Protein: RPN12
26S proteasome regulatory subunit RPN12 (Nuclear integrity protein 1)

Gene: RPN12
Organism: Saccharomyces cerevisiae S288C
Interactions: 95
UniProt ID: P32496

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008541 - proteasome regulatory particle, lid subcomplex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

691508

RPN5
26S proteasome regulatory subunit RPN5

10

2

Small-scale

0.975

High

691507

RPN8
26S proteasome regulatory subunit RPN8

8

3

Small-scale

0.973

High

691503

RPN7
26S proteasome regulatory subunit RPN7

9

3

Small-scale

0.972

High

691473

RPN3
26S proteasome regulatory subunit RPN3

7

2

Small-scale

0.965

High

691509

RPN6
26S proteasome regulatory subunit RPN6

8

2

Small-scale

0.963

High

691498

RPN9
26S proteasome regulatory subunit RPN9

6

3

Small-scale

0.945

High

691484

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

27

5

Small-scale

0.767

High

691456

PRS7
26S proteasome regulatory subunit 7 homolog

9

6

Small-scale

0.752

High

604768

PSB4
Proteasome subunit beta type-4

9

7

Small-scale

0.750

High

691468

RPN10
26S proteasome regulatory subunit RPN10

7

2

Small-scale

0.747

High

691467

RPN1
26S proteasome regulatory subunit RPN1

8

7

Small-scale

0.746

High

691495

PRS8
26S proteasome regulatory subunit 8 homolog

6

8

Small-scale

0.732

High

691455

PRS6B
26S proteasome regulatory subunit 6B homolog

5

6

Small-scale

0.716

High

691450

RPN2
26S proteasome regulatory subunit RPN2

5

7

Small-scale

0.712

High

691453

RAD23
UV excision repair protein RAD23

5

8

Small-scale

0.703

High

691478

PRS4
26S proteasome regulatory subunit 4 homolog

4

7

High-throughput

0.694

High

691493

PRS10
26S proteasome subunit RPT4

4

7

High-throughput

0.694

High

691454

PRS6A
26S proteasome regulatory subunit 6A

4

7

High-throughput

0.691

High

691490

PSD10
Probable 26S proteasome regulatory subunit p28

4

1

Small-scale

0.689

High

294105

SEM1
26S proteasome complex subunit SEM1

5

0

Small-scale

0.679

High

691461

HSM3
DNA mismatch repair protein HSM3

5

0

Small-scale

0.676

High

691466

ECM29
Proteasome component ECM29

3

1

High-throughput

0.662

High

691476

PSA6
Proteasome subunit alpha type-6

3

5

High-throughput

0.662

High

691449

RPN12
26S proteasome regulatory subunit RPN12

1

1

High-throughput

0.618

High

691485

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

2

1

High-throughput

0.601

High

691492

RPN14
26S proteasome regulatory subunit RPN14

2

1

High-throughput

0.594

High

597215

PSA7
Probable proteasome subunit alpha type-7

2

5

Small-scale

0.586

High

619339

PSA3
Proteasome subunit alpha type-3

2

3

Small-scale

0.586

High

141836

RPN13
26S proteasome regulatory subunit RPN13

2

0

High-throughput

0.585

High

619431

PSA2
Proteasome subunit alpha type-2

2

4

High-throughput

0.584

High

625918

PSB2
Proteasome subunit beta type-2

2

5

Small-scale

0.584

High

691477

PSA4
Proteasome subunit alpha type-4

2

4

Small-scale

0.584

High

691502

DON1
Donuts protein 1

2

0

High-throughput

0.565

High

691496

RPN4
Protein RPN4

2

0

Small-scale

0.559

High

510627

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

691451

HSP7F
Heat shock protein homolog SSE1

2

1

High-throughput

0.552

High

691486

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

1

High-throughput

0.536

High

679854

FUN30
ATP-dependent helicase FUN30

1

1

High-throughput

0.515

High

477184

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

450291

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.493

High

586467

PRP9
Pre-mRNA-splicing factor PRP9

1

0

High-throughput

0.493

High

687667

BTAF1
TATA-binding protein-associated factor MOT1

1

0

High-throughput

0.493

High

691452

TOR2
Serine/threonine-protein kinase TOR2

1

0

High-throughput

0.493

High

691458

TFC3
Transcription factor tau 138 kDa subunit

1

0

High-throughput

0.493

High

691469

VPS45
Vacuolar protein sorting-associated protein 45

1

0

High-throughput

0.493

High

691501

CSM3
Chromosome segregation in meiosis protein 3

1

0

High-throughput

0.493

High

691512

NOP14
Nucleolar complex protein 14

1

0

High-throughput

0.493

High

578514

SEC18
Vesicular-fusion protein SEC18

1

1

High-throughput

0.479

High

597301

PSA1
Proteasome subunit alpha type-1

1

3

High-throughput

0.479

High

619959

PSB6
Proteasome subunit beta type-6

1

8

High-throughput

0.479

High

632474

PSB3
Proteasome subunit beta type-3

1

7

High-throughput

0.479

High

675398

PSB5
Proteasome subunit beta type-5

1

6

High-throughput

0.479

High

675450

PSB7
Proteasome subunit beta type-7

1

5

High-throughput

0.479

High

689158

PSA5
Proteasome subunit alpha type-5

1

3

High-throughput

0.479

High

691462

PSB1
Proteasome subunit beta type-1

1

6

High-throughput

0.479

High

691463

STS1
Tethering factor for nuclear proteasome STS1

1

1

Small-scale

0.479

High

691474

DDI1
DNA damage-inducible protein 1

1

1

Small-scale

0.479

High

691481

PSMD9
Probable 26S proteasome regulatory subunit p27

1

2

Small-scale

0.479

High

691488

DSK2
Ubiquitin domain-containing protein DSK2

1

9

Small-scale

0.479

High

691506

NOB1
20S-pre-rRNA D-site endonuclease NOB1

1

0

Small-scale

0.460

High

406887

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

416767

CDC31
Cell division control protein 31

1

0

Small-scale

0.458

High

543398

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

557943

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

627821

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

661648

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

691457

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

691459

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

691483

BLM10
Proteasome activator BLM10

1

0

High-throughput

0.458

High

691491

INO80
Chromatin-remodeling ATPase INO80

1

0

Small-scale

0.458

High

691494

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

High-throughput

0.458

High

691500

UFO1
Ubiquitin ligase complex F-box protein UFO1

1

0

Small-scale

0.458

High

691504

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

691511

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.458

High

691475

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

691472

PAC2
Protein PAC2

1

2

Small-scale

0.437

High

691480

MLP2
Protein MLP2

1

1

High-throughput

0.437

High

493465

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

498471

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.426

High

691460

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.426

High

691465

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

691482

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

691497

ESC1
Silent chromatin protein ESC1

2

0

High-throughput

0.305

High

599962

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.279

Low

691499

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.279

Low

691510

LAS17
Proline-rich protein LAS17

1

0

High-throughput

0.279

Low

593511

DBP3
ATP-dependent RNA helicase DBP3

1

0

High-throughput

0.269

Low

691464

KIC1
Serine/threonine-protein kinase KIC1

1

0

High-throughput

0.269

Low

691470

MPT5
Suppressor protein MPT5

1

0

High-throughput

0.269

Low

691471

ERV46
ER-derived vesicles protein ERV46

1

0

High-throughput

0.269

Low

691487

XPT1
Xanthine phosphoribosyltransferase 1

1

0

High-throughput

0.265

Low

691479

YTA12
Mitochondrial inner membrane m-AAA protease component YTA12

1

0

High-throughput

0.249

Low

691489

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

691505

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024