Protein: SMYD2
N-lysine methyltransferase SMYD2 (EC 2.1.1.-) (HSKM-B) (Histone methyltransferase SMYD2) (EC 2.1.1.354) (Lysine N-methyltransferase 3C) (SET and MYND domain-containing protein 2)

Gene: SMYD2
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q9NRG4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000993 - RNA polymerase II complex binding
GO:0002039 - p53 binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

387584

P53
Cellular tumor antigen p53

5

2

Small-scale

0.730

High

1034632

GOGA4
Golgin subfamily A member 4

3

3

High-throughput

0.667

High

1069527

TEBP
Prostaglandin E synthase 3

3

1

High-throughput

0.667

High

591108

BTF3
Transcription factor BTF3

3

1

High-throughput

0.665

High

1174670

H32
Histone H3.2

1

7

Small-scale

0.647

High

317865

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

2

2

High-throughput

0.628

High

1083009

CDC37
Hsp90 co-chaperone Cdc37

2

1

High-throughput

0.621

High

1230463

AHI1
Jouberin

1

1

High-throughput

0.618

High

871487

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

1

High-throughput

0.611

High

230434

ZC3H1
Zinc finger C3H1 domain-containing protein

2

0

High-throughput

0.602

High

351549

ANF
Natriuretic peptides A

2

0

High-throughput

0.602

High

1318368

FOXP3
Forkhead box protein P3

2

0

High-throughput

0.602

High

1334212

ZN408
Zinc finger protein 408

2

0

High-throughput

0.602

High

1344733

CELA1
Chymotrypsin-like elastase family member 1

2

0

High-throughput

0.602

High

1344735

CILK1
Serine/threonine-protein kinase ICK

2

0

High-throughput

0.595

High

432292

HS90A
Heat shock protein HSP 90-alpha

2

6

Small-scale

0.595

High

1295287

JPH4
Junctophilin-4

1

0

High-throughput

0.578

High

1344736

E41L3
Band 4.1-like protein 3

2

0

Small-scale

0.576

High

414380

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.554

High

1295760

BT3L4
Transcription factor BTF3 homolog 4

2

1

High-throughput

0.553

High

1344737

SNX11
Sorting nexin-11

2

1

High-throughput

0.553

High

883199

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

2

High-throughput

0.541

High

1020950

TRAF2
TNF receptor-associated factor 2

1

0

Small-scale

0.537

High

147292

TXND9
Thioredoxin domain-containing protein 9

1

1

High-throughput

0.536

High

320920

HS74L
Heat shock 70 kDa protein 4L

1

2

High-throughput

0.536

High

776192

ARL1
ADP-ribosylation factor-like protein 1

1

1

High-throughput

0.536

High

863026

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

1

High-throughput

0.536

High

874184

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

High-throughput

0.536

High

1045225

NACA
Nascent polypeptide-associated complex subunit alpha

1

1

High-throughput

0.536

High

1102533

ZXDC
Zinc finger protein ZXDC

1

1

High-throughput

0.536

High

1175362

RS27L
Ribosomal protein eS27-like

1

1

High-throughput

0.536

High

1310732

PELO
Protein pelota homolog

1

1

High-throughput

0.536

High

1315982

BEX2
Protein BEX2

1

1

High-throughput

0.536

High

1331988

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

3

High-throughput

0.536

High

1335446

BEX1
Protein BEX1

1

1

High-throughput

0.536

High

836019

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.515

High

515955

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

685046

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.513

High

848491

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

871072

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.513

High

911059

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.513

High

942125

RPP30
Ribonuclease P protein subunit p30

1

0

High-throughput

0.513

High

986551

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

High-throughput

0.513

High

1029331

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1216302

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

0

High-throughput

0.513

High

1224075

TRM2A
tRNA

1

0

High-throughput

0.513

High

1255857

MORC4
MORC family CW-type zinc finger protein 4

1

0

High-throughput

0.513

High

1344734

DIM1
Probable dimethyladenosine transferase

1

0

High-throughput

0.513

High

1344738

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

370513

ESR1
Estrogen receptor

1

1

Small-scale

0.501

High

170725

AXIN1
Axin-1

1

0

High-throughput

0.493

High

1344730

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

0

High-throughput

0.493

High

1344732

AKA11
A-kinase anchor protein 11

1

0

High-throughput

0.493

High

146729

NCKP5
Nck-associated protein 5

1

1

High-throughput

0.489

High

522571

MYH1
Myosin-1

1

2

High-throughput

0.479

High

528394

MYH6
Myosin-6

1

2

High-throughput

0.479

High

910586

RS14
Small ribosomal subunit protein uS11

1

1

High-throughput

0.479

High

1074244

SF3A1
Splicing factor 3A subunit 1

1

2

High-throughput

0.479

High

1224801

ASPM
Abnormal spindle-like microcephaly-associated protein

1

3

High-throughput

0.479

High

1296253

Z512B
Zinc finger protein 512B

1

1

High-throughput

0.479

High

1307575

AKAP9
A-kinase anchor protein 9

1

3

High-throughput

0.479

High

157773

GEMI2
Gem-associated protein 2

1

0

High-throughput

0.458

High

254637

CLAP2
CLIP-associating protein 2

1

0

High-throughput

0.458

High

264746

VP26A
Vacuolar protein sorting-associated protein 26A

1

0

High-throughput

0.458

High

417032

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.458

High

441379

RU2B
U2 small nuclear ribonucleoprotein B''

1

0

High-throughput

0.458

High

541173

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

0

High-throughput

0.458

High

671705

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.458

High

916402

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

1043607

CUL4B
Cullin-4B

1

0

Small-scale

0.458

High

1288195

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.458

High

1344729

SMC4
Structural maintenance of chromosomes protein 4

1

0

High-throughput

0.458

High

1344731

GSKIP
GSK3B-interacting protein

1

0

High-throughput

0.458

High

1295219

RADIL
Ras-associating and dilute domain-containing protein

1

1

High-throughput

0.437

High

1319395

CCSE1
Serine-rich coiled-coil domain-containing protein 1

2

0

High-throughput

0.328

High

1333221

RDD1
Required for drug-induced death protein 1

1

0

High-throughput

0.279

Low

1165613

MPZL3
Myelin protein zero-like protein 3

1

0

High-throughput

0.269

Low


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Last updated: 15 Jul 2024