Protein: MICA
MHC class I polypeptide-related sequence A (MIC-A)

Gene: MICA
Organism: Homo sapiens
Interactions: 89
UniProt ID: Q29983

Gene Ontology (top 5):
GO:0001913 - T cell mediated cytotoxicity
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002418 - immune response to tumor cell
GO:0002476 - antigen processing and presentation of endogenous peptide antigen via MHC class Ib
GO:0002486 - antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

154370

TR10B
Tumor necrosis factor receptor superfamily member 10B

3

1

High-throughput

0.861

High

1069919

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

5

High-throughput

0.861

High

1072510

EPHA7
Ephrin type-A receptor 7

2

5

High-throughput

0.811

High

644710

NKG2D
NKG2-D type II integral membrane protein

2

20

Small-scale

0.778

High

409521

HEPS
Serine protease hepsin

1

14

High-throughput

0.691

High

532874

TF
Tissue factor

1

1

High-throughput

0.691

High

686295

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

3

High-throughput

0.691

High

1085200

PRSS8
Prostasin

1

12

High-throughput

0.691

High

1100195

MICB
MHC class I polypeptide-related sequence B

1

16

High-throughput

0.691

High

1100233

I27RA
Interleukin-27 receptor subunit alpha

1

5

High-throughput

0.691

High

1100258

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

5

High-throughput

0.691

High

168404

SCAM1
Secretory carrier-associated membrane protein 1

3

1

High-throughput

0.667

High

713812

RYK
Tyrosine-protein kinase RYK

3

17

High-throughput

0.667

High

783241

TNFL9
Tumor necrosis factor ligand superfamily member 9

3

2

High-throughput

0.667

High

1079329

VAMP3
Vesicle-associated membrane protein 3

3

2

High-throughput

0.667

High

1100262

TNPO3
Transportin-3

3

4

High-throughput

0.667

High

1100264

FLVC1
Heme transporter FLVCR1

3

1

High-throughput

0.667

High

1100244

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.656

High

155579

TNPO2
Transportin-2

3

1

High-throughput

0.656

High

1100252

PHF7
PHD finger protein 7

3

0

High-throughput

0.638

High

1100254

ADAP2
Arf-GAP with dual PH domain-containing protein 2

3

0

High-throughput

0.638

High

965237

DEF5
Defensin alpha 5

2

1

High-throughput

0.628

High

1100226

TECT1
Tectonic-1

2

5

High-throughput

0.628

High

1100231

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

1

20

High-throughput

0.618

High

1084705

TAZ
Tafazzin

3

2

High-throughput

0.609

High

328126

SG1D1
Secretoglobin family 1D member 1

2

0

High-throughput

0.602

High

1100234

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.602

High

1100246

GGH
Gamma-glutamyl hydrolase

2

0

High-throughput

0.585

High

1100249

PGRP3
Peptidoglycan recognition protein 3

2

0

High-throughput

0.585

High

170858

PGRC2
Membrane-associated progesterone receptor component 2

1

3

High-throughput

0.553

High

272874

KS6A4
Ribosomal protein S6 kinase alpha-4

1

1

High-throughput

0.536

High

306802

VAMP5
Vesicle-associated membrane protein 5

1

2

High-throughput

0.536

High

328331

S1PR4
Sphingosine 1-phosphate receptor 4

1

3

High-throughput

0.536

High

674161

HMOX2
Heme oxygenase 2

1

2

High-throughput

0.536

High

702353

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

1

High-throughput

0.536

High

787498

MTOR
Serine/threonine-protein kinase mTOR

1

7

High-throughput

0.536

High

845858

RAB13
Ras-related protein Rab-13

1

2

High-throughput

0.536

High

887037

DEF1
Neutrophil defensin 1

1

1

High-throughput

0.536

High

946021

DLK1
Protein delta homolog 1

1

2

High-throughput

0.536

High

993885

PCDH1
Protocadherin-1

1

4

High-throughput

0.536

High

1056194

I13R2
Interleukin-13 receptor subunit alpha-2

1

6

High-throughput

0.536

High

1070214

RAB35
Ras-related protein Rab-35

1

5

High-throughput

0.536

High

1083567

SGCA
Alpha-sarcoglycan

1

1

High-throughput

0.536

High

1100237

TAFA3
Chemokine-like protein TAFA-3

1

1

High-throughput

0.536

High

1100239

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

2

High-throughput

0.536

High

1100241

S39AB
Zinc transporter ZIP11

1

6

High-throughput

0.536

High

1100242

TAFA2
Chemokine-like protein TAFA-2

1

1

High-throughput

0.536

High

1100247

ESPB1
Epididymal sperm-binding protein 1

1

2

High-throughput

0.536

High

1100253

AP1M1
AP-1 complex subunit mu-1

1

2

High-throughput

0.536

High

1100260

ITM2B
Integral membrane protein 2B

1

6

High-throughput

0.536

High

351577

NEU2
Vasopressin-neurophysin 2-copeptin

1

0

High-throughput

0.513

High

353064

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.513

High

873703

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.513

High

975381

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

High-throughput

0.513

High

1078792

MSMO1
Methylsterol monooxygenase 1

1

0

High-throughput

0.513

High

1100227

DB136
Defensin beta 136

1

0

High-throughput

0.513

High

1100235

IGFL3
Insulin growth factor-like family member 3

1

0

High-throughput

0.513

High

1100236

SE6L2
Seizure 6-like protein 2

1

0

High-throughput

0.513

High

1100240

D107A
Beta-defensin 107

1

0

High-throughput

0.513

High

1100243

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.513

High

1100245

LCN9
Epididymal-specific lipocalin-9

1

0

High-throughput

0.513

High

1100250

MYADM
Myeloid-associated differentiation marker

1

0

High-throughput

0.513

High

1100251

RETNB
Resistin-like beta

1

0

High-throughput

0.513

High

1100257

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.513

High

572369

LEG3
Galectin-3

1

0

Small-scale

0.493

High

1087150

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.493

High

1100238

WFDC3
WAP four-disulfide core domain protein 3

1

0

High-throughput

0.493

High

156510

SCAM3
Secretory carrier-associated membrane protein 3

1

1

High-throughput

0.489

High

217810

ORC4
Origin recognition complex subunit 4

1

1

High-throughput

0.489

High

824927

DNSL1
Deoxyribonuclease-1-like 1

1

4

High-throughput

0.489

High

205454

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

1100255

T106B
Transmembrane protein 106B

1

6

High-throughput

0.479

High

1100259

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.458

High

209239

PSCA
Prostate stem cell antigen

1

2

High-throughput

0.445

High

1100230

Q4LE60
TNPO2 variant protein

1

1

High-throughput

0.445

High

997377

VAC14
Protein VAC14 homolog

1

3

High-throughput

0.437

High

1066192

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.437

High

1100229

DB109
Putative beta-defensin 109B

1

0

High-throughput

0.426

High

1100248

ERLEC
Endoplasmic reticulum lectin 1

3

0

High-throughput

0.347

High

1100261

AAR2
Protein AAR2 homolog

2

0

High-throughput

0.318

High

1100256

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.282

High

237365

ISK4
Serine protease inhibitor Kazal-type 4

1

0

High-throughput

0.279

Low

473810

S31D3
Spermatogenesis-associated protein 31D3

1

0

High-throughput

0.279

Low

882069

EP3B
Epididymal secretory protein E3-beta

1

0

High-throughput

0.279

Low

1015896

NU160
Nuclear pore complex protein Nup160

1

0

High-throughput

0.279

Low

1032337

MFAP5
Microfibrillar-associated protein 5

1

0

High-throughput

0.279

Low

1100228

DB135
Beta-defensin 135

1

0

High-throughput

0.279

Low

1100232

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

1100263

INSL5
Insulin-like peptide INSL5

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024