Protein: DPOLB
DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18)

Gene: DPOLB, POLB
Organism: Homo sapiens
Interactions: 61
UniProt ID: P06746

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0003684 - damaged DNA binding
GO:0003887 - DNA-directed DNA polymerase activity
GO:0003906 - DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

417804

XRCC1
DNA repair protein XRCC1

13

1

Small-scale

0.985

High

417795

PARP1
Poly [ADP-ribose] polymerase 1

5

2

Small-scale

0.721

High

417837

PNKP
Bifunctional polynucleotide phosphatase/kinase

4

1

Small-scale

0.702

High

417842

TYDP1
Tyrosyl-DNA phosphodiesterase 1

4

0

High-throughput

0.670

High

417796

H2A1
Histone H2A type 1

3

1

High-throughput

0.667

High

417800

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

3

1

High-throughput

0.667

High

417805

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

3

1

High-throughput

0.667

High

417811

DNLI3
DNA ligase 3

3

2

High-throughput

0.667

High

417821

SSRP1
FACT complex subunit SSRP1

3

3

High-throughput

0.667

High

417828

APTX
Aprataxin

3

1

High-throughput

0.667

High

417845

PARP2
Poly [ADP-ribose] polymerase 2

3

1

High-throughput

0.667

High

417847

SP16H
FACT complex subunit SPT16

3

1

High-throughput

0.667

High

417807

TPP2
Tripeptidyl-peptidase 2

3

0

High-throughput

0.654

High

417817

XPC
DNA repair protein complementing XP-C cells

3

0

High-throughput

0.638

High

417831

APLF
Aprataxin and PNK-like factor

3

0

High-throughput

0.638

High

417799

PCNA
Proliferating cell nuclear antigen

2

4

Small-scale

0.624

High

417806

APEX1
DNA repair nuclease/redox regulator APEX1

3

0

Small-scale

0.620

High

417810

CETN2
Centrin-2

2

1

High-throughput

0.611

High

417830

H2A2B
Histone H2A type 2-B

2

1

High-throughput

0.611

High

417822

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.578

High

417815

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.569

High

417841

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

1

0

Small-scale

0.549

High

417809

BRCA1
Breast cancer type 1 susceptibility protein

1

0

Small-scale

0.537

High

417825

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.536

High

417827

H2B2E
Histone H2B type 2-E

1

5

High-throughput

0.536

High

309646

KAT7
Histone acetyltransferase KAT7

1

0

High-throughput

0.518

High

417818

TLE1
Transducin-like enhancer protein 1

1

0

High-throughput

0.518

High

207001

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

417798

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

417802

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.513

High

417816

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

417819

EMX2
Homeobox protein EMX2

1

0

High-throughput

0.513

High

417824

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.513

High

417840

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.513

High

417823

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

1

Small-scale

0.501

High

417829

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

Small-scale

0.501

High

238249

RAD1
Cell cycle checkpoint protein RAD1

1

0

Small-scale

0.480

High

245870

HUS1
Checkpoint protein HUS1

1

0

Small-scale

0.480

High

417833

NEIL1
Endonuclease 8-like 1

1

0

Small-scale

0.480

High

417838

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.480

High

417846

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

Small-scale

0.480

High

243803

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

417814

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.479

High

417826

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.479

High

417844

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

233147

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

417803

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

417808

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

417813

H4
Histone H4

1

0

High-throughput

0.458

High

417820

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

417834

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

0

Small-scale

0.458

High

417835

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

0

Small-scale

0.458

High

417836

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

417839

CND3
Condensin complex subunit 3

1

0

Small-scale

0.458

High

417843

DNM3B
DNA

1

0

Small-scale

0.458

High

417794

HMGB1
High mobility group protein B1

1

3

Small-scale

0.445

High

417797

CALM3
Calmodulin-3

1

0

High-throughput

0.426

High

417801

UNG
Uracil-DNA glycosylase

1

0

Small-scale

0.426

High

417812

DHB7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

3

0

High-throughput

0.347

High

417832

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

281506

WFS1
Wolframin

1

0

High-throughput

0.268

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024