Protein: ERF3
Eukaryotic peptide chain release factor GTP-binding subunit (EC 3.6.5.-) (ERF-3) (ERF3) (ERF2) (G1 to S phase transition protein 1) (Omnipotent suppressor protein 2) (PSI no more protein 2) (Polypeptide release factor 3) (Translation release factor 3)

Gene: ERF3, SUP35
Organism: Saccharomyces cerevisiae S288C
Interactions: 245
UniProt ID: P05453

Gene Ontology (top 5):
GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0003729 - mRNA binding
GO:0003747 - translation release factor activity
GO:0003924 - GTPase activity
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

402829

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

37

11

Small-scale

0.995

High

402857

ERF1
Eukaryotic peptide chain release factor subunit 1

19

3

Small-scale

0.989

High

367590

EF1A
Elongation factor 1-alpha

3

9

Small-scale

0.817

High

402843

IF2B
Eukaryotic translation initiation factor 2 subunit beta

2

1

High-throughput

0.802

High

402906

EF2
Elongation factor 2

2

6

Small-scale

0.757

High

402903

HS104
Heat shock protein 104

11

3

Small-scale

0.756

High

402852

HSP71
Heat shock protein SSA1

10

6

Small-scale

0.752

High

376568

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

7

9

Small-scale

0.746

High

402886

SIS1
Protein SIS1

6

5

Small-scale

0.723

High

402901

RENT1
ATP-dependent helicase NAM7

5

7

Small-scale

0.714

High

402856

SSB1
Ribosome-associated molecular chaperone SSB1

4

6

Small-scale

0.686

High

402889

MAS5
Mitochondrial protein import protein MAS5

4

6

Small-scale

0.680

High

402865

HSC82
ATP-dependent molecular chaperone HSC82

4

7

Small-scale

0.678

High

402964

SSB2
Ribosome-associated molecular chaperone SSB2

4

6

Small-scale

0.666

High

402887

RNQ1
[PIN+] prion protein RNQ1

3

0

Small-scale

0.639

High

402833

RS3
Small ribosomal subunit protein uS3

3

3

Small-scale

0.633

High

402853

HSP72
Heat shock protein SSA2

3

6

Small-scale

0.633

High

402913

HSP7F
Heat shock protein homolog SSE1

3

8

Small-scale

0.633

High

403014

NAB6
RNA-binding protein NAB6

2

1

High-throughput

0.621

High

403048

RM23
Large ribosomal subunit protein uL13m

2

4

High-throughput

0.621

High

403055

VPS5
Vacuolar protein sorting-associated protein 5

2

2

High-throughput

0.621

High

402963

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

1

Small-scale

0.618

High

334857

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

2

3

Small-scale

0.601

High

402918

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

2

3

Small-scale

0.595

High

402943

MIP6
RNA-binding protein MIP6

2

11

High-throughput

0.588

High

402950

NAB3
Nuclear polyadenylated RNA-binding protein 3

2

2

High-throughput

0.588

High

402994

NRD1
Protein NRD1

2

1

High-throughput

0.588

High

402849

RS6A
Small ribosomal subunit protein eS6A

2

3

Small-scale

0.584

High

402934

GBLP
Small ribosomal subunit protein RACK1

2

5

Small-scale

0.584

High

402940

RS20
Small ribosomal subunit protein uS10

2

4

Small-scale

0.584

High

402941

YHI0
Putative proline--tRNA ligase YHR020W

2

1

Small-scale

0.584

High

402974

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

12

High-throughput

0.584

High

403011

RLI1
Translation initiation factor RLI1

2

4

Small-scale

0.584

High

402993

LSB1
LAS seventeen-binding protein 1

2

4

Small-scale

0.584

High

403027

PIN3
[PSI+] inducibility protein 3

2

4

Small-scale

0.584

High

399244

RLA0
Large ribosomal subunit protein uL10

1

4

High-throughput

0.575

High

365530

HSP82
ATP-dependent molecular chaperone HSP82

2

7

High-throughput

0.571

High

402832

RL26A
Large ribosomal subunit protein uL24A

2

4

High-throughput

0.571

High

402855

RL4A
Large ribosomal subunit protein uL4A

2

2

Small-scale

0.571

High

402871

VATB
V-type proton ATPase subunit B

2

2

Small-scale

0.571

High

402922

HSP78
Heat shock protein 78, mitochondrial

2

4

Small-scale

0.571

High

402924

RS3A1
Small ribosomal subunit protein eS1A

2

4

High-throughput

0.571

High

342804

ENO2
Enolase 2

2

0

Small-scale

0.561

High

402912

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

14

Small-scale

0.561

High

402945

NMD2
Nonsense-mediated mRNA decay protein 2

1

1

Small-scale

0.561

High

403024

EIF3J
Eukaryotic translation initiation factor 3 subunit J

2

0

Small-scale

0.559

High

402933

LONM
Lon protease homolog, mitochondrial

1

7

Small-scale

0.553

High

403041

SGT2
Small glutamine-rich tetratricopeptide repeat-containing protein 2

1

6

Small-scale

0.552

High

402982

UPF3
Nonsense-mediated mRNA decay protein 3

1

0

Small-scale

0.537

High

402893

RL16B
Large ribosomal subunit protein uL13B

1

4

High-throughput

0.536

High

402902

XPO1
Exportin-1

1

8

High-throughput

0.536

High

402997

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

403006

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

5

High-throughput

0.536

High

403013

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.536

High

402908

ARP2
Actin-related protein 2

2

3

Small-scale

0.535

High

402921

SLA2
Protein SLA2

2

1

Small-scale

0.535

High

402980

ARP3
Actin-related protein 3

2

3

Small-scale

0.535

High

403043

GLE1
mRNA export factor GLE1

1

4

Small-scale

0.534

High

403002

ACT
Actin

2

2

Small-scale

0.533

High

402953

TCPZ
T-complex protein 1 subunit zeta

2

2

High-throughput

0.521

High

402915

RAD23
UV excision repair protein RAD23

1

7

High-throughput

0.515

High

402975

RS10B
Small ribosomal subunit protein eS10B

1

3

High-throughput

0.515

High

403052

DCP1
mRNA-decapping enzyme subunit 1

1

1

Small-scale

0.515

High

402835

KAPA
cAMP-dependent protein kinase type 1

1

7

Small-scale

0.501

High

402870

HSP26
Heat shock protein 26

1

3

Small-scale

0.501

High

403022

ITT1
E3 ubiquitin-protein ligase ITT1

1

8

Small-scale

0.501

High

403044

HSP42
Heat shock protein 42

1

3

Small-scale

0.501

High

402860

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.493

High

402884

VPS3
Vacuolar protein sorting-associated protein 3

1

0

High-throughput

0.493

High

402935

AHP1
Peroxiredoxin AHP1

1

0

High-throughput

0.493

High

403019

TYW2
tRNA wybutosine-synthesizing protein 2

1

0

High-throughput

0.493

High

403035

PLB3
Lysophospholipase 3

1

0

High-throughput

0.493

High

403045

SCM3
Protein SCM3

1

0

High-throughput

0.493

High

402928

SPT7
Transcriptional activator SPT7

1

7

High-throughput

0.489

High

402951

END3
Actin cytoskeleton-regulatory complex protein END3

1

1

Small-scale

0.481

High

141033

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

333653

ADH1
Alcohol dehydrogenase 1

1

1

Small-scale

0.479

High

334398

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

3

Small-scale

0.479

High

339950

KPYK1
Pyruvate kinase 1

1

2

Small-scale

0.479

High

341071

CBPY
Carboxypeptidase Y

1

1

Small-scale

0.479

High

357760

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.479

High

360681

TBB
Tubulin beta chain

1

1

Small-scale

0.479

High

382831

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.479

High

393495

PMA1
Plasma membrane ATPase 1

1

2

Small-scale

0.479

High

402831

RL6B
Large ribosomal subunit protein eL6B

1

3

Small-scale

0.479

High

402834

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

402836

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

402838

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

Small-scale

0.479

High

402839

PYR1
Multifunctional protein URA2

1

2

Small-scale

0.479

High

402840

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.479

High

402842

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

3

Small-scale

0.479

High

402845

TBA1
Tubulin alpha-1 chain

1

2

Small-scale

0.479

High

402846

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

402847

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.479

High

402848

HSP77
Import motor subunit, mitochondrial

1

6

Small-scale

0.479

High

402850

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.479

High

402851

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

402861

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

402863

RL3
Large ribosomal subunit protein uL3

1

2

Small-scale

0.479

High

402867

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

3

Small-scale

0.479

High

402868

STI1
Heat shock protein STI1

1

7

Small-scale

0.479

High

402869

ABP1
Actin-binding protein

1

1

Small-scale

0.479

High

402872

BIP
Endoplasmic reticulum chaperone BiP

1

3

Small-scale

0.479

High

402873

EF3A
Elongation factor 3A

1

8

Small-scale

0.479

High

402875

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

2

Small-scale

0.479

High

402876

VATA
V-type proton ATPase catalytic subunit A

1

4

Small-scale

0.479

High

402879

DDR48
Stress protein DDR48

1

1

Small-scale

0.479

High

402882

HSP74
Heat shock protein SSA4

1

6

Small-scale

0.479

High

402885

CG22
G2/mitotic-specific cyclin-2

1

1

Small-scale

0.479

High

402888

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

402891

CDC48
Cell division control protein 48

1

6

Small-scale

0.479

High

402892

RL16A
Large ribosomal subunit protein uL13A

1

4

High-throughput

0.479

High

402894

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

402895

SPT5
Transcription elongation factor SPT5

1

3

Small-scale

0.479

High

402897

URA7
CTP synthase 1

1

3

Small-scale

0.479

High

402899

BMH1
Protein BMH1

1

6

High-throughput

0.479

High

402909

HOG1
Mitogen-activated protein kinase HOG1

1

8

High-throughput

0.479

High

402910

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

4

Small-scale

0.479

High

402914

FIMB
Fimbrin

1

2

Small-scale

0.479

High

402916

ECM32
Putative ATP-dependent RNA helicase ECM32

1

7

Small-scale

0.479

High

402919

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.479

High

402920

UFD4
Ubiquitin fusion degradation protein 4

1

10

Small-scale

0.479

High

402925

GCN1
eIF-2-alpha kinase activator GCN1

1

9

Small-scale

0.479

High

402929

DEF1
RNA polymerase II degradation factor 1

1

5

High-throughput

0.479

High

402930

RS27A
Small ribosomal subunit protein eS27A

1

4

High-throughput

0.479

High

402932

SA190
SIT4-associating protein SAP190

1

3

Small-scale

0.479

High

402937

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

3

Small-scale

0.479

High

402944

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.479

High

402946

RPN10
26S proteasome regulatory subunit RPN10

1

2

High-throughput

0.479

High

402955

DHH1
ATP-dependent RNA helicase DHH1

1

6

High-throughput

0.479

High

402957

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

402960

ARB1
ABC transporter ATP-binding protein ARB1

1

5

High-throughput

0.479

High

402962

IMB4
Importin subunit beta-4

1

5

Small-scale

0.479

High

402965

RL13B
Large ribosomal subunit protein eL13B

1

2

Small-scale

0.479

High

402966

TM108
Protein TMA108

1

1

High-throughput

0.479

High

402968

SA185
SIT4-associating protein SAP185

1

3

Small-scale

0.479

High

402969

ARF3
ADP-ribosylation factor 3

1

5

High-throughput

0.479

High

402979

TCPQ
T-complex protein 1 subunit theta

1

3

Small-scale

0.479

High

402981

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

3

Small-scale

0.479

High

402983

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

402989

AIF1
Apoptosis-inducing factor 1

1

2

Small-scale

0.479

High

402990

MCM6
DNA replication licensing factor MCM6

1

6

Small-scale

0.479

High

402991

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

2

Small-scale

0.479

High

402999

NST1
Stress response protein NST1

1

2

High-throughput

0.479

High

403000

APJ1
J domain-containing protein APJ1

1

7

High-throughput

0.479

High

403005

ACAC
Acetyl-CoA carboxylase

1

4

Small-scale

0.479

High

403007

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

403008

RL21A
Large ribosomal subunit protein eL21A

1

1

Small-scale

0.479

High

403009

UTP17
NET1-associated nuclear protein 1

1

3

Small-scale

0.479

High

403010

KA120
Importin beta-like protein KAP120

1

8

High-throughput

0.479

High

403012

TOM1
E3 ubiquitin-protein ligase TOM1

1

5

High-throughput

0.479

High

403015

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

403016

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

403017

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

10

Small-scale

0.479

High

403020

PUF6
Pumilio homology domain family member 6

1

6

Small-scale

0.479

High

403023

RRP5
rRNA biogenesis protein RRP5

1

2

Small-scale

0.479

High

403028

NAT3
N-terminal acetyltransferase B complex catalytic subunit NAT3

1

5

High-throughput

0.479

High

403036

SGO1
Shugoshin

1

1

High-throughput

0.479

High

403037

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.479

High

403046

NOP56
Nucleolar protein 56

1

3

Small-scale

0.479

High

403050

NOP58
Nucleolar protein 58

1

3

Small-scale

0.479

High

403051

CMR1
DNA damage-binding protein CMR1

1

4

High-throughput

0.479

High

403004

REG1
Resistance to glucose repression protein 1

1

0

Small-scale

0.460

High

402837

FAS1
Fatty acid synthase subunit beta

1

0

Small-scale

0.458

High

402854

METK1
S-adenosylmethionine synthase 1

1

0

Small-scale

0.458

High

402864

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

Small-scale

0.458

High

402880

FAS2
Fatty acid synthase subunit alpha

1

0

Small-scale

0.458

High

402881

HSP60
Heat shock protein 60, mitochondrial

1

0

Small-scale

0.458

High

402896

PYRD
Dihydroorotate dehydrogenase

1

0

Small-scale

0.458

High

402917

MCES
mRNA cap guanine-N7 methyltransferase

1

0

High-throughput

0.458

High

402923

SPC29
Spindle pole component 29

1

0

High-throughput

0.458

High

402926

YBF5
Deoxyribonuclease Tat-D

1

0

High-throughput

0.458

High

402927

TSA1
Peroxiredoxin TSA1

1

0

Small-scale

0.458

High

402931

EAP1
Protein EAP1

1

0

High-throughput

0.458

High

402938

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

402959

VAB2
Biogenesis of lysosome-related organelles complex 1 subunit VAB2

1

0

High-throughput

0.458

High

402961

TPA1
Prolyl 3,4-dihydroxylase TPA1

1

0

Small-scale

0.458

High

402987

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.458

High

402996

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.458

High

403021

UFO1
Ubiquitin ligase complex F-box protein UFO1

1

0

Small-scale

0.458

High

403040

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

403053

YK018
Uncharacterized protein YKL018C-A

1

0

High-throughput

0.458

High

403056

IZH4
ADIPOR-like receptor IZH4

1

0

High-throughput

0.458

High

402977

TOH1
Probable circularly permuted 1,3-beta-glucanase YJL171C

1

1

Small-scale

0.457

High

402830

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.445

High

402952

TCPB
T-complex protein 1 subunit beta

1

4

High-throughput

0.445

High

402954

CAJ1
Protein CAJ1

1

6

High-throughput

0.445

High

402958

HSP7E
Heat shock protein SSC3, mitochondrial

1

6

High-throughput

0.445

High

402972

MPG1
Mannose-1-phosphate guanyltransferase

1

3

High-throughput

0.445

High

403031

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

6

High-throughput

0.445

High

402905

PROB
Glutamate 5-kinase

1

0

High-throughput

0.438

High

381510

GAL4
Regulatory protein GAL4

1

1

Small-scale

0.437

High

402841

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

Small-scale

0.437

High

402844

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

Small-scale

0.437

High

402866

SEC23
Protein transport protein SEC23

1

3

Small-scale

0.437

High

402878

ADT2
ADP,ATP carrier protein 2

1

1

Small-scale

0.437

High

402883

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

3

High-throughput

0.437

High

402890

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.437

High

402898

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

402900

LCF1
Long-chain-fatty-acid--CoA ligase 1

1

4

Small-scale

0.437

High

402907

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

3

High-throughput

0.437

High

402911

RPN2
26S proteasome regulatory subunit RPN2

1

3

Small-scale

0.437

High

402936

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

402939

ARPC1
Actin-related protein 2/3 complex subunit 1

1

6

Small-scale

0.437

High

402947

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

2

Small-scale

0.437

High

402949

ATC2
Calcium-transporting ATPase 2

1

2

High-throughput

0.437

High

402967

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

402971

COPB2
Coatomer subunit beta'

1

2

Small-scale

0.437

High

402973

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

402984

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

402992

UTP8
U3 small nucleolar RNA-associated protein 8

1

1

Small-scale

0.437

High

402995

COPA
Coatomer subunit alpha

1

2

Small-scale

0.437

High

403001

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

403003

H3
Histone H3

1

4

High-throughput

0.437

High

403018

DHR1
Probable ATP-dependent RNA helicase DHR1

1

7

High-throughput

0.437

High

403026

CORO
Coronin-like protein

1

2

Small-scale

0.437

High

403029

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.437

High

403030

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

5

Small-scale

0.437

High

403032

UTP4
U3 small nucleolar RNA-associated protein 4

1

4

Small-scale

0.437

High

403033

VPS13
Intermembrane lipid transfer protein VPS13

1

1

Small-scale

0.437

High

403034

NOC3
Nucleolar complex-associated protein 3

1

1

Small-scale

0.437

High

403039

AP3D
AP-3 complex subunit delta

1

3

High-throughput

0.437

High

403042

RRP6
Exosome complex exonuclease RRP6

1

3

High-throughput

0.437

High

403047

RUVB2
RuvB-like protein 2

1

2

Small-scale

0.437

High

403049

RLF2
Chromatin assembly factor 1 subunit p90

1

5

High-throughput

0.437

High

402956

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

402976

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

402978

NOP9
Nucleolar protein 9

1

0

High-throughput

0.426

High

402985

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.426

High

402858

TCPA
T-complex protein 1 subunit alpha

1

4

High-throughput

0.407

High

402986

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.279

Low

403054

SUS1
Transcription and mRNA export factor SUS1

1

0

High-throughput

0.279

Low

402859

BAR1
Barrierpepsin

1

0

Small-scale

0.249

Low

402862

TBP
TATA-box-binding protein

1

0

High-throughput

0.249

Low

402874

HEMH
Ferrochelatase, mitochondrial

1

0

Small-scale

0.249

Low

402877

PDI
Protein disulfide-isomerase

1

0

Small-scale

0.249

Low

402904

COPG
Coatomer subunit gamma

1

0

Small-scale

0.249

Low

402942

PHS
Putative pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.249

Low

402970

COPB
Coatomer subunit beta

1

0

Small-scale

0.249

Low

402988

EXG2
Glucan 1,3-beta-glucosidase 2

1

0

High-throughput

0.249

Low

402998

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

Small-scale

0.249

Low

403025

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

403038

TIM18
Mitochondrial import inner membrane translocase subunit TIM18

1

0

High-throughput

0.238

Low

402948

SPT8
Transcription factor SPT8

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024