Protein: LEM2
Lap-Emerin-Man domain protein 2 (LEM domain protein 2)

Gene: LEM2
Organism: Schizosaccharomyces pombe 972h-
Interactions: 143
UniProt ID: Q10109

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0003690 - double-stranded DNA binding
GO:0005635 - nuclear envelope
GO:0005637 - nuclear inner membrane
GO:0005721 - pericentric heterochromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

238229

BQT4
Bouquet formation protein 4

3

1

Small-scale

0.642

High

1068607

SAD1
Spindle pole body-associated protein sad1

3

1

Small-scale

0.639

High

150821

IINMP
Integral inner nuclear membrane protein ima1

2

1

Small-scale

0.584

High

1018127

MU154
Meiotically up-regulated gene 154 protein

2

0

Small-scale

0.561

High

1008976

VTC4
Vacuolar transporter chaperone complex subunit 4

2

2

Small-scale

0.535

High

237626

LAC1
Sphingosine N-acyltransferase lac1

1

3

High-throughput

0.481

High

268312

PMP31
Plasma membrane proteolipid 31

1

1

High-throughput

0.481

High

1018090

DGK1
CTP-dependent diacylglycerol kinase 1

1

1

High-throughput

0.481

High

237975

IMB4
Probable importin subunit beta-4

1

2

Small-scale

0.479

High

267750

IMB3
Importin subunit beta-3

1

1

Small-scale

0.479

High

785676

BIP
Endoplasmic reticulum chaperone BiP

1

4

Small-scale

0.479

High

821649

CSK2A
Casein kinase II subunit alpha

1

1

Small-scale

0.479

High

151021

MUG61
Meiotically up-regulated gene 61 protein

1

0

High-throughput

0.460

High

153436

MUG69
SRP-independent targeting protein 2 homolog

1

0

High-throughput

0.460

High

237952

DID2
Vacuolar protein-sorting-associated protein 46

1

0

High-throughput

0.460

High

267789

BQT3
Bouquet formation protein 3

1

0

High-throughput

0.460

High

1082655

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

0

High-throughput

0.460

High

1082660

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.460

High

1082663

MUG31
Meiotically up-regulated gene 31 protein

1

0

High-throughput

0.460

High

1082665

SPO7
Sporulation-specific protein spo7

1

0

High-throughput

0.460

High

1082670

DYLT
Dynein light chain Tctex-type

1

0

High-throughput

0.460

High

1082671

YOP1
Protein yop1

1

0

High-throughput

0.460

High

237803

IMA3
Probable importin c550.11

1

0

Small-scale

0.458

High

1082647

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

0

Small-scale

0.458

High

151126

VTC2
Vacuolar transporter chaperone complex subunit 2

1

2

High-throughput

0.439

High

151328

SEC62
Translocation protein sec62

1

1

High-throughput

0.439

High

151832

SCS7
Ceramide very long chain fatty acid hydroxylase scs7

1

3

High-throughput

0.439

High

152014

BET1
Protein transport protein bet1

1

1

High-throughput

0.439

High

152068

RBX1
RING-box protein pip1

1

1

High-throughput

0.439

High

153496

TVP15
Golgi apparatus membrane protein tvp15

1

1

High-throughput

0.439

High

153634

PSA6
Probable proteasome subunit alpha type-6

1

1

High-throughput

0.439

High

205945

UBC6
Ubiquitin-conjugating enzyme E2 6

1

1

High-throughput

0.439

High

206109

YFH5
Uncharacterized membrane protein C23A1.05

1

1

High-throughput

0.439

High

206918

YBA9
Uncharacterized protein C119.09c

1

1

High-throughput

0.439

High

206927

YBAG
Uncharacterized protein C119.16c

1

1

High-throughput

0.439

High

207121

SC61B
Protein transport protein sec61 subunit beta

1

1

High-throughput

0.439

High

237600

FNX2
Vacuolar membrane amino acid uptake transporter fnx2

1

1

High-throughput

0.439

High

237711

YCCC
Uncharacterized protein C1795.12c

1

1

High-throughput

0.439

High

267875

SURF4
Surfeit locus protein 4 homolog

1

1

High-throughput

0.439

High

267984

YEA4
UDP-N-acetylglucosamine transporter yea4

1

4

High-throughput

0.439

High

313921

YIP1
Protein transport protein yip1

1

1

High-throughput

0.439

High

314045

CYB51
Probable cytochrome b5 1

1

2

High-throughput

0.439

High

314311

PSA1
Probable proteasome subunit alpha type-1

1

2

High-throughput

0.439

High

314320

YQ13
ER membrane protein complex subunit 4

1

1

High-throughput

0.439

High

314463

PSA2
Probable proteasome subunit alpha type-2

1

1

High-throughput

0.439

High

782913

ERG4
Delta(24(24(1)))-sterol reductase

1

2

High-throughput

0.439

High

1008955

VTI1
Vesicle transport v-SNARE protein vti1

1

1

High-throughput

0.439

High

1009089

LAG1
Sphingosine N-acyltransferase lag1

1

3

High-throughput

0.439

High

1018065

YIF1
Protein transport protein yif1

1

1

High-throughput

0.439

High

1030536

SAR1
Small COPII coat GTPase sar1

1

4

High-throughput

0.439

High

1066866

ERG24
Delta(14)-sterol reductase erg24

1

2

High-throughput

0.439

High

1068358

PSA3
Probable proteasome subunit alpha type-3

1

1

High-throughput

0.439

High

1068400

AKR1
Palmitoyltransferase akr1

1

3

High-throughput

0.439

High

1068642

GOS1
Protein transport protein gos1

1

1

High-throughput

0.439

High

1082645

EMA19
Efficient mitochondria targeting-associated protein 19

1

1

High-throughput

0.439

High

1082646

AREH1
Probable sterol O-acyltransferase 1

1

1

High-throughput

0.439

High

1082648

YDE2
Uncharacterized protein C12B10.02c

1

1

High-throughput

0.439

High

1082650

HUT1
UDP-galactose transporter homolog 1

1

3

High-throughput

0.439

High

1082661

VTC1
Vacuolar transporter chaperone complex subunit 1

1

2

High-throughput

0.439

High

1082664

CYB52
Probable cytochrome b5 2

1

2

High-throughput

0.439

High

1082673

YIY4
Uncharacterized transporter C22F8.04

1

1

High-throughput

0.439

High

1082678

COX10
Protoheme IX farnesyltransferase, mitochondrial

1

1

High-throughput

0.439

High

150459

YNF5
Uncharacterized J domain-containing protein C17A3.05c

1

4

Small-scale

0.437

High

238189

RL7C
Large ribosomal subunit protein uL30C

1

2

Small-scale

0.437

High

665218

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

Small-scale

0.437

High

840590

RAD25
Checkpoint signal transducer rad25

1

2

Small-scale

0.437

High

1008973

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

1

Small-scale

0.437

High

1009124

RL6
Large ribosomal subunit protein eL6

1

1

Small-scale

0.437

High

1068556

PYR1
Multifunctional protein ura1

1

1

Small-scale

0.437

High

1082638

GCN1
eIF-2-alpha kinase activator gcn1

1

4

Small-scale

0.437

High

1082651

MCD4
GPI ethanolamine phosphate transferase 1

1

1

Small-scale

0.437

High

314323

ACO1
Probable acyl-CoA desaturase

2

0

Small-scale

0.306

High

91422

YKQP
Uncharacterized membrane protein C688.16

1

0

High-throughput

0.251

Low

91434

VMA21
Vacuolar ATPase assembly integral membrane protein vma21

1

0

High-throughput

0.251

Low

107765

YND9
Putative uncharacterized protein C30B4.09

1

0

High-throughput

0.251

Low

107772

SPC1
Signal peptidase complex subunit 1

1

0

High-throughput

0.251

Low

107775

KISH
Protein kish

1

0

High-throughput

0.251

Low

107779

TAM14
Protein tam14

1

0

High-throughput

0.251

Low

151324

USE1
Protein transport protein use1

1

0

High-throughput

0.251

Low

152895

TGL4
Triacylglycerol lipase ptl2

1

0

High-throughput

0.251

Low

205832

YEKI
Uncharacterized WD repeat-containing protein C4F10.18

1

0

High-throughput

0.251

Low

206970

PRS7
26S proteasome regulatory subunit 7 homolog

1

0

High-throughput

0.251

Low

207005

PHO88
SRP-independent targeting protein 3 homolog

1

0

High-throughput

0.251

Low

207149

YGV4
Uncharacterized protein C354.04

1

0

High-throughput

0.251

Low

237591

DEGS
Sphingolipid delta(4)-desaturase

1

0

High-throughput

0.251

Low

237685

YJMB
ER membrane protein complex subunit 6

1

0

High-throughput

0.251

Low

238040

SCS2
Vesicle-associated membrane protein-associated protein scs2

1

0

High-throughput

0.251

Low

267618

ATC9
Probable cation-transporting ATPase C1672.11c

1

0

High-throughput

0.251

Low

268780

VPS25
Vacuolar protein-sorting-associated protein 25

1

0

High-throughput

0.251

Low

268815

YJZI
Uncharacterized membrane protein C338.18

1

0

High-throughput

0.251

Low

313729

SEC13
Protein transport protein sec13

1

0

High-throughput

0.251

Low

314111

YHKH
Uncharacterized membrane protein C660.17c

1

0

High-throughput

0.251

Low

314195

YFFH
Uncharacterized derlin-like protein C1687.17c

1

0

High-throughput

0.251

Low

314334

UFE1
Syntaxin ufe1

1

0

High-throughput

0.251

Low

314626

DPM3
Dolichol-phosphate mannosyltransferase subunit 3

1

0

High-throughput

0.251

Low

314691

GPC1
Glycerophosphocholine acyltransferase 1

1

0

High-throughput

0.251

Low

314704

PDAT
Phospholipid:diacylglycerol acyltransferase

1

0

High-throughput

0.251

Low

510948

YKV6
Uncharacterized protein C959.06c

1

0

High-throughput

0.251

Low

1017829

MAM4
Protein-S-isoprenylcysteine O-methyltransferase

1

0

High-throughput

0.251

Low

1017836

GMS1
UDP-galactose transporter

1

0

High-throughput

0.251

Low

1068496

SFT1
Protein transport protein sft1

1

0

High-throughput

0.251

Low

1082643

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.251

Low

1082649

RNK
V-type proton ATPase subunit f

1

0

High-throughput

0.251

Low

1082652

OST4
Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase 4 kDa subunit

1

0

High-throughput

0.251

Low

1082653

IVN1
Phospholipid-transporting ATPase accessory subunit ivn1

1

0

High-throughput

0.251

Low

1082654

ALG2
Alpha-1,3/1,6-mannosyltransferase alg2

1

0

High-throughput

0.251

Low

1082656

ERG1
Squalene epoxidase erg1

1

0

High-throughput

0.251

Low

1082657

MIM1
Mitochondrial import protein 1

1

0

High-throughput

0.251

Low

1082658

YLZ7
Uncharacterized GPI-anchored protein SPAC750.07c

1

0

High-throughput

0.251

Low

1082662

GGT1
Glutathione hydrolase proenzyme 1

1

0

High-throughput

0.251

Low

1082666

CTR6
Copper transport protein ctr6

1

0

High-throughput

0.251

Low

1082667

INP2
Inheritance of peroxisomes protein 2

1

0

High-throughput

0.251

Low

1082669

SPC2
Signal peptidase complex subunit 2

1

0

High-throughput

0.251

Low

1082674

SKP1
Suppressor of kinetochore protein 1

1

0

High-throughput

0.251

Low

1082675

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

High-throughput

0.251

Low

1082676

SEC22
Protein transport protein sec22

1

0

High-throughput

0.251

Low

1082677

INS1
INSIG family protein

1

0

High-throughput

0.251

Low

149417

DED1
ATP-dependent RNA helicase ded1

1

0

Small-scale

0.249

Low

150716

RL8
Large ribosomal subunit protein eL8

1

0

Small-scale

0.249

Low

151739

ERG5
C-22 sterol desaturase ERG5

1

0

Small-scale

0.249

Low

206896

YBN1
Putative inorganic phosphate transporter C8E4.01c

1

0

Small-scale

0.249

Low

207000

PFKA
ATP-dependent 6-phosphofructokinase

1

0

Small-scale

0.249

Low

237876

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1

1

0

Small-scale

0.249

Low

238164

LCF1
Long-chain-fatty-acid--CoA ligase 1

1

0

Small-scale

0.249

Low

267344

RL13
Large ribosomal subunit protein eL13

1

0

Small-scale

0.249

Low

267491

TCPG
T-complex protein 1 subunit gamma

1

0

Small-scale

0.249

Low

268097

CHO2
Phosphatidylethanolamine N-methyltransferase

1

0

Small-scale

0.249

Low

268383

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.249

Low

313614

YGX1
UPF0674 endoplasmic reticulum membrane protein C2G5.01

1

0

Small-scale

0.249

Low

313911

STT3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt3

1

0

Small-scale

0.249

Low

314283

YN67
Putative enoyl reductase C646.07c

1

0

Small-scale

0.249

Low

358435

ADH
Alcohol dehydrogenase

1

0

Small-scale

0.249

Low

775793

RL4A
Large ribosomal subunit protein uL4A

1

0

Small-scale

0.249

Low

836224

BFR1
Brefeldin A resistance protein

1

0

Small-scale

0.249

Low

1068504

CP51
Lanosterol 14-alpha demethylase erg11

1

0

Small-scale

0.249

Low

1068550

RS3A1
Small ribosomal subunit protein eS1A

1

0

Small-scale

0.249

Low

1068680

MET10
Probable sulfite reductase [NADPH] flavoprotein component

1

0

Small-scale

0.249

Low

1082630

YAOE
Uncharacterized protein C11D3.14c

1

0

Small-scale

0.249

Low

1082644

OST1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

Small-scale

0.249

Low

1082659

MPCP
Probable mitochondrial phosphate carrier protein

1

0

Small-scale

0.249

Low

1082668

APE1
Aminopeptidase 1

1

0

Small-scale

0.249

Low

1082672

FAS1
Fatty acid synthase subunit beta

1

0

Small-scale

0.249

Low

1082679

HOSM
Homocitrate synthase, mitochondrial

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025