Protein: NOP2
25S rRNA (cytosine(2870)-C(5))-methyltransferase (EC 2.1.1.310) (Nucleolar protein 2)

Gene: NOP2
Organism: Saccharomyces cerevisiae S288C
Interactions: 226
UniProt ID: P40991

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470 - maturation of LSU-rRNA
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

778882

NIP7
60S ribosome subunit biogenesis protein NIP7

7

2

Small-scale

0.963

High

778803

NOP2
25S rRNA

3

4

Small-scale

0.827

High

766648

NUG1
Nuclear GTP-binding protein NUG1

12

2

Small-scale

0.756

High

778843

NOG1
Nucleolar GTP-binding protein 1

9

3

Small-scale

0.750

High

754133

CIC1
Proteasome-interacting protein CIC1

8

2

Small-scale

0.748

High

638782

SPB4
ATP-dependent rRNA helicase SPB4

8

9

Small-scale

0.746

High

764193

NOC2
Nucleolar complex protein 2

7

2

Small-scale

0.745

High

778821

NSA1
Ribosome biogenesis protein NSA1

8

1

Small-scale

0.744

High

778824

PESC
Pescadillo homolog

8

2

Small-scale

0.744

High

733846

RPF2
Ribosome biogenesis protein RPF2

7

2

Small-scale

0.744

High

778845

HAS1
ATP-dependent RNA helicase HAS1

7

12

Small-scale

0.742

High

778885

YTM1
Ribosome biogenesis protein YTM1

7

6

Small-scale

0.742

High

754871

SSF1
Ribosome biogenesis protein SSF1

7

2

Small-scale

0.737

High

715454

RRP1
Ribosomal RNA-processing protein 1

6

4

Small-scale

0.732

High

778857

ERB1
Ribosome biogenesis protein ERB1

6

4

Small-scale

0.732

High

703065

MRT4
Ribosome assembly factor MRT4

6

4

Small-scale

0.729

High

742025

NOP4
Nucleolar protein 4

6

2

Small-scale

0.729

High

778894

DBP10
ATP-dependent RNA helicase DBP10

6

8

Small-scale

0.729

High

710890

URB1
Nucleolar pre-ribosomal-associated protein 1

5

1

Small-scale

0.712

High

778807

LOC1
60S ribosomal subunit assembly/export protein LOC1

5

1

Small-scale

0.712

High

755294

RPF1
Ribosome production factor 1

5

3

Small-scale

0.709

High

778855

PUF6
Pumilio homology domain family member 6

5

2

Small-scale

0.709

High

768009

NSA2
Ribosome biogenesis protein NSA2

5

2

Small-scale

0.709

High

778871

RLP24
Ribosome biogenesis protein RLP24

5

1

Small-scale

0.703

High

776436

RLP7
Ribosome biogenesis protein RLP7

5

4

Small-scale

0.702

High

778874

BRX1
Ribosome biogenesis protein BRX1

4

12

Small-scale

0.694

High

699692

DRS1
ATP-dependent RNA helicase DRS1

4

10

Small-scale

0.691

High

744202

MAK5
ATP-dependent RNA helicase MAK5

4

10

Small-scale

0.691

High

778858

RRP5
rRNA biogenesis protein RRP5

4

4

Small-scale

0.691

High

778890

MAK21
Ribosome biogenesis protein MAK21

4

5

Small-scale

0.691

High

778899

IF6
Eukaryotic translation initiation factor 6

4

1

Small-scale

0.691

High

594050

MAK11
Protein MAK11

4

3

Small-scale

0.686

High

778870

NOC3
Nucleolar complex-associated protein 3

4

3

Small-scale

0.683

High

778831

NOP15
Ribosome biogenesis protein 15

4

2

Small-scale

0.676

High

549419

FBRL
rRNA 2'-O-methyltransferase fibrillarin

3

3

High-throughput

0.671

High

778861

FKBP4
FK506-binding protein 4

3

5

High-throughput

0.662

High

535024

RL3
Large ribosomal subunit protein uL3

3

2

Small-scale

0.656

High

640974

RL5
Large ribosomal subunit protein uL18

3

3

Small-scale

0.656

High

733133

DBP7
ATP-dependent RNA helicase DBP7

3

9

Small-scale

0.650

High

778881

RRS1
Regulator of ribosome biosynthesis

3

2

Small-scale

0.650

High

383196

RL25
Large ribosomal subunit protein uL23

3

2

Small-scale

0.640

High

634418

SPB1
27S pre-rRNA

3

5

Small-scale

0.640

High

731823

EBP2
rRNA-processing protein EBP2

3

2

Small-scale

0.640

High

778886

NOP53
Ribosome biogenesis protein NOP53

3

1

Small-scale

0.640

High

778823

UTP22
U3 small nucleolar RNA-associated protein 22

3

0

High-throughput

0.622

High

778883

BMS1
Ribosome biogenesis protein BMS1

2

2

High-throughput

0.621

High

778896

NOP56
Nucleolar protein 56

2

2

High-throughput

0.621

High

778834

RCM1
25S rRNA

1

4

High-throughput

0.618

High

778850

RRP17
Ribosomal RNA-processing protein 17

3

0

High-throughput

0.613

High

145745

RL36B
Large ribosomal subunit protein eL36B

2

3

Small-scale

0.611

High

778830

NOP13
Nucleolar protein 13

2

1

High-throughput

0.611

High

778891

RL7B
Large ribosomal subunit protein uL30B

2

4

Small-scale

0.611

High

778889

YRA1
RNA annealing protein YRA1

2

4

Small-scale

0.601

High

655854

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

2

0

Small-scale

0.585

High

405673

RL26A
Large ribosomal subunit protein uL24A

2

4

Small-scale

0.584

High

498966

RL4A
Large ribosomal subunit protein uL4A

2

4

Small-scale

0.584

High

501225

MAK16
Protein MAK16

2

1

Small-scale

0.584

High

766575

NOP16
Nucleolar protein 16

2

1

Small-scale

0.584

High

778827

TR112
Multifunctional methyltransferase subunit TRM112

2

1

Small-scale

0.584

High

778829

NOG2
Nucleolar GTP-binding protein 2

2

2

Small-scale

0.584

High

778863

DBP9
ATP-dependent RNA helicase DBP9

2

6

Small-scale

0.584

High

778873

NOP12
Nucleolar protein 12

2

4

Small-scale

0.584

High

778888

SSF2
Ribosome biogenesis protein SSF2

2

2

Small-scale

0.584

High

778828

BRE5
UBP3-associated protein BRE5

2

4

High-throughput

0.567

High

481037

RL23B
Large ribosomal subunit protein uL14B

2

0

Small-scale

0.559

High

732223

RRP14
Ribosomal RNA-processing protein 14

2

0

Small-scale

0.559

High

748630

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.559

High

756833

RIX1
Pre-rRNA-processing protein RIX1

2

0

Small-scale

0.559

High

778806

UTP10
U3 small nucleolar RNA-associated protein 10

2

0

High-throughput

0.559

High

778865

RRP15
Ribosomal RNA-processing protein 15

2

0

Small-scale

0.559

High

778875

NOP8
60S ribosome subunit biogenesis protein NOP8

2

0

Small-scale

0.559

High

765636

BEM2
GTPase-activating protein BEM2/IPL2

2

2

High-throughput

0.537

High

406011

RL33A
Large ribosomal subunit protein eL33A

1

1

High-throughput

0.536

High

471408

RL11A
Large ribosomal subunit protein uL5A

1

3

High-throughput

0.536

High

550062

CSK21
Casein kinase II subunit alpha

1

3

High-throughput

0.536

High

667204

RL8B
Large ribosomal subunit protein eL8B

1

2

High-throughput

0.536

High

676133

XPO1
Exportin-1

1

1

High-throughput

0.536

High

696352

PP12
Serine/threonine-protein phosphatase PP1-2

1

1

High-throughput

0.536

High

770397

RL13B
Large ribosomal subunit protein eL13B

1

2

High-throughput

0.536

High

778816

RL4B
Large ribosomal subunit protein uL4B

1

4

High-throughput

0.536

High

778840

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

4

High-throughput

0.536

High

778878

ULS1
ATP-dependent helicase ULS1

1

2

High-throughput

0.536

High

778902

RL11B
Large ribosomal subunit protein uL5B

1

3

High-throughput

0.536

High

368152

EF1A
Elongation factor 1-alpha

2

1

High-throughput

0.533

High

472240

RL31A
Large ribosomal subunit protein eL31A

2

2

Small-scale

0.533

High

704360

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

Small-scale

0.517

High

756358

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.513

High

778808

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.513

High

778851

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.513

High

778869

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

778876

DNLI4
DNA ligase 4

1

0

High-throughput

0.513

High

778839

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

3

High-throughput

0.489

High

778879

HRK1
Serine/threonine-protein kinase HRK1

1

1

High-throughput

0.489

High

560694

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.481

High

706021

NIP80
Protein NIP100

1

2

High-throughput

0.481

High

381463

GAL1
Galactokinase

1

0

High-throughput

0.479

High

778897

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.479

High

141381

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

382761

RL24A
Large ribosomal subunit protein eL24A

1

1

Small-scale

0.479

High

405027

RL6B
Large ribosomal subunit protein eL6B

1

1

Small-scale

0.479

High

407111

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

407968

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

413559

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

425998

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

480153

RS6A
Small ribosomal subunit protein eS6A

1

4

High-throughput

0.479

High

481169

RL1A
Large ribosomal subunit protein uL1A

1

4

High-throughput

0.479

High

481354

RL2A
Large ribosomal subunit protein uL2A

1

3

High-throughput

0.479

High

481655

RL18B
Large ribosomal subunit protein eL18B

1

2

Small-scale

0.479

High

564313

RL8A
Large ribosomal subunit protein eL8A

1

2

Small-scale

0.479

High

604569

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

1

High-throughput

0.479

High

628164

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

630871

NLE1
Ribosome assembly protein 4

1

3

High-throughput

0.479

High

631929

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

645226

RL16B
Large ribosomal subunit protein uL13B

1

1

Small-scale

0.479

High

645499

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

650311

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

662488

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

663880

TF3B
Transcription factor IIIB 70 kDa subunit

1

4

High-throughput

0.479

High

664888

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

688282

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

688778

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

2

High-throughput

0.479

High

698841

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

729957

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

742842

GBLP
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.479

High

746246

YBC8
UPF0642 protein YBL028C

1

1

High-throughput

0.479

High

753671

RL14B
Large ribosomal subunit protein eL14B

1

1

Small-scale

0.479

High

757290

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

5

High-throughput

0.479

High

775189

ULP2
Ubiquitin-like-specific protease 2

1

2

High-throughput

0.479

High

778804

RL33B
Large ribosomal subunit protein eL33B

1

1

Small-scale

0.479

High

778810

RL17B
Large ribosomal subunit protein uL22B

1

1

Small-scale

0.479

High

778817

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.479

High

778820

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

2

Small-scale

0.479

High

778826

DBP6
ATP-dependent RNA helicase DBP6

1

11

Small-scale

0.479

High

778832

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

778835

RL15B
Large ribosomal subunit protein eL15B

1

2

Small-scale

0.479

High

778841

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

778844

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

778852

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

778853

RRB1
Ribosome assembly protein RRB1

1

6

High-throughput

0.479

High

778856

UTP14
U3 small nucleolar RNA-associated protein 14

1

1

High-throughput

0.479

High

778862

JIP5
WD repeat-containing protein JIP5

1

3

High-throughput

0.479

High

778866

NOC4
Nucleolar complex protein 4

1

5

High-throughput

0.479

High

778867

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

4

Small-scale

0.479

High

778880

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

778898

NOP58
Nucleolar protein 58

1

2

High-throughput

0.479

High

778809

TAF1
Transcription initiation factor TFIID subunit 1

1

0

High-throughput

0.460

High

778887

SAS10
Something about silencing protein 10

1

0

High-throughput

0.460

High

357688

RL28
Large ribosomal subunit protein uL15

1

0

Small-scale

0.458

High

406556

RL22A
Large ribosomal subunit protein eL22A

1

0

Small-scale

0.458

High

408388

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

482736

RL19B
Large ribosomal subunit protein eL19

1

0

Small-scale

0.458

High

482885

RL35A
Large ribosomal subunit protein uL29A

1

0

Small-scale

0.458

High

624113

DBP2
ATP-dependent RNA helicase DBP2

1

0

Small-scale

0.458

High

634649

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

733664

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

764970

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

Small-scale

0.458

High

774577

BMT5
25S rRNA

1

0

High-throughput

0.458

High

775739

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

778812

URB2
Nucleolar pre-ribosomal-associated protein 2

1

0

Small-scale

0.458

High

778814

RL37A
Large ribosomal subunit protein eL37A

1

0

Small-scale

0.458

High

778825

SDA1
Protein SDA1

1

0

High-throughput

0.458

High

778836

RL34A
Large ribosomal subunit protein eL34A

1

0

Small-scale

0.458

High

778842

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

778847

ARX1
Probable metalloprotease ARX1

1

0

High-throughput

0.458

High

778848

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

778849

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

778854

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

778859

RSA3
Ribosome assembly protein 3

1

0

Small-scale

0.458

High

778860

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

778864

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

778872

BUD20
Bud site selection protein 20

1

0

High-throughput

0.458

High

778877

SGO1
Shugoshin

1

0

High-throughput

0.458

High

778884

MDN1
Midasin

1

0

High-throughput

0.458

High

778893

BMT6
25S rRNA

1

0

Small-scale

0.458

High

342045

ATPB
ATP synthase subunit beta, mitochondrial

1

2

High-throughput

0.457

High

360917

TBB
Tubulin beta chain

1

1

High-throughput

0.457

High

423863

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

High-throughput

0.457

High

556107

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.457

High

588116

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.457

High

778805

TCPH
T-complex protein 1 subunit eta

1

1

High-throughput

0.457

High

416007

DED1
ATP-dependent RNA helicase DED1

1

1

High-throughput

0.445

High

491519

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

494207

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

511663

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

761242

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

778838

SEN1
Helicase SEN1

1

1

Small-scale

0.445

High

358109

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

471106

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

478912

RL20B
Large ribosomal subunit protein eL20B

1

1

Small-scale

0.437

High

479125

RL43B
Large ribosomal subunit protein eL43B

1

1

High-throughput

0.437

High

480721

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

482304

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.437

High

543917

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.437

High

700464

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.437

High

706324

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

743272

RL32
Large ribosomal subunit protein eL32

1

1

Small-scale

0.437

High

752502

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.437

High

761960

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.437

High

762289

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

778813

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

778837

NUM1
Nuclear migration protein NUM1

1

4

High-throughput

0.437

High

554670

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

478275

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.407

High

778892

HER1
HMG2-induced ER-remodeling protein 1

2

0

High-throughput

0.307

High

471790

RL27A
Large ribosomal subunit protein eL27A

2

0

Small-scale

0.305

High

336142

COX6
Cytochrome c oxidase subunit 6, mitochondrial

1

0

High-throughput

0.279

Low

628714

PHO84
Inorganic phosphate transporter PHO84

1

0

High-throughput

0.279

Low

778757

FET4
Low-affinity Fe(2+) transport protein

1

0

High-throughput

0.279

Low

778819

NBP1
NAP1-binding protein

1

0

Small-scale

0.279

Low

778900

RQC2
Ribosome quality control complex subunit 2

1

0

High-throughput

0.279

Low

697644

FADH
S-(hydroxymethyl)glutathione dehydrogenase

1

0

High-throughput

0.269

Low

446172

MYO1
Myosin-1

1

0

High-throughput

0.251

Low

778895

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.251

Low

701473

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

745713

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

778811

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.249

Low

778815

RL38
Large ribosomal subunit protein eL38

1

0

Small-scale

0.249

Low

778818

RL9B
Large ribosomal subunit protein uL6B

1

0

Small-scale

0.249

Low

778822

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

778833

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

778846

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

778868

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

778901

RL21B
Large ribosomal subunit protein eL21B

1

0

Small-scale

0.249

Low

424569

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

705292

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024