Protein: IF2A
Eukaryotic translation initiation factor 2 subunit alpha (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha)

Gene: IF2A, SUI2
Organism: Saccharomyces cerevisiae S288C
Interactions: 113
UniProt ID: P20459

Gene Ontology (top 5):
GO:0001731 - formation of translation preinitiation complex
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

593826

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

14

8

Small-scale

0.986

High

521169

EI2BD
Translation initiation factor eIF2B subunit delta

6

4

Small-scale

0.944

High

593829

EI2BB
Translation initiation factor eIF2B subunit beta

5

4

Small-scale

0.919

High

539946

EI2BA
Translation initiation factor eIF2B subunit alpha

4

4

Small-scale

0.892

High

548509

GCN2
eIF-2-alpha kinase GCN2

2

10

Small-scale

0.778

High

446963

EI2BG
Translation initiation factor eIF2B subunit gamma

11

1

Small-scale

0.758

High

593828

EI2BE
Translation initiation factor eIF2B subunit epsilon

11

1

Small-scale

0.757

High

593843

IF5
Eukaryotic translation initiation factor 5

10

7

Small-scale

0.755

High

447154

IF2B
Eukaryotic translation initiation factor 2 subunit beta

8

6

Small-scale

0.747

High

593831

PP12
Serine/threonine-protein phosphatase PP1-2

5

4

Small-scale

0.716

High

593842

EIF3A
Eukaryotic translation initiation factor 3 subunit A

4

2

Small-scale

0.694

High

412654

KAPA
cAMP-dependent protein kinase type 1

1

1

Small-scale

0.647

High

593873

PKH1
Serine/threonine-protein kinase PKH1

1

3

Small-scale

0.647

High

593844

KSP1
Serine/threonine-protein kinase KSP1

1

2

High-throughput

0.646

High

405427

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.618

High

593832

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.618

High

593853

IF2P
Eukaryotic translation initiation factor 5B

1

5

Small-scale

0.618

High

555803

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.613

High

593854

IF4F1
Eukaryotic initiation factor 4F subunit p150

2

3

High-throughput

0.611

High

593877

CD123
Translation initiation factor eIF2 assembly protein

2

0

Small-scale

0.602

High

410074

EIF3B
Eukaryotic translation initiation factor 3 subunit B

2

1

Small-scale

0.601

High

593836

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.586

High

593845

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.586

High

510234

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.584

High

543178

HSC82
ATP-dependent molecular chaperone HSC82

2

3

High-throughput

0.584

High

593825

HS104
Heat shock protein 104

2

3

High-throughput

0.584

High

593857

EIF3I
Eukaryotic translation initiation factor 3 subunit I

2

4

Small-scale

0.584

High

593863

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

367732

EF1A
Elongation factor 1-alpha

1

2

Small-scale

0.575

High

365775

HSP82
ATP-dependent molecular chaperone HSP82

2

3

High-throughput

0.571

High

593816

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.553

High

593861

CSN11
Cop9 signalosome complex subunit 11

1

0

Small-scale

0.537

High

485640

IF4A
ATP-dependent RNA helicase eIF4A

1

3

High-throughput

0.536

High

593824

XPO1
Exportin-1

1

4

High-throughput

0.536

High

593855

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

3

High-throughput

0.536

High

593870

H3
Histone H3

2

2

High-throughput

0.521

High

593822

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.517

High

424811

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

555745

THRC
Threonine synthase

1

0

High-throughput

0.513

High

593860

FKH1
Fork head protein homolog 1

1

0

High-throughput

0.513

High

334433

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

High-throughput

0.500

High

334887

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

1

High-throughput

0.500

High

410903

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.500

High

593876

POC1
Proteasome chaperone 1

1

0

High-throughput

0.493

High

593840

TAF5
Transcription initiation factor TFIID subunit 5

1

3

High-throughput

0.489

High

593884

FAL1
ATP-dependent RNA helicase FAL1

1

3

High-throughput

0.489

High

520910

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.479

High

375272

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

High-throughput

0.479

High

389049

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

406778

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

408269

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

2

High-throughput

0.479

High

425104

LEUC
3-isopropylmalate dehydratase

1

1

High-throughput

0.479

High

472016

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

480478

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.479

High

482079

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

490312

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.479

High

500641

AK
Aspartokinase

1

1

High-throughput

0.479

High

546137

SYKC
Lysine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

593815

PP11
Serine/threonine-protein phosphatase PP1-1

1

4

Small-scale

0.479

High

593817

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

Small-scale

0.479

High

593818

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

593819

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

593833

SUI1
Eukaryotic translation initiation factor eIF-1

1

1

Small-scale

0.479

High

593838

GBLP
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.479

High

593846

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

593847

OTU2
OTU domain-containing protein 2

1

1

Small-scale

0.479

High

593871

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

593872

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

593874

UTP15
U3 small nucleolar RNA-associated protein 15

1

5

High-throughput

0.470

High

141150

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

341704

HIS2
Histidine biosynthesis trifunctional protein [Includes: Phosphoribosyl-AMP cyclohydrolase

1

0

High-throughput

0.458

High

357881

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

372800

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

0

High-throughput

0.458

High

382947

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

407722

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

425762

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

470860

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

479918

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

531657

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

High-throughput

0.458

High

593820

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

593821

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

593823

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

593827

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.458

High

593834

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

593837

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

593848

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

593849

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

593851

STM1
Suppressor protein STM1

1

0

Small-scale

0.458

High

593852

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

593859

TM108
Protein TMA108

1

0

High-throughput

0.458

High

593864

3HAO
3-hydroxyanthranilate 3,4-dioxygenase

1

0

High-throughput

0.458

High

593866

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

593867

MTHR2
Methylenetetrahydrofolate reductase 2

1

0

High-throughput

0.458

High

593879

SGO1
Shugoshin

1

0

High-throughput

0.458

High

593880

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

350760

RAS1
Ras-like protein 1

1

1

High-throughput

0.445

High

593830

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

593835

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

593856

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

593868

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.445

High

356242

H4
Histone H4

1

1

High-throughput

0.437

High

593858

MLP2
Protein MLP2

1

2

High-throughput

0.437

High

593881

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.437

High

593839

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

593841

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

593850

GGC1
Mitochondrial GTP/GDP carrier protein 1

1

0

High-throughput

0.249

Low

593862

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

593865

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.249

Low

593869

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

593878

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

593882

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

593875

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.232

Low

593883

HFI1
Transcriptional coactivator HFI1/ADA1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024