Protein: SHPRH
E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)

Gene: SHPRH
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q149N8

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000786 - nucleosome
GO:0003677 - DNA binding
GO:0004386 - helicase activity
GO:0004842 - ubiquitin-protein transferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

934774

H31
Histone H3.1

5

20

Small-scale

0.922

High

917287

H4
Histone H4

3

18

Small-scale

0.853

High

896444

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

12

Small-scale

0.757

High

1055115

HLTF
Helicase-like transcription factor

2

16

Small-scale

0.754

High

1061755

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

13

Small-scale

0.734

High

997730

RBBP4
Histone-binding protein RBBP4

4

20

High-throughput

0.699

High

1061758

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

1061786

RAD18
E3 ubiquitin-protein ligase RAD18

3

7

Small-scale

0.674

High

1061757

RBBP7
Histone-binding protein RBBP7

3

20

High-throughput

0.667

High

849332

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

12

Small-scale

0.647

High

1061752

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

16

Small-scale

0.647

High

517262

PCNA
Proliferating cell nuclear antigen

3

7

Small-scale

0.646

High

927753

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

8

Small-scale

0.646

High

391708

H2A1B
Histone H2A type 1-B/E

1

20

High-throughput

0.618

High

658674

SMCA1
Probable global transcription activator SNF2L1

1

17

High-throughput

0.618

High

668695

PML
Protein PML

1

19

High-throughput

0.618

High

828232

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

829005

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

8

Small-scale

0.618

High

952345

H33
Histone H3.3

1

20

High-throughput

0.618

High

1018487

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

17

High-throughput

0.618

High

1059620

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

17

High-throughput

0.618

High

1061766

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

18

High-throughput

0.618

High

1061787

DTL
Denticleless protein homolog

2

17

Small-scale

0.584

High

740914

FDFT
Squalene synthase

1

1

High-throughput

0.541

High

1061773

FBXW7
F-box/WD repeat-containing protein 7

1

12

High-throughput

0.541

High

455457

PARP1
Poly [ADP-ribose] polymerase 1

1

20

High-throughput

0.536

High

638958

S100P
Protein S100-P

1

16

High-throughput

0.536

High

1061754

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

614325

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

3

High-throughput

0.515

High

751633

GRP75
Stress-70 protein, mitochondrial

1

16

High-throughput

0.515

High

1061762

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

9

High-throughput

0.515

High

1061789

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

7

High-throughput

0.515

High

661260

S10A2
Protein S100-A2

1

16

High-throughput

0.489

High

796085

MAGA9
Melanoma-associated antigen 9

1

11

High-throughput

0.489

High

146818

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

10

High-throughput

0.479

High

158792

HAT1
Histone acetyltransferase type B catalytic subunit

1

4

High-throughput

0.479

High

197987

PHF1
PHD finger protein 1

1

13

High-throughput

0.479

High

257784

SIN3B
Paired amphipathic helix protein Sin3b

1

18

High-throughput

0.479

High

265206

SAP30
Histone deacetylase complex subunit SAP30

1

6

High-throughput

0.479

High

268098

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

296026

MTA2
Metastasis-associated protein MTA2

1

20

High-throughput

0.479

High

296307

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

12

Small-scale

0.479

High

300538

NFAT5
Nuclear factor of activated T-cells 5

1

16

Small-scale

0.479

High

317112

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

8

Small-scale

0.479

High

328560

MBD3
Methyl-CpG-binding domain protein 3

1

20

High-throughput

0.479

High

486912

MYBB
Myb-related protein B

1

20

High-throughput

0.479

High

567699

UBF1
Nucleolar transcription factor 1

1

20

Small-scale

0.479

High

776323

MLH1
DNA mismatch repair protein Mlh1

1

2

Small-scale

0.479

High

919978

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.479

High

920463

RS25
Small ribosomal subunit protein eS25

1

3

High-throughput

0.479

High

921267

RBX1
E3 ubiquitin-protein ligase RBX1

1

2

High-throughput

0.479

High

1017298

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

High-throughput

0.479

High

1031859

MTA1
Metastasis-associated protein MTA1

1

20

High-throughput

0.479

High

1034857

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

9

High-throughput

0.479

High

1041598

CUL3
Cullin-3

1

14

High-throughput

0.479

High

1061753

SUZ12
Polycomb protein SUZ12

1

9

High-throughput

0.479

High

1061756

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.479

High

1061759

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

1061761

LIN9
Protein lin-9 homolog

1

5

High-throughput

0.479

High

1061763

P66A
Transcriptional repressor p66-alpha

1

15

High-throughput

0.479

High

1061764

BAP18
Chromatin complexes subunit BAP18

1

5

High-throughput

0.479

High

1061765

FBX22
F-box only protein 22

1

4

High-throughput

0.479

High

1061767

GATD1
GATA zinc finger domain-containing protein 1

1

2

High-throughput

0.479

High

1061769

P66B
Transcriptional repressor p66-beta

1

15

High-throughput

0.479

High

1061771

KAT6A
Histone acetyltransferase KAT6A

1

19

High-throughput

0.479

High

1061775

LIN37
Protein lin-37 homolog

1

5

High-throughput

0.479

High

1061777

Z512B
Zinc finger protein 512B

1

16

High-throughput

0.479

High

1061780

SIN3A
Paired amphipathic helix protein Sin3a

1

18

High-throughput

0.479

High

1061781

MTA3
Metastasis-associated protein MTA3

1

20

High-throughput

0.479

High

1061782

BC11B
B-cell lymphoma/leukemia 11B

1

13

High-throughput

0.479

High

1061784

BC11A
B-cell lymphoma/leukemia 11A

1

13

High-throughput

0.479

High

1061785

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

11

High-throughput

0.479

High

1061790

ZN219
Zinc finger protein 219

1

3

High-throughput

0.479

High

1061791

MBD2
Methyl-CpG-binding domain protein 2

1

20

High-throughput

0.479

High

1061792

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1061793

HMGX4
HMG domain-containing protein 4

1

20

High-throughput

0.479

High

1061794

ZN330
Zinc finger protein 330

1

7

High-throughput

0.479

High

1061795

MTF2
Metal-response element-binding transcription factor 2

1

14

High-throughput

0.479

High

1061796

TRRAP
Transformation/transcription domain-associated protein

1

12

High-throughput

0.479

High

1061772

LPP
Lipoma-preferred partner

1

0

High-throughput

0.438

High

1061760

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

11

High-throughput

0.437

High

1061770

BBX
HMG box transcription factor BBX

1

20

High-throughput

0.437

High

1061776

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

1061779

PWP2A
PWWP domain-containing protein 2A

1

14

High-throughput

0.437

High

1061783

SP130
Histone deacetylase complex subunit SAP130

1

13

High-throughput

0.437

High

1061788

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

6

High-throughput

0.407

High

1061768

EDAD
Ectodysplasin-A receptor-associated adapter protein

1

0

High-throughput

0.299

High

1061774

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.299

High

1061778

AP4AT
AP-4 complex accessory subunit Tepsin

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024