Protein: PRPK
EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase)

Gene: PRPK, TP53RK
Organism: Homo sapiens
Interactions: 56
UniProt ID: Q96S44

Gene Ontology (top 5):
GO:0000408 - EKC/KEOPS complex
GO:0002039 - p53 binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1301682

TPRKB
EKC/KEOPS complex subunit TPRKB

11

1

Small-scale

0.982

High

1301677

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

7

1

Small-scale

0.751

High

1301670

GON7
EKC/KEOPS complex subunit GON7

7

0

Small-scale

0.715

High

1056522

LAGE3
EKC/KEOPS complex subunit LAGE3

4

1

Small-scale

0.699

High

1244443

NUP43
Nucleoporin Nup43

4

2

High-throughput

0.699

High

1025513

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

4

14

High-throughput

0.699

High

1301678

MBIP1
MAP3K12-binding inhibitory protein 1

3

0

High-throughput

0.638

High

1271528

NELL1
Protein kinase C-binding protein NELL1

2

3

High-throughput

0.628

High

1301673

UBA5
Ubiquitin-like modifier-activating enzyme 5

2

2

High-throughput

0.628

High

1301683

COMDA
COMM domain-containing protein 10

2

1

High-throughput

0.628

High

1127129

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

7

High-throughput

0.628

High

387346

P53
Cellular tumor antigen p53

2

5

Small-scale

0.595

High

856153

CHIO
Beta-chimaerin

2

5

High-throughput

0.576

High

1301676

GORS2
Golgi reassembly-stacking protein 2

2

1

High-throughput

0.553

High

1051423

DCTN1
Dynactin subunit 1

1

6

High-throughput

0.541

High

1244126

SYNE1
Nesprin-1

1

10

High-throughput

0.541

High

681991

AKT1
RAC-alpha serine/threonine-protein kinase

1

12

Small-scale

0.536

High

212494

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

6

High-throughput

0.536

High

451723

CLCB
Clathrin light chain B

1

1

High-throughput

0.536

High

1019095

TP53B
TP53-binding protein 1

1

2

High-throughput

0.536

High

1084580

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

4

High-throughput

0.536

High

1246426

INADL
InaD-like protein

1

9

High-throughput

0.536

High

1254780

DDX54
ATP-dependent RNA helicase DDX54

1

4

High-throughput

0.536

High

1301671

PDIP3
Polymerase delta-interacting protein 3

1

2

High-throughput

0.536

High

275656

POP7
Ribonuclease P protein subunit p20

1

0

High-throughput

0.513

High

856191

SPSY
Spermine synthase

1

0

High-throughput

0.513

High

1301669

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

0

High-throughput

0.513

High

1301681

CYH4
Cytohesin-4

1

0

High-throughput

0.513

High

833800

CLK1
Dual specificity protein kinase CLK1

1

7

High-throughput

0.501

High

962928

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.501

High

1301672

LRRC2
Leucine-rich repeat-containing protein 2

1

5

High-throughput

0.494

High

1242394

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

1

High-throughput

0.489

High

347656

MYC
Myc proto-oncogene protein

1

13

High-throughput

0.479

High

432181

HS90A
Heat shock protein HSP 90-alpha

1

17

High-throughput

0.479

High

438453

HS90B
Heat shock protein HSP 90-beta

1

17

High-throughput

0.479

High

504613

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

553493

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

617639

CRCM
Colorectal mutant cancer protein

1

3

High-throughput

0.479

High

652020

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

721220

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

943749

PRAME
Melanoma antigen preferentially expressed in tumors

1

1

Small-scale

0.479

High

1029767

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.479

High

1171338

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

1188751

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1301675

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.479

High

1301679

MTMRA
Myotubularin-related protein 10

1

3

High-throughput

0.479

High

1301680

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

824299

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

837840

MEOX1
Homeobox protein MOX-1

1

0

High-throughput

0.458

High

1301674

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.458

High

310217

CCDB1
Cyclin-D1-binding protein 1

1

1

High-throughput

0.457

High

1233508

STX19
Syntaxin-19

1

5

High-throughput

0.437

High

1103895

ANO4
Anoctamin-4

1

0

High-throughput

0.279

Low

1292432

PLPR2
Phospholipid phosphatase-related protein type 2

1

0

High-throughput

0.279

Low

352225

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1217025

LUR1L
Leucine rich adaptor protein 1-like

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024