Protein: RPN6
26S proteasome regulatory subunit RPN6 (Proteasome non-ATPase subunit 4)

Gene: RPN6
Organism: Saccharomyces cerevisiae S288C
Interactions: 108
UniProt ID: Q12377

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005198 - structural molecule activity
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008541 - proteasome regulatory particle, lid subcomplex
GO:0034515 - proteasome storage granule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

797651

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

28

20

Small-scale

0.990

High

1015374

RPN5
26S proteasome regulatory subunit RPN5

20

19

Small-scale

0.987

High

978512

RPN9
26S proteasome regulatory subunit RPN9

11

20

Small-scale

0.976

High

996269

RPN8
26S proteasome regulatory subunit RPN8

10

20

Small-scale

0.974

High

985895

RPN7
26S proteasome regulatory subunit RPN7

10

17

Small-scale

0.972

High

766899

RPN3
26S proteasome regulatory subunit RPN3

9

13

Small-scale

0.967

High

691509

RPN12
26S proteasome regulatory subunit RPN12

8

2

Small-scale

0.963

High

604844

PSB4
Proteasome subunit beta type-4

4

20

Small-scale

0.881

High

294168

SEM1
26S proteasome complex subunit SEM1

4

0

Small-scale

0.836

High

619525

PSA2
Proteasome subunit alpha type-2

3

20

Small-scale

0.834

High

771394

PSA4
Proteasome subunit alpha type-4

2

20

High-throughput

0.789

High

597279

PSA7
Probable proteasome subunit alpha type-7

2

20

Small-scale

0.754

High

753987

RPN1
26S proteasome regulatory subunit RPN1

9

15

Small-scale

0.748

High

757050

RPN10
26S proteasome regulatory subunit RPN10

8

3

Small-scale

0.748

High

703976

PRS7
26S proteasome regulatory subunit 7 homolog

8

20

Small-scale

0.747

High

703867

PRS6B
26S proteasome regulatory subunit 6B homolog

6

20

Small-scale

0.734

High

703763

PRS6A
26S proteasome regulatory subunit 6A

6

20

Small-scale

0.730

High

968100

PRS8
26S proteasome regulatory subunit 8 homolog

5

20

High-throughput

0.716

High

693378

RPN2
26S proteasome regulatory subunit RPN2

5

14

Small-scale

0.709

High

771751

PRS4
26S proteasome regulatory subunit 4 homolog

4

20

High-throughput

0.694

High

797736

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

4

3

High-throughput

0.694

High

862691

PRS10
26S proteasome subunit RPT4

4

20

High-throughput

0.694

High

753455

ECM29
Proteasome component ECM29

4

2

High-throughput

0.691

High

697128

RAD23
UV excision repair protein RAD23

4

20

Small-scale

0.683

High

860044

RPN14
26S proteasome regulatory subunit RPN14

3

4

High-throughput

0.667

High

1015535

RPN6
26S proteasome regulatory subunit RPN6

1

18

High-throughput

0.665

High

141880

RPN13
26S proteasome regulatory subunit RPN13

4

0

High-throughput

0.664

High

837216

PSD10
Probable 26S proteasome regulatory subunit p28

4

3

Small-scale

0.630

High

492884

HSP71
Heat shock protein SSA1

3

4

High-throughput

0.624

High

597356

PSA1
Proteasome subunit alpha type-1

1

20

High-throughput

0.618

High

619400

PSA3
Proteasome subunit alpha type-3

1

20

High-throughput

0.618

High

625966

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.618

High

632511

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.618

High

675494

PSB7
Proteasome subunit beta type-7

1

20

High-throughput

0.618

High

689219

PSA5
Proteasome subunit alpha type-5

1

20

High-throughput

0.618

High

751188

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.618

High

771361

PSA6
Proteasome subunit alpha type-6

1

20

High-throughput

0.618

High

544620

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.584

High

495341

HSP72
Heat shock protein SSA2

2

4

High-throughput

0.552

High

775502

PSMD9
Probable 26S proteasome regulatory subunit p27

2

2

Small-scale

0.533

High

979200

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.529

High

513257

SSB1
Ribosome-associated molecular chaperone SSB1

2

4

High-throughput

0.504

High

539427

KSS1
Mitogen-activated protein kinase KSS1

1

2

High-throughput

0.489

High

761518

PEX7
Peroxisomal targeting signal 2 receptor

1

6

High-throughput

0.489

High

961945

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

2

High-throughput

0.489

High

367106

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

865893

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

4

High-throughput

0.479

High

975873

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

679880

FUN30
ATP-dependent helicase FUN30

1

1

High-throughput

0.470

High

687770

BTAF1
TATA-binding protein-associated factor MOT1

1

1

High-throughput

0.470

High

758057

VPS45
Vacuolar protein sorting-associated protein 45

1

2

High-throughput

0.470

High

728346

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

477496

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

17

High-throughput

0.457

High

523327

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

3

Small-scale

0.437

High

578580

SEC18
Vesicular-fusion protein SEC18

1

1

High-throughput

0.437

High

706560

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

730951

CENPA
Histone H3-like centromeric protein CSE4

1

1

High-throughput

0.437

High

866571

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.437

High

1015041

RTK1
Probable serine/threonine-protein kinase RTK1

1

1

High-throughput

0.437

High

520017

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.407

High

681096

HS104
Heat shock protein 104

1

1

High-throughput

0.407

High

705823

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

748475

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

15

High-throughput

0.407

High

769839

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.407

High

775690

DJP1
DnaJ-like protein 1

1

1

High-throughput

0.407

High

988620

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

3

High-throughput

0.407

High

748968

HSM3
DNA mismatch repair protein HSM3

5

0

Small-scale

0.369

High

978386

SCC2
Sister chromatid cohesion protein 2

2

0

High-throughput

0.313

High

340766

PGK
Phosphoglycerate kinase

2

0

High-throughput

0.307

High

628606

SIS1
Protein SIS1

2

0

High-throughput

0.305

High

977149

ESC1
Silent chromatin protein ESC1

2

0

High-throughput

0.305

High

746369

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

0

High-throughput

0.279

Low

748406

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.279

Low

861496

BUD32
EKC/KEOPS complex subunit BUD32

1

0

High-throughput

0.279

Low

687123

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

0

High-throughput

0.269

Low

704499

DHE2
NAD-specific glutamate dehydrogenase

1

0

High-throughput

0.269

Low

710102

TFC3
Transcription factor tau 138 kDa subunit

1

0

High-throughput

0.269

Low

732617

TCD2
tRNA threonylcarbamoyladenosine dehydratase 2

1

0

High-throughput

0.269

Low

763799

ERV46
ER-derived vesicles protein ERV46

1

0

High-throughput

0.269

Low

368764

GCN4
General control transcription factor GCN4

1

0

High-throughput

0.265

Low

358317

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

407401

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

524487

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

566246

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.249

Low

606785

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

632152

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

636241

FUB1
Silencing boundary-establishment protein FUB1

1

0

High-throughput

0.249

Low

663710

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

688497

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

692099

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.249

Low

752733

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

768326

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.249

Low

792634

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

820240

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

822963

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

967830

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

976422

RPN4
Protein RPN4

1

0

Small-scale

0.249

Low

979085

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

986290

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

987074

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

1015513

CSN10
COP9 signalosome complex subunit 10

1

0

Small-scale

0.249

Low

1015536

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.249

Low

629935

ATX10
Ataxin-10 homolog

1

0

High-throughput

0.238

Low

629083

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.232

Low

700689

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.232

Low

767988

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.232

Low

810207

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024