Protein: GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4 (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4) (EC 1.11.1.9)

Gene: GPX4
Organism: Homo sapiens
Interactions: 50
UniProt ID: P36969

Gene Ontology (top 5):
GO:0004602 - glutathione peroxidase activity
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

739403

OTUB1
Ubiquitin thioesterase OTUB1

3

0

Small-scale

0.606

High

739402

RNF31
E3 ubiquitin-protein ligase RNF31

1

1

Small-scale

0.561

High

739391

CYTM
Cystatin-M

1

1

High-throughput

0.536

High

739398

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

739409

GSTO2
Glutathione S-transferase omega-2

1

1

High-throughput

0.536

High

173851

MK13
Mitogen-activated protein kinase 13

1

0

High-throughput

0.518

High

614261

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

1

High-throughput

0.515

High

687127

CDD
Cytidine deaminase

1

0

High-throughput

0.513

High

739377

OMP
Olfactory marker protein

1

0

High-throughput

0.513

High

739387

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

739406

GPA33
Cell surface A33 antigen

1

0

High-throughput

0.513

High

739410

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.513

High

739390

IL18
Interleukin-18

1

0

High-throughput

0.493

High

739401

RPE
Ribulose-phosphate 3-epimerase

1

0

High-throughput

0.493

High

739404

OTUD5
OTU domain-containing protein 5

1

0

High-throughput

0.493

High

739378

CY561
Transmembrane ascorbate-dependent reductase CYB561

1

3

High-throughput

0.489

High

739396

LHPL4
LHFPL tetraspan subfamily member 4 protein

1

1

High-throughput

0.489

High

670669

PRDX6
Peroxiredoxin-6

1

1

High-throughput

0.481

High

179567

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

318585

EYA4
Eyes absent homolog 4

1

1

High-throughput

0.479

High

739383

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

2

High-throughput

0.479

High

739386

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

Small-scale

0.479

High

739397

TAXB1
Tax1-binding protein 1

1

2

Small-scale

0.479

High

739400

MTMRE
Myotubularin-related protein 14

1

1

High-throughput

0.479

High

739393

SNR48
U11/U12 small nuclear ribonucleoprotein 48 kDa protein

1

0

High-throughput

0.460

High

177656

BIRC5
Baculoviral IAP repeat-containing protein 5

1

0

Small-scale

0.458

High

226706

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

584890

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.458

High

739376

COIL
Coilin

1

0

High-throughput

0.458

High

739379

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

739380

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

739381

H31
Histone H3.1

1

0

High-throughput

0.458

High

739382

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

739388

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

739389

CUL3
Cullin-3

1

0

High-throughput

0.458

High

739392

CE170
Centrosomal protein of 170 kDa

1

0

High-throughput

0.458

High

739395

UBP31
Ubiquitin carboxyl-terminal hydrolase 31

1

0

Small-scale

0.458

High

739405

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

0

Small-scale

0.458

High

739407

SHRPN
Sharpin

1

0

Small-scale

0.458

High

496460

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

344947

CYTN
Cystatin-SN

1

1

Small-scale

0.437

High

601024

ZP3
Zona pellucida sperm-binding protein 3

1

2

Small-scale

0.437

High

739384

ZP2
Zona pellucida sperm-binding protein 2

1

2

Small-scale

0.437

High

739385

ZP4
Zona pellucida sperm-binding protein 4

1

2

Small-scale

0.437

High

739394

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

739399

TRI59
Tripartite motif-containing protein 59

1

1

Small-scale

0.437

High

739408

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

401539

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

150014

VCY1
Testis-specific basic protein Y 1

1

0

High-throughput

0.279

Low

739411

FLOWR
Calcium channel flower homolog

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024