Protein: MP2K5
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)

Gene: MP2K5, MAP2K5
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q13163

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000165 - MAPK cascade
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1026825

M3K3
Mitogen-activated protein kinase kinase kinase 3

10

16

Small-scale

0.981

High

1026841

M3K2
Mitogen-activated protein kinase kinase kinase 2

9

16

Small-scale

0.978

High

1026805

MK07
Mitogen-activated protein kinase 7

7

20

Small-scale

0.974

High

1026808

SQSTM
Sequestosome-1

7

9

Small-scale

0.966

High

431806

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.881

High

438128

HS90B
Heat shock protein HSP 90-beta

4

20

High-throughput

0.881

High

1026804

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

3

15

Small-scale

0.840

High

1026812

CDC37
Hsp90 co-chaperone Cdc37

4

12

High-throughput

0.797

High

1026817

ZN620
Zinc finger protein 620

2

3

High-throughput

0.783

High

1026827

ZN426
Zinc finger protein 426

2

6

High-throughput

0.783

High

783996

KPCI
Protein kinase C iota type

2

20

Small-scale

0.754

High

983823

KPCZ
Protein kinase C zeta type

1

20

Small-scale

0.747

High

243385

DNJA2
DnaJ homolog subfamily A member 2

2

18

High-throughput

0.737

High

681423

DNJA1
DnaJ homolog subfamily A member 1

2

18

High-throughput

0.737

High

1026831

DUS21
Dual specificity protein phosphatase 21

2

9

High-throughput

0.700

High

1026844

MRCKB
Serine/threonine-protein kinase MRCK beta

1

20

High-throughput

0.698

High

1026819

LNX2
Ligand of Numb protein X 2

3

10

High-throughput

0.658

High

374156

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.647

High

383775

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

441495

MET
Hepatocyte growth factor receptor

1

13

High-throughput

0.647

High

488702

ARAF
Serine/threonine-protein kinase A-Raf

1

20

High-throughput

0.647

High

515418

CDK4
Cyclin-dependent kinase 4

1

20

High-throughput

0.647

High

557110

PGFRA
Platelet-derived growth factor receptor alpha

1

12

High-throughput

0.647

High

607954

FGFR4
Fibroblast growth factor receptor 4

1

16

High-throughput

0.647

High

665231

EPHA2
Ephrin type-A receptor 2

1

15

High-throughput

0.647

High

681821

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

High-throughput

0.647

High

805405

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

17

High-throughput

0.647

High

854725

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

18

High-throughput

0.647

High

960163

CDK6
Cyclin-dependent kinase 6

1

20

High-throughput

0.647

High

1026811

STK11
Serine/threonine-protein kinase STK11

1

16

High-throughput

0.647

High

1026829

GLIS2
Zinc finger protein GLIS2

1

13

High-throughput

0.647

High

1026836

LATS2
Serine/threonine-protein kinase LATS2

1

17

High-throughput

0.647

High

1026834

PAR6A
Partitioning defective 6 homolog alpha

1

8

Small-scale

0.637

High

575416

EGR1
Early growth response protein 1

1

7

High-throughput

0.618

High

835715

GSK3B
Glycogen synthase kinase-3 beta

1

20

High-throughput

0.618

High

924537

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

1026828

SCRT1
Transcriptional repressor scratch 1

1

11

High-throughput

0.618

High

1026835

SCRT2
Transcriptional repressor scratch 2

1

8

High-throughput

0.618

High

475699

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

14

High-throughput

0.579

High

673068

CCND2
G1/S-specific cyclin-D2

1

9

High-throughput

0.579

High

790928

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

20

High-throughput

0.579

High

790970

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

19

High-throughput

0.579

High

1026816

TRAF7
E3 ubiquitin-protein ligase TRAF7

2

13

High-throughput

0.574

High

180302

MAGB2
Melanoma-associated antigen B2

2

3

High-throughput

0.571

High

388410

HSPB1
Heat shock protein beta-1

2

9

High-throughput

0.571

High

428177

TBB5
Tubulin beta chain

2

20

High-throughput

0.571

High

504010

HSP7C
Heat shock cognate 71 kDa protein

2

18

High-throughput

0.571

High

564067

HSP76
Heat shock 70 kDa protein 6

2

19

High-throughput

0.571

High

573240

TCPA
T-complex protein 1 subunit alpha

2

16

High-throughput

0.571

High

636912

ATPA
ATP synthase subunit alpha, mitochondrial

2

8

High-throughput

0.571

High

770811

TCPZ
T-complex protein 1 subunit zeta

2

15

High-throughput

0.571

High

821189

TCPE
T-complex protein 1 subunit epsilon

2

19

High-throughput

0.571

High

826640

TCPG
T-complex protein 1 subunit gamma

2

19

High-throughput

0.571

High

842850

TCPQ
T-complex protein 1 subunit theta

2

20

High-throughput

0.571

High

843180

TCPD
T-complex protein 1 subunit delta

2

14

High-throughput

0.571

High

933422

TBA4A
Tubulin alpha-4A chain

2

20

High-throughput

0.571

High

933781

TBB4B
Tubulin beta-4B chain

2

20

High-throughput

0.571

High

943210

TCPB
T-complex protein 1 subunit beta

2

19

High-throughput

0.571

High

1026826

TCPH
T-complex protein 1 subunit eta

2

19

High-throughput

0.571

High

1026824

PFD5
Prefoldin subunit 5

2

1

High-throughput

0.553

High

838802

EMD
Emerin

2

0

High-throughput

0.547

High

523715

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.541

High

926998

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.541

High

470010

H2AZ
Histone H2A.Z

1

6

High-throughput

0.536

High

564881

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

684012

1433S
14-3-3 protein sigma

1

20

High-throughput

0.536

High

1026806

CBX3
Chromobox protein homolog 3

1

5

High-throughput

0.536

High

1026838

BCLF1
Bcl-2-associated transcription factor 1

1

5

High-throughput

0.536

High

1026839

H2AW
Core histone macro-H2A.2

1

4

High-throughput

0.536

High

1026842

TR150
Thyroid hormone receptor-associated protein 3

1

8

High-throughput

0.536

High

323726

BAG2
BAG family molecular chaperone regulator 2

2

2

High-throughput

0.521

High

933188

TBA1B
Tubulin alpha-1B chain

2

20

High-throughput

0.521

High

959195

S25A3
Solute carrier family 25 member 3

2

11

High-throughput

0.521

High

973914

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

2

8

High-throughput

0.521

High

1026815

RL22L
Ribosomal protein eL22-like

2

1

High-throughput

0.521

High

1026830

GHC2
Mitochondrial glutamate carrier 2

2

8

High-throughput

0.521

High

1026833

GHC1
Mitochondrial glutamate carrier 1

2

8

High-throughput

0.521

High

508973

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

857462

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.513

High

154024

TERT
Telomerase reverse transcriptase

1

2

High-throughput

0.501

High

169285

MDM4
Protein Mdm4

1

3

High-throughput

0.501

High

346681

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.501

High

386648

P53
Cellular tumor antigen p53

1

4

High-throughput

0.501

High

536134

HGF
Hepatocyte growth factor

1

3

High-throughput

0.501

High

555136

CD44
CD44 antigen

1

4

High-throughput

0.501

High

649095

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

13

High-throughput

0.501

High

719471

MERL
Merlin

1

10

High-throughput

0.501

High

790761

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

20

High-throughput

0.501

High

1026810

TEAD2
Transcriptional enhancer factor TEF-4

1

3

High-throughput

0.501

High

1026813

HIF1A
Hypoxia-inducible factor 1-alpha

1

13

High-throughput

0.501

High

806509

RL28
Large ribosomal subunit protein eL28

1

2

High-throughput

0.494

High

396929

HMGN1
Non-histone chromosomal protein HMG-14

1

1

High-throughput

0.489

High

1026820

LS14A
Protein LSM14 homolog A

1

3

High-throughput

0.489

High

317726

STABP
STAM-binding protein

1

0

High-throughput

0.486

High

510017

ERR1
Steroid hormone receptor ERR1

1

20

High-throughput

0.481

High

417263

ENOA
Alpha-enolase

1

3

Small-scale

0.479

High

443488

VIME
Vimentin

1

8

High-throughput

0.470

High

1026818

ASGL1
Isoaspartyl peptidase/L-asparaginase

1

2

High-throughput

0.464

High

1026807

GRM1
Metabotropic glutamate receptor 1

1

1

High-throughput

0.457

High

1026809

BECN1
Beclin-1

1

3

High-throughput

0.457

High

1026822

TSC1
Hamartin

1

20

High-throughput

0.457

High

1026840

FZR1
Fizzy-related protein homolog

1

10

High-throughput

0.457

High

822596

HSP77
Putative heat shock 70 kDa protein 7

1

20

High-throughput

0.445

High

675829

GCH1
GTP cyclohydrolase 1

1

1

Small-scale

0.437

High

1026837

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

8

Small-scale

0.437

High

1026832

PAAT
ATPase PAAT

2

0

High-throughput

0.328

High

1026814

CC036
Uncharacterized protein C3orf36

2

0

High-throughput

0.316

High

1026823

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High

1026843

CHTOP
Chromatin target of PRMT1 protein

1

0

High-throughput

0.279

Low

1026821

CR032
UPF0729 protein C18orf32

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024