Protein: TLR4
Toll-like receptor 4 (hToll) (CD antigen CD284)

Gene: TLR4
Organism: Homo sapiens
Interactions: 84
UniProt ID: O00206

Gene Ontology (top 5):
GO:0001530 - lipopolysaccharide binding
GO:0001540 - amyloid-beta binding
GO:0001726 - ruffle
GO:0001875 - lipopolysaccharide immune receptor activity
GO:0001891 - phagocytic cup

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

126350

LY96
Lymphocyte antigen 96

19

2

Small-scale

0.987

High

126268

TLR4
Toll-like receptor 4

5

17

Small-scale

0.901

High

126298

KSYK
Tyrosine-protein kinase SYK

3

20

Small-scale

0.827

High

126287

MBL2
Mannose-binding protein C

2

13

Small-scale

0.819

High

126338

IRAK4
Interleukin-1 receptor-associated kinase 4

2

20

Small-scale

0.789

High

126288

SRC
Proto-oncogene tyrosine-protein kinase Src

2

12

Small-scale

0.776

High

126315

SIGIR
Single Ig IL-1-related receptor

2

18

Small-scale

0.776

High

126301

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

12

3

Small-scale

0.761

High

126332

MYD88
Myeloid differentiation primary response protein MyD88

15

18

Small-scale

0.761

High

126296

SFTPD
Pulmonary surfactant-associated protein D

2

11

Small-scale

0.754

High

126299

IRAK1
Interleukin-1 receptor-associated kinase 1

2

20

Small-scale

0.754

High

126319

TCAM2
TIR domain-containing adapter molecule 2

8

8

Small-scale

0.747

High

126320

TCAM1
TIR domain-containing adapter molecule 1

4

8

Small-scale

0.683

High

126271

SIGL5
Sialic acid-binding Ig-like lectin 5

1

20

Small-scale

0.681

High

126273

SIGL6
Sialic acid-binding Ig-like lectin 6

1

20

Small-scale

0.681

High

126346

SIGL9
Sialic acid-binding Ig-like lectin 9

1

20

Small-scale

0.681

High

126277

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.665

High

126313

TLR1
Toll-like receptor 1

1

17

Small-scale

0.665

High

126308

BTK
Tyrosine-protein kinase BTK

1

18

Small-scale

0.656

High

126293

PGS1
Biglycan

1

20

Small-scale

0.647

High

126330

SIG11
Sialic acid-binding Ig-like lectin 11

1

20

Small-scale

0.647

High

126344

SIGL7
Sialic acid-binding Ig-like lectin 7

1

20

Small-scale

0.647

High

126345

TLR6
Toll-like receptor 6

1

18

Small-scale

0.646

High

126334

TOLIP
Toll-interacting protein

2

3

Small-scale

0.634

High

126272

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

20

Small-scale

0.618

High

126275

TLR5
Toll-like receptor 5

1

16

Small-scale

0.618

High

126276

LY86
Lymphocyte antigen 86

1

4

Small-scale

0.618

High

126282

PGS2
Decorin

1

20

Small-scale

0.618

High

126283

CD14
Monocyte differentiation antigen CD14

1

10

Small-scale

0.618

High

126303

RAB1A
Ras-related protein Rab-1A

1

3

Small-scale

0.618

High

126307

KPCZ
Protein kinase C zeta type

1

11

Small-scale

0.618

High

126317

TRIL
TLR4 interactor with leucine rich repeats

1

19

Small-scale

0.618

High

126335

TREM1
Triggering receptor expressed on myeloid cells 1

1

1

Small-scale

0.618

High

126339

TBK1
Serine/threonine-protein kinase TBK1

1

7

Small-scale

0.618

High

126310

TRAF3
TNF receptor-associated factor 3

2

17

Small-scale

0.611

High

126323

SFTA1
Pulmonary surfactant-associated protein A1

1

11

Small-scale

0.595

High

126336

NOX4
NADPH oxidase 4

2

1

Small-scale

0.591

High

126302

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

0

Small-scale

0.586

High

126333

CNPY3
Protein canopy homolog 3

2

14

Small-scale

0.584

High

126348

TRAF6
TNF receptor-associated factor 6

2

14

Small-scale

0.584

High

126284

HMGB1
High mobility group protein B1

2

6

Small-scale

0.571

High

126322

SFPA2
Pulmonary surfactant-associated protein A2

1

12

Small-scale

0.553

High

126337

RN216
E3 ubiquitin-protein ligase RNF216

2

6

Small-scale

0.548

High

126347

TMED7
Transmembrane emp24 domain-containing protein 7

2

1

Small-scale

0.544

High

126290

CD36
Platelet glycoprotein 4

1

1

Small-scale

0.536

High

126324

S11IP
Serine/threonine-protein kinase 11-interacting protein

1

19

High-throughput

0.536

High

126341

UBQL1
Ubiquilin-1

1

1

Small-scale

0.508

High

126269

FCN1
Ficolin-1

1

5

Small-scale

0.501

High

126278

FIBG
Fibrinogen gamma chain

1

5

Small-scale

0.501

High

126279

FINC
Fibronectin

1

7

Small-scale

0.501

High

126294

TENA
Tenascin

1

9

Small-scale

0.501

High

126325

TENR
Tenascin-R

1

7

Small-scale

0.501

High

126343

TENN
Tenascin-N

1

8

Small-scale

0.501

High

126304

SMAD3
Mothers against decapentaplegic homolog 3

1

1

High-throughput

0.481

High

126270

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

3

Small-scale

0.479

High

126281

P53
Cellular tumor antigen p53

1

6

Small-scale

0.479

High

126286

HSP7C
Heat shock cognate 71 kDa protein

1

8

Small-scale

0.479

High

126289

ENPL
Endoplasmin

1

5

Small-scale

0.479

High

126291

SPI1
Transcription factor PU.1

1

5

Small-scale

0.479

High

126300

PAR2
Proteinase-activated receptor 2

1

1

Small-scale

0.479

High

126305

IRF8
Interferon regulatory factor 8

1

14

Small-scale

0.479

High

126306

CAV1
Caveolin-1

1

1

Small-scale

0.479

High

126309

HSP7E
Heat shock 70 kDa protein 14

1

8

Small-scale

0.479

High

126311

CUL4A
Cullin-4A

1

2

High-throughput

0.479

High

126312

IRF4
Interferon regulatory factor 4

1

14

Small-scale

0.479

High

126316

BCAP
Phosphoinositide 3-kinase adapter protein 1

1

1

Small-scale

0.479

High

126318

TRI69
E3 ubiquitin-protein ligase TRIM69

1

6

Small-scale

0.479

High

126327

PAQR1
Adiponectin receptor protein 1

1

6

Small-scale

0.479

High

126328

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

2

Small-scale

0.479

High

126329

TRI44
Tripartite motif-containing protein 44

1

4

Small-scale

0.479

High

126331

NEUR1
Sialidase-1

1

3

Small-scale

0.479

High

126342

CHIP
E3 ubiquitin-protein ligase CHIP

1

7

Small-scale

0.479

High

126349

RN115
E3 ubiquitin-protein ligase RNF115

1

5

Small-scale

0.479

High

126340

SRTD1
SERTA domain-containing protein 1

1

0

High-throughput

0.460

High

126274

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

Small-scale

0.458

High

126297

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

0

Small-scale

0.458

High

126314

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.458

High

126285

CH60
60 kDa heat shock protein, mitochondrial

1

6

Small-scale

0.445

High

126280

FETUA
Alpha-2-HS-glycoprotein

1

2

Small-scale

0.437

High

126295

HSP74
Heat shock 70 kDa protein 4

1

10

Small-scale

0.437

High

126326

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

1

Small-scale

0.437

High

126292

MAL
Myelin and lymphocyte protein

1

0

Small-scale

0.249

Low

126321

MFN1
Mitofusin-1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025