Protein: PTK2
Serine/threonine-protein kinase PTK2/STK2 (EC 2.7.11.1)

Gene: PTK2
Organism: Saccharomyces cerevisiae S288C
Interactions: 234
UniProt ID: P47116

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000296 - spermine transport
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

339723

CDK1
Cyclin-dependent kinase 1

2

17

Small-scale

0.807

High

757302

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

9

High-throughput

0.691

High

811911

PKH1
Serine/threonine-protein kinase PKH1

1

18

High-throughput

0.691

High

416792

CDC31
Cell division control protein 31

1

17

High-throughput

0.665

High

409659

KAPC
cAMP-dependent protein kinase type 3

1

12

High-throughput

0.647

High

434767

PBS2
MAP kinase kinase PBS2

1

19

High-throughput

0.647

High

485551

SSBP1
Single-stranded nucleic acid-binding protein

1

5

High-throughput

0.647

High

539261

YAK1
Dual specificity protein kinase YAK1

1

19

High-throughput

0.647

High

605665

KIN3
Serine/threonine-protein kinase KIN3

1

19

High-throughput

0.647

High

618336

STE11
Serine/threonine-protein kinase STE11

1

17

High-throughput

0.647

High

648392

NSR1
Nuclear localization sequence-binding protein

1

8

High-throughput

0.647

High

659873

PRR1
Serine/threonine-protein kinase PRR1

1

16

High-throughput

0.647

High

730521

KKQ8
Probable serine/threonine-protein kinase KKQ8

1

17

High-throughput

0.647

High

743460

YPK3
Serine/threonine-protein kinase YPK3

1

20

High-throughput

0.647

High

743894

AKL1
Serine/threonine-protein kinase AKL1

1

17

High-throughput

0.647

High

753789

YHI2
Uncharacterized protein YHR022C

1

3

High-throughput

0.647

High

774395

HOS4
Protein HOS4

1

2

High-throughput

0.647

High

811894

FPK1
Flippase kinase 1

1

14

High-throughput

0.647

High

811899

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.647

High

811912

TDA1
Serine/threonine-protein kinase TDA1

1

18

High-throughput

0.647

High

811918

AVO2
Target of rapamycin complex 2 subunit AVO2

1

2

High-throughput

0.647

High

811941

YGK3
Glycogen synthase kinase-3 homolog YGK3

1

19

High-throughput

0.647

High

491705

HSP71
Heat shock protein SSA1

3

19

High-throughput

0.633

High

811934

NOP12
Nucleolar protein 12

1

8

High-throughput

0.618

High

544018

HSC82
ATP-dependent molecular chaperone HSC82

1

20

High-throughput

0.618

High

694103

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

5

High-throughput

0.618

High

811871

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

18

High-throughput

0.618

High

707029

MSN4
Zinc finger protein MSN4

1

0

High-throughput

0.614

High

783859

AZF1
Transcription factor AZF1

1

0

High-throughput

0.614

High

770374

SIP5
Protein SIP5

2

3

High-throughput

0.602

High

588138

HSP60
Heat shock protein 60, mitochondrial

2

15

High-throughput

0.602

High

773679

6P21
6-phosphofructo-2-kinase 1

2

7

High-throughput

0.585

High

635967

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

20

High-throughput

0.579

High

450469

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

3

High-throughput

0.536

High

676177

XPO1
Exportin-1

1

7

High-throughput

0.536

High

764987

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.536

High

767060

ARB1
ABC transporter ATP-binding protein ARB1

1

3

High-throughput

0.536

High

811950

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.513

High

340194

KPYK1
Pyruvate kinase 1

1

2

High-throughput

0.501

High

393590

PMA1
Plasma membrane ATPase 1

1

4

Small-scale

0.501

High

417590

PHSG
Glycogen phosphorylase

1

2

High-throughput

0.501

High

524374

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.501

High

586421

PRP6
Pre-mRNA-splicing factor 6

1

4

High-throughput

0.501

High

613825

TKT1
Transketolase 1

1

1

High-throughput

0.501

High

621169

FPS1
Glycerol uptake/efflux facilitator protein

1

9

High-throughput

0.501

High

622046

SSD1
Protein SSD1

1

1

High-throughput

0.501

High

622173

MCM3
DNA replication licensing factor MCM3

1

8

High-throughput

0.501

High

629433

PUF4
Pumilio homology domain family member 4

1

1

High-throughput

0.501

High

629914

YCR3
Major facilitator superfamily domain-containing protein YCR023C

1

4

High-throughput

0.501

High

636666

CDC48
Cell division control protein 48

1

8

High-throughput

0.501

High

648995

PHO91
Low-affinity phosphate transporter PHO91

1

3

High-throughput

0.501

High

657797

MGLL
Monoglyceride lipase

1

1

High-throughput

0.501

High

680290

VATC
V-type proton ATPase subunit C

1

2

High-throughput

0.501

High

685414

MLF3
Protein MLF3

1

1

High-throughput

0.501

High

689191

PSA5
Proteasome subunit alpha type-5

1

6

High-throughput

0.501

High

689728

MDHP
Malate dehydrogenase, peroxisomal

1

3

High-throughput

0.501

High

693440

PAH1
Phosphatidic acid phosphohydrolase 1

1

3

High-throughput

0.501

High

698171

AFG2
ATPase family gene 2 protein

1

8

High-throughput

0.501

High

699699

DRS1
ATP-dependent RNA helicase DRS1

1

9

High-throughput

0.501

High

699795

KPR1
Ribose-phosphate pyrophosphokinase 1

1

1

High-throughput

0.501

High

704946

PGM1
Phosphoglucomutase 1

1

1

High-throughput

0.501

High

710565

UBX1
UBX domain-containing protein 1

1

1

High-throughput

0.501

High

715089

UBL1
Ubiquitin carboxyl-terminal hydrolase YUH1

1

4

High-throughput

0.501

High

733052

ALY1
Arrestin-related trafficking adapter 6

1

5

High-throughput

0.501

High

734138

PXL1
Paxillin-like protein 1

1

6

High-throughput

0.501

High

740828

SOL2
6-phosphogluconolactonase-like protein 2

1

1

High-throughput

0.501

High

741422

PAM1
Protein PAM1

1

1

High-throughput

0.501

High

753117

YHR2
Uncharacterized trans-sulfuration enzyme YHR112C

1

1

High-throughput

0.501

High

756262

KEL1
Kelch repeat-containing protein 1

1

3

High-throughput

0.501

High

758882

MSS4
Phosphatidylinositol 4-phosphate 5-kinase MSS4

1

6

High-throughput

0.501

High

760894

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.501

High

762748

PHO90
Low-affinity phosphate transporter PHO90

1

2

High-throughput

0.501

High

765312

RSP5
E3 ubiquitin-protein ligase RSP5

1

8

High-throughput

0.501

High

767337

ICP55
Intermediate cleaving peptidase 55

1

2

High-throughput

0.501

High

773892

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

High-throughput

0.501

High

774051

NDC80
Kinetochore protein NDC80

1

20

High-throughput

0.501

High

774169

VHS2
Protein VHS2

1

1

High-throughput

0.501

High

774879

SER33
D-3-phosphoglycerate dehydrogenase 2

1

2

High-throughput

0.501

High

774923

MAM33
Mitochondrial acidic protein MAM33

1

4

High-throughput

0.501

High

792367

YG4I
Uncharacterized GTP-binding protein YGR210C

1

3

High-throughput

0.501

High

796994

AQY3
Aquaglycerol porin AQY3

1

9

High-throughput

0.501

High

797002

ALR2
Magnesium transporter ALR2

1

2

High-throughput

0.501

High

805045

ARC1
tRNA-aminoacylation cofactor ARC1

1

4

High-throughput

0.501

High

810661

ALY2
Arrestin-related trafficking adapter 3

1

5

High-throughput

0.501

High

811873

MET7
Cystathionine gamma-synthase

1

1

High-throughput

0.501

High

811874

GYP3
GTPase-activating protein GYP3

1

2

High-throughput

0.501

High

811875

SF3B1
U2 snRNP component HSH155

1

11

High-throughput

0.501

High

811881

MGA1
Protein MGA1

1

6

High-throughput

0.501

High

811883

HUL5
E3 ubiquitin-protein ligase HUL5

1

10

High-throughput

0.501

High

811887

GYP2
GTPase-activating protein GYP2

1

2

High-throughput

0.501

High

811891

REXO1
RNA exonuclease 1

1

3

High-throughput

0.501

High

811896

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

High-throughput

0.501

High

811898

ESBP6
Uncharacterized transporter ESBP6

1

4

High-throughput

0.501

High

811900

SLM2
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2

1

3

High-throughput

0.501

High

811909

NGL2
RNA exonuclease NGL2

1

1

High-throughput

0.501

High

811910

GCN5
Histone acetyltransferase GCN5

1

7

High-throughput

0.501

High

811914

ENT5
Epsin-5

1

2

High-throughput

0.501

High

811916

YM54
Uncharacterized protein YMR196W

1

2

High-throughput

0.501

High

811917

ASND1
Asparagine synthetase domain-containing protein YML096W

1

2

High-throughput

0.501

High

811921

YTH1
mRNA 3'-end-processing protein YTH1

1

1

High-throughput

0.501

High

811922

RGC1
Regulator of the glycerol channel 1

1

3

High-throughput

0.501

High

811924

YL257
Uncharacterized protein YLR257W

1

1

High-throughput

0.501

High

811928

BDF2
Bromodomain-containing factor 2

1

9

High-throughput

0.501

High

811931

FRA1
Putative Xaa-Pro aminopeptidase FRA1

1

1

High-throughput

0.501

High

811932

ENT4
Epsin-4

1

2

High-throughput

0.501

High

811935

ALR1
Magnesium transporter ALR1

1

2

High-throughput

0.501

High

811937

LKHA4
Leucine aminopeptidase 2

1

1

High-throughput

0.501

High

811940

WTM2
Transcriptional modulator WTM2

1

1

High-throughput

0.501

High

811943

WTM1
Transcriptional modulator WTM1

1

1

High-throughput

0.501

High

811944

YN11A
Transposon Ty1-NL1 Gag polyprotein

1

3

High-throughput

0.501

High

141901

DIF1
Damage-regulated import facilitator 1

1

0

High-throughput

0.480

High

439577

DCOR
Ornithine decarboxylase

1

0

High-throughput

0.480

High

440156

ERG20
Farnesyl pyrophosphate synthase

1

0

High-throughput

0.480

High

540196

NMT
Glycylpeptide N-tetradecanoyltransferase

1

0

High-throughput

0.480

High

562989

STF2
ATPase-stabilizing factor 15 kDa protein

1

0

High-throughput

0.480

High

576118

MET16
Phosphoadenosine phosphosulfate reductase

1

0

High-throughput

0.480

High

587916

PNPP
4-nitrophenylphosphatase

1

0

High-throughput

0.480

High

594103

KICH
Choline kinase

1

0

High-throughput

0.480

High

598600

UTR1
NAD(+) kinase

1

0

High-throughput

0.480

High

648325

GYS2
Glycogen [starch] synthase isoform 2

1

0

High-throughput

0.480

High

688695

TREA
Cytosolic neutral trehalase

1

0

High-throughput

0.480

High

691701

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.480

High

715896

ATG19
Autophagy-related protein 19

1

0

High-throughput

0.480

High

732498

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.480

High

733076

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.480

High

733480

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.480

High

757096

SET5
Histone-lysine N-methyltransferase SET5

1

0

High-throughput

0.480

High

758972

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.480

High

763266

NPT1
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.480

High

771531

SECU
Securin

1

0

High-throughput

0.480

High

772620

YJH0
Inactive deaminase YJL070C

1

0

High-throughput

0.480

High

777411

YAP4
AP-1-like transcription factor YAP4

1

0

High-throughput

0.480

High

783875

BUD6
Bud site selection protein 6

1

0

High-throughput

0.480

High

797777

IGD1
Inhibitor of glycogen debranching 1

1

0

High-throughput

0.480

High

798082

RMD8
Sporulation protein RMD8

1

0

High-throughput

0.480

High

809693

IDS2
IME2-dependent-signaling protein

1

0

High-throughput

0.480

High

810555

MTC1
Maintenance of telomere capping protein 1

1

0

High-throughput

0.480

High

811865

YJ26
Uncharacterized protein YJR056C

1

0

High-throughput

0.480

High

811872

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.480

High

811876

PSP1
Protein PSP1

1

0

High-throughput

0.480

High

811878

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.480

High

811882

NIF3
NGG1-interacting factor 3

1

0

High-throughput

0.480

High

811884

NPY1
NAD-capped RNA hydrolase NPY1

1

0

High-throughput

0.480

High

811885

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.480

High

811888

RTS3
Protein phosphatase type 2A regulatory subunit RTS3

1

0

High-throughput

0.480

High

811889

AP18B
Clathrin coat assembly protein AP180B

1

0

High-throughput

0.480

High

811890

YG5L
Uncharacterized protein YGR266W

1

0

High-throughput

0.480

High

811901

SKO1
CRE-binding bZIP protein SKO1

1

0

High-throughput

0.480

High

811905

YMY9
Glucose-6-phosphate 1-epimerase

1

0

High-throughput

0.480

High

811908

ADD37
Alpha1-proteinase inhibitor-degradation deficient protein 37

1

0

High-throughput

0.480

High

811920

HRI1
Protein HRI1

1

0

High-throughput

0.480

High

811925

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.480

High

811926

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

1

0

High-throughput

0.480

High

811929

CYK3
Cytokinesis protein 3

1

0

High-throughput

0.480

High

811930

HBT1
Protein HBT1

1

0

High-throughput

0.480

High

811933

CMS1
Protein CMS1

1

0

High-throughput

0.480

High

811939

TIP41
Type 2A phosphatase activator TIP41

1

0

High-throughput

0.480

High

811945

WHI5
G1-specific transcriptional repressor WHI5

1

0

High-throughput

0.480

High

811946

STB3
Protein STB3

1

0

High-throughput

0.480

High

811948

RKM4
Ribosomal lysine N-methyltransferase 4

1

0

High-throughput

0.480

High

342966

ENO2
Enolase 2

1

2

High-throughput

0.479

High

416018

DED1
ATP-dependent RNA helicase DED1

1

3

High-throughput

0.479

High

478326

HSP77
Import motor subunit, mitochondrial

1

14

High-throughput

0.479

High

494345

HSP72
Heat shock protein SSA2

1

19

High-throughput

0.479

High

662659

TF2B
Transcription initiation factor IIB

1

11

High-throughput

0.479

High

700973

SMY2
Protein SMY2

1

3

High-throughput

0.479

High

705377

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.479

High

715704

TAF14
Transcription initiation factor TFIID subunit 14

1

1

High-throughput

0.479

High

811879

SAP4
SIT4-associating protein SAP4

1

3

High-throughput

0.479

High

811938

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

768157

RTR1
RNA polymerase II subunit B1 CTD phosphatase RTR1

1

0

High-throughput

0.458

High

532793

ACOX
Acyl-coenzyme A oxidase

1

1

High-throughput

0.457

High

548486

DPOD
DNA polymerase delta catalytic subunit

1

4

High-throughput

0.457

High

612949

AIM17
Probable oxidoreductase AIM17

1

1

High-throughput

0.457

High

687611

DGR2
2-deoxy-glucose resistant protein 2

1

7

High-throughput

0.457

High

693862

SRP40
Suppressor protein SRP40

1

2

High-throughput

0.457

High

710294

TGL1
Sterol esterase TGL1

1

1

High-throughput

0.457

High

728082

MNR2
Manganese resistance protein MNR2

1

2

High-throughput

0.457

High

732071

AVT3
Vacuolar amino acid transporter 3

1

8

High-throughput

0.457

High

743782

PDX3
Pyridoxamine 5'-phosphate oxidase

1

1

High-throughput

0.457

High

747557

AIM3
Altered inheritance of mitochondria protein 3

1

4

High-throughput

0.457

High

751986

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

2

High-throughput

0.457

High

755720

TOM71
Protein TOM71

1

5

High-throughput

0.457

High

774420

SEC24
Protein transport protein SEC24

1

1

High-throughput

0.457

High

810861

IRC8
Uncharacterized protein IRC8

1

2

High-throughput

0.457

High

811118

BBC1
Myosin tail region-interacting protein MTI1

1

1

High-throughput

0.457

High

811520

AVT1
Vacuolar amino acid transporter 1

1

8

High-throughput

0.457

High

811877

AVT4
Vacuolar amino acid transporter 4

1

8

High-throughput

0.457

High

811886

ORM1
Protein ORM1

1

3

High-throughput

0.457

High

811892

ARE2
Sterol O-acyltransferase 2

1

1

High-throughput

0.457

High

811902

VTC3
Vacuolar transporter chaperone 3 complex subunit 3

1

1

High-throughput

0.457

High

811903

YP077
Uncharacterized protein YPL077C

1

1

High-throughput

0.457

High

811906

YMZ2
WD repeat-containing protein YMR102C

1

7

High-throughput

0.457

High

811907

NGL3
Probable RNA exonuclease NGL3

1

1

High-throughput

0.457

High

811913

YMD7
Uncharacterized protein YML037C

1

2

High-throughput

0.457

High

811915

NUP53
Nucleoporin NUP53

1

1

Small-scale

0.457

High

811923

ORM2
Protein ORM2

1

3

High-throughput

0.457

High

811927

NVJ2
Nucleus-vacuole junction protein 2

1

1

High-throughput

0.457

High

811936

GYP1
GTPase-activating protein GYP1

1

3

High-throughput

0.457

High

811949

RL21B
Large ribosomal subunit protein eL21B

1

1

High-throughput

0.457

High

811951

RS21B
Small ribosomal subunit protein eS21B

1

2

High-throughput

0.457

High

397605

OTC
Ornithine carbamoyltransferase

1

7

High-throughput

0.457

High

754520

SSZ1
Ribosome-associated complex subunit SSZ1

1

6

High-throughput

0.445

High

768826

SSB2
Ribosome-associated molecular chaperone SSB2

1

18

High-throughput

0.445

High

811942

HSP42
Heat shock protein 42

1

3

High-throughput

0.445

High

692833

SPT16
FACT complex subunit SPT16

1

3

Small-scale

0.437

High

762354

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

252713

MRP10
Small ribosomal subunit protein mS37

1

0

High-throughput

0.261

Low

411142

CCHL
Holocytochrome-c synthase

1

0

High-throughput

0.261

Low

488460

PT122
Protein PET122, mitochondrial

1

0

High-throughput

0.261

Low

562042

RGP1
Guanine nucleotide exchange factor subunit RGP1

1

0

High-throughput

0.261

Low

565245

SPO16
Sporulation-specific protein 16

1

0

High-throughput

0.261

Low

596996

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.261

Low

617235

MBR1
Mitochondrial biogenesis regulation protein 1

1

0

High-throughput

0.261

Low

659176

LAC1
Ceramide synthase LAC1

1

0

High-throughput

0.261

Low

691173

ISF1
Increasing suppression factor 1

1

0

High-throughput

0.261

Low

703304

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.261

Low

728114

BLI1
Biogenesis of lysosome-related organelles complex 1 subunit BLI1

1

0

High-throughput

0.261

Low

734163

SKG1
Suppressor of lethality of KEX2 GAS1 double null mutant protein 1

1

0

High-throughput

0.261

Low

746912

PFF1
Vacuolar membrane protease

1

0

High-throughput

0.261

Low

747758

ICS2
Increased copper sensitivity protein 2

1

0

High-throughput

0.261

Low

748921

BIT2
Probable target of rapamycin complex 2 subunit BIT2

1

0

High-throughput

0.261

Low

755510

YPT35
Endosomal/vacuolar adapter protein YPT35

1

0

High-throughput

0.261

Low

756475

SSP1
Sporulation-specific protein 1

1

0

High-throughput

0.261

Low

766739

RRAAH
4-hydroxy-4-methyl-2-oxoglutarate aldolase

1

0

High-throughput

0.261

Low

811826

VPS55
Vacuolar protein sorting-associated protein 55

1

0

High-throughput

0.261

Low

811880

PSD2
Phosphatidylserine decarboxylase proenzyme 2

1

0

High-throughput

0.261

Low

811893

ZRG17
Protein ZRG17

1

0

High-throughput

0.261

Low

811895

CWC25
Pre-mRNA-splicing factor CWC25

1

0

High-throughput

0.261

Low

811897

BNI5
Bud neck protein 5

1

0

High-throughput

0.261

Low

811904

ATG21
Autophagy-related protein 21

1

0

High-throughput

0.261

Low

811919

IVY1
Protein IVY1

1

0

High-throughput

0.261

Low

811947

FMP16
Protein FMP16, mitochondrial

1

0

High-throughput

0.261

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024