Protein: O83745
HD-GYP domain-containing protein

Gene: O83745, TP_0764
Organism: Treponema pallidum subsp. pallidum str. Nichols
Interactions: 135
UniProt ID: O83745

Gene Ontology (top 5):

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

308594

Y007
Uncharacterized protein TP_0007

1

1

High-throughput

0.417

High

308622

Y013
Uncharacterized protein TP_0013

1

1

High-throughput

0.417

High

308813

O83093
RNA 2-O ribose methyltransferase substrate binding domain-containing protein

1

1

High-throughput

0.417

High

309253

O83137
Uridylate kinase

1

1

High-throughput

0.417

High

309285

O83147
rRNA methylase, putative

1

1

High-throughput

0.417

High

309297

HFLC
Protein HflC

1

1

High-throughput

0.417

High

309394

O83178
Thiamine ABC transporter, ATP-binding protein, putative

1

1

High-throughput

0.417

High

309607

O83261
Anti-sigma factor antagonist

1

1

High-throughput

0.417

High

310298

O83404
Cell division protein FtsA

1

1

High-throughput

0.417

High

310709

DNAG
DNA primase

1

1

High-throughput

0.417

High

310914

O83551
Anti-sigma factor antagonist

1

1

High-throughput

0.417

High

311173

O83638
protein-glutamate O-methyltransferase

1

1

High-throughput

0.417

High

311185

CHEB
Protein-glutamate methylesterase/protein-glutamine glutaminase

1

1

High-throughput

0.417

High

311269

O83665
Flagellar hook-associated protein 3

1

2

High-throughput

0.417

High

311488

O83851
ABC transporter, ATP-binding protein

1

1

High-throughput

0.417

High

311495

O83927
Flagellar basal-body rod protein

1

1

High-throughput

0.417

High

311496

Y968
Uncharacterized protein TP_0968

1

1

High-throughput

0.417

High

311497

Y969
Uncharacterized protein TP_0969

1

1

High-throughput

0.417

High

311500

O83946
diguanylate cyclase

1

10

High-throughput

0.417

High

311508

FLAB2
Flagellin FlaB2

1

2

High-throughput

0.417

High

311509

FLAB3
Flagellin FlaB3

1

2

High-throughput

0.417

High

147328

RNZ
Ribonuclease Z

1

0

High-throughput

0.238

Low

147352

GYRB
DNA gyrase subunit B

1

0

High-throughput

0.238

Low

266276

RL31
Large ribosomal subunit protein bL31

1

0

High-throughput

0.238

Low

308613

Y012
Uncharacterized protein TP_0012

1

0

High-throughput

0.238

Low

308679

O83071
Hemolysin, putative

1

0

High-throughput

0.238

Low

308682

Y031
Uncharacterized protein TP_0031

1

0

High-throughput

0.238

Low

308704

LDHD
D-lactate dehydrogenase

1

0

High-throughput

0.238

Low

308708

Y039
Uncharacterized protein TP_0039

1

0

High-throughput

0.238

Low

308714

O83083
Soluble lytic transglycosylase, putative

1

0

High-throughput

0.238

Low

308774

O83087
Polymer-forming cytoskeletal protein

1

0

High-throughput

0.238

Low

308804

O83091
Release factor glutamine methyltransferase

1

0

High-throughput

0.238

Low

308865

Y059
Uncharacterized protein TP_0059

1

0

High-throughput

0.238

Low

309019

RLMN
Probable dual-specificity RNA methyltransferase RlmN

1

0

High-throughput

0.238

Low

309033

O83111
Glutaredoxin domain-containing protein

1

0

High-throughput

0.238

Low

309034

Y073
Uncharacterized protein TP_0073

1

0

High-throughput

0.238

Low

309042

O83113
Sugar ABC transporter, periplasmic binding protein

1

0

High-throughput

0.238

Low

309054

O83118
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead domain-containing protein

1

0

High-throughput

0.238

Low

309091

Y084
Uncharacterized protein TP_0084

1

0

High-throughput

0.238

Low

309106

O83123
PTS system, nitrogen regulatory IIA component

1

0

High-throughput

0.238

Low

309176

O83130
RNA polymerase sigma-24 factor

1

0

High-throughput

0.238

Low

309236

IF1
Translation initiation factor IF-1

1

0

High-throughput

0.238

Low

309266

O83141
ATP-dependent DNA helicase RecQ

1

0

High-throughput

0.238

Low

309273

5NTD
Probable 5'-nucleotidase

1

0

High-throughput

0.238

Low

309282

O83145
LicC protein

1

0

High-throughput

0.238

Low

309290

RP54
RNA polymerase sigma-54 factor

1

0

High-throughput

0.238

Low

309295

HFLK
Protein HflK

1

0

High-throughput

0.238

Low

309310

Y121
Putative L-lysine 2,3-aminomutase

1

0

High-throughput

0.238

Low

309318

O83161
Ribosome-binding ATPase YchF

1

0

High-throughput

0.238

Low

309332

Y128
Uncharacterized protein TP_0128

1

0

High-throughput

0.238

Low

309336

Y129
Uncharacterized protein TP_0129

1

0

High-throughput

0.238

Low

309339

O83167
Uncharacterized protein

1

0

High-throughput

0.238

Low

309363

Y132
Uncharacterized protein TP_0132

1

0

High-throughput

0.238

Low

309379

Y135
Uncharacterized protein TP_0135

1

0

High-throughput

0.238

Low

309386

O83176
K+ transport protein

1

0

High-throughput

0.238

Low

309485

SSRP
SsrA-binding protein

1

0

High-throughput

0.238

Low

309489

O83215
Signal peptidase I

1

0

High-throughput

0.238

Low

309499

RS19
Small ribosomal subunit protein uS19

1

0

High-throughput

0.238

Low

309503

RL22
Large ribosomal subunit protein uL22

1

0

High-throughput

0.238

Low

309507

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.238

Low

309592

O83257
Type-4 uracil-DNA glycosylase

1

0

High-throughput

0.238

Low

309595

Y232
Uncharacterized protein TP_0232

1

0

High-throughput

0.238

Low

309628

RL33
Large ribosomal subunit protein bL33

1

0

High-throughput

0.238

Low

309651

RL11
Large ribosomal subunit protein uL11

1

0

High-throughput

0.238

Low

309683

LNT1
Apolipoprotein N-acyltransferase 1

1

0

High-throughput

0.238

Low

309831

Y260
Uncharacterized protein TP_0260

1

0

High-throughput

0.238

Low

309857

PARB
Probable chromosome-partitioning protein ParB

1

0

High-throughput

0.238

Low

309921

Y282
TPR repeat-containing protein TP_0282

1

0

High-throughput

0.238

Low

309928

Y284
Uncharacterized protein TP_0284

1

0

High-throughput

0.238

Low

310058

MUTS
DNA mismatch repair protein MutS

1

0

High-throughput

0.238

Low

310163

Y359
Uncharacterized protein TP_0359

1

0

High-throughput

0.238

Low

310176

O83382
Chromosome partition protein Smc

1

0

High-throughput

0.238

Low

310186

Y368
Uncharacterized protein TP_0368

1

0

High-throughput

0.238

Low

310194

ISPE
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

1

0

High-throughput

0.238

Low

310204

Y374
Uncharacterized protein TP_0374

1

0

High-throughput

0.238

Low

310238

O83395
DNA 3'-5' helicase

1

0

High-throughput

0.238

Low

310383

FLIE
Flagellar hook-basal body complex protein FliE

1

0

High-throughput

0.238

Low

310429

O83415
Flagellar motor switch protein FliG

1

0

High-throughput

0.238

Low

310436

O83418
Flagellar FliJ protein

1

0

High-throughput

0.238

Low

310524

Y437
Uncharacterized protein TP_0437

1

0

High-throughput

0.238

Low

310526

CHEW
Chemotaxis protein CheW

1

0

High-throughput

0.238

Low

310556

ISPG
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase

1

0

High-throughput

0.238

Low

310614

O83470
Uncharacterized protein

1

0

High-throughput

0.238

Low

310645

Y462
Uncharacterized lipoprotein TP_0462/TP_0463

1

0

High-throughput

0.238

Low

310656

Y465
Uncharacterized protein TP_0465

1

0

High-throughput

0.238

Low

310729

O83510
Cell shape-determining protein MreB

1

0

High-throughput

0.238

Low

310787

O83522
Alkyl hydroperoxide reductase C

1

0

High-throughput

0.238

Low

310858

O83533
DNA polymerase III, gamma and tau subunits, putative

1

0

High-throughput

0.238

Low

310862

EFP
Elongation factor P

1

0

High-throughput

0.238

Low

310864

O83538
RNA helicase

1

0

High-throughput

0.238

Low

310872

VATD2
V-type ATP synthase subunit D 2

1

0

High-throughput

0.238

Low

310901

O83543
V-type ATPase, subunit F, putative

1

0

High-throughput

0.238

Low

310908

Y539
Uncharacterized protein TP_0539

1

0

High-throughput

0.238

Low

310923

ISPH
4-hydroxy-3-methylbut-2-enyl diphosphate reductase

1

0

High-throughput

0.238

Low

311053

O83587
Cell division protein

1

0

High-throughput

0.238

Low

311095

Y587
Uncharacterized protein TP_0587

1

0

High-throughput

0.238

Low

311153

Y625
Uncharacterized protein TP_0625

1

0

High-throughput

0.238

Low

311164

O83636
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.238

Low

311205

SYH
Histidine--tRNA ligase

1

0

High-throughput

0.238

Low

311211

O83654
Tetratricopeptide repeat protein

1

0

High-throughput

0.238

Low

311251

Y656
Uncharacterized protein TP_0656

1

0

High-throughput

0.238

Low

311327

O83670
Flagellar filament outer layer protein

1

0

High-throughput

0.238

Low

311348

Y679
Uncharacterized protein TP_0679

1

0

High-throughput

0.238

Low

311379

O83704
LysM domain-containing protein

1

0

High-throughput

0.238

Low

311401

IOJAP
Ribosomal silencing factor RsfS

1

0

High-throughput

0.238

Low

311425

O83726
Ribosomal processing cysteine protease Prp

1

0

High-throughput

0.238

Low

311452

FMT
Methionyl-tRNA formyltransferase

1

0

High-throughput

0.238

Low

311481

Y772
Uncharacterized protein TP_0772

1

0

High-throughput

0.238

Low

311482

O83758
DedA protein

1

0

High-throughput

0.238

Low

311483

SYM
Methionine--tRNA ligase

1

0

High-throughput

0.238

Low

311484

O83783
Exoribonuclease II

1

0

High-throughput

0.238

Low

311485

Y816
Uncharacterized protein TP_0816

1

0

High-throughput

0.238

Low

311486

O83799
YbbR-like domain-containing protein

1

0

High-throughput

0.238

Low

311487

RL20
Large ribosomal subunit protein bL20

1

0

High-throughput

0.238

Low

311489

RL19
Large ribosomal subunit protein bL19

1

0

High-throughput

0.238

Low

311490

O83884
Uncharacterized protein

1

0

High-throughput

0.238

Low

311491

O83885
Restriction endonuclease type IV Mrr domain-containing protein

1

0

High-throughput

0.238

Low

311492

Y928
Uncharacterized protein TP_0928

1

0

High-throughput

0.238

Low

311493

O83909
Pyruvate oxidoreductase

1

0

High-throughput

0.238

Low

311494

Y959
Uncharacterized protein TP_0959

1

0

High-throughput

0.238

Low

311498

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.238

Low

311499

Y976
Uncharacterized protein TP_0976

1

0

High-throughput

0.238

Low

311501

SYDND
Aspartate--tRNA(Asp/Asn) ligase

1

0

High-throughput

0.238

Low

311502

O83954
P26

1

0

High-throughput

0.238

Low

311503

O83959
Uncharacterized protein

1

0

High-throughput

0.238

Low

311504

PTH
Peptidyl-tRNA hydrolase

1

0

High-throughput

0.238

Low

311505

RS9
Small ribosomal subunit protein uS9

1

0

High-throughput

0.238

Low

311506

O83996
PNPLA domain-containing protein

1

0

High-throughput

0.238

Low

311507

Y1037
UPF0073 membrane protein TP_1037

1

0

High-throughput

0.238

Low

311510

PROB
Glutamate 5-kinase

1

0

High-throughput

0.238

Low

311511

TROB
Zinc transport system ATP-binding protein TroB

1

0

High-throughput

0.238

Low

311512

MTNN
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

1

0

High-throughput

0.238

Low

311513

Y688
Putative carboxypeptidase TP_0688

1

0

High-throughput

0.238

Low

311514

TP75
Protein Tp75

1

0

High-throughput

0.238

Low

311515

Q56343
Regulatory protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025