Protein: STAT2
Signal transducer and activator of transcription 2 (p113)

Gene: STAT2
Organism: Homo sapiens
Interactions: 93
UniProt ID: P52630

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001932 - regulation of protein phosphorylation
GO:0003700 - DNA-binding transcription factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

786284

STAT1
Signal transducer and activator of transcription 1-alpha/beta

22

16

Small-scale

0.988

High

855289

IRF9
Interferon regulatory factor 9

14

20

Small-scale

0.983

High

855311

CBP
CREB-binding protein

4

14

Small-scale

0.913

High

855313

IRF7
Interferon regulatory factor 7

4

20

Small-scale

0.881

High

855291

EP300
Histone acetyltransferase p300

3

13

Small-scale

0.853

High

338166

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

176413

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

2

1

High-throughput

0.811

High

855331

TRRAP
Transformation/transcription domain-associated protein

2

3

High-throughput

0.811

High

669149

TYK2
Non-receptor tyrosine-protein kinase TYK2

2

20

Small-scale

0.789

High

786472

STAT6
Signal transducer and activator of transcription 6

2

16

Small-scale

0.776

High

819579

INAR2
Interferon alpha/beta receptor 2

8

2

Small-scale

0.753

High

566017

INAR1
Interferon alpha/beta receptor 1

7

15

Small-scale

0.745

High

855329

UBP18
Ubl carboxyl-terminal hydrolase 18

6

7

Small-scale

0.733

High

855286

EPHB4
Ephrin type-B receptor 4

1

11

High-throughput

0.691

High

456157

IFI6
Interferon alpha-inducible protein 6

4

1

Small-scale

0.676

High

456214

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

4

4

Small-scale

0.676

High

855284

STAT2
Signal transducer and activator of transcription 2

1

17

Small-scale

0.652

High

397859

ISG15
Ubiquitin-like protein ISG15

3

2

Small-scale

0.640

High

855330

LIPT
Lipoyl amidotransferase LIPT1, mitochondrial

3

0

High-throughput

0.638

High

296282

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

2

4

High-throughput

0.628

High

362184

GLPA
Glycophorin-A

2

2

High-throughput

0.628

High

472687

FBSP1
F-box/SPRY domain-containing protein 1

2

6

High-throughput

0.628

High

855306

FBX11
F-box only protein 11

2

1

High-throughput

0.628

High

855317

EP400
E1A-binding protein p400

2

6

High-throughput

0.628

High

855321

ZN692
Zinc finger protein 692

2

1

High-throughput

0.628

High

855326

SYIM
Isoleucine--tRNA ligase, mitochondrial

2

1

High-throughput

0.628

High

855315

FBXW7
F-box/WD repeat-containing protein 7

2

4

Small-scale

0.620

High

616771

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.618

High

776621

STAT3
Signal transducer and activator of transcription 3

1

16

Small-scale

0.618

High

855295

IRF5
Interferon regulatory factor 5

1

20

Small-scale

0.618

High

264024

TACC1
Transforming acidic coiled-coil-containing protein 1

2

0

High-throughput

0.602

High

270596

MYCB2
E3 ubiquitin-protein ligase MYCBP2

2

0

High-throughput

0.602

High

855305

DPP9
Dipeptidyl peptidase 9

2

0

High-throughput

0.602

High

855309

DOK4
Docking protein 4

2

2

High-throughput

0.594

High

525876

IFM1
Interferon-induced transmembrane protein 1

2

4

Small-scale

0.584

High

225361

MED14
Mediator of RNA polymerase II transcription subunit 14

1

6

Small-scale

0.578

High

855299

DCST1
E3 ubiquitin-protein ligase DCST1

2

0

Small-scale

0.576

High

855301

KLH10
Kelch-like protein 10

2

1

High-throughput

0.574

High

846903

SMCA4
Transcription activator BRG1

1

5

Small-scale

0.561

High

855303

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.553

High

855318

IWS1
Protein IWS1 homolog

1

1

High-throughput

0.541

High

568959

CAN2
Calpain-2 catalytic subunit

1

3

High-throughput

0.536

High

853549

IMA5
Importin subunit alpha-5

1

3

Small-scale

0.536

High

855320

NPAS1
Neuronal PAS domain-containing protein 1

1

4

High-throughput

0.536

High

487000

LYAG
Lysosomal alpha-glucosidase

1

0

High-throughput

0.518

High

826392

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

0

High-throughput

0.518

High

585427

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

11

Small-scale

0.515

High

855293

HDAC1
Histone deacetylase 1

1

10

Small-scale

0.515

High

855328

INT6
Integrator complex subunit 6

1

0

High-throughput

0.513

High

160458

AURKA
Aurora kinase A

1

3

Small-scale

0.501

High

835290

GSK3A
Glycogen synthase kinase-3 alpha

1

4

Small-scale

0.501

High

835597

GSK3B
Glycogen synthase kinase-3 beta

1

5

Small-scale

0.501

High

150320

CXL11
C-X-C motif chemokine 11

1

3

Small-scale

0.479

High

162533

XPO1
Exportin-1

1

1

High-throughput

0.479

High

388325

HSPB1
Heat shock protein beta-1

1

4

Small-scale

0.479

High

430101

PROF1
Profilin-1

1

1

High-throughput

0.479

High

431678

HS90A
Heat shock protein HSP 90-alpha

1

5

High-throughput

0.479

High

438018

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.479

High

456264

IFIT1
Interferon-induced protein with tetratricopeptide repeats 1

1

4

Small-scale

0.479

High

501022

IRF1
Interferon regulatory factor 1

1

20

Small-scale

0.479

High

521821

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

528212

CCL2
C-C motif chemokine 2

1

5

Small-scale

0.479

High

668536

PML
Protein PML

1

13

Small-scale

0.479

High

690109

GBP1
Guanylate-binding protein 1

1

2

Small-scale

0.479

High

749265

BRCA1
Breast cancer type 1 susceptibility protein

1

7

Small-scale

0.479

High

855287

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

5

Small-scale

0.479

High

855290

IFM3
Interferon-induced transmembrane protein 3

1

4

Small-scale

0.479

High

855292

SMAD4
Mothers against decapentaplegic homolog 4

1

2

High-throughput

0.479

High

855296

CUL1
Cullin-1

1

4

Small-scale

0.479

High

855297

CCDC6
Coiled-coil domain-containing protein 6

1

4

High-throughput

0.479

High

855300

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

Small-scale

0.479

High

855304

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

7

Small-scale

0.479

High

855307

PARP9
Protein mono-ADP-ribosyltransferase PARP9

1

7

Small-scale

0.479

High

855308

SMRC2
SWI/SNF complex subunit SMARCC2

1

4

Small-scale

0.479

High

855310

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

855312

SMRC1
SWI/SNF complex subunit SMARCC1

1

7

Small-scale

0.479

High

855314

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

3

Small-scale

0.479

High

855316

PDLI2
PDZ and LIM domain protein 2

1

2

Small-scale

0.479

High

855323

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

855324

IL21
Interleukin-21

1

3

Small-scale

0.479

High

344076

OAS1
2'-5'-oligoadenylate synthase 1

1

0

Small-scale

0.458

High

840446

VASP
Vasodilator-stimulated phosphoprotein

1

0

High-throughput

0.458

High

855285

RCAN1
Calcipressin-1

1

0

Small-scale

0.458

High

855288

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

855327

TNIK
TRAF2 and NCK-interacting protein kinase

1

4

High-throughput

0.457

High

855294

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.445

High

667326

IL12A
Interleukin-12 subunit alpha

1

1

Small-scale

0.437

High

855319

CCL19
C-C motif chemokine 19

1

5

Small-scale

0.437

High

855302

INSY2
Inhibitory synaptic factor 2A

2

0

High-throughput

0.328

High

855322

SELO
Protein adenylyltransferase SelO, mitochondrial

2

0

High-throughput

0.328

High

855298

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

855325

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024