Protein: ACAC
Acetyl-CoA carboxylase (ACC) (EC 6.4.1.2) (Fatty acid synthetase 3) (mRNA transport-defective protein 7) [Includes: Biotin carboxylase (EC 6.3.4.14)]

Gene: ACAC, ACC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 150
UniProt ID: Q00955

Gene Ontology (top 5):
GO:0003989 - acetyl-CoA carboxylase activity
GO:0004075 - biotin carboxylase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

962615

ACAC
Acetyl-CoA carboxylase

3

15

Small-scale

0.821

High

594356

PP11
Serine/threonine-protein phosphatase PP1-1

4

5

High-throughput

0.699

High

699582

HFA1
Acetyl-CoA carboxylase, mitochondrial

1

16

High-throughput

0.665

High

366744

HSP82
ATP-dependent molecular chaperone HSP82

3

9

High-throughput

0.640

High

772915

TCPE
T-complex protein 1 subunit epsilon

2

1

High-throughput

0.628

High

632539

DMC1
Meiotic recombination protein DMC1

2

5

Small-scale

0.614

High

628366

SIS1
Protein SIS1

2

7

High-throughput

0.601

High

680932

HS104
Heat shock protein 104

2

6

High-throughput

0.584

High

544253

HSC82
ATP-dependent molecular chaperone HSC82

2

9

High-throughput

0.571

High

492143

HSP71
Heat shock protein SSA1

2

16

High-throughput

0.552

High

494719

HSP72
Heat shock protein SSA2

2

16

High-throughput

0.552

High

512369

SSB1
Ribosome-associated molecular chaperone SSB1

2

18

High-throughput

0.552

High

769195

SSB2
Ribosome-associated molecular chaperone SSB2

2

18

High-throughput

0.552

High

743178

BOB1
Protein BOB1

1

2

High-throughput

0.541

High

962628

MYO5
Myosin-5

1

1

High-throughput

0.541

High

730462

PTK1
Serine/threonine-protein kinase PTK1/STK1

1

9

High-throughput

0.536

High

731004

MAOM
NAD-dependent malic enzyme, mitochondrial

1

2

High-throughput

0.536

High

864586

BRE5
UBP3-associated protein BRE5

1

3

High-throughput

0.536

High

865709

RM22
Large ribosomal subunit protein uL22m

1

2

High-throughput

0.536

High

962616

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

8

High-throughput

0.536

High

962627

KU80
ATP-dependent DNA helicase II subunit 2

1

2

High-throughput

0.536

High

962636

SHS1
Seventh homolog of septin 1

1

3

High-throughput

0.536

High

962648

SKS1
Serine/threonine-protein kinase SKS1

1

7

High-throughput

0.536

High

962642

AP3D
AP-3 complex subunit delta

2

3

Small-scale

0.535

High

753641

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

4

High-throughput

0.494

High

755657

BZZ1
Protein BZZ1

1

1

High-throughput

0.494

High

811138

BBC1
Myosin tail region-interacting protein MTI1

1

2

High-throughput

0.494

High

772624

YJH0
Inactive deaminase YJL070C

1

0

High-throughput

0.493

High

429753

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

5

High-throughput

0.489

High

785165

MPG1
Mannose-1-phosphate guanyltransferase

1

3

High-throughput

0.489

High

837450

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

3

High-throughput

0.489

High

962626

UTP5
U3 small nucleolar RNA-associated protein 5

1

8

High-throughput

0.489

High

520637

YPK1
Serine/threonine-protein kinase YPK1

1

9

Small-scale

0.481

High

634178

SRO9
RNA-binding protein SRO9

1

4

Small-scale

0.481

High

697245

BRR2
Pre-mRNA-splicing helicase BRR2

1

1

Small-scale

0.481

High

710518

PP2C3
Protein phosphatase 2C homolog 3

1

2

Small-scale

0.481

High

755031

NADE
Glutamine-dependent NAD(+) synthetase

1

1

Small-scale

0.481

High

765811

VAC8
Vacuolar protein 8

1

2

Small-scale

0.481

High

962618

OSH6
Oxysterol-binding protein homolog 6

1

1

Small-scale

0.481

High

141470

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

358208

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.479

High

375475

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.479

High

383298

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

403005

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

4

Small-scale

0.479

High

405777

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.479

High

407249

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

408062

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

410440

SC160
Protein SCP160

1

2

High-throughput

0.479

High

413658

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

426098

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

471199

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

472345

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

480256

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.479

High

482403

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

485806

IF4A
ATP-dependent RNA helicase eIF4A

1

5

High-throughput

0.479

High

604825

PSB4
Proteasome subunit beta type-4

1

1

Small-scale

0.479

High

632031

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

645103

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

645594

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

663049

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

700569

RSSA1
Small ribosomal subunit protein uS2A

1

4

High-throughput

0.479

High

701040

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

706431

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.479

High

730065

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

733228

SA190
SIT4-associating protein SAP190

1

5

High-throughput

0.479

High

752608

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

762008

DHH1
ATP-dependent RNA helicase DHH1

1

4

High-throughput

0.479

High

762469

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

772315

ATAD2
ATPase histone chaperone YTA7

1

5

High-throughput

0.479

High

792544

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.479

High

811203

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.479

High

812075

MOG1
Nuclear import protein MOG1

1

3

High-throughput

0.479

High

820114

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

860572

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

866779

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

872787

ORC1
Origin recognition complex subunit 1

1

3

High-throughput

0.479

High

959836

NUM1
Nuclear migration protein NUM1

1

5

High-throughput

0.479

High

962617

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

962620

MLP1
Protein MLP1

1

3

High-throughput

0.479

High

962624

RUVB1
RuvB-like protein 1

1

6

High-throughput

0.479

High

962631

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.479

High

962638

MCA1
Metacaspase-1

1

2

High-throughput

0.479

High

962641

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

962643

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

962646

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

2

Small-scale

0.479

High

962647

RUVB2
RuvB-like protein 2

1

6

High-throughput

0.479

High

962649

SMC6
Structural maintenance of chromosomes protein 6

1

8

High-throughput

0.479

High

416054

DED1
ATP-dependent RNA helicase DED1

1

0

Small-scale

0.460

High

619379

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.460

High

743423

RIB1
GTP cyclohydrolase-2

1

0

Small-scale

0.460

High

784708

THI6
Thiamine biosynthetic bifunctional enzyme [Includes: Thiamine-phosphate synthase

1

0

Small-scale

0.460

High

962630

SVF1
Ceramide-binding protein SVF1

1

0

Small-scale

0.460

High

962639

FOLE
Folylpolyglutamate synthase

1

0

Small-scale

0.460

High

731605

EAP1
Protein EAP1

1

0

High-throughput

0.458

High

755066

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

792663

SET4
SET domain-containing protein 4

1

0

Small-scale

0.458

High

962622

ESP1
Separin

1

0

High-throughput

0.458

High

693051

RPD3
Histone deacetylase RPD3

1

15

Small-scale

0.457

High

360994

TBB
Tubulin beta chain

1

3

High-throughput

0.445

High

368325

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

478439

HSP77
Import motor subunit, mitochondrial

1

10

High-throughput

0.445

High

556237

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

561257

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

1

High-throughput

0.445

High

605758

NPR1
Nitrogen permease reactivator protein

1

9

High-throughput

0.445

High

629025

SCJ1
DnaJ-related protein SCJ1

1

3

High-throughput

0.445

High

633489

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.445

High

648230

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

High-throughput

0.445

High

695313

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

705534

HSP78
Heat shock protein 78, mitochondrial

1

6

High-throughput

0.445

High

760670

TCPB
T-complex protein 1 subunit beta

1

2

High-throughput

0.445

High

773725

6P21
6-phosphofructo-2-kinase 1

1

1

High-throughput

0.445

High

817287

HLJ1
Protein HLJ1

1

3

High-throughput

0.445

High

686143

CHMU
Chorismate mutase

1

1

Small-scale

0.439

High

770010

VID27
Vacuolar import and degradation protein 27

1

1

Small-scale

0.439

High

356658

H4
Histone H4

1

6

High-throughput

0.437

High

524417

CAF20
Cap-associated protein CAF20

1

4

High-throughput

0.437

High

633888

SGF29
SAGA-associated factor 29

1

1

Small-scale

0.437

High

665000

BMH1
Protein BMH1

1

5

High-throughput

0.437

High

730885

CENPA
Histone H3-like centromeric protein CSE4

1

3

High-throughput

0.437

High

748170

AIM4
Altered inheritance of mitochondria protein 4

1

1

High-throughput

0.437

High

753433

ECM29
Proteasome component ECM29

1

2

High-throughput

0.437

High

774132

TM108
Protein TMA108

1

2

High-throughput

0.437

High

775820

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

776488

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

817364

HGH1
Protein HGH1

1

1

Small-scale

0.437

High

822900

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

901998

H3
Histone H3

1

3

High-throughput

0.437

High

960605

RAGAB
GTP-binding protein GTR1

1

1

Small-scale

0.437

High

962623

TOM1
E3 ubiquitin-protein ligase TOM1

1

10

High-throughput

0.437

High

962632

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.437

High

962637

SGO1
Shugoshin

1

1

High-throughput

0.437

High

962645

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.437

High

783554

SYS1
Protein SYS1

1

0

High-throughput

0.426

High

962621

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.426

High

706163

MFT1
THO complex subunit MFT1

1

1

High-throughput

0.407

High

757452

SPT8
Transcription factor SPT8

1

1

High-throughput

0.407

High

962619

ADA2
Transcriptional adapter 2

1

2

High-throughput

0.407

High

962634

SSK1
Osmolarity two-component system protein SSK1

1

1

High-throughput

0.407

High

946205

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.282

High

962635

CYK3
Cytokinesis protein 3

1

0

High-throughput

0.282

High

962629

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.279

Low

962633

VAC14
Vacuole morphology and inheritance protein 14

1

0

High-throughput

0.279

Low

962578

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

0

High-throughput

0.265

Low

526732

PYRE
Orotate phosphoribosyltransferase 1

1

0

Small-scale

0.251

Low

865286

GIS2
Zinc finger protein GIS2

1

0

Small-scale

0.251

Low

962640

RPN8
26S proteasome regulatory subunit RPN8

1

0

Small-scale

0.251

Low

962625

SND1
SRP-independent targeting protein 1

1

0

High-throughput

0.249

Low

854658

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.232

Low

962644

NSL1
Kinetochore-associated protein NSL1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024