Protein: MPK1
Mitogen-activated protein kinase mpk-1 (EC 2.7.11.24) (MAP kinase sur-1)

Gene: MPK1, mpk-1
Organism: Caenorhabditis elegans
Interactions: 92
UniProt ID: P39745

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001556 - oocyte maturation
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

814434

MEK2
Dual specificity mitogen-activated protein kinase kinase mek-2

4

20

Small-scale

0.889

High

814441

UNC98
Zinc finger protein unc-98

3

1

High-throughput

0.862

High

110755

G5ECD7
cGMP-dependent protein kinase interacting domain-containing protein

3

5

High-throughput

0.847

High

264249

KCC2D
Calcium/calmodulin-dependent protein kinase type II

3

10

High-throughput

0.847

High

814476

DHYS
Deoxyhypusine synthase

2

3

High-throughput

0.791

High

814442

Q19467
Arf-GAP domain-containing protein

3

7

High-throughput

0.757

High

814465

DNJ10
DnaJ homolog dnj-10

2

8

High-throughput

0.743

High

814433

MLRH
Myosin regulatory light chain

1

5

High-throughput

0.698

High

814457

KS6A1
Putative ribosomal protein S6 kinase alpha-1

1

20

High-throughput

0.698

High

814436

SPDL1
Spindly-like protein spdl-1

5

0

High-throughput

0.682

High

814432

NHR69
Nuclear hormone receptor family member nhr-69

3

13

High-throughput

0.668

High

814439

Q18318
RRM domain-containing protein

2

7

High-throughput

0.665

High

112467

NFYA1
Nuclear transcription factor Y subunit nfya-1

3

9

High-throughput

0.656

High

195318

FIGL1
Fidgetin-like protein 1

3

4

High-throughput

0.656

High

814428

IFA1
Intermediate filament protein ifa-1

3

3

High-throughput

0.656

High

814450

IFC2
Intermediate filament protein ifc-2

3

7

High-throughput

0.656

High

814435

GLD1
Female germline-specific tumor suppressor gld-1

3

1

Small-scale

0.651

High

115831

GCK1
Germinal center kinase 1

1

9

Small-scale

0.647

High

814472

GSK3
Glycogen synthase kinase-3

1

14

Small-scale

0.647

High

116150

H2L2C3
Rap-GAP domain-containing protein

3

4

High-throughput

0.639

High

759259

ESS2
Splicing factor ESS-2

3

0

High-throughput

0.628

High

814445

HUTH1
Histidine ammonia-lyase

3

0

High-throughput

0.628

High

814440

RSP6
Probable splicing factor, arginine/serine-rich 6

1

7

High-throughput

0.621

High

758691

PLK1
Serine/threonine-protein kinase plk-1

1

17

High-throughput

0.618

High

814466

MBK1
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1

1

18

High-throughput

0.618

High

86645

B9WRT8
C3H1-type domain-containing protein

4

1

Small-scale

0.617

High

814463

Q86G90
Nuclear Pore complex Protein

2

5

High-throughput

0.613

High

115295

H2KYX3
FERM domain-containing protein

3

4

High-throughput

0.599

High

145920

IFA2
Intermediate filament protein ifa-2

3

3

High-throughput

0.599

High

145872

O02289
C3H1-type domain-containing protein

2

1

High-throughput

0.596

High

145690

O02174
C3H1-type domain-containing protein

2

1

High-throughput

0.595

High

626040

VINC
Vinculin

2

0

High-throughput

0.587

High

814462

Q5FC73
Uncharacterized protein

3

1

High-throughput

0.583

High

814443

SAS5
Spindle assembly abnormal protein 5

2

0

High-throughput

0.551

High

814464

GLS1
Germline survival defective-1

2

0

High-throughput

0.551

High

233650

NHR64
Nuclear hormone receptor family member nhr-64

1

13

High-throughput

0.541

High

814429

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.541

High

814454

LMN1
Lamin-1

2

3

High-throughput

0.526

High

814461

Q23463
Tr-type G domain-containing protein

2

5

High-throughput

0.526

High

264138

O62216
Regulator of microtubule dynamics protein 1

1

0

High-throughput

0.518

High

814458

Q21829
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.518

High

814460

YGH1
Uncharacterized protein T27F2.1

1

0

High-throughput

0.518

High

145185

CPB3
Cytoplasmic polyadenylation element-binding protein 3

1

0

Small-scale

0.504

High

196714

O18056
RNA helicase

1

6

Small-scale

0.501

High

814467

PPME1
Probable protein phosphatase methylesterase 1

1

1

High-throughput

0.494

High

814468

Q9N3Y1
PDZ GRASP-type domain-containing protein

1

6

High-throughput

0.494

High

111790

G5EDL0
ETS domain-containing protein

1

18

Small-scale

0.481

High

113247

G5EFG1
PDZ and LIM domain protein Zasp

1

6

High-throughput

0.481

High

233936

NH111
Nuclear hormone receptor family member nhr-111

1

14

High-throughput

0.481

High

760179

SKN1
Protein skinhead-1

1

0

Small-scale

0.480

High

113714

BRC2
DNA repair protein brc-2

1

0

High-throughput

0.460

High

264355

O62486
Nanos-type domain-containing protein

1

0

Small-scale

0.460

High

814446

CEP1
Transcription factor cep-1

1

0

Small-scale

0.460

High

303813

O76388
Biogenesis of lysosome-related organelles complex 1 subunit 1

1

0

Small-scale

0.458

High

814470

Q9TXM1
Uncharacterized protein

1

0

High-throughput

0.458

High

110233

G5EBY5
Rap-GAP domain-containing protein

1

4

High-throughput

0.457

High

111530

KLHL8
Kelch-like protein 8

1

2

High-throughput

0.457

High

115496

H2KZI3
C3H1-type domain-containing protein

1

1

High-throughput

0.457

High

814449

Q21021
Nuclear Pore complex Protein

1

5

High-throughput

0.457

High

814459

MIG5
Segment polarity protein dishevelled homolog mig-5

1

8

High-throughput

0.457

High

113863

G5EGG0
Uso1_p115_head domain-containing protein

1

1

High-throughput

0.439

High

116182

H2L2C8
Alpha-actinin, sarcomeric

1

7

High-throughput

0.439

High

195440

O16369
AP complex subunit sigma

1

2

High-throughput

0.439

High

814427

P90848
FAS1 domain-containing protein

1

3

High-throughput

0.439

High

814437

Q17746
ZZ-type domain-containing protein

1

6

High-throughput

0.439

High

814447

Q20771
Uncharacterized protein

1

1

High-throughput

0.417

High

814474

Q9XVU8
Alpha-actinin, sarcomeric

1

7

High-throughput

0.417

High

814452

Q21229
Uncharacterized protein

3

0

High-throughput

0.348

High

814473

Q9XUF2
Coiled-coil domain-containing protein 176

3

0

High-throughput

0.348

High

231920

O44150
MATH

3

0

High-throughput

0.342

High

759212

YLU3
Uncharacterized protein F10E9.3

3

0

High-throughput

0.342

High

814444

Q20330
Intermediate Filament Organize

3

0

High-throughput

0.342

High

814453

Q21234
Integrase zinc-binding domain-containing protein

3

0

High-throughput

0.342

High

90497

C0Z1Y1
MKRN2 opposite strand protein-like C-terminal domain-containing protein

3

0

High-throughput

0.333

High

814431

LST1
Lateral signaling target 1 protein

3

0

High-throughput

0.331

High

115226

PICC1
PAC-1 interacting and coiled-coil domain-containing protein 1

2

0

High-throughput

0.319

High

814456

Q21648

2

0

High-throughput

0.319

High

196893

O18246
PRKCA-binding protein

2

0

High-throughput

0.300

High

195954

O17109
Methyltransf_11 domain-containing protein

1

0

High-throughput

0.282

High

814430

P91249
Nematode cuticle collagen N-terminal domain-containing protein

1

0

High-throughput

0.282

High

814448

GCDH
Probable glutaryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.282

High

198242

O18687
Cytochrome c oxidase polypeptide VIIc

1

0

High-throughput

0.257

Low

115747

H2L025
RNA-directed RNA polymerase

1

0

High-throughput

0.251

Low

116719

I2HA96
Cat eye syndrome critical region protein 5

1

0

High-throughput

0.251

Low

263909

O61900
THUMP domain-containing protein

1

0

High-throughput

0.251

Low

814438

YTE4
Uncharacterized protein C09G1.4

1

0

High-throughput

0.251

Low

814451

Q21088
GEX Interacting protein

1

0

High-throughput

0.251

Low

814455

Q21462
WW domain-containing protein

1

0

High-throughput

0.251

Low

814469

Q9N582
RanBP2-type domain-containing protein

1

0

High-throughput

0.251

Low

814471

Q9U211
EB domain-containing protein

1

0

High-throughput

0.251

Low

814477

Q9XXU2
Uncharacterized protein

1

0

High-throughput

0.251

Low

814475

FLH1
FLYWCH transcription factor 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025