Protein: RUNX2
Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit)

Gene: RUNX2
Organism: Mus musculus
Interactions: 103
UniProt ID: Q08775

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1061492

PEBB
Core-binding factor subunit beta

1

8

High-throughput

0.621

High

74276

EP300
Histone acetyltransferase p300

2

8

Small-scale

0.584

High

1064951

WWTR1
WW domain-containing transcription regulator protein 1

2

19

Small-scale

0.584

High

1064963

SKP2
S-phase kinase-associated protein 2

2

2

Small-scale

0.584

High

1042474

MSX2
Homeobox protein MSX-2

1

1

Small-scale

0.561

High

1017765

OSTCN
Osteocalcin

2

0

Small-scale

0.559

High

1064919

HDAC4
Histone deacetylase 4

1

16

Small-scale

0.515

High

1064913

TLE1
Transducin-like enhancer protein 1

1

11

Small-scale

0.501

High

683551

UBF1
Nucleolar transcription factor 1

1

7

Small-scale

0.500

High

561638

RB
Retinoblastoma-associated protein

1

2

High-throughput

0.481

High

1064917

RBL2
Retinoblastoma-like protein 2

1

2

High-throughput

0.481

High

1021223

TAF1A
TATA box-binding protein-associated factor RNA polymerase I subunit A

1

0

Small-scale

0.479

High

59027

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

11

Small-scale

0.479

High

63102

A5D6Q2
Nuclear receptor coactivator 3

1

5

Small-scale

0.479

High

204277

PHB2
Prohibitin-2

1

1

Small-scale

0.479

High

204422

SMAD6
Mothers against decapentaplegic homolog 6

1

16

Small-scale

0.479

High

205467

SOCS3
Suppressor of cytokine signaling 3

1

6

Small-scale

0.479

High

205488

RING1
E3 ubiquitin-protein ligase RING1

1

6

Small-scale

0.479

High

312585

MEN1
Menin

1

1

Small-scale

0.479

High

518510

MYOD1
Myoblast determination protein 1

1

1

Small-scale

0.479

High

644303

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

1

6

High-throughput

0.479

High

666050

PAX3
Paired box protein Pax-3

1

2

Small-scale

0.479

High

671891

CCND1
G1/S-specific cyclin-D1

1

1

Small-scale

0.479

High

721464

HMGB2
High mobility group protein B2

1

5

Small-scale

0.479

High

852299

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

5

Small-scale

0.479

High

861868

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

11

Small-scale

0.479

High

871149

VDR
Vitamin D3 receptor

1

4

Small-scale

0.479

High

946948

GMEB2
Glucocorticoid modulatory element-binding protein 2

1

1

Small-scale

0.479

High

960627

PSME3
Proteasome activator complex subunit 3

1

1

Small-scale

0.479

High

984363

GNB5
Guanine nucleotide-binding protein subunit beta-5

1

2

Small-scale

0.479

High

1000225

SMAD1
Mothers against decapentaplegic homolog 1

1

16

Small-scale

0.479

High

1000282

NCOA1
Nuclear receptor coactivator 1

1

5

Small-scale

0.479

High

1022211

SHC1
SHC-transforming protein 1

1

4

Small-scale

0.479

High

1064910

NDST1
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

1

1

Small-scale

0.479

High

1064911

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

1

Small-scale

0.479

High

1064912

KPCD1
Serine/threonine-protein kinase D1

1

1

Small-scale

0.479

High

1064916

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

4

High-throughput

0.479

High

1064921

Q78ZM0
Sorting nexin-3

1

1

Small-scale

0.479

High

1064925

Q8BTS0
Probable ATP-dependent RNA helicase DDX5

1

3

Small-scale

0.479

High

1064926

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

2

Small-scale

0.479

High

1064931

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

1

Small-scale

0.479

High

1064933

INT9
Integrator complex subunit 9

1

2

Small-scale

0.479

High

1064938

SOCS4
Suppressor of cytokine signaling 4

1

3

Small-scale

0.479

High

1064939

MED1
Mediator of RNA polymerase II transcription subunit 1

1

2

Small-scale

0.479

High

1064940

FOXP3
Forkhead box protein P3

1

5

Small-scale

0.479

High

1064944

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

11

Small-scale

0.479

High

1064945

TWST2
Twist-related protein 2

1

6

Small-scale

0.479

High

1064948

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

11

Small-scale

0.479

High

1064949

RNF6
E3 ubiquitin-protein ligase RNF6

1

2

Small-scale

0.479

High

1064954

BRD4
Bromodomain-containing protein 4

1

4

Small-scale

0.479

High

1064955

ANM1
Protein arginine N-methyltransferase 1

1

3

Small-scale

0.479

High

1064956

DDX21
Nucleolar RNA helicase 2

1

5

Small-scale

0.479

High

1064957

Q9JM08
Histone deacetylase

1

8

Small-scale

0.479

High

1064964

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

1

Small-scale

0.479

High

1064965

MBD2
Methyl-CpG-binding domain protein 2

1

1

Small-scale

0.479

High

98208

E9Q7C1
Mediator of RNA polymerase II transcription subunit 15

1

0

Small-scale

0.458

High

148101

PRDX6
Peroxiredoxin-6

1

0

Small-scale

0.458

High

204819

XBP1
X-box-binding protein 1

1

0

Small-scale

0.458

High

205610

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.458

High

237307

DMP1
Dentin matrix acidic phosphoprotein 1

1

0

Small-scale

0.458

High

483995

HMGN2
Non-histone chromosomal protein HMG-17

1

0

Small-scale

0.458

High

534031

OSTP
Osteopontin

1

0

Small-scale

0.458

High

570330

RS16
Small ribosomal subunit protein uS9

1

0

Small-scale

0.458

High

636967

BMP4
Bone morphogenetic protein 4

1

0

Small-scale

0.458

High

699352

VAV
Proto-oncogene vav

1

0

Small-scale

0.458

High

871191

DCE1
Glutamate decarboxylase 1

1

0

Small-scale

0.458

High

1000070

NOS3
Nitric oxide synthase 3

1

0

Small-scale

0.458

High

1000447

STX4
Syntaxin-4

1

0

Small-scale

0.458

High

1064914

NUP62
Nuclear pore glycoprotein p62

1

0

Small-scale

0.458

High

1064915

MEF2D
Myocyte-specific enhancer factor 2D

1

0

Small-scale

0.458

High

1064918

ZN521
Zinc finger protein 521

1

0

Small-scale

0.458

High

1064920

XPO1
Exportin-1

1

0

Small-scale

0.458

High

1064929

APOA5
Apolipoprotein A-V

1

0

Small-scale

0.458

High

1064930

THIC
Acetyl-CoA acetyltransferase, cytosolic

1

0

Small-scale

0.458

High

1064932

CAR11
Caspase recruitment domain-containing protein 11

1

0

Small-scale

0.458

High

1064935

SATB2
DNA-binding protein SATB2

1

0

Small-scale

0.458

High

1064936

WWOX
WW domain-containing oxidoreductase

1

0

Small-scale

0.458

High

1064937

VPS36
Vacuolar protein-sorting-associated protein 36

1

0

Small-scale

0.458

High

1064941

ABCF2
ATP-binding cassette sub-family F member 2

1

0

Small-scale

0.458

High

1064942

VPS25
Vacuolar protein-sorting-associated protein 25

1

0

Small-scale

0.458

High

1064943

SNW1
SNW domain-containing protein 1

1

0

Small-scale

0.458

High

1064946

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

0

Small-scale

0.458

High

1064953

RT29
Small ribosomal subunit protein mS29

1

0

Small-scale

0.458

High

1064958

EDF1
Endothelial differentiation-related factor 1

1

0

Small-scale

0.458

High

1064959

GAB1
GRB2-associated-binding protein 1

1

0

Small-scale

0.458

High

1064961

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

Small-scale

0.458

High

1064962

NRF1
Nuclear respiratory factor 1

1

0

Small-scale

0.458

High

810516

DYN1
Dynamin-1

1

1

Small-scale

0.437

High

1021248

PSME1
Proteasome activator complex subunit 1

1

1

Small-scale

0.437

High

1052619

TSP3
Thrombospondin-3

1

2

Small-scale

0.437

High

1064923

Q8BH76
DNA polymerase delta subunit 3

1

1

Small-scale

0.437

High

1064928

DYN3
Dynamin-3

1

1

Small-scale

0.437

High

204413

NRG3
Pro-neuregulin-3, membrane-bound isoform

1

0

Small-scale

0.249

Low

940600

AP4A
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

1

0

Small-scale

0.249

Low

1000062

STIM1
Stromal interaction molecule 1

1

0

Small-scale

0.249

Low

1064922

MOGT2
2-acylglycerol O-acyltransferase 2

1

0

Small-scale

0.249

Low

1064924

NOL11
Nucleolar protein 11

1

0

Small-scale

0.249

Low

1064927

TYW4
tRNA wybutosine-synthesizing protein 4

1

0

Small-scale

0.249

Low

1064934

TMC1
Transmembrane channel-like protein 1

1

0

Small-scale

0.249

Low

1064947

PBDC1
Protein PBDC1

1

0

Small-scale

0.249

Low

1064950

PXDC2
Plexin domain-containing protein 2

1

0

Small-scale

0.249

Low

1064952

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

1

0

Small-scale

0.249

Low

1064960

GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025