Protein: RN126
E3 ubiquitin-protein ligase RNF126 (EC 2.3.2.27) (RING finger protein 126)

Gene: RN126, RNF126
Organism: Homo sapiens
Interactions: 138
UniProt ID: Q9BV68

Gene Ontology (top 5):
GO:0005154 - epidermal growth factor receptor binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

803725

BAG6
Large proline-rich protein BAG6

15

10

Small-scale

0.986

High

919840

UB2D2
Ubiquitin-conjugating enzyme E2 D2

9

20

Small-scale

0.970

High

849428

UB2D1
Ubiquitin-conjugating enzyme E2 D1

6

20

Small-scale

0.952

High

895894

UB2D3
Ubiquitin-conjugating enzyme E2 D3

5

20

Small-scale

0.923

High

476301

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

20

Small-scale

0.885

High

1313503

RN126
E3 ubiquitin-protein ligase RNF126

4

11

Small-scale

0.885

High

1313520

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

20

High-throughput

0.862

High

475173

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

3

20

High-throughput

0.861

High

509726

UBL4A
Ubiquitin-like protein 4A

2

20

Small-scale

0.768

High

1237129

UBL4B
Ubiquitin-like protein 4B

1

11

High-throughput

0.691

High

1184855

GET4
Golgi to ER traffic protein 4 homolog

4

0

High-throughput

0.670

High

275508

CAN15
Calpain-15

3

1

High-throughput

0.667

High

396411

APOD
Apolipoprotein D

3

1

High-throughput

0.667

High

1031264

SKP2
S-phase kinase-associated protein 2

3

2

High-throughput

0.667

High

1201895

TAXB1
Tax1-binding protein 1

3

7

High-throughput

0.667

High

1313511

KLH42
Kelch-like protein 42

3

1

High-throughput

0.667

High

896532

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

1060192

CRYM
Ketimine reductase mu-crystallin

3

0

High-throughput

0.638

High

1234647

MINY1
Ubiquitin carboxyl-terminal hydrolase MINDY-1

3

0

High-throughput

0.638

High

1313513

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

3

0

High-throughput

0.638

High

1237379

TSYL6
Testis-specific Y-encoded-like protein 6

2

1

High-throughput

0.628

High

1291563

OTUB1
Ubiquitin thioesterase OTUB1

2

4

Small-scale

0.625

High

758326

CDN1A
Cyclin-dependent kinase inhibitor 1

2

1

Small-scale

0.624

High

1282338

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.621

High

1297364

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

High-throughput

0.621

High

909054

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.618

High

1148200

RNF43
E3 ubiquitin-protein ligase RNF43

1

8

High-throughput

0.618

High

1245297

PJA1
E3 ubiquitin-protein ligase Praja-1

1

9

High-throughput

0.618

High

1313514

UBQL2
Ubiquilin-2

1

10

High-throughput

0.618

High

210939

GET3
ATPase GET3

2

1

High-throughput

0.611

High

557343

GDC
Solute carrier family 25 member 16

3

1

High-throughput

0.609

High

1272017

RAD50
DNA repair protein RAD50

2

4

Small-scale

0.584

High

1313505

AICDA
Single-stranded DNA cytosine deaminase

1

0

Small-scale

0.561

High

338928

EGFR
Epidermal growth factor receptor

1

2

Small-scale

0.561

High

523980

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.561

High

525045

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.561

High

684299

1433S
14-3-3 protein sigma

1

12

Small-scale

0.561

High

787555

MTOR
Serine/threonine-protein kinase mTOR

1

4

Small-scale

0.561

High

1025940

TADBP
TAR DNA-binding protein 43

1

3

Small-scale

0.561

High

1223725

RN168
E3 ubiquitin-protein ligase RNF168

1

1

Small-scale

0.561

High

734756

TRI23
E3 ubiquitin-protein ligase TRIM23

1

17

High-throughput

0.541

High

921413

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

High-throughput

0.541

High

962949

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

High-throughput

0.541

High

1019364

TRI26
Tripartite motif-containing protein 26

1

3

High-throughput

0.541

High

1283576

TRI52
E3 ubiquitin-protein ligase TRIM52

1

5

High-throughput

0.541

High

1290878

TRI11
E3 ubiquitin-protein ligase TRIM11

1

3

High-throughput

0.541

High

963677

E2F1
Transcription factor E2F1

1

0

Small-scale

0.537

High

1083722

FRDA
Frataxin, mitochondrial

1

0

Small-scale

0.537

High

1313517

ABCG2
Broad substrate specificity ATP-binding cassette transporter ABCG2

1

0

Small-scale

0.537

High

871875

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

1

1

High-throughput

0.536

High

893599

SEM1
26S proteasome complex subunit SEM1

1

1

Small-scale

0.536

High

1085496

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.536

High

1244835

BBS1
Bardet-Biedl syndrome 1 protein

1

1

High-throughput

0.536

High

1287163

FAF2
FAS-associated factor 2

1

10

High-throughput

0.536

High

1313510

GDE1
Glycerophosphodiester phosphodiesterase 1

1

1

High-throughput

0.536

High

1306571

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.518

High

571205

EGLN
Endoglin

1

0

High-throughput

0.513

High

1239133

CAST3
Putative protein CASTOR3P

1

0

High-throughput

0.513

High

861916

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.508

High

1028424

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

2

Small-scale

0.501

High

991948

SCN1B
Sodium channel subunit beta-1

1

1

High-throughput

0.489

High

305087

SPN1
Snurportin-1

1

0

High-throughput

0.486

High

329125

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.486

High

729229

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

0

High-throughput

0.486

High

931831

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

271177

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

5

High-throughput

0.481

High

1288087

OTUB2
Ubiquitin thioesterase OTUB2

1

4

High-throughput

0.481

High

1313521

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

High-throughput

0.481

High

151886

IRS4
Insulin receptor substrate 4

1

1

High-throughput

0.479

High

207991

XPOT
Exportin-T

1

2

High-throughput

0.479

High

244881

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

282727

RNF8
E3 ubiquitin-protein ligase RNF8

1

6

Small-scale

0.479

High

302201

AP2A2
AP-2 complex subunit alpha-2

1

3

High-throughput

0.479

High

387425

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

431037

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

1

High-throughput

0.479

High

455825

PARP1
Poly [ADP-ribose] polymerase 1

1

2

Small-scale

0.479

High

708505

MCM4
DNA replication licensing factor MCM4

1

2

High-throughput

0.479

High

725541

COPB2
Coatomer subunit beta'

1

4

High-throughput

0.479

High

794306

MSH2
DNA mismatch repair protein Msh2

1

1

High-throughput

0.479

High

814526

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.479

High

832155

PSB2
Proteasome subunit beta type-2

1

7

Small-scale

0.479

High

832687

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

855542

MSH6
DNA mismatch repair protein Msh6

1

1

High-throughput

0.479

High

863311

COPB
Coatomer subunit beta

1

2

High-throughput

0.479

High

863539

COPA
Coatomer subunit alpha

1

4

High-throughput

0.479

High

868316

ATX3
Ataxin-3

1

3

High-throughput

0.479

High

875278

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

890830

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

942024

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

1

High-throughput

0.479

High

979349

UBXN1
UBX domain-containing protein 1

1

7

Small-scale

0.479

High

1024750

TRAF3
TNF receptor-associated factor 3

1

7

Small-scale

0.479

High

1031602

ATM
Serine-protein kinase ATM

1

4

Small-scale

0.479

High

1038164

ATR
Serine/threonine-protein kinase ATR

1

4

Small-scale

0.479

High

1042438

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1049633

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

5

High-throughput

0.479

High

1057378

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

High-throughput

0.479

High

1138216

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

3

High-throughput

0.479

High

1174845

LARP4
La-related protein 4

1

2

High-throughput

0.479

High

1230808

NUP93
Nuclear pore complex protein Nup93

1

1

High-throughput

0.479

High

1273840

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

8

High-throughput

0.479

High

1290122

CHFR
E3 ubiquitin-protein ligase CHFR

1

1

Small-scale

0.479

High

1306374

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

7

High-throughput

0.479

High

1313504

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

1

High-throughput

0.479

High

1313506

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1313507

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1313512

WRP73
WD repeat-containing protein WRAP73

1

2

High-throughput

0.479

High

1313515

MYO6
Unconventional myosin-VI

1

5

High-throughput

0.479

High

1313516

FAF1
FAS-associated factor 1

1

10

High-throughput

0.479

High

1313518

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.479

High

1313522

TRAF6
TNF receptor-associated factor 6

1

8

High-throughput

0.479

High

1313523

COPG1
Coatomer subunit gamma-1

1

2

High-throughput

0.479

High

1153172

CENPP
Centromere protein P

1

0

High-throughput

0.460

High

1266476

PSMF1
Proteasome inhibitor PI31 subunit

1

0

High-throughput

0.460

High

1310593

MIEN1
Migration and invasion enhancer 1

1

0

High-throughput

0.460

High

246274

NBN
Nibrin

1

0

Small-scale

0.458

High

397492

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.458

High

621273

RIR1
Ribonucleoside-diphosphate reductase large subunit

1

0

High-throughput

0.458

High

658426

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

724671

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.458

High

787007

MTREX
Exosome RNA helicase MTR4

1

0

High-throughput

0.458

High

837078

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

966760

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

High-throughput

0.458

High

986541

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

High-throughput

0.458

High

1063275

SART3
Squamous cell carcinoma antigen recognized by T-cells 3

1

0

High-throughput

0.458

High

1284789

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.458

High

1313508

ABCB6
ATP-binding cassette sub-family B member 6

1

0

High-throughput

0.458

High

1313509

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1313519

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.458

High

561670

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

3

High-throughput

0.437

High

1165915

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

1056554

BLTP2
Bridge-like lipid transfer protein family member 2

3

0

High-throughput

0.347

High

1130964

CF136
Uncharacterized protein C6orf136

1

0

High-throughput

0.279

Low

648288

G0S2
G0/G1 switch protein 2

1

0

Small-scale

0.261

Low

305862

UBL3
Ubiquitin-like protein 3

1

0

High-throughput

0.251

Low

156550

SCAM3
Secretory carrier-associated membrane protein 3

1

0

Small-scale

0.249

Low

1088622

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

1252040

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024