Protein: SIR2
NAD-dependent histone deacetylase sir2 (EC 2.3.1.286) (Regulatory protein sir2) (Silent information regulator 2)

Gene: SIR2
Organism: Schizosaccharomyces pombe 972h-
Interactions: 14
UniProt ID: O94640

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003714 - transcription corepressor activity
GO:0004407 - histone deacetylase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

293882

DPB4
DNA polymerase epsilon subunit D

1

0

Small-scale

0.513

High

293881

H4
Histone H4

1

5

High-throughput

0.501

High

223942

CBH2
CENP-B homolog protein 2

1

1

High-throughput

0.481

High

251356

SOL1
SWI/SNF chromatin-remodeling complex subunit sol1

1

5

High-throughput

0.481

High

293209

IMA2
Importin subunit alpha-2

1

7

High-throughput

0.481

High

293884

YAWC
Uncharacterized bHLH domain-containing protein C3F10.12c

1

9

High-throughput

0.481

High

194271

FFT3
ATP-dependent helicase fft3

1

12

High-throughput

0.479

High

293883

RRP6
Exosome complex exonuclease rrp6

1

4

High-throughput

0.479

High

224022

YH7G
Putative transcriptional regulatory protein C16G5.16

1

0

High-throughput

0.460

High

293880

TAS3
RNA-induced transcriptional silencing complex protein tas3

1

0

High-throughput

0.460

High

293739

JHD1
Putative JmjC domain-containing histone demethylation protein 1

1

0

High-throughput

0.458

High

293886

MDV1
Mitochondrial division protein 1

1

5

High-throughput

0.439

High

293885

MUG79
Meiotically up-regulated gene 79 protein

1

0

High-throughput

0.251

Low

293887

SWI5
Mating-type switching protein swi5

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024