Protein: TLR3
Toll-like receptor 3 (CD antigen CD283)

Gene: TLR3
Organism: Homo sapiens
Interactions: 66
UniProt ID: O15455

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001774 - microglial cell activation
GO:0002224 - toll-like receptor signaling pathway
GO:0002730 - regulation of dendritic cell cytokine production
GO:0003725 - double-stranded RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

191191

TLR3
Toll-like receptor 3

3

20

Small-scale

0.843

High

191193

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

20

Small-scale

0.789

High

191204

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

3

Small-scale

0.776

High

191215

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

20

Small-scale

0.754

High

191244

TBK1
Serine/threonine-protein kinase TBK1

2

6

Small-scale

0.754

High

191224

TCAM1
TIR domain-containing adapter molecule 1

7

8

Small-scale

0.739

High

191197

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

4

Small-scale

0.724

High

191196

CHK2
Serine/threonine-protein kinase Chk2

1

2

High-throughput

0.698

High

191207

BLK
Tyrosine-protein kinase Blk

1

13

High-throughput

0.691

High

191232

CNO6L
CCR4-NOT transcription complex subunit 6-like

1

20

High-throughput

0.691

High

191240

LRC40
Leucine-rich repeat-containing protein 40

1

20

High-throughput

0.691

High

191249

TRAF6
TNF receptor-associated factor 6

4

10

Small-scale

0.687

High

191192

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

20

Small-scale

0.665

High

191208

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

3

Small-scale

0.647

High

188582

SIGL5
Sialic acid-binding Ig-like lectin 5

1

20

Small-scale

0.618

High

191194

SIGL6
Sialic acid-binding Ig-like lectin 6

1

20

Small-scale

0.618

High

191198

CD14
Monocyte differentiation antigen CD14

1

10

Small-scale

0.618

High

191200

MBL2
Mannose-binding protein C

1

13

Small-scale

0.618

High

191201

SRC
Proto-oncogene tyrosine-protein kinase Src

1

13

Small-scale

0.618

High

191205

BASI
Basigin

1

20

High-throughput

0.618

High

191206

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

191222

TRIL
TLR4 interactor with leucine rich repeats

1

20

Small-scale

0.618

High

191231

SIG10
Sialic acid-binding Ig-like lectin 10

1

20

Small-scale

0.618

High

191233

SIG11
Sialic acid-binding Ig-like lectin 11

1

20

Small-scale

0.618

High

191246

SIGL7
Sialic acid-binding Ig-like lectin 7

1

20

Small-scale

0.618

High

191247

SIGL9
Sialic acid-binding Ig-like lectin 9

1

20

Small-scale

0.618

High

191199

IRF1
Interferon regulatory factor 1

2

13

Small-scale

0.601

High

49983

IRGM
Immunity-related GTPase family M protein

2

0

Small-scale

0.598

High

191239

UN93B
Protein unc-93 homolog B1

2

7

Small-scale

0.584

High

191219

CASP8
Caspase-8

2

0

Small-scale

0.559

High

191202

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

191230

RN170
E3 ubiquitin-protein ligase RNF170

1

0

Small-scale

0.537

High

191210

TRAF3
TNF receptor-associated factor 3

1

13

High-throughput

0.536

High

191228

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

9

High-throughput

0.536

High

191237

TOLIP
Toll-interacting protein

1

3

High-throughput

0.536

High

191209

IRF8
Interferon regulatory factor 8

1

13

Small-scale

0.515

High

191217

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

191227

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.513

High

191235

MYD88
Myeloid differentiation primary response protein MyD88

1

20

Small-scale

0.501

High

178106

NPC1
NPC intracellular cholesterol transporter 1

1

3

High-throughput

0.479

High

191195

TRIM3
Tripartite motif-containing protein 3

1

2

Small-scale

0.479

High

191203

IRF2
Interferon regulatory factor 2

1

13

Small-scale

0.479

High

191211

FADD
FAS-associated death domain protein

1

4

Small-scale

0.479

High

191212

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

Small-scale

0.479

High

191213

BIRC2
Baculoviral IAP repeat-containing protein 2

1

4

Small-scale

0.479

High

191216

SREC
Scavenger receptor class F member 1

1

3

Small-scale

0.479

High

191220

RBP1
RalA-binding protein 1

1

4

Small-scale

0.479

High

191221

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

191223

TRI69
E3 ubiquitin-protein ligase TRIM69

1

3

Small-scale

0.479

High

191225

WDFY1
WD repeat and FYVE domain-containing protein 1

1

4

Small-scale

0.479

High

191226

TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

1

4

Small-scale

0.479

High

191229

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

Small-scale

0.479

High

191234

NEUR1
Sialidase-1

1

3

Small-scale

0.479

High

191236

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

8

Small-scale

0.479

High

191238

SHRPN
Sharpin

1

2

Small-scale

0.479

High

191242

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

3

Small-scale

0.479

High

191243

KCND2
A-type voltage-gated potassium channel KCND2

1

3

Small-scale

0.479

High

191245

KCND3
A-type voltage-gated potassium channel KCND3

1

3

Small-scale

0.479

High

191250

RN115
E3 ubiquitin-protein ligase RNF115

1

5

Small-scale

0.479

High

191251

NEMO
NF-kappa-B essential modulator

1

6

Small-scale

0.479

High

191214

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

191248

TMED7
Transmembrane emp24 domain-containing protein 7

1

1

Small-scale

0.457

High

170561

CLGN
Calmegin

1

5

High-throughput

0.445

High

191241

RN216
E3 ubiquitin-protein ligase RNF216

1

6

Small-scale

0.439

High

191218

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025