HitPredict

Interactor 1: RB27A (P51159)
Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram)
Gene: RAB27A

Interactor 2: MELPH (Q9BV36)
Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a)
Gene: MLPH

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	15059972, 11773082, 33961781, 12062444, 11980908, 12446441, 12897212, 25312756, 17045265
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	FYVE_2~Ras
Common GO terms	GO:0030425 - dendrite GO:0032402 - melanosome transport GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 221 Hs			1 600
+	Mm
		1265039 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		MELPH_MOUSE (1-599): 0: 650: 63.85
+	Hs
		845927 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL3_HUMAN (1-390): 7.31e-82: 270: 19.47
+	Hs
		845940 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL5_HUMAN (2-403): 5.42e-78: 263: 18.69
+	Mm
		1193404 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		SYTL5_MOUSE (2-289): 7.9e-77: 260: 22.30
+	Mm
		1307888 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		SYTL3_MOUSE (1-390): 3.63e-76: 255: 17.79
+	Hs
		320135 RAB3D_HUMAN (2-221): 9.57e-86: 254: 38.64		SYTL4_HUMAN (1-251): 2.21e-67: 233: 20.85
+	Hs
		845942 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL4_HUMAN (1-251): 2.21e-67: 233: 20.85
+	Mm
		722679 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RP3A_MOUSE (8-264): 5.78e-64: 224: 17.63
+	Mm
		812778 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		RP3A_MOUSE (8-264): 5.78e-64: 224: 17.63
+	Rn
		926103 RAB3A_RAT (2-219): 1.05e-85: 254: 41.28		RIMS2_RAT (3-475): 3.53e-61: 222: 16.10
+	Rn
		812780 RAB3A_RAT (2-219): 1.05e-85: 254: 41.28		RP3A_RAT (8-260): 7.8e-59: 210: 16.73
+	Mm
		722683 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RPH3L_MOUSE (10-279): 8.35e-61: 206: 15.33
+	Mm
		1176143 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		RPH3L_MOUSE (10-279): 8.35e-61: 206: 15.33
+	Rn
		222478 RAB3A_RAT (2-219): 1.05e-85: 254: 41.28		RPH3L_RAT (10-278): 3.06e-60: 204: 15.75
+	Mm
		722693 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RIMS2_MOUSE (3-475): 4.6e-55: 204: 14.71
+	Hs
		845961 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		RP3A_HUMAN (8-267): 9.04e-57: 204: 14.93
+	Hs
		845960 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		RPH3L_HUMAN (9-266): 3.65e-58: 199: 15.97
+	Ce
		104432 G5EBS5_CAEEL (4-213): 1.78e-87: 258: 59.05		RBF1_CAEEL (9-263): 2.41e-43: 169: 14.86
+	Hs
		845939 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		MYRIP_HUMAN (1-151): 5.23e-43: 167: 51.66
+	Mm
		722691 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RIMS1_MOUSE (1-252): 2.63e-41: 162: 13.48