Protein: CARD8
Caspase recruitment domain-containing protein 8 (EC 3.4.-.-) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor up-regulated CARD-containing antagonist of CASP9) (TUCAN) [Cleaved into: Caspase recruitment domain-containing protein 8, C-terminus (CARD8-CT); Caspase recruitment domain-containing protein 8, N-terminus (CARD8-NT)]

Gene: CARD8
Organism: Homo sapiens
Interactions: 60
UniProt ID: Q9Y2G2

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008233 - peptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1377204

CARD8
Caspase recruitment domain-containing protein 8

4

4

Small-scale

0.876

High

667502

CASP1
Caspase-1

3

10

Small-scale

0.821

High

598385

FLNA
Filamin-A

3

1

High-throughput

0.667

High

1159820

NFRKB
Nuclear factor related to kappa-B-binding protein

3

1

High-throughput

0.667

High

1169958

CO039
Uncharacterized protein C15orf39

3

1

High-throughput

0.667

High

1170101

SRCAP
Helicase SRCAP

3

1

High-throughput

0.667

High

1332903

PEAK1
Inactive tyrosine-protein kinase PEAK1

3

2

High-throughput

0.667

High

1348532

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

3

1

High-throughput

0.667

High

1356949

YETS2
YEATS domain-containing protein 2

3

1

High-throughput

0.667

High

1357654

LHX6
LIM/homeobox protein Lhx6

3

1

High-throughput

0.667

High

1315075

CARD6
Caspase recruitment domain-containing protein 6

1

2

Small-scale

0.665

High

1336263

Q9HCK3
KIAA1569 protein

3

1

High-throughput

0.640

High

177410

HDAC3
Histone deacetylase 3

3

0

High-throughput

0.638

High

201475

M3K7
Mitogen-activated protein kinase kinase kinase 7

3

0

High-throughput

0.638

High

265735

E2F6
Transcription factor E2F6

3

0

High-throughput

0.638

High

266454

TAD2A
Transcriptional adapter 2-alpha

3

0

High-throughput

0.638

High

1079917

VPS72
Vacuolar protein sorting-associated protein 72 homolog

3

0

High-throughput

0.638

High

1133143

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

3

0

High-throughput

0.638

High

1167346

BCOR
BCL-6 corepressor

3

0

High-throughput

0.638

High

1218739

MGAP
MAX gene-associated protein

3

0

High-throughput

0.638

High

1223214

ZZZ3
ZZ-type zinc finger-containing protein 3

3

0

High-throughput

0.638

High

1305726

ATX2
Ataxin-2

3

0

High-throughput

0.638

High

1318085

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

3

0

High-throughput

0.638

High

1333507

CSR2B
Cysteine-rich protein 2-binding protein

3

0

High-throughput

0.638

High

1336312

CHD8
Chromodomain-helicase-DNA-binding protein 8

3

0

High-throughput

0.638

High

1345380

MBIP1
MAP3K12-binding inhibitory protein 1

3

0

High-throughput

0.638

High

1347223

BCD1
Box C/D snoRNA protein 1

3

0

High-throughput

0.638

High

1377205

SALL2
Sal-like protein 2

3

0

High-throughput

0.638

High

877006

CASP9
Caspase-9

1

10

Small-scale

0.618

High

1125554

CAR16
Caspase recruitment domain-containing protein 16

1

5

Small-scale

0.618

High

1335699

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

13

Small-scale

0.618

High

267719

TADA3
Transcriptional adapter 3

2

0

High-throughput

0.602

High

1290318

SGF29
SAGA-associated factor 29

2

0

High-throughput

0.602

High

1316716

PCGF6
Polycomb group RING finger protein 6

2

0

High-throughput

0.602

High

1077986

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

2

0

High-throughput

0.585

High

1164159

WDR74
WD repeat-containing protein 74

2

0

High-throughput

0.585

High

1326057

ARP6
Actin-related protein 6

2

0

High-throughput

0.585

High

1174139

UBP54
Inactive ubiquitin carboxyl-terminal hydrolase 54

2

1

High-throughput

0.558

High

1256632

CE192
Centrosomal protein of 192 kDa

2

1

High-throughput

0.552

High

1377207

NEMO
NF-kappa-B essential modulator

1

1

Small-scale

0.515

High

1271471

KAT2A
Histone acetyltransferase KAT2A

1

0

High-throughput

0.513

High

1349883

SOX
Peroxisomal sarcosine oxidase

1

0

High-throughput

0.513

High

1354517

DNJB4
DnaJ homolog subfamily B member 4

1

0

High-throughput

0.513

High

1050850

FHL2
Four and a half LIM domains protein 2

1

0

Small-scale

0.484

High

723725

HXD13
Homeobox protein Hox-D13

1

1

High-throughput

0.479

High

1052962

FLNC
Filamin-C

1

1

High-throughput

0.479

High

1299048

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

13

Small-scale

0.479

High

595650

HXA5
Homeobox protein Hox-A5

1

0

High-throughput

0.458

High

684408

1433S
14-3-3 protein sigma

1

0

High-throughput

0.458

High

847933

BRCA2
Breast cancer type 2 susceptibility protein

1

0

High-throughput

0.458

High

978944

TF65
Transcription factor p65

1

0

Small-scale

0.458

High

1138524

ZN318
Zinc finger protein 318

1

0

High-throughput

0.458

High

1188078

SETX
Probable helicase senataxin

1

0

High-throughput

0.458

High

1254321

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.458

High

1342752

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.458

High

1377206

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

1044470

PTC1
Protein patched homolog 1

1

1

Small-scale

0.437

High

1138593

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

2

0

High-throughput

0.328

High

1021897

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024