Protein: GRK6
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)

Gene: GRK6
Organism: Homo sapiens
Interactions: 132
UniProt ID: P43250

Gene Ontology (top 5):
GO:0004703 - G protein-coupled receptor kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

428959

ADRB2
Beta-2 adrenergic receptor

3

9

Small-scale

0.861

High

686795

GP183
G-protein coupled receptor 183

3

13

High-throughput

0.861

High

437972

HS90B
Heat shock protein HSP 90-beta

3

20

Small-scale

0.855

High

431631

HS90A
Heat shock protein HSP 90-alpha

3

20

Small-scale

0.847

High

687020

GRK4
G protein-coupled receptor kinase 4

2

17

High-throughput

0.802

High

794389

DDB1
DNA damage-binding protein 1

2

7

High-throughput

0.789

High

794377

CD83
CD83 antigen

2

0

High-throughput

0.770

High

794444

CSEN
Calsenilin

1

6

Small-scale

0.747

High

118703

AIP
AH receptor-interacting protein

1

20

High-throughput

0.691

High

282844

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

8

High-throughput

0.691

High

636265

DNJB1
DnaJ homolog subfamily B member 1

1

13

High-throughput

0.691

High

714495

GRK5
G protein-coupled receptor kinase 5

1

16

High-throughput

0.691

High

794374

CDC42
Cell division control protein 42 homolog

1

13

High-throughput

0.691

High

794375

DCAF7
DDB1- and CUL4-associated factor 7

1

6

High-throughput

0.691

High

794379

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

20

High-throughput

0.691

High

794380

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

20

High-throughput

0.691

High

794384

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

20

High-throughput

0.691

High

794390

CDC37
Hsp90 co-chaperone Cdc37

1

13

High-throughput

0.691

High

794393

DCAF8
DDB1- and CUL4-associated factor 8

1

8

High-throughput

0.691

High

794401

DJC10
DnaJ homolog subfamily C member 10

1

1

High-throughput

0.691

High

794405

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

2

High-throughput

0.691

High

794411

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

11

High-throughput

0.691

High

794419

DNJC7
DnaJ homolog subfamily C member 7

1

12

High-throughput

0.691

High

794421

CLPB
Mitochondrial disaggregase

1

3

High-throughput

0.691

High

794368

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.656

High

600871

TA2R
Thromboxane A2 receptor

1

20

Small-scale

0.647

High

621341

FSHR
Follicle-stimulating hormone receptor

1

19

Small-scale

0.647

High

794364

GRK6
G protein-coupled receptor kinase 6

1

18

Small-scale

0.647

High

584341

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

9

High-throughput

0.628

High

794385

NOLC1
Nucleolar and coiled-body phosphoprotein 1

2

10

High-throughput

0.628

High

794396

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

2

5

High-throughput

0.628

High

71082

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

2

High-throughput

0.618

High

794371

RD23B
UV excision repair protein RAD23 homolog B

1

9

High-throughput

0.618

High

794383

RCN2
Reticulocalbin-2

1

3

High-throughput

0.618

High

794407

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

2

High-throughput

0.618

High

794436

AFF4
AF4/FMR2 family member 4

1

2

High-throughput

0.618

High

348561

RASN
GTPase NRas

1

8

High-throughput

0.618

High

349953

RASK
GTPase KRas

1

8

High-throughput

0.618

High

719796

RECO
Recoverin

1

6

Small-scale

0.618

High

794399

RHOU
Rho-related GTP-binding protein RhoU

1

13

High-throughput

0.618

High

794417

MMS19
MMS19 nucleotide excision repair protein homolog

2

1

High-throughput

0.611

High

794402

SMIP4
Sperm-associated microtubule inner protein 4

2

0

High-throughput

0.602

High

794412

MRAP2
Melanocortin-2 receptor accessory protein 2

2

0

High-throughput

0.602

High

794427

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.602

High

794413

DAA10
Dynein axonemal assembly factor 10

1

0

High-throughput

0.578

High

794391

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.575

High

611395

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

2

15

High-throughput

0.574

High

794382

NUCG
Endonuclease G, mitochondrial

2

2

High-throughput

0.574

High

443051

ITA5
Integrin alpha-5

1

4

High-throughput

0.541

High

123529

PGRC1
Membrane-associated progesterone receptor component 1

1

2

High-throughput

0.536

High

156001

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

2

High-throughput

0.536

High

162479

XPO1
Exportin-1

1

8

High-throughput

0.536

High

171586

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.536

High

295604

RMP
Unconventional prefoldin RPB5 interactor 1

1

1

High-throughput

0.536

High

323400

TTC4
Tetratricopeptide repeat protein 4

1

20

High-throughput

0.536

High

335064

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.536

High

393090

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

6

High-throughput

0.536

High

451860

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

1

High-throughput

0.536

High

571688

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

5

High-throughput

0.536

High

613946

TBG1
Tubulin gamma-1 chain

1

18

High-throughput

0.536

High

653186

PYR1
Multifunctional protein CAD

1

6

High-throughput

0.536

High

654145

CALX
Calnexin

1

2

High-throughput

0.536

High

672642

CD6
T-cell differentiation antigen CD6

1

1

High-throughput

0.536

High

794365

MAP1B
Microtubule-associated protein 1B

1

2

High-throughput

0.536

High

794369

PPP5
Serine/threonine-protein phosphatase 5

1

16

High-throughput

0.536

High

794372

XPO2
Exportin-2

1

6

High-throughput

0.536

High

794376

PRKDC
DNA-dependent protein kinase catalytic subunit

1

16

High-throughput

0.536

High

794378

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

5

High-throughput

0.536

High

794381

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

2

High-throughput

0.536

High

794404

RN149
E3 ubiquitin-protein ligase RNF149

1

5

High-throughput

0.536

High

794409

GCN1
Stalled ribosome sensor GCN1

1

14

High-throughput

0.536

High

794414

AIFM3
Apoptosis-inducing factor 3

1

2

High-throughput

0.536

High

794416

RUFY1
RUN and FYVE domain-containing protein 1

1

20

High-throughput

0.536

High

794418

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

2

High-throughput

0.536

High

794429

SDF2L
Stromal cell-derived factor 2-like protein 1

1

1

High-throughput

0.536

High

794430

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

12

High-throughput

0.536

High

794431

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.536

High

794434

VAPA
Vesicle-associated membrane protein-associated protein A

1

6

High-throughput

0.536

High

794437

STML2
Stomatin-like protein 2, mitochondrial

1

1

High-throughput

0.536

High

794439

AKP8L
A-kinase anchor protein 8-like

1

4

High-throughput

0.536

High

794440

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

8

High-throughput

0.536

High

794441

CHIP
E3 ubiquitin-protein ligase CHIP

1

9

High-throughput

0.536

High

794442

MAGD2
Melanoma-associated antigen D2

1

6

High-throughput

0.536

High

794443

NUDC
Nuclear migration protein nudC

1

2

High-throughput

0.536

High

794448

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

394285

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.515

High

50107

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.513

High

179154

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

726074

BASI
Basigin

1

0

High-throughput

0.513

High

740894

FDFT
Squalene synthase

1

0

High-throughput

0.513

High

794366

ATPO
ATP synthase subunit O, mitochondrial

1

0

High-throughput

0.513

High

794392

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

1

0

High-throughput

0.513

High

794394

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.513

High

794398

FBX38
F-box only protein 38

1

0

High-throughput

0.513

High

794406

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

0

High-throughput

0.513

High

794438

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.513

High

794447

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

282772

SYUG
Gamma-synuclein

1

15

Small-scale

0.501

High

742110

SYUA
Alpha-synuclein

1

15

Small-scale

0.501

High

794388

SYUB
Beta-synuclein

1

15

Small-scale

0.501

High

794446

FBX7
F-box only protein 7

1

4

High-throughput

0.501

High

118228

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.489

High

314256

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

3

High-throughput

0.489

High

794367

SERPH
Serpin H1

1

8

High-throughput

0.489

High

794370

LIPR2
Pancreatic lipase-related protein 2

1

1

High-throughput

0.489

High

794386

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.489

High

794400

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

10

High-throughput

0.489

High

794425

RPAP3
RNA polymerase II-associated protein 3

1

13

High-throughput

0.489

High

794428

CYBP
Calcyclin-binding protein

1

2

High-throughput

0.489

High

794433

HPBP1
Hsp70-binding protein 1

1

2

High-throughput

0.489

High

794435

DIC
Mitochondrial dicarboxylate carrier

1

11

High-throughput

0.489

High

794445

SGT1
Protein SGT1 homolog

1

10

High-throughput

0.489

High

794373

MLF1
Myeloid leukemia factor 1

1

5

High-throughput

0.479

High

794387

MLF2
Myeloid leukemia factor 2

1

5

High-throughput

0.479

High

794410

Q96BE0
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.479

High

794422

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

552148

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

650584

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

719887

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

794426

PACER
Protein associated with UVRAG as autophagy enhancer

2

0

High-throughput

0.328

High

304532

PRS23
Serine protease 23

1

0

High-throughput

0.282

High

583665

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.279

Low

794395

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.279

Low

794397

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.279

Low

794403

EIF1A
Probable RNA-binding protein EIF1AD

1

0

High-throughput

0.279

Low

794408

FACR1
Fatty acyl-CoA reductase 1

1

0

High-throughput

0.279

Low

794415

CC85A
Coiled-coil domain-containing protein 85A

1

0

High-throughput

0.279

Low

794420

METH
Methionine synthase

1

0

High-throughput

0.279

Low

794423

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.279

Low

794424

TRABD
TraB domain-containing protein

1

0

High-throughput

0.279

Low

794432

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024