Protein: ACON
Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)

Gene: ACON, ACO1
Organism: Saccharomyces cerevisiae S288C
Interactions: 129
UniProt ID: P19414

Gene Ontology (top 5):
GO:0000002 - mitochondrial genome maintenance
GO:0003690 - double-stranded DNA binding
GO:0003697 - single-stranded DNA binding
GO:0003994 - aconitate hydratase activity
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

584113

ACON
Aconitate hydratase, mitochondrial

2

6

Small-scale

0.783

High

477881

HSP77
Import motor subunit, mitochondrial

4

11

Small-scale

0.676

High

490288

HSP71
Heat shock protein SSA1

3

10

Small-scale

0.660

High

510208

SSB1
Ribosome-associated molecular chaperone SSB1

3

11

Small-scale

0.656

High

567919

MDHM
Malate dehydrogenase, mitochondrial

3

3

Small-scale

0.640

High

493159

HSP72
Heat shock protein SSA2

3

10

Small-scale

0.633

High

584148

HSP78
Heat shock protein 78, mitochondrial

3

4

High-throughput

0.633

High

367528

EFTU
Elongation factor Tu, mitochondrial

2

2

High-throughput

0.584

High

423753

ATPA
ATP synthase subunit alpha, mitochondrial

2

4

High-throughput

0.584

High

584141

NFU1
NifU-like protein, mitochondrial

2

4

Small-scale

0.584

High

584174

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

2

4

High-throughput

0.584

High

584185

ABF2
ARS-binding factor 2, mitochondrial

2

1

Small-scale

0.584

High

423574

ADH3
Alcohol dehydrogenase 3, mitochondrial

2

2

High-throughput

0.571

High

584163

ILV3
Dihydroxy-acid dehydratase, mitochondrial

2

1

High-throughput

0.571

High

584200

HSP42
Heat shock protein 42

2

1

High-throughput

0.537

High

584119

RFA1
Replication factor A protein 1

1

1

High-throughput

0.536

High

584203

YPT6
GTP-binding protein YPT6

1

1

High-throughput

0.536

High

584157

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

Small-scale

0.529

High

584146

UFD4
Ubiquitin fusion degradation protein 4

1

3

High-throughput

0.515

High

420468

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD

1

0

High-throughput

0.513

High

498432

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.513

High

584131

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

584135

APE2
Aminopeptidase 2, mitochondrial

1

0

High-throughput

0.513

High

584153

ATR
Serine/threonine-protein kinase MEC1

1

0

High-throughput

0.513

High

584165

FHP
Flavohemoprotein

1

0

High-throughput

0.513

High

584169

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.513

High

584171

PSMD9
Probable 26S proteasome regulatory subunit p27

1

0

High-throughput

0.513

High

584196

DNLI4
DNA ligase 4

1

0

High-throughput

0.513

High

584161

PEX7
Peroxisomal targeting signal 2 receptor

1

4

High-throughput

0.500

High

584187

IMA1
Importin subunit alpha

1

1

High-throughput

0.500

High

584137

MYO4
Myosin-4

1

0

High-throughput

0.493

High

584170

RAD26
DNA repair and recombination protein RAD26

1

1

High-throughput

0.489

High

584191

ERB1
Ribosome biogenesis protein ERB1

1

1

High-throughput

0.489

High

584116

FKBP
FK506-binding protein 1

1

0

High-throughput

0.479

High

584122

RV161
Reduced viability upon starvation protein 161

1

0

High-throughput

0.479

High

584150

VPS21
Vacuolar protein sorting-associated protein 21

1

0

High-throughput

0.479

High

334431

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

Small-scale

0.479

High

334610

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

1

Small-scale

0.479

High

341914

ATPB
ATP synthase subunit beta, mitochondrial

1

4

High-throughput

0.479

High

365761

HSP82
ATP-dependent molecular chaperone HSP82

1

4

High-throughput

0.479

High

367722

EF1A
Elongation factor 1-alpha

1

2

Small-scale

0.479

High

410751

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

1

High-throughput

0.479

High

413293

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

425527

PUT2
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

5

High-throughput

0.479

High

427171

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.479

High

439500

FUMH
Fumarate hydratase, mitochondrial

1

1

High-throughput

0.479

High

470851

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

520786

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.479

High

543163

HSC82
ATP-dependent molecular chaperone HSC82

1

4

High-throughput

0.479

High

558555

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

3

High-throughput

0.479

High

584115

HSP60
Heat shock protein 60, mitochondrial

1

4

High-throughput

0.479

High

584118

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

1

High-throughput

0.479

High

584121

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

584125

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

1

1

High-throughput

0.479

High

584129

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

1

High-throughput

0.479

High

584130

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

584132

HS104
Heat shock protein 104

1

4

High-throughput

0.479

High

584138

ZUO1
Zuotin

1

3

Small-scale

0.479

High

584139

HSP7F
Heat shock protein homolog SSE1

1

14

Small-scale

0.479

High

584143

PREP
Presequence protease, mitochondrial

1

1

High-throughput

0.479

High

584149

MDJ1
DnaJ homolog 1, mitochondrial

1

1

High-throughput

0.479

High

584152

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

584166

BOL3
BolA-like protein 3

1

2

Small-scale

0.479

High

584167

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

3

High-throughput

0.479

High

584168

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

Small-scale

0.479

High

584173

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

584183

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

584184

COX12
Cytochrome c oxidase subunit 12, mitochondrial

1

1

High-throughput

0.479

High

584193

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

1

High-throughput

0.479

High

584180

MLC1
Myosin light chain 1

1

1

High-throughput

0.470

High

336124

COX6
Cytochrome c oxidase subunit 6, mitochondrial

1

0

High-throughput

0.458

High

357199

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

416280

SIR3
Regulatory protein SIR3

1

0

High-throughput

0.458

High

424172

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.458

High

425590

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

Small-scale

0.458

High

481278

RL2A
Large ribosomal subunit protein uL2A

1

0

Small-scale

0.458

High

584120

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.458

High

584123

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.458

High

584124

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.458

High

584126

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

0

High-throughput

0.458

High

584127

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.458

High

584128

COQ8
Atypical kinase COQ8, mitochondrial

1

0

High-throughput

0.458

High

584133

MSS51
Protein MSS51, mitochondrial

1

0

Small-scale

0.458

High

584134

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

584136

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.458

High

584140

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

584142

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

584144

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

584151

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

584155

FMP23
Protein FMP23, mitochondrial

1

0

High-throughput

0.458

High

584156

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

584164

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

584172

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

584178

RL4B
Large ribosomal subunit protein uL4B

1

0

Small-scale

0.458

High

584181

MNP1
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.458

High

584186

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

584188

YP107
UPF0651 protein YPL107W, mitochondrial

1

0

High-throughput

0.458

High

584189

ISU1
Iron sulfur cluster assembly protein 1, mitochondrial

1

0

High-throughput

0.458

High

584194

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

584198

BMS1
Ribosome biogenesis protein BMS1

1

0

High-throughput

0.458

High

584199

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

584201

FMP16
Protein FMP16, mitochondrial

1

0

High-throughput

0.458

High

584202

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

584179

SEH1
Nucleoporin SEH1

1

2

High-throughput

0.457

High

449901

HSP73
Heat shock protein SSA3

1

10

High-throughput

0.445

High

333686

ADH1
Alcohol dehydrogenase 1

1

2

Small-scale

0.437

High

539303

KSS1
Mitogen-activated protein kinase KSS1

1

1

High-throughput

0.437

High

584158

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

1

Small-scale

0.437

High

584162

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.437

High

584195

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

584197

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

584160

TCPB
T-complex protein 1 subunit beta

1

2

High-throughput

0.407

High

388078

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.279

Low

584176

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.279

Low

584190

DIG2
Down-regulator of invasive growth 2

1

0

High-throughput

0.279

Low

584192

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

420221

CALM
Calmodulin

1

0

High-throughput

0.269

Low

429623

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.261

Low

584114

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.261

Low

584147

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.261

Low

584159

TEM1
Protein TEM1

1

0

High-throughput

0.261

Low

340014

KPYK1
Pyruvate kinase 1

1

0

Small-scale

0.249

Low

584117

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

Small-scale

0.249

Low

584145

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

584154

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

584175

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.232

Low

584177

SEC16
COPII coat assembly protein SEC16

1

0

High-throughput

0.232

Low

584182

ALG12
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024