and activator of transcription 6

1

8

Small-scale

0.647

High

749527

BRCA1
Breast cancer type 1 susceptibility protein

3

12

Small-scale

0.639

High

796278

MAGAB
Melanoma-associated antigen 11

2

12

Small-scale

0.631

High

386797

P53
Cellular tumor antigen p53

2

8

High-throughput

0.624

High

265869

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

20

Small-scale

0.621

High

490101

COT1
COUP transcription factor 1

1

20

Small-scale

0.621

High

782551

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

Small-scale

0.621

High

611445

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

20

Small-scale

0.618

High

1028471

SLAP1
Src-like-adapter

2

7

High-throughput

0.612

High

1075379

CARM1
Histone-arginine methyltransferase CARM1

2

8

Small-scale

0.602

High

668710

PML
Protein PML

2

11

Small-scale

0.595

High

818079

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.584

High

1075399

KLF15
Krueppel-like factor 15

2

12

High-throughput

0.584

High

656117

PSB9
Proteasome subunit beta type-9

1

3

Small-scale

0.573

High

345443

FOS
Protein c-Fos

1

13

Small-scale

0.561

High

1075371

TAF9
Transcription initiation factor TFIID subunit 9

1

1

High-throughput

0.561

High

535849

MIF
Macrophage migration inhibitory factor

1

2

High-throughput

0.536

High

1029239

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

2

High-throughput

0.536

High

1075392

EGLN3
Prolyl hydroxylase EGLN3

1

14

High-throughput

0.536

High

1075396

FOXJ2
Forkhead box protein J2

1

14

High-throughput

0.536

High

883415

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.518

High

515441

CDK4
Cyclin-dependent kinase 4

1

6

Small-scale

0.501

High

673151

CCND3
G1/S-specific cyclin-D3

1

5

Small-scale

0.501

High

840435

ETV1
ETS translocation variant 1

1

20

Small-scale

0.501

High

917325

H4
Histone H4

1

7

Small-scale

0.501

High

987218

MEF2C
Myocyte-specific enhancer factor 2C

1

5

Small-scale

0.501

High

1023164

FLII
Protein flightless-1 homolog

1

1

Small-scale

0.501

High

1075373

H31T
Histone H3.1t

1

6

Small-scale

0.501

High

1075377

ANR11
Ankyrin repeat domain-containing protein 11

1

5

Small-scale

0.501

High

1075388

ANM1
Protein arginine N-methyltransferase 1

1

8

Small-scale

0.501

High

323776

BAG2
BAG family molecular chaperone regulator 2

1

4

High-throughput

0.489

High

259658

LIPA4
Liprin-alpha-4

1

5

Small-scale

0.481

High

799107

NKX21
Homeobox protein Nkx-2.1

1

20

Small-scale

0.481

High

1075393

TRXR2
Thioredoxin reductase 2, mitochondrial

1

1

Small-scale

0.481

High

1075402

EID1
EP300-interacting inhibitor of differentiation 1

1

0

Small-scale

0.480

High

171032

TBXT
T-box transcription factor T

1

7

High-throughput

0.479

High

197712

CRX
Cone-rod homeobox protein

1

18

High-throughput

0.479

High

211859

TLX3
T-cell leukemia homeobox protein 3

1

14

High-throughput

0.479

High

225746

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

236769

CCNT1
Cyclin-T1

1

2

Small-scale

0.479

High

240739

USO1
General vesicular transport factor p115

1

10

Small-scale

0.479

High

274351

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

9

Small-scale

0.479

High

304178

UBR5
E3 ubiquitin-protein ligase UBR5

1

8

Small-scale

0.479

High

316893

KLF8
Krueppel-like factor 8

1

14

High-throughput

0.479

High

318623

EYA4
Eyes absent homolog 4

1

6

High-throughput

0.479

High

505219

EGR2
E3 SUMO-protein ligase EGR2

1

4

High-throughput

0.479

High

507434

ERG
Transcriptional regulator ERG

1

19

High-throughput

0.479

High

552811

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

653268

PYR1
Multifunctional protein CAD

1

1

Small-scale

0.479

High

679109

TLX1
T-cell leukemia homeobox protein 1

1

15

High-throughput

0.479

High

717108

CTNB1
Catenin beta-1

1

20

Small-scale

0.479

High

727523

HNF1B
Hepatocyte nuclear factor 1-beta

1

19

High-throughput

0.479

High

727872

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

794543

ETV4
ETS translocation variant 4

1

20

High-throughput

0.479

High

831354

CEBPA
CCAAT/enhancer-binding protein alpha

1

14

High-throughput

0.479

High

871577

HSP72
Heat shock-related 70 kDa protein 2

1

8

Small-scale

0.479

High

878410

PAX9
Paired box protein Pax-9

1

15

High-throughput

0.479

High

881806

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.479

High

980757

TLE3
Transducin-like enhancer protein 3

1

16

High-throughput

0.479

High

988765

PAX8
Paired box protein Pax-8

1

15

High-throughput

0.479

High

1014130

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

7

High-throughput

0.479

High

1018226

NFIA
Nuclear factor 1 A-type

1

5

High-throughput

0.479

High

1025290

LIPA1
Liprin-alpha-1

1

9

Small-scale

0.479

High

1038118

ATR
Serine/threonine-protein kinase ATR

1

6

Small-scale

0.479

High

1046689

KLF5
Krueppel-like factor 5

1

14

High-throughput

0.479

High

1057760

NCOA6
Nuclear receptor coactivator 6

1

11

Small-scale

0.479

High

1075372

TBR1
T-box brain protein 1

1

7

High-throughput

0.479

High

1075374

TRXR1
Thioredoxin reductase 1, cytoplasmic

1

1

Small-scale

0.479

High

1075375

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

7

Small-scale

0.479

High

1075376

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

5

Small-scale

0.479

High

1075378

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1075380

NUP35
Nucleoporin NUP35

1

3

High-throughput

0.479

High

1075381

SP7
Transcription factor Sp7

1

14

High-throughput

0.479

High

1075382

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

High-throughput

0.479

High

1075385

LHX4
LIM/homeobox protein Lhx4

1

5

High-throughput

0.479

High

1075387

FEV
Protein FEV

1

19

High-throughput

0.479

High

1075389

SOX7
Transcription factor SOX-7

1

20

High-throughput

0.479

High

1075390

WWTR1
WW domain-containing transcription regulator protein 1

1

6

High-throughput

0.479

High

1075391

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

1075395

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

1075398

TBK1
Serine/threonine-protein kinase TBK1

1

6

Small-scale

0.479

High

1075401

MED23
Mediator of RNA polymerase II transcription subunit 23

1

2

High-throughput

0.479

High

1075386

TECT2
Tectonic-2

1

0

High-throughput

0.458

High

1075400

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.458

High

1075404

PIAS3
E3 SUMO-protein ligase PIAS3

1

7

Small-scale

0.445

High

994891

GOGA2
Golgin subfamily A member 2

1

10

High-throughput

0.437

High

1075394

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

13

High-throughput

0.437

High

217888

PRKY
Putative serine/threonine-protein kinase PRKY

1

3

High-throughput

0.407

High

799568

MMP13
Collagenase 3

1

0

Small-scale

0.249

Low

991250

NKG2E
NKG2-E type II integral membrane protein

1

0

Small-scale

0.249

Low

1075397

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024