Protein: IL1R1
Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]

Gene: IL1R1
Organism: Homo sapiens
Interactions: 37
UniProt ID: P14778

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0003953 - NAD+ nucleosidase activity
GO:0004888 - transmembrane signaling receptor activity
GO:0004908 - interleukin-1 receptor activity
GO:0004909 - interleukin-1, type I, activating receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

540402

IL1AP
Interleukin-1 receptor accessory protein

6

13

Small-scale

0.935

High

540381

IL1RA
Interleukin-1 receptor antagonist protein

3

9

Small-scale

0.853

High

352979

IL1B
Interleukin-1 beta

3

12

Small-scale

0.840

High

540388

MFAP3
Microfibril-associated glycoprotein 3

2

0

High-throughput

0.770

High

540394

SIGIR
Single Ig IL-1-related receptor

2

13

Small-scale

0.754

High

540387

IRAK1
Interleukin-1 receptor-associated kinase 1

10

10

Small-scale

0.753

High

540400

MYD88
Myeloid differentiation primary response protein MyD88

11

13

Small-scale

0.752

High

540406

TRAF6
TNF receptor-associated factor 6

8

8

Small-scale

0.746

High

154299

TR10B
Tumor necrosis factor receptor superfamily member 10B

2

6

High-throughput

0.628

High

540385

BMR1A
Bone morphogenetic protein receptor type-1A

2

1

High-throughput

0.628

High

352959

IL1A
Interleukin-1 alpha

1

2

Small-scale

0.618

High

452340

PGFRB
Platelet-derived growth factor receptor beta

1

17

Small-scale

0.618

High

540382

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

13

Small-scale

0.584

High

540401

TOLIP
Toll-interacting protein

2

7

Small-scale

0.584

High

540391

TBB8
Tubulin beta-8 chain

2

6

High-throughput

0.574

High

540404

CILK1
Serine/threonine-protein kinase ICK

2

7

High-throughput

0.574

High

540398

VPS39
Vam6/Vps39-like protein

1

5

High-throughput

0.536

High

197881

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

12

Small-scale

0.515

High

540386

MATR3
Matrin-3

1

3

High-throughput

0.515

High

540395

TCAM2
TIR domain-containing adapter molecule 2

1

1

Small-scale

0.515

High

540403

IRAK4
Interleukin-1 receptor-associated kinase 4

1

2

Small-scale

0.515

High

540396

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

2

High-throughput

0.489

High

241145

TOM1
Target of Myb1 membrane trafficking protein

1

17

Small-scale

0.479

High

433237

YES
Tyrosine-protein kinase Yes

1

20

Small-scale

0.479

High

433553

LYN
Tyrosine-protein kinase Lyn

1

18

Small-scale

0.479

High

522741

SRC
Proto-oncogene tyrosine-protein kinase Src

1

18

Small-scale

0.479

High

540379

CSF2R
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

1

16

Small-scale

0.479

High

540380

EGR1
Early growth response protein 1

1

3

High-throughput

0.479

High

540383

AKT1
RAC-alpha serine/threonine-protein kinase

1

11

Small-scale

0.479

High

540389

RAC1
Ras-related C3 botulinum toxin substrate 1

1

12

Small-scale

0.479

High

540392

FREM1
FRAS1-related extracellular matrix protein 1

1

5

Small-scale

0.479

High

540393

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

3

Small-scale

0.479

High

540384

MYH10
Myosin-10

1

1

High-throughput

0.470

High

540390

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

Small-scale

0.458

High

540399

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

11

Small-scale

0.445

High

540397

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

1

Small-scale

0.437

High

540405

TMED7
Transmembrane emp24 domain-containing protein 7

1

3

Small-scale

0.437

High


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Last updated: 15 Jul 2024