HitPredict

Interactor 1: EZ (P42124)
Histone-lysine N-methyltransferase E(z) (EC 2.1.1.356) (Lysine N-methyltransferase 6) (Protein enhancer of zeste)
Gene: E(z)

Interactor 2: H2A (P84051)
Histone H2A
Gene: His2A

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24837194
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~preSET_CXC, Histone~SET
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 760 Dm			1 124
+	Hs
		1080241 EZH2_HUMAN (3-759): 0: 658: 51.64		H2A1H_HUMAN (1-122): 1.04e-61: 186: 89.43
+	Hs
		391719 EZH2_HUMAN (3-759): 0: 658: 51.64		H2A1B_HUMAN (1-122): 3.57e-61: 185: 88.62
+	Hs
		470396 EZH2_HUMAN (3-759): 0: 658: 51.64		H2A1_HUMAN (1-122): 3.27e-61: 185: 89.43
+	Hs
		203730 SUV91_HUMAN (438-760): 1.31e-87: 284: 22.04		H2A2B_HUMAN (1-122): 1.38e-62: 188: 90.24
+	Hs
		203696 SUV91_HUMAN (438-760): 1.31e-87: 284: 22.04		H2A2C_HUMAN (1-122): 1.62e-61: 185: 89.43
+	Hs
		555602 EHMT2_HUMAN (505-757): 2.83e-66: 241: 24.91		H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91
+	Hs
		470506 EHMT2_HUMAN (505-757): 2.83e-66: 241: 24.91		H2A1_HUMAN (1-122): 3.27e-61: 185: 89.43
+	Hs
		470560 EHMT1_HUMAN (507-757): 1.81e-66: 241: 23.66		H2A1_HUMAN (1-122): 3.27e-61: 185: 89.43
+	Hs
		331703 NSD2_HUMAN (566-752): 1.89e-56: 212: 29.95		H2A1_HUMAN (1-122): 3.27e-61: 185: 89.43
+	Hs
		331824 NSD2_HUMAN (566-752): 1.89e-56: 212: 29.95		H2A2C_HUMAN (1-122): 1.62e-61: 185: 89.43
+	Hs
		331860 NSD2_HUMAN (566-752): 1.89e-56: 212: 29.95		H2A1C_HUMAN (1-122): 2.09e-61: 185: 90.24
+	Sc
		392487 SET2_YEAST (485-757): 2.03e-59: 216: 26.57		H2A2_YEAST (15-124): 5.28e-53: 164: 80.91
+	Hs
		391662 KMT2A_HUMAN (633-742): 5.65e-18: 91.7: 43.24		H2A1B_HUMAN (1-122): 3.57e-61: 185: 88.62
+	Hs
		470359 KMT2A_HUMAN (633-742): 5.65e-18: 91.7: 43.24		H2A1_HUMAN (1-122): 3.27e-61: 185: 89.43