Protein: RBX1
RING-box protein HRT1 (RING-box protein 1) (E3 ubiquitin-protein ligase complex SCF subunit HRT1) (High level expression reduces Ty3 transposition protein 1) (Regulator of cullins protein 1)

Gene: RBX1, HRT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 188
UniProt ID: Q08273

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000409 - regulation of transcription by galactose
GO:0000781 - chromosome, telomeric region
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

539491

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

21

20

Small-scale

0.990

High

994548

CDC53
Cell division control protein 53

15

20

Small-scale

0.986

High

860122

CUL3
Cullin-3

4

20

Small-scale

0.883

High

859863

YBP2
YAP1-binding protein 2

3

0

High-throughput

0.782

High

549843

UBC4
Ubiquitin-conjugating enzyme E2 4

2

20

Small-scale

0.778

High

549867

UBC5
Ubiquitin-conjugating enzyme E2-16 kDa

2

20

Small-scale

0.778

High

854625

UBC12
NEDD8-conjugating enzyme UBC12

2

20

Small-scale

0.778

High

431152

CDC4
Cell division control protein 4

8

12

Small-scale

0.750

High

853187

SKP1
Suppressor of kinetochore protein 1

6

3

Small-scale

0.727

High

811013

CUL8
Cullin-8

4

20

Small-scale

0.703

High

624320

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

4

5

Small-scale

0.690

High

775542

YIA1
Ankyrin repeat-containing protein YIL001W

4

17

High-throughput

0.677

High

994556

APC2
Anaphase-promoting complex subunit 2

1

20

Small-scale

0.656

High

986564

MMS1
E3 ubiquitin-protein ligase linker protein MMS1

4

0

Small-scale

0.652

High

759333

MET30
F-box protein MET30

3

13

Small-scale

0.650

High

477471

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

6

High-throughput

0.618

High

994555

DCN1
Defective in cullin neddylation protein 1

2

9

Small-scale

0.602

High

539283

YAK1
Dual specificity protein kinase YAK1

2

3

High-throughput

0.590

High

994553

HRT3
F-box protein HRT3

2

1

Small-scale

0.585

High

361055

TBB
Tubulin beta chain

2

6

High-throughput

0.584

High

633640

MAS5
Mitochondrial protein import protein MAS5

2

2

High-throughput

0.584

High

977842

RUB1
NEDD8-like protein RUB1

1

4

High-throughput

0.575

High

985453

UCC1
F-box protein UCC1

2

0

Small-scale

0.560

High

141670

YA11B
Truncated transposon Ty1-A Gag-Pol polyprotein

1

1

High-throughput

0.536

High

501417

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

High-throughput

0.536

High

525219

GAL3
Protein GAL3

1

1

High-throughput

0.536

High

562293

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

2

High-throughput

0.536

High

585382

MYO2
Myosin-2

1

8

High-throughput

0.536

High

676432

XPO1
Exportin-1

1

1

High-throughput

0.536

High

692670

DUR1
Urea amidolyase [Includes: Urea carboxylase

1

5

High-throughput

0.536

High

753444

ECM29
Proteasome component ECM29

1

6

High-throughput

0.536

High

753967

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.536

High

809512

GUF1
Translation factor GUF1, mitochondrial

1

2

High-throughput

0.536

High

814728

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

2

High-throughput

0.536

High

992246

RIX7
Ribosome biogenesis ATPase RIX7

1

8

High-throughput

0.536

High

994547

RPN8
26S proteasome regulatory subunit RPN8

1

8

High-throughput

0.536

High

994549

MDN1
Midasin

1

7

High-throughput

0.536

High

749023

SAF1
SCF-associated factor 1

1

0

High-throughput

0.530

High

865467

ELOA1
Elongin-A

2

0

Small-scale

0.528

High

763204

RRF2M
Ribosome-releasing factor 2, mitochondrial

2

1

High-throughput

0.516

High

994560

HSH49
Protein HSH49

1

1

High-throughput

0.515

High

423705

ADR1
Regulatory protein ADR1

1

0

High-throughput

0.513

High

615306

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.513

High

636185

NOT1
General negative regulator of transcription subunit 1

1

0

High-throughput

0.513

High

777148

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.513

High

961630

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.513

High

988676

UBX5
UBX domain-containing protein 5

1

2

High-throughput

0.508

High

810422

DAS1
F-box protein DAS1

1

1

Small-scale

0.501

High

975898

TFB3
RNA polymerase II transcription factor B subunit 3

1

1

Small-scale

0.501

High

977830

YD131
F-box protein YDR131C

1

1

Small-scale

0.501

High

368456

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.500

High

381496

GAL1
Galactokinase

1

1

High-throughput

0.500

High

424748

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.500

High

454482

TBA1
Tubulin alpha-1 chain

1

5

High-throughput

0.500

High

454664

TBA3
Tubulin alpha-3 chain

1

6

High-throughput

0.500

High

498607

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.500

High

556339

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.500

High

562445

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

2

High-throughput

0.500

High

636764

CDC48
Cell division control protein 48

1

8

High-throughput

0.500

High

693370

RPN2
26S proteasome regulatory subunit RPN2

1

2

High-throughput

0.500

High

715862

MDJ1
DnaJ homolog 1, mitochondrial

1

3

High-throughput

0.500

High

767749

IMB4
Importin subunit beta-4

1

8

High-throughput

0.500

High

811480

TCPQ
T-complex protein 1 subunit theta

1

2

High-throughput

0.500

High

887697

ACT
Actin

1

4

High-throughput

0.500

High

586211

PMA2
Plasma membrane ATPase 2

1

3

High-throughput

0.489

High

707944

GCN1
eIF-2-alpha kinase activator GCN1

1

3

High-throughput

0.489

High

811156

BBC1
Myosin tail region-interacting protein MTI1

1

2

High-throughput

0.489

High

791224

SKP2
F-box protein SKP2

1

0

Small-scale

0.480

High

979763

UFO1
Ubiquitin ligase complex F-box protein UFO1

1

0

Small-scale

0.480

High

985281

MDM30
Mitochondrial distribution and morphology protein 30

1

0

Small-scale

0.480

High

988525

YD306
F-box protein YDR306C

1

0

Small-scale

0.480

High

994546

DIA2
Protein DIA2

1

0

Small-scale

0.480

High

421702

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.479

High

554759

HSP26
Heat shock protein 26

1

0

High-throughput

0.479

High

785246

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.479

High

544525

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.479

High

663514

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

694282

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

2

High-throughput

0.479

High

994551

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

994557

CMR1
DNA damage-binding protein CMR1

1

7

High-throughput

0.479

High

994558

SMC6
Structural maintenance of chromosomes protein 6

1

6

High-throughput

0.479

High

675564

MCM4
DNA replication licensing factor MCM4

1

0

Small-scale

0.458

High

976276

SLD5
DNA replication complex GINS protein SLD5

1

0

Small-scale

0.458

High

986265

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

429578

LYS2
L-2-aminoadipate reductase

1

2

High-throughput

0.457

High

710320

SIP2
SNF1 protein kinase subunit beta-2

1

1

High-throughput

0.457

High

728773

BDF1
Bromodomain-containing factor 1

1

2

High-throughput

0.457

High

744950

YPT10
GTP-binding protein YPT10

1

1

High-throughput

0.457

High

772493

RAD26
DNA repair and recombination protein RAD26

1

1

High-throughput

0.457

High

810935

MTR4
ATP-dependent RNA helicase DOB1

1

3

High-throughput

0.457

High

819917

CLA4
Serine/threonine-protein kinase CLA4

1

1

High-throughput

0.457

High

865829

RIA1
Ribosome assembly protein 1

1

2

High-throughput

0.457

High

342125

ATPB
ATP synthase subunit beta, mitochondrial

1

3

High-throughput

0.457

High

378407

LEU3
3-isopropylmalate dehydrogenase

1

1

High-throughput

0.457

High

423920

ATPA
ATP synthase subunit alpha, mitochondrial

1

3

High-throughput

0.457

High

583264

METK2
S-adenosylmethionine synthase 2

1

1

High-throughput

0.457

High

867528

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

1

High-throughput

0.457

High

367003

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.445

High

450214

HSP73
Heat shock protein SSA3

1

5

High-throughput

0.445

High

515208

SCH9
Serine/threonine-protein kinase SCH9

1

4

High-throughput

0.445

High

713027

BMH2
Protein BMH2

1

4

High-throughput

0.445

High

766249

HSP7E
Heat shock protein SSC3, mitochondrial

1

9

High-throughput

0.445

High

768403

GPP2
Glycerol-1-phosphate phosphohydrolase 2

1

1

High-throughput

0.445

High

769656

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

974451

ELOC
Elongin-C

1

2

Small-scale

0.445

High

389420

HXKB
Hexokinase-2

1

0

High-throughput

0.438

High

419400

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.438

High

425253

PHO2
Regulatory protein PHO2

1

0

High-throughput

0.438

High

509202

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

High-throughput

0.438

High

728011

MRP8
Uncharacterized protein MRP8

1

0

High-throughput

0.438

High

732456

FRMSR
Free methionine-R-sulfoxide reductase

1

0

High-throughput

0.438

High

744836

ERT1
Transcription activator of gluconeogenesis ERT1

1

0

High-throughput

0.438

High

765886

ACA1
ATF/CREB activator 1

1

0

High-throughput

0.438

High

793578

NSE4
Non-structural maintenance of chromosome element 4

1

0

High-throughput

0.438

High

797312

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.438

High

798357

MHP1
MAP-homologous protein 1

1

0

High-throughput

0.438

High

811364

NOP9
Nucleolar protein 9

1

0

High-throughput

0.438

High

965378

BLH1
Cysteine proteinase 1, mitochondrial

1

0

High-throughput

0.438

High

969466

YKZ1
Uncharacterized protein YKR011C

1

0

High-throughput

0.438

High

979276

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

0

High-throughput

0.438

High

979401

MIX14
Mitochondrial intermembrane space cysteine motif-containing protein MIX14

1

0

High-throughput

0.438

High

979484

LCD1
DNA damage checkpoint protein LCD1

1

0

High-throughput

0.438

High

981032

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.438

High

988569

CENPO
Inner kinetochore subunit MCM21

1

0

High-throughput

0.438

High

988701

CDC73
Cell division control protein 73

1

0

High-throughput

0.438

High

994562

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.438

High

141877

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.426

High

478684

IPB2
Protease B inhibitor 2

1

0

High-throughput

0.426

High

747627

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.426

High

755965

NDT80
Meiosis-specific transcription factor NDT80

1

0

High-throughput

0.426

High

763190

FHP
Flavohemoprotein

1

0

High-throughput

0.426

High

962612

STP1
Transcription factor STP1

1

0

High-throughput

0.426

High

979415

BUD22
Bud site selection protein 22

1

0

High-throughput

0.426

High

987495

YL352
F-box protein YLR352W

1

0

High-throughput

0.426

High

992216

ISA1
Iron-sulfur assembly protein 1

1

0

High-throughput

0.426

High

994554

CSN10
COP9 signalosome complex subunit 10

1

0

High-throughput

0.426

High

546132

SYDM
Aspartate--tRNA ligase, mitochondrial

1

1

High-throughput

0.417

High

753464

WSC4
Cell wall integrity and stress response component 4

1

3

High-throughput

0.417

High

762863

MST28
Multicopy suppressor of SEC21 protein 28

1

1

High-throughput

0.417

High

773828

CSS1
Secreted protein CSS1

1

4

High-throughput

0.417

High

799870

ROK1
ATP-dependent RNA helicase ROK1

1

2

High-throughput

0.417

High

859838

MRH4
ATP-dependent RNA helicase MRH4, mitochondrial

1

2

High-throughput

0.417

High

865165

COS1
Protein COS1

1

1

High-throughput

0.417

High

979254

UTP15
U3 small nucleolar RNA-associated protein 15

1

3

High-throughput

0.417

High

994552

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

1

High-throughput

0.417

High

342393

CISY1
Citrate synthase, mitochondrial

1

2

High-throughput

0.407

High

994559

LAG2
Cullin-associated NEDD8-dissociated protein 1 homolog

2

0

Small-scale

0.328

High

762743

ACON2
Homocitrate dehydratase, mitochondrial

2

0

High-throughput

0.307

High

994441

CRT10
Protein CRT10

2

0

Small-scale

0.298

High

660938

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

0

High-throughput

0.279

Low

746962

ECM33
Cell wall protein ECM33

1

0

High-throughput

0.279

Low

750969

YGP1
Protein YGP1

1

0

High-throughput

0.279

Low

784439

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.279

Low

992460

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.279

Low

716135

CBF3C
Centromere DNA-binding protein complex CBF3 subunit C

1

0

Small-scale

0.261

Low

762731

RCY1
Recyclin-1

1

0

Small-scale

0.261

Low

381725

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

453034

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.261

Low

581325

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.261

Low

630834

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.261

Low

400197

PLMT
Phosphatidyl-N-methylethanolamine N-methyltransferase

1

0

High-throughput

0.238

Low

598684

OSM1
Fumarate reductase 2

1

0

High-throughput

0.238

Low

607514

RM20
Large ribosomal subunit protein mL58

1

0

High-throughput

0.238

Low

660271

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.238

Low

693262

SCM4
Protein SCM4

1

0

High-throughput

0.238

Low

693510

SNQ2
Protein SNQ2

1

0

High-throughput

0.238

Low

693906

STE14
Protein-S-isoprenylcysteine O-methyltransferase

1

0

High-throughput

0.238

Low

699144

SEC6
Exocyst complex component SEC6

1

0

High-throughput

0.238

Low

732616

TCD2
tRNA threonylcarbamoyladenosine dehydratase 2

1

0

High-throughput

0.238

Low

746105

RRT1
Regulator of rDNA transcription protein 1

1

0

High-throughput

0.238

Low

746117

YBE4
Uncharacterized protein YBL044W

1

0

High-throughput

0.238

Low

748223

CS111
F-box protein COS111

1

0

High-throughput

0.238

Low

755382

YHP5
Putative uncharacterized protein YHR095W

1

0

High-throughput

0.238

Low

755993

YHT0
Uncharacterized protein YHR130C

1

0

High-throughput

0.238

Low

768379

YE17
Uncharacterized protein YER187W

1

0

High-throughput

0.238

Low

812541

ENT3
Epsin-3

1

0

High-throughput

0.238

Low

858743

ERG25
C-4 methylsterol oxidase ERG25

1

0

High-throughput

0.238

Low

971995

SMA1
Spore membrane assembly protein 1

1

0

High-throughput

0.238

Low

973750

RT51
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.238

Low

991517

SNA4
Protein SNA4

1

0

High-throughput

0.238

Low

994550

VPS54
Vacuolar protein sorting-associated protein 54

1

0

High-throughput

0.238

Low

994561

AP2M
AP-2 complex subunit mu

1

0

High-throughput

0.238

Low

350926

YPT1
GTP-binding protein YPT1

1

0

High-throughput

0.232

Low

448521

PRTB
Cerevisin

1

0

High-throughput

0.232

Low

746482

DSF2
Protein DSF2

1

0

High-throughput

0.232

Low

753492

NPR3
Nitrogen permease regulator 3

1

0

High-throughput

0.232

Low

986195

BOP2
Protein BOP2

1

0

High-throughput

0.232

Low

991494

ATG20
Autophagy-related protein 20

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024