Protein: A4
Amyloid-beta precursor protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99) (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (APP-C59) (Amyloid intracellular domain 59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (APP-C57) (Amyloid intracellular domain 57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AID(50)) (Gamma-CTF(50)); C31]

Gene: A4, App
Organism: Mus musculus
Interactions: 189
UniProt ID: P12023

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000278 - mitotic cell cycle
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001967 - suckling behavior
GO:0004867 - serine-type endopeptidase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

551421

APLP1
Amyloid beta precursor like protein 1

2

12

Small-scale

0.806

High

551422

APLP2
Amyloid beta precursor like protein 2

2

12

Small-scale

0.789

High

551519

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

13

Small-scale

0.776

High

551394

EPHB2
Ephrin type-B receptor 2

1

9

Small-scale

0.747

High

551414

DAB1
Disabled homolog 1

2

17

Small-scale

0.743

High

551418

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

2

12

Small-scale

0.737

High

312043

SORL
Sortilin-related receptor

2

15

Small-scale

0.730

High

420076

PRIO
Major prion protein

4

3

Small-scale

0.689

High

551372

CNTN1
Contactin-1

1

8

Small-scale

0.665

High

551373

NCAM1
Neural cell adhesion molecule 1

1

11

Small-scale

0.665

High

551419

CBPE
Carboxypeptidase E

1

3

Small-scale

0.665

High

551455

NFASC
Neurofascin

1

10

Small-scale

0.665

High

551509

APBB1
Amyloid beta precursor protein binding family B member 1

1

15

Small-scale

0.653

High

59263

A2AFG8
Neural cell adhesion molecule L1

1

8

Small-scale

0.647

High

551417

DAB2
Disabled homolog 2

1

17

Small-scale

0.647

High

551370

A4
Amyloid-beta precursor protein

1

14

Small-scale

0.618

High

551511

NUMB
Protein numb homolog

1

16

Small-scale

0.618

High

551374

CALR
Calreticulin

2

3

Small-scale

0.601

High

551475

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

1

15

Small-scale

0.590

High

551498

APBB2
Amyloid beta precursor protein binding family B member 2

1

15

Small-scale

0.590

High

551501

CSTN1
Calsyntenin-1

2

3

Small-scale

0.588

High

551434

RELN
Reelin

2

5

Small-scale

0.584

High

467733

APOE
Apolipoprotein E

2

5

Small-scale

0.571

High

551516

CHIP
E3 ubiquitin-protein ligase CHIP

2

3

Small-scale

0.563

High

551436

SHC3
SHC-transforming protein 3

1

20

Small-scale

0.553

High

551502

STX12
Syntaxin-12

2

5

Small-scale

0.553

High

205633

CALU
Calumenin

1

3

Small-scale

0.515

High

378926

THY1
Thy-1 membrane glycoprotein

1

1

Small-scale

0.515

High

465801

ENPL
Endoplasmin

1

4

Small-scale

0.515

High

551378

BIP
Endoplasmic reticulum chaperone BiP

1

5

Small-scale

0.515

High

551379

CYTC
Cystatin-C

1

6

Small-scale

0.515

High

551380

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

3

Small-scale

0.515

High

551385

CALX
Calnexin

1

3

Small-scale

0.515

High

551479

SPON1
Spondin-1

1

10

Small-scale

0.515

High

551486

PDIA6
Protein disulfide-isomerase A6

1

8

Small-scale

0.515

High

551487

CSTN3
Calsyntenin-3

1

7

Small-scale

0.515

High

551493

ERP44
Endoplasmic reticulum resident protein 44

1

8

Small-scale

0.515

High

551494

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

1

3

Small-scale

0.515

High

551507

HYOU1
Hypoxia up-regulated protein 1

1

6

Small-scale

0.515

High

551512

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

4

Small-scale

0.515

High

551517

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

1

Small-scale

0.515

High

551518

E41L3
Band 4.1-like protein 3

1

7

Small-scale

0.515

High

456034

TTHY
Transthyretin

1

1

Small-scale

0.501

High

551468

CRBN
Protein cereblon

1

1

Small-scale

0.501

High

551473

GGA1
ADP-ribosylation factor-binding protein GGA1

1

6

Small-scale

0.501

High

551461

GANAB
Neutral alpha-glucosidase AB

1

0

Small-scale

0.493

High

551386

SYT1
Synaptotagmin-1

2

7

Small-scale

0.492

High

551387

SYT2
Synaptotagmin-2

2

7

Small-scale

0.492

High

551398

SNP25
Synaptosomal-associated protein 25

2

1

Small-scale

0.492

High

551408

VAMP2
Vesicle-associated membrane protein 2

2

3

Small-scale

0.492

High

551428

VGLU1
Vesicular glutamate transporter 1

2

8

Small-scale

0.492

High

551458

SV2B
Synaptic vesicle glycoprotein 2B

2

3

Small-scale

0.492

High

551505

SV2A
Synaptic vesicle glycoprotein 2A

2

3

Small-scale

0.492

High

204220

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

11

Small-scale

0.479

High

237087

SYUA
Alpha-synuclein

1

4

Small-scale

0.479

High

313323

ITM2B
Integral membrane protein 2B

1

5

Small-scale

0.479

High

370836

FOS
Protein c-Fos

1

10

Small-scale

0.479

High

376570

EGF
Pro-epidermal growth factor

1

15

Small-scale

0.479

High

432056

JUN
Transcription factor Jun

1

7

Small-scale

0.479

High

551371

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

1

High-throughput

0.479

High

551377

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

6

Small-scale

0.479

High

551382

RGRF1
Ras-specific guanine nucleotide-releasing factor 1

1

7

Small-scale

0.479

High

551409

RANB9
Ran-binding protein 9

1

4

Small-scale

0.479

High

551410

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

5

Small-scale

0.479

High

551416

JDP2
Jun dimerization protein 2

1

6

Small-scale

0.479

High

551423

CLUS
Clusterin

1

2

Small-scale

0.479

High

551424

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.479

High

551435

USF1
Upstream stimulatory factor 1

1

8

Small-scale

0.479

High

551437

HSP74
Heat shock 70 kDa protein 4

1

4

Small-scale

0.479

High

551438

NBL1
Neuroblastoma suppressor of tumorigenicity 1

1

1

Small-scale

0.479

High

551439

DLG4
Disks large homolog 4

1

3

Small-scale

0.479

High

551443

USF2
Upstream stimulatory factor 2

1

8

Small-scale

0.479

High

551446

SORT
Sortilin

1

5

Small-scale

0.479

High

551460

FLRT3
Leucine-rich repeat transmembrane protein FLRT3

1

6

Small-scale

0.479

High

551503

S40A1
Ferroportin

1

1

Small-scale

0.479

High

551522

VPP1
V-type proton ATPase 116 kDa subunit a 1

2

0

Small-scale

0.471

High

551384

OAT
Ornithine aminotransferase, mitochondrial

1

2

Small-scale

0.470

High

551465

RCN2
Reticulocalbin-2

1

3

Small-scale

0.470

High

551483

METK1
S-adenosylmethionine synthase isoform type-1

1

1

Small-scale

0.470

High

551500

IPP2
Protein phosphatase inhibitor 2

1

1

Small-scale

0.470

High

313110

HDAC3
Histone deacetylase 3

1

0

Small-scale

0.458

High

551405

RB11A
Ras-related protein Rab-11A

1

4

Small-scale

0.445

High

45806

A0A1I9GFB9
TGF-b1-induced anti-apoptotic factor 1

1

1

Small-scale

0.437

High

551412

SPRL1
SPARC-like protein 1

1

2

Small-scale

0.437

High

551430

Q3U2G2
Heat shock 70 kDa protein 4

1

4

Small-scale

0.437

High

551431

Q3UH16
plus-end-directed kinesin ATPase

1

9

Small-scale

0.437

High

551456

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

5

Small-scale

0.437

High

58985

CUL4B
Cullin-4B

1

7

Small-scale

0.408

High

59677

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

Small-scale

0.408

High

60467

FXL16
F-box/LRR-repeat protein 16

1

3

Small-scale

0.408

High

147926

STXB1
Syntaxin-binding protein 1

1

3

Small-scale

0.408

High

204915

STX1A
Syntaxin-1A

1

6

Small-scale

0.408

High

205294

VIAAT
Vesicular inhibitory amino acid transporter

1

1

Small-scale

0.408

High

205603

CSN5
COP9 signalosome complex subunit 5

1

4

Small-scale

0.408

High

237134

SNG1
Synaptogyrin-1

1

1

Small-scale

0.408

High

312541

CSN3
COP9 signalosome complex subunit 3

1

4

Small-scale

0.408

High

312552

CSN4
COP9 signalosome complex subunit 4

1

1

Small-scale

0.408

High

312562

CSN6
COP9 signalosome complex subunit 6

1

3

Small-scale

0.408

High

313170

SYN1
Synapsin-1

1

2

Small-scale

0.408

High

313462

VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A

1

1

Small-scale

0.408

High

530692

TAU
Microtubule-associated protein tau

1

5

Small-scale

0.408

High

551375

AP2A1
AP-2 complex subunit alpha-1

1

4

Small-scale

0.408

High

551376

AP2A2
AP-2 complex subunit alpha-2

1

4

Small-scale

0.408

High

551388

NSF
Vesicle-fusing ATPase

1

2

Small-scale

0.408

High

551389

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

Small-scale

0.408

High

551390

VATA
V-type proton ATPase catalytic subunit A

1

2

Small-scale

0.408

High

551391

VATE1
V-type proton ATPase subunit E 1

1

1

Small-scale

0.408

High

551393

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

3

Small-scale

0.408

High

551399

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

2

Small-scale

0.408

High

551400

CSN2
COP9 signalosome complex subunit 2

1

5

Small-scale

0.408

High

551401

STX1B
Syntaxin-1B

1

6

Small-scale

0.408

High

551402

PRS4
26S proteasome regulatory subunit 4

1

5

Small-scale

0.408

High

551403

PRS8
26S proteasome regulatory subunit 8

1

5

Small-scale

0.408

High

551404

PRS10
26S proteasome regulatory subunit 10B

1

5

Small-scale

0.408

High

551406

VATB2
V-type proton ATPase subunit B, brain isoform

1

1

Small-scale

0.408

High

551407

RAB3A
Ras-related protein Rab-3A

1

8

Small-scale

0.408

High

551411

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

Small-scale

0.408

High

551413

AP2M1
AP-2 complex subunit mu

1

1

Small-scale

0.408

High

551415

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

1

3

Small-scale

0.408

High

551420

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

5

Small-scale

0.408

High

551425

CUL4A
Cullin-4A

1

7

Small-scale

0.408

High

551432

UBR3
E3 ubiquitin-protein ligase UBR3

1

1

Small-scale

0.408

High

551433

GRB2
Growth factor receptor-bound protein 2

1

11

Small-scale

0.408

High

551440

SYPH
Synaptophysin

1

2

Small-scale

0.408

High

551441

VAMP1
Vesicle-associated membrane protein 1

1

3

Small-scale

0.408

High

551442

SYN2
Synapsin-2

1

3

Small-scale

0.408

High

551444

SV2C
Synaptic vesicle glycoprotein 2C

1

3

Small-scale

0.408

High

551445

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

Small-scale

0.408

High

551447

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O

1

5

Small-scale

0.408

High

551448

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

Small-scale

0.408

High

551450

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

Small-scale

0.408

High

551451

OTUB1
Ubiquitin thioesterase OTUB1

1

2

Small-scale

0.408

High

551453

UBR5
E3 ubiquitin-protein ligase UBR5

1

6

Small-scale

0.408

High

551454

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

3

Small-scale

0.408

High

551459

SYNPR
Synaptoporin

1

2

Small-scale

0.408

High

551464

VGLU2
Vesicular glutamate transporter 2

1

8

Small-scale

0.408

High

551466

CSN7B
COP9 signalosome complex subunit 7b

1

4

Small-scale

0.408

High

551469

TRI32
E3 ubiquitin-protein ligase TRIM32

1

4

Small-scale

0.408

High

551470

SCAM1
Secretory carrier-associated membrane protein 1

1

3

Small-scale

0.408

High

551471

HECW1
E3 ubiquitin-protein ligase HECW1

1

4

Small-scale

0.408

High

551472

DCAF8
DDB1- and CUL4-associated factor 8

1

4

Small-scale

0.408

High

551474

SNG3
Synaptogyrin-3

1

1

Small-scale

0.408

High

551476

UBQL1
Ubiquilin-1

1

8

Small-scale

0.408

High

551477

MIB2
E3 ubiquitin-protein ligase MIB2

1

1

Small-scale

0.408

High

551482

RAB14
Ras-related protein Rab-14

1

6

Small-scale

0.408

High

551484

SYT17
Synaptotagmin-17

1

7

Small-scale

0.408

High

551485

SYT12
Synaptotagmin-12

1

7

Small-scale

0.408

High

551488

PARK7
Parkinson disease protein 7 homolog

1

1

Small-scale

0.408

High

551489

UBQL4
Ubiquilin-4

1

9

Small-scale

0.408

High

551496

SNAA
Alpha-soluble NSF attachment protein

1

3

Small-scale

0.408

High

551497

AP2B1
AP-2 complex subunit beta

1

6

Small-scale

0.408

High

551504

RNF14
E3 ubiquitin-protein ligase RNF14

1

4

Small-scale

0.408

High

551506

SCAM5
Secretory carrier-associated membrane protein 5

1

3

Small-scale

0.408

High

551508

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

2

Small-scale

0.408

High

551510

UBQL2
Ubiquilin-2

1

9

Small-scale

0.408

High

551513

SYT5
Synaptotagmin-5

1

7

Small-scale

0.408

High

551514

VINEX
Vinexin

1

6

Small-scale

0.408

High

551523

ARI1
E3 ubiquitin-protein ligase ARIH1

1

4

Small-scale

0.408

High

551392

VA0D1
V-type proton ATPase subunit d 1

1

0

Small-scale

0.391

High

551397

VATD
V-type proton ATPase subunit D

1

0

Small-scale

0.391

High

551429

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.391

High

551463

S6A17
Sodium-dependent neutral amino acid transporter SLC6A17

1

0

Small-scale

0.391

High

551478

CSN8
COP9 signalosome complex subunit 8

1

0

Small-scale

0.391

High

551521

VATC1
V-type proton ATPase subunit C 1

1

0

Small-scale

0.391

High

107990

G3UXW9
COP9 signalosome complex subunit 1

1

3

Small-scale

0.373

High

204484

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

Small-scale

0.373

High

204964

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

Small-scale

0.373

High

205190

SCAM3
Secretory carrier-associated membrane protein 3

1

3

Small-scale

0.373

High

551381

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

4

Small-scale

0.373

High

551383

SNAB
Beta-soluble NSF attachment protein

1

3

Small-scale

0.373

High

551395

PRS6B
26S proteasome regulatory subunit 6B

1

5

Small-scale

0.373

High

551396

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

5

Small-scale

0.373

High

551426

CBLB
E3 ubiquitin-protein ligase CBL-B

1

2

Small-scale

0.373

High

551427

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

Small-scale

0.373

High

551449

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

2

Small-scale

0.373

High

551452

DCAF5
DDB1- and CUL4-associated factor 5

1

5

Small-scale

0.373

High

551457

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

4

Small-scale

0.373

High

551462

MAL2
Protein MAL2

1

1

Small-scale

0.373

High

551481

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

Small-scale

0.373

High

551491

CSN7A
COP9 signalosome complex subunit 7a

1

4

Small-scale

0.373

High

551495

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

5

Small-scale

0.373

High

551499

FBX3
F-box only protein 3

1

1

Small-scale

0.373

High

551515

VATG2
V-type proton ATPase subunit G 2

1

1

Small-scale

0.373

High

551520

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

4

Small-scale

0.373

High

551467

VATH
V-type proton ATPase subunit H

1

0

Small-scale

0.213

Low

551480

FBX21
F-box only protein 21

1

0

Small-scale

0.213

Low

551490

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

Small-scale

0.213

Low

551492

VATF
V-type proton ATPase subunit F

1

0

Small-scale

0.213

Low


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Last updated: 11Aug2025