Protein: MTDC
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]

Gene: MTDC, MTHFD2
Organism: Homo sapiens
Interactions: 83
UniProt ID: P13995

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity
GO:0004487 - methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

534327

MTD2L
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial

2

5

High-throughput

0.811

High

534335

NAGK
N-acetyl-D-glucosamine kinase

4

1

High-throughput

0.629

High

349099

RASH
GTPase HRas

3

2

High-throughput

0.604

High

534283

ACADL
Long-chain specific acyl-CoA dehydrogenase, mitochondrial

2

0

High-throughput

0.602

High

534307

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

534291

SRP09
Signal recognition particle 9 kDa protein

2

1

High-throughput

0.574

High

534300

TFCP2
Alpha-globin transcription factor CP2

2

1

High-throughput

0.574

High

534330

UBIP1
Upstream-binding protein 1

2

1

High-throughput

0.574

High

534310

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

3

High-throughput

0.552

High

452604

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

534316

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

534292

DAPK1
Death-associated protein kinase 1

1

5

High-throughput

0.489

High

534285

MYH9
Myosin-9

1

1

High-throughput

0.489

High

534289

MAPK2
MAP kinase-activated protein kinase 2

1

1

High-throughput

0.489

High

534298

CALD1
Caldesmon

1

2

High-throughput

0.489

High

534302

CUL3
Cullin-3

1

3

High-throughput

0.489

High

155258

NRP1
Neuropilin-1

1

1

High-throughput

0.479

High

226408

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

262697

CISY
Citrate synthase, mitochondrial

1

1

High-throughput

0.479

High

440327

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

486455

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

499502

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.479

High

503354

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

534284

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

534286

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

534287

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

534288

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

534290

EFTU
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.479

High

534299

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

534306

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

534309

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

534312

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

534315

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

534322

TR61B
tRNA

1

1

High-throughput

0.479

High

534323

BRD8
Bromodomain-containing protein 8

1

5

High-throughput

0.479

High

534324

MTG2
Mitochondrial ribosome-associated GTPase 2

1

2

High-throughput

0.479

High

534326

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

534331

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

264828

MPPB
Mitochondrial-processing peptidase subunit beta

1

0

High-throughput

0.458

High

534293

ATX3
Ataxin-3

1

0

Small-scale

0.458

High

534297

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

534303

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

534311

MIC10
MICOS complex subunit MIC10

1

0

Small-scale

0.458

High

534319

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

534321

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

534294

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.457

High

298113

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.437

High

317896

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

3

High-throughput

0.437

High

326413

SNAI1
Zinc finger protein SNAI1

1

2

High-throughput

0.437

High

345821

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

378971

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.437

High

528463

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.437

High

534281

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.437

High

534282

CRCM
Colorectal mutant cancer protein

1

3

High-throughput

0.437

High

534295

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

534296

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.437

High

534301

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

3

High-throughput

0.437

High

534304

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.437

High

534305

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

534308

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

534313

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

534325

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

534329

ANLN
Anillin

1

2

High-throughput

0.437

High

534332

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

534333

UBQL2
Ubiquilin-2

1

1

High-throughput

0.437

High

534336

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.437

High

348492

RASN
GTPase NRas

1

3

High-throughput

0.407

High

447729

THIK
3-ketoacyl-CoA thiolase, peroxisomal

2

0

High-throughput

0.318

High

173425

RER1
Protein RER1

1

0

High-throughput

0.279

Low

197213

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.279

Low

534314

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

534317

CB073
Uncharacterized protein C2orf73

1

0

High-throughput

0.279

Low

534320

MACD1
ADP-ribose glycohydrolase MACROD1

1

0

High-throughput

0.279

Low

534338

MB212
Protein mab-21-like 2

1

0

High-throughput

0.279

Low

534337

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.269

Low

534339

PARP3
Protein mono-ADP-ribosyltransferase PARP3

1

0

High-throughput

0.269

Low

359618

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.251

Low

182529

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

411577

LCK
Tyrosine-protein kinase Lck

1

0

High-throughput

0.249

Low

534328

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.249

Low

534334

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.249

Low

200488

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.232

Low

534318

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024