Protein: MACD1
ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-)

Gene: MACD1, MACROD1
Organism: Homo sapiens
Interactions: 53
UniProt ID: Q9BQ69

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006974 - DNA damage response
GO:0016798 - hydrolase activity, acting on glycosyl bonds
GO:0019213 - deacetylase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

455808

PARP1
Poly [ADP-ribose] polymerase 1

3

10

Small-scale

0.681

High

555623

H2AX
Histone H2AX

2

8

High-throughput

0.628

High

781591

CETN2
Centrin-2

2

1

High-throughput

0.628

High

967072

XPC
DNA repair protein complementing XP-C cells

2

2

High-throughput

0.628

High

996861

SSRP1
FACT complex subunit SSRP1

2

5

High-throughput

0.628

High

1309096

PARP2
Poly [ADP-ribose] polymerase 2

2

6

High-throughput

0.628

High

1309097

SP16H
FACT complex subunit SPT16

2

2

High-throughput

0.628

High

652082

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

4

High-throughput

0.611

High

370307

ESR1
Estrogen receptor

2

6

Small-scale

0.608

High

978874

TF65
Transcription factor p65

1

1

Small-scale

0.586

High

853693

IMA5
Importin subunit alpha-5

2

0

High-throughput

0.580

High

936072

HBA
Hemoglobin subunit alpha

2

1

High-throughput

0.574

High

1309098

NEMO
NF-kappa-B essential modulator

1

3

Small-scale

0.561

High

1136691

H37
Histone H3-7

2

11

High-throughput

0.552

High

452865

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

408913

K1C18
Keratin, type I cytoskeletal 18

1

1

Small-scale

0.513

High

836770

DNLI3
DNA ligase 3

1

0

High-throughput

0.513

High

1159920

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

1309092

HTAI2
Oxidoreductase HTATIP2

1

0

High-throughput

0.513

High

1309094

UXT
Protein UXT

1

0

Small-scale

0.494

High

355205

HBE
Hemoglobin subunit epsilon

1

1

High-throughput

0.489

High

665321

EPHA2
Ephrin type-A receptor 2

1

6

High-throughput

0.489

High

228499

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

504656

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

523971

XRCC6
X-ray repair cross-complementing protein 6

1

3

Small-scale

0.479

High

525040

XRCC5
X-ray repair cross-complementing protein 5

1

3

Small-scale

0.479

High

553555

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

719361

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

1

High-throughput

0.479

High

721280

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

962319

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

Small-scale

0.479

High

994310

DHX9
ATP-dependent RNA helicase A

1

1

Small-scale

0.479

High

1022310

CSTF3
Cleavage stimulation factor subunit 3

1

2

Small-scale

0.479

High

1043192

CUL4A
Cullin-4A

1

3

High-throughput

0.479

High

1309093

DDX21
Nucleolar RNA helicase 2

1

1

Small-scale

0.479

High

1309095

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

158536

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

0

Small-scale

0.458

High

324583

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

585541

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

Small-scale

0.458

High

665948

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

0

High-throughput

0.458

High

672266

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

Small-scale

0.458

High

931368

YBOX1
Y-box-binding protein 1

1

0

Small-scale

0.458

High

1274595

TP4A1
Protein tyrosine phosphatase type IVA 1

1

0

High-throughput

0.458

High

1171435

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

1216147

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

4

Small-scale

0.437

High

581843

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.407

High

238010

EXOC3
Exocyst complex component 3

2

0

High-throughput

0.328

High

534320

MTDC
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase

1

0

High-throughput

0.279

Low

815423

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.279

Low

1071354

K1H1
Keratin, type I cuticular Ha1

1

0

High-throughput

0.279

Low

1136078

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.279

Low

1257242

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.279

Low

329920

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

1130505

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024