Protein: RPA49
DNA-directed RNA polymerase I subunit RPA49 (A49) (DNA-directed RNA polymerase I 49 kDa polypeptide)

Gene: RPA49
Organism: Saccharomyces cerevisiae S288C
Interactions: 111
UniProt ID: Q01080

Gene Ontology (top 5):
GO:0001054 - RNA polymerase I activity
GO:0001188 - RNA polymerase I preinitiation complex assembly
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

501399

RPA1
DNA-directed RNA polymerase I subunit RPA190

9

3

Small-scale

0.968

High

604601

RPA2
DNA-directed RNA polymerase I subunit RPA135

9

5

Small-scale

0.966

High

810442

RPA34
DNA-directed RNA polymerase I subunit RPA34

7

0

Small-scale

0.906

High

692700

RPA12
DNA-directed RNA polymerase I subunit RPA12

3

3

Small-scale

0.830

High

963162

RPA49
DNA-directed RNA polymerase I subunit RPA49

3

0

High-throughput

0.796

High

805016

RPA43
DNA-directed RNA polymerase I subunit RPA43

8

1

Small-scale

0.745

High

429754

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

6

3

High-throughput

0.735

High

593177

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

4

1

High-throughput

0.694

High

593257

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

4

1

High-throughput

0.694

High

963187

NOP58
Nucleolar protein 58

3

3

High-throughput

0.657

High

593338

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

1

High-throughput

0.601

High

604709

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

1

High-throughput

0.601

High

655645

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

2

2

High-throughput

0.601

High

810713

NET1
Nucleolar protein NET1

2

1

High-throughput

0.601

High

650365

SPT5
Transcription elongation factor SPT5

2

1

Small-scale

0.595

High

963174

RRP45
Exosome complex component RRP45

2

0

High-throughput

0.585

High

837514

RPA14
DNA-directed RNA polymerase I subunit RPA14

2

0

High-throughput

0.576

High

961458

CDC14
Tyrosine-protein phosphatase CDC14

2

0

High-throughput

0.576

High

732116

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

1

1

Small-scale

0.575

High

512370

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

959987

SEN1
Helicase SEN1

2

0

Small-scale

0.547

High

514204

NHP6A
Non-histone chromosomal protein 6A

1

1

High-throughput

0.541

High

676288

XPO1
Exportin-1

1

2

High-throughput

0.536

High

963163

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

530021

STE12
Protein STE12

1

0

High-throughput

0.518

High

589093

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

1

2

High-throughput

0.515

High

615172

BUR1
Serine/threonine-protein kinase BUR1

1

1

High-throughput

0.515

High

865603

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.515

High

963176

YL455
PWWP domain-containing protein YLR455W

1

1

High-throughput

0.515

High

963185

NSI1
RNA polymerase I termination factor

1

1

High-throughput

0.515

High

733902

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.513

High

859406

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

High-throughput

0.513

High

628367

SIS1
Protein SIS1

1

0

High-throughput

0.493

High

701188

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

0

High-throughput

0.493

High

356659

H4
Histone H4

1

1

High-throughput

0.479

High

416243

SIR2
NAD-dependent histone deacetylase SIR2

1

2

High-throughput

0.479

High

480257

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

558202

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

634732

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

704403

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

High-throughput

0.479

High

742940

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

773006

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.479

High

775232

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.479

High

792545

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.479

High

901999

H3
Histone H3

1

1

High-throughput

0.479

High

963165

TOF2
Topoisomerase 1-associated factor 2

1

1

High-throughput

0.479

High

963169

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

963172

RRP5
rRNA biogenesis protein RRP5

1

3

High-throughput

0.479

High

963173

HRQ1
ATP-dependent helicase HRQ1

1

1

Small-scale

0.479

High

963183

MAK21
Ribosome biogenesis protein MAK21

1

2

High-throughput

0.479

High

963186

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.479

High

141471

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

392535

H2A2
Histone H2A.2

1

0

High-throughput

0.458

High

407250

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

408063

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

408435

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

413659

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

630242

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

632032

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

645595

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

663050

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

688376

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

698906

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

710573

UBX1
UBX domain-containing protein 1

1

0

Small-scale

0.458

High

746386

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.458

High

772316

ATAD2
ATPase histone chaperone YTA7

1

0

High-throughput

0.458

High

775821

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

812076

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

862511

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.458

High

963166

RNT1
Ribonuclease 3

1

0

Small-scale

0.458

High

963167

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.458

High

963168

HOT1
High-osmolarity-induced transcription protein 1

1

0

Small-scale

0.458

High

963171

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

963175

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

963177

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.458

High

963179

IWR1
RNA polymerase II nuclear localization protein IWR1

1

0

High-throughput

0.458

High

963180

SGO1
Shugoshin

1

0

High-throughput

0.458

High

963182

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

963184

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

769196

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

472346

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

730066

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.437

High

754632

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

866121

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.426

High

963170

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.426

High

524418

CAF20
Cap-associated protein CAF20

2

0

High-throughput

0.305

High

797215

BUD27
Bud site selection protein 27

2

0

Small-scale

0.305

High

615294

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.269

Low

765251

RS26B
Small ribosomal subunit protein eS26B

1

0

High-throughput

0.269

Low

775955

INA22
Inner membrane assembly complex subunit 22

1

0

High-throughput

0.269

Low

358209

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

383299

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

405778

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

426099

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

471200

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

480823

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

482404

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

544254

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

579843

PGTB1
Geranylgeranyl transferase type-1 subunit beta

1

0

High-throughput

0.249

Low

700570

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

706432

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

731606

EAP1
Protein EAP1

1

0

High-throughput

0.249

Low

752609

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

762470

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

820115

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

859910

ERV14
ER-derived vesicles protein ERV14

1

0

High-throughput

0.249

Low

959837

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

963164

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

963178

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

963181

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024