Protein: CSL4
Exosome complex component CSL4 (CEP1 synthetic lethal protein 4)

Gene: CSL4
Organism: Saccharomyces cerevisiae S288C
Interactions: 108
UniProt ID: P53859

Gene Ontology (top 5):
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

860795

RRP46
Exosome complex component RRP46

15

10

Small-scale

0.983

High

809572

RRP41
Exosome complex component SKI6

12

13

Small-scale

0.979

High

865419

RRP45
Exosome complex component RRP45

12

11

Small-scale

0.978

High

816960

MTR3
Exosome complex component MTR3

11

0

Small-scale

0.926

High

630237

RRP43
Exosome complex component RRP43

10

0

Small-scale

0.923

High

865428

RRP44
Exosome complex exonuclease DIS3

13

4

Small-scale

0.760

High

865435

RRP6
Exosome complex exonuclease RRP6

14

2

Small-scale

0.760

High

865430

SKI7
Superkiller protein 7

10

1

Small-scale

0.756

High

865438

RRP42
Exosome complex component RRP42

10

11

Small-scale

0.754

High

754980

RRP4
Exosome complex component RRP4

9

5

Small-scale

0.751

High

865429

RRP40
Exosome complex component RRP40

7

1

Small-scale

0.741

High

755187

LRP1
Exosome complex protein LRP1

6

0

Small-scale

0.691

High

864427

MPP6
M-phase phosphoprotein 6 homolog

5

0

Small-scale

0.685

High

748673

ENP1
Essential nuclear protein 1

4

0

High-throughput

0.648

High

635620

PWP2
Periodic tryptophan protein 2

3

2

Small-scale

0.640

High

865413

UTP5
U3 small nucleolar RNA-associated protein 5

3

1

Small-scale

0.640

High

865420

UTP13
U3 small nucleolar RNA-associated protein 13

3

2

Small-scale

0.640

High

865426

UTP4
U3 small nucleolar RNA-associated protein 4

3

2

Small-scale

0.640

High

792531

UTP10
U3 small nucleolar RNA-associated protein 10

3

0

High-throughput

0.613

High

865414

DHR1
Probable ATP-dependent RNA helicase DHR1

3

0

High-throughput

0.613

High

865416

UTP14
U3 small nucleolar RNA-associated protein 14

3

0

High-throughput

0.613

High

865424

NOC4
Nucleolar complex protein 4

3

0

High-throughput

0.613

High

775989

YIV5
Uncharacterized oxidoreductase YIR035C

2

0

High-throughput

0.595

High

865405

CSL4
Exosome complex component CSL4

1

0

High-throughput

0.586

High

707119

DCA13
Protein SOF1

2

1

High-throughput

0.584

High

810890

MTR4
ATP-dependent RNA helicase DOB1

2

3

High-throughput

0.584

High

865411

UTP17
NET1-associated nuclear protein 1

2

4

High-throughput

0.584

High

865415

UTP15
U3 small nucleolar RNA-associated protein 15

2

1

High-throughput

0.584

High

865421

UTP21
U3 small nucleolar RNA-associated protein 21

2

4

High-throughput

0.584

High

865423

RRP9
Ribosomal RNA-processing protein 9

2

3

High-throughput

0.584

High

865437

UTP12
U3 small nucleolar RNA-associated protein 12

2

3

High-throughput

0.584

High

865439

NOP56
Nucleolar protein 56

2

1

High-throughput

0.584

High

865440

NOP58
Nucleolar protein 58

2

1

High-throughput

0.584

High

865410

IMA1
Importin subunit alpha

2

0

High-throughput

0.563

High

630520

RRP7
Ribosomal RNA-processing protein 7

2

0

High-throughput

0.559

High

634715

KRR1
KRR1 small subunit processome component

2

0

High-throughput

0.559

High

645574

RS7A
Small ribosomal subunit protein eS7A

2

0

Small-scale

0.559

High

711060

UTP11
U3 small nucleolar RNA-associated protein 11

2

0

High-throughput

0.559

High

715961

UTP20
U3 small nucleolar RNA-associated protein 20

2

0

High-throughput

0.559

High

756766

UTP9
U3 small nucleolar RNA-associated protein 9

2

0

High-throughput

0.559

High

767394

UTP7
U3 small nucleolar RNA-associated protein 7

2

0

High-throughput

0.559

High

772659

UTP18
U3 small nucleolar RNA-associated protein 18

2

0

High-throughput

0.559

High

784516

DIM1
Dimethyladenosine transferase

2

0

High-throughput

0.559

High

811537

MPP10
U3 small nucleolar RNA-associated protein MPP10

2

0

High-throughput

0.559

High

860709

UTP22
U3 small nucleolar RNA-associated protein 22

2

0

High-throughput

0.559

High

861008

UTP8
U3 small nucleolar RNA-associated protein 8

2

0

High-throughput

0.559

High

865408

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

2

0

High-throughput

0.559

High

865409

UTP6
U3 small nucleolar RNA-associated protein 6

2

0

High-throughput

0.559

High

865417

RRP5
rRNA biogenesis protein RRP5

2

0

High-throughput

0.559

High

865418

FCF1
rRNA-processing protein FCF1

2

0

High-throughput

0.559

High

865422

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

2

0

High-throughput

0.559

High

865427

RCL1
RNA 3'-terminal phosphate cyclase-like protein

2

0

High-throughput

0.559

High

865431

UTP16
U3 small nucleolar RNA-associated protein 16

2

0

High-throughput

0.559

High

865432

BMS1
Ribosome biogenesis protein BMS1

2

0

High-throughput

0.559

High

865433

FCF2
rRNA-processing protein FCF2

2

0

High-throughput

0.559

High

865434

SAS10
Something about silencing protein 10

2

0

High-throughput

0.559

High

865444

NOP14
Nucleolar complex protein 14

2

0

High-throughput

0.559

High

769097

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

High-throughput

0.552

High

494622

HSP72
Heat shock protein SSA2

2

0

High-throughput

0.528

High

863160

NRD1
Protein NRD1

1

0

Small-scale

0.513

High

420150

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.493

High

608718

UBA1
Ubiquitin-activating enzyme E1 1

1

0

High-throughput

0.493

High

623492

KPC1
Protein kinase C-like 1

1

0

High-throughput

0.493

High

730583

MYO3
Myosin-3

1

0

High-throughput

0.493

High

141456

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

479796

RS4A
Small ribosomal subunit protein eS4A

1

1

High-throughput

0.479

High

481806

RS16B
Small ribosomal subunit protein uS9B

1

1

High-throughput

0.479

High

700083

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

1

High-throughput

0.479

High

716198

SKI2
Antiviral helicase SKI2

1

3

High-throughput

0.479

High

408044

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

413639

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

426080

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

480237

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

482387

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

549454

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

571913

SKI3
Superkiller protein 3

1

0

High-throughput

0.458

High

644935

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.458

High

662953

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

730047

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

733582

RL1D1
Ribosome biogenesis protein UTP30

1

0

High-throughput

0.458

High

753474

RIM4
Meiotic activator RIM4

1

0

Small-scale

0.458

High

766333

SNU13
13 kDa ribonucleoprotein-associated protein

1

0

High-throughput

0.458

High

774265

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

775376

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

775802

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

799838

ROK1
ATP-dependent RNA helicase ROK1

1

0

High-throughput

0.458

High

816886

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

865406

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.458

High

865425

BFR2
Protein BFR2

1

0

High-throughput

0.458

High

865436

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

865441

NOT5
General negative regulator of transcription subunit 5

1

0

Small-scale

0.458

High

865442

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

865445

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

512244

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

865407

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

471182

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

478410

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.426

High

735523

RM24
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.269

Low

865412

PKH3
Serine/threonine-protein kinase PKH3

1

0

High-throughput

0.261

Low

479367

RS23B
Small ribosomal subunit protein uS12B

1

0

High-throughput

0.249

Low

479511

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.249

Low

480804

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

481542

RS11B
Small ribosomal subunit protein uS17B

1

0

High-throughput

0.249

Low

706410

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

865443

RS28A
Small ribosomal subunit protein eS28A

1

0

High-throughput

0.249

Low

592957

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.232

Low

772575

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024