Protein: LGMN
Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (AEP) (Protease, cysteine 1)

Gene: LGMN
Organism: Homo sapiens
Interactions: 46
UniProt ID: Q99538

Gene Ontology (top 5):
GO:0003014 - renal system process
GO:0004197 - cysteine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005737 - cytoplasm
GO:0005764 - lysosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1079055

CYTM
Cystatin-M

2

3

Small-scale

0.860

High

344829

CYTC
Cystatin-C

2

3

Small-scale

0.855

High

1304390

LGMN
Legumain

1

1

Small-scale

0.692

High

1304395

FBX6
F-box only protein 6

3

3

High-throughput

0.656

High

345130

CYTA
Cystatin-A

1

1

Small-scale

0.647

High

376110

CYTB
Cystatin-B

1

1

Small-scale

0.647

High

311746

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

3

0

High-throughput

0.638

High

345010

CYTN
Cystatin-SN

1

3

Small-scale

0.618

High

1055309

PDIA5
Protein disulfide-isomerase A5

3

1

High-throughput

0.609

High

1304397

TRAF6
TNF receptor-associated factor 6

2

0

Small-scale

0.607

High

887058

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

497486

TAU
Microtubule-associated protein tau

2

0

Small-scale

0.577

High

963883

SET
Protein SET

1

0

Small-scale

0.537

High

606931

IDS
Iduronate 2-sulfatase

1

1

High-throughput

0.536

High

654695

CALX
Calnexin

1

2

High-throughput

0.536

High

863799

LIMK1
LIM domain kinase 1

1

1

High-throughput

0.536

High

1304396

FBX2
F-box only protein 2

1

3

High-throughput

0.536

High

257283

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

0

High-throughput

0.513

High

296479

ACL6B
Actin-like protein 6B

1

0

High-throughput

0.513

High

336583

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

389489

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

0

High-throughput

0.513

High

982418

1433F
14-3-3 protein eta

1

0

High-throughput

0.513

High

1165339

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.513

High

1165535

LYZL1
Lysozyme-like protein 1

1

0

High-throughput

0.513

High

1218926

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1163945

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

1

Small-scale

0.512

High

679297

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

0

High-throughput

0.493

High

942892

SRPK2
SRSF protein kinase 2

1

0

Small-scale

0.480

High

382116

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

398073

ISG15
Ubiquitin-like protein ISG15

1

2

High-throughput

0.479

High

1171380

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1304392

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1304398

LAMC3
Laminin subunit gamma-3

1

0

High-throughput

0.460

High

719077

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

1042361

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1304393

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1304394

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

306284

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.445

High

205876

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

1013376

U17LO
Ubiquitin carboxyl-terminal hydrolase 17-like protein 24

1

1

High-throughput

0.437

High

1304391

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.407

High

275287

RNH2A
Ribonuclease H2 subunit A

1

0

High-throughput

0.279

Low

854204

JAK3
Tyrosine-protein kinase JAK3

1

0

High-throughput

0.279

Low

1282109

P2R3C
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

1

0

High-throughput

0.279

Low

827759

AMPH
Amphiphysin

1

0

Small-scale

0.261

Low


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Last updated: 15 Jul 2024