Protein: ZAP70
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)

Gene: ZAP70
Organism: Homo sapiens
Interactions: 71
UniProt ID: P43403

Gene Ontology (top 5):
GO:0001772 - immunological synapse
GO:0001784 - phosphotyrosine residue binding
GO:0002250 - adaptive immune response
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

411632

LCK
Tyrosine-protein kinase Lck

7

19

Small-scale

0.957

High

338092

EGFR
Epidermal growth factor receptor

5

20

High-throughput

0.924

High

666034

SHC1
SHC-transforming protein 1

4

20

Small-scale

0.888

High

580955

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

3

20

Small-scale

0.834

High

548655

VAV
Proto-oncogene vav

3

20

Small-scale

0.827

High

601842

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.778

High

796468

LCP2
Lymphocyte cytosolic protein 2

2

20

Small-scale

0.778

High

796490

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

20

Small-scale

0.777

High

665817

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

Small-scale

0.768

High

596514

CD3Z
T-cell surface glycoprotein CD3 zeta chain

20

7

Small-scale

0.761

High

796460

CRK
Adapter molecule crk

2

20

Small-scale

0.755

High

796459

ZAP70
Tyrosine-protein kinase ZAP-70

2

20

Small-scale

0.754

High

796465

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.754

High

610285

CBL
E3 ubiquitin-protein ligase CBL

9

20

Small-scale

0.752

High

796487

DBNL
Drebrin-like protein

1

20

Small-scale

0.747

High

796467

3BP2
SH3 domain-binding protein 2

1

19

Small-scale

0.724

High

796472

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.724

High

796492

ASB3
Ankyrin repeat and SOCS box protein 3

1

11

High-throughput

0.698

High

441465

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

499245

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

796462

DAPK1
Death-associated protein kinase 1

1

19

High-throughput

0.692

High

796475

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

High-throughput

0.692

High

430690

CD3E
T-cell surface glycoprotein CD3 epsilon chain

4

4

Small-scale

0.686

High

207431

LAT
Linker for activation of T-cells family member 1

3

6

Small-scale

0.651

High

383681

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

782752

CSK
Tyrosine-protein kinase CSK

1

20

Small-scale

0.647

High

796471

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

796485

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

16

Small-scale

0.647

High

454118

CD3G
T-cell surface glycoprotein CD3 gamma chain

3

6

Small-scale

0.640

High

796469

CBLB
E3 ubiquitin-protein ligase CBL-B

3

20

Small-scale

0.631

High

337385

ABL1
Tyrosine-protein kinase ABL1

1

19

Small-scale

0.618

High

412075

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.618

High

596374

RASA1
Ras GTPase-activating protein 1

1

20

Small-scale

0.618

High

655259

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.618

High

796461

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

17

Small-scale

0.618

High

796463

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

20

Small-scale

0.618

High

796470

SLAP1
Src-like-adapter

1

20

Small-scale

0.618

High

796480

SHC3
SHC-transforming protein 3

1

20

Small-scale

0.618

High

796484

SLAP2
Src-like-adapter 2

1

20

Small-scale

0.618

High

796489

GAB2
GRB2-associated-binding protein 2

1

20

Small-scale

0.618

High

380364

CD3D
T-cell surface glycoprotein CD3 delta chain

2

6

Small-scale

0.584

High

796478

THMS1
Protein THEMIS

1

1

Small-scale

0.569

High

554283

MUC1
Mucin-1

1

12

Small-scale

0.561

High

796477

TBA1A
Tubulin alpha-1A chain

1

20

Small-scale

0.561

High

796483

RNF41
E3 ubiquitin-protein ligase NRDP1

1

20

Small-scale

0.561

High

796473

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

3

High-throughput

0.541

High

796486

APC11
Anaphase-promoting complex subunit 11

1

0

High-throughput

0.518

High

271050

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

11

Small-scale

0.501

High

394290

A4
Amyloid-beta precursor protein

1

15

High-throughput

0.501

High

796482

FCRL3
Fc receptor-like protein 3

1

20

Small-scale

0.501

High

796479

HAVR2
Hepatitis A virus cellular receptor 2

1

4

Small-scale

0.484

High

796481

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

Small-scale

0.480

High

259268

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

5

Small-scale

0.479

High

353273

CD4
T-cell surface glycoprotein CD4

1

3

Small-scale

0.479

High

410612

CD5
T-cell surface glycoprotein CD5

1

5

Small-scale

0.479

High

428077

TBB5
Tubulin beta chain

1

17

Small-scale

0.479

High

431633

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.479

High

589562

CD33
Myeloid cell surface antigen CD33

1

18

Small-scale

0.479

High

590690

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

623725

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

5

Small-scale

0.479

High

670430

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

5

Small-scale

0.479

High

714128

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.479

High

796464

CXCR4
C-X-C chemokine receptor type 4

1

11

Small-scale

0.479

High

796466

TBA1B
Tubulin alpha-1B chain

1

20

Small-scale

0.479

High

796474

RHOH
Rho-related GTP-binding protein RhoH

1

20

Small-scale

0.479

High

796491

SIT1
Signaling threshold-regulating transmembrane adapter 1

1

4

Small-scale

0.479

High

796476

PEAR1
Platelet endothelial aggregation receptor 1

1

19

Small-scale

0.437

High

217298

TYOBP
TYRO protein tyrosine kinase-binding protein

1

1

Small-scale

0.408

High

796488

CBLC
E3 ubiquitin-protein ligase CBL-C

1

20

Small-scale

0.408

High

306513

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

High-throughput

0.282

High


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Last updated: 15 Jul 2024