Protein: RFA1
Replication factor A protein 1 (RF-A protein 1) (DNA-binding protein BUF2) (Replication protein A 69 kDa DNA-binding subunit) (Single-stranded DNA-binding protein)

Gene: RFA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 226
UniProt ID: P22336

Gene Ontology (top 5):
GO:0000723 - telomere maintenance
GO:0000722 - telomere maintenance via recombination
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region
GO:0000794 - condensed nuclear chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

607216

RFA2
Replication factor A protein 2

17

9

Small-scale

0.986

High

607217

RFA3
Replication factor A protein 3

18

0

Small-scale

0.935

High

607259

ATR
Serine/threonine-protein kinase MEC1

12

8

Small-scale

0.761

High

419596

RAD52
DNA repair and recombination protein RAD52

12

4

Small-scale

0.759

High

607271

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

11

3

Small-scale

0.757

High

607200

RFA1
Replication factor A protein 1

2

3

Small-scale

0.754

High

607287

MPH1
ATP-dependent DNA helicase MPH1

8

10

Small-scale

0.747

High

607319

H3
Histone H3

6

6

Small-scale

0.732

High

607211

RAD51
DNA repair protein RAD51

5

3

Small-scale

0.714

High

607343

IMB1
Importin subunit beta-1

5

7

Small-scale

0.712

High

607250

SGS1
ATP-dependent helicase SGS1

4

13

Small-scale

0.710

High

607335

LCD1
DNA damage checkpoint protein LCD1

6

0

Small-scale

0.705

High

607278

RT105
Regulator of Ty1 transposition protein 105

4

0

Small-scale

0.682

High

607222

MCM2
DNA replication licensing factor MCM2

4

7

Small-scale

0.676

High

607214

MSH2
DNA mismatch repair protein MSH2

3

5

Small-scale

0.662

High

607331

MSH6
DNA mismatch repair protein MSH6

3

5

Small-scale

0.662

High

355784

H2B2
Histone H2B.2

3

4

Small-scale

0.650

High

356258

H4
Histone H4

3

1

Small-scale

0.640

High

365809

HSP82
ATP-dependent molecular chaperone HSP82

3

3

High-throughput

0.640

High

607339

POB3
FACT complex subunit POB3

2

1

Small-scale

0.634

High

425410

PIF1
ATP-dependent DNA helicase PIF1

2

1

Small-scale

0.624

High

607232

SPT16
FACT complex subunit SPT16

2

3

Small-scale

0.624

High

607349

BRE1
E3 ubiquitin-protein ligase BRE1

2

7

Small-scale

0.624

High

340618

PGK
Phosphoglycerate kinase

2

1

High-throughput

0.621

High

607330

SLD5
DNA replication complex GINS protein SLD5

2

1

Small-scale

0.611

High

607333

RUVB1
RuvB-like protein 1

2

3

Small-scale

0.611

High

607371

CMR1
DNA damage-binding protein CMR1

2

5

High-throughput

0.611

High

607236

FIMB
Fimbrin

2

9

Small-scale

0.606

High

607202

BUR1
Serine/threonine-protein kinase BUR1

2

7

Small-scale

0.601

High

607203

MCM3
DNA replication licensing factor MCM3

2

7

Small-scale

0.595

High

607359

SIZ2
E3 SUMO-protein ligase SIZ2

2

1

Small-scale

0.595

High

514235

NHP6B
Non-histone chromosomal protein 6B

2

8

High-throughput

0.588

High

607276

HSP7E
Heat shock protein SSC3, mitochondrial

2

6

High-throughput

0.588

High

607340

RNH1
Ribonuclease H

2

1

High-throughput

0.588

High

355354

H2B1
Histone H2B.1

2

4

Small-scale

0.584

High

392299

H2A2
Histone H2A.2

2

4

Small-scale

0.584

High

419526

RAD1
DNA repair protein RAD1

2

2

Small-scale

0.584

High

607310

INO80
Chromatin-remodeling ATPase INO80

2

11

Small-scale

0.584

High

607322

CTF4
DNA polymerase alpha-binding protein

2

6

Small-scale

0.584

High

607350

CDC45
Cell division control protein 45

2

1

Small-scale

0.584

High

607354

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

2

11

Small-scale

0.584

High

500603

RAD18
Postreplication repair E3 ubiquitin-protein ligase RAD18

1

2

Small-scale

0.573

High

543216

HSC82
ATP-dependent molecular chaperone HSC82

2

3

High-throughput

0.571

High

607208

SIS1
Protein SIS1

2

5

High-throughput

0.571

High

607201

HSP12
12 kDa heat shock protein

2

0

High-throughput

0.563

High

607253

BDF1
Bromodomain-containing factor 1

1

6

Small-scale

0.561

High

554557

HSP26
Heat shock protein 26

2

0

High-throughput

0.559

High

607228

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

2

0

Small-scale

0.559

High

607280

SSB2
Ribosome-associated molecular chaperone SSB2

2

3

High-throughput

0.552

High

584119

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.536

High

607210

MSH3
DNA mismatch repair protein MSH3

1

5

High-throughput

0.536

High

607215

CDC20
APC/C activator protein CDC20

1

3

High-throughput

0.536

High

607257

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.536

High

607277

ICP55
Intermediate cleaving peptidase 55

1

2

High-throughput

0.536

High

607281

PRS4
26S proteasome regulatory subunit 4 homolog

1

5

High-throughput

0.536

High

607314

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

607323

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

5

High-throughput

0.536

High

607336

KU80
ATP-dependent DNA helicase II subunit 2

1

5

Small-scale

0.534

High

607242

XRS2
DNA repair protein XRS2

1

0

Small-scale

0.529

High

521110

RAD50
DNA repair protein RAD50

1

6

Small-scale

0.527

High

375279

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

High-throughput

0.515

High

607229

ASF1
Histone chaperone ASF1

1

1

High-throughput

0.515

High

607334

HMO1
High mobility group protein 1

1

8

High-throughput

0.515

High

607344

TERT
Telomerase reverse transcriptase

1

1

Small-scale

0.515

High

607308

MDM34
Mitochondrial distribution and morphology protein 34

1

0

Small-scale

0.513

High

607338

DPB4
DNA polymerase epsilon subunit D

1

0

High-throughput

0.513

High

607218

FEN1
Flap endonuclease 1

1

2

Small-scale

0.501

High

607258

ATM
Serine/threonine-protein kinase TEL1

1

7

Small-scale

0.501

High

607273

HAL5
Serine/threonine-protein kinase HAL5

1

9

High-throughput

0.501

High

607302

DPB11
DNA replication regulator DPB11

1

1

Small-scale

0.501

High

607353

ESA1
Histone acetyltransferase ESA1

1

2

Small-scale

0.501

High

343536

PMG1
Phosphoglycerate mutase 1

1

3

High-throughput

0.500

High

360745

TBB
Tubulin beta chain

1

3

High-throughput

0.500

High

397576

OTC
Ornithine carbamoyltransferase

1

2

High-throughput

0.500

High

423764

ATPA
ATP synthase subunit alpha, mitochondrial

1

3

High-throughput

0.500

High

424348

PYR1
Multifunctional protein URA2

1

4

High-throughput

0.500

High

454188

TBA1
Tubulin alpha-1 chain

1

4

High-throughput

0.500

High

454553

TBA3
Tubulin alpha-3 chain

1

5

High-throughput

0.500

High

520915

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.500

High

555818

VATB
V-type proton ATPase subunit B

1

4

High-throughput

0.500

High

560566

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.500

High

604350

CLH
Clathrin heavy chain

1

2

High-throughput

0.500

High

607209

SCJ1
DnaJ-related protein SCJ1

1

4

High-throughput

0.500

High

607318

ACT
Actin

1

4

High-throughput

0.500

High

607324

PRS8
26S proteasome regulatory subunit 8 homolog

1

6

High-throughput

0.500

High

607352

RTC1
Restriction of telomere capping protein 1

1

5

High-throughput

0.500

High

607239

CDC13
Cell division control protein 13

1

0

Small-scale

0.493

High

607227

ARP2
Actin-related protein 2

1

5

High-throughput

0.489

High

333693

ADH1
Alcohol dehydrogenase 1

1

2

Small-scale

0.481

High

367529

EFTU
Elongation factor Tu, mitochondrial

1

3

Small-scale

0.481

High

421574

FAS1
Fatty acid synthase subunit beta

1

3

Small-scale

0.481

High

607205

KPC1
Protein kinase C-like 1

1

6

Small-scale

0.481

High

607223

MCM5
Minichromosome maintenance protein 5

1

7

Small-scale

0.481

High

607237

RAD24
Checkpoint protein RAD24

1

8

Small-scale

0.481

High

607240

MRE11
Double-strand break repair protein MRE11

1

1

Small-scale

0.481

High

607248

UBL1
Ubiquitin carboxyl-terminal hydrolase YUH1

1

2

Small-scale

0.481

High

607249

PP2C1
Protein phosphatase 2C homolog 1

1

3

Small-scale

0.481

High

607268

VPS29
Vacuolar protein sorting-associated protein 29

1

1

Small-scale

0.481

High

607357

AIM7
Protein AIM7

1

2

Small-scale

0.481

High

607364

PMG3
Phosphoglycerate mutase 3

1

3

Small-scale

0.481

High

566129

EST1
Telomere elongation protein EST1

1

0

Small-scale

0.480

High

381422

GAL1
Galactokinase

1

0

High-throughput

0.479

High

392055

H2A1
Histone H2A.1

1

4

Small-scale

0.479

High

420083

TOP2
DNA topoisomerase 2

1

2

Small-scale

0.479

High

526819

DPOLA
DNA polymerase alpha catalytic subunit A

1

2

High-throughput

0.479

High

550515

PCNA
Proliferating cell nuclear antigen

1

3

High-throughput

0.479

High

599236

REB1
DNA-binding protein REB1

1

1

Small-scale

0.479

High

599420

VPS1
Vacuolar protein sorting-associated protein 1

1

3

Small-scale

0.479

High

603276

SNF2
Transcription regulatory protein SNF2

1

9

Small-scale

0.479

High

606543

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

3

High-throughput

0.479

High

607220

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

607221

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.479

High

607224

FUN30
ATP-dependent helicase FUN30

1

11

Small-scale

0.479

High

607226

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

607230

HIR2
Protein HIR2

1

7

Small-scale

0.479

High

607234

SWI3
SWI/SNF complex subunit SWI3

1

4

Small-scale

0.479

High

607235

STH1
Nuclear protein STH1/NPS1

1

9

Small-scale

0.479

High

607246

GCN1
eIF-2-alpha kinase activator GCN1

1

7

Small-scale

0.479

High

607247

TSA1
Peroxiredoxin TSA1

1

5

Small-scale

0.479

High

607251

TAF14
Transcription initiation factor TFIID subunit 14

1

2

Small-scale

0.479

High

607254

CENPA
Histone H3-like centromeric protein CSE4

1

6

High-throughput

0.479

High

607260

DPOA2
DNA polymerase alpha subunit B

1

1

High-throughput

0.479

High

607261

MCM7
DNA replication licensing factor MCM7

1

6

High-throughput

0.479

High

607262

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

11

Small-scale

0.479

High

607267

ECM29
Proteasome component ECM29

1

9

High-throughput

0.479

High

607270

TRA1
Transcription-associated protein 1

1

7

Small-scale

0.479

High

607279

IMB4
Importin subunit beta-4

1

7

Small-scale

0.479

High

607282

ATAD2
ATPase histone chaperone YTA7

1

3

High-throughput

0.479

High

607286

ULP2
Ubiquitin-like-specific protease 2

1

2

High-throughput

0.479

High

607297

RSC8
Chromatin structure-remodeling complex protein RSC8

1

2

Small-scale

0.479

High

607307

MSN5
Protein MSN5

1

6

Small-scale

0.479

High

607309

MCM6
DNA replication licensing factor MCM6

1

8

High-throughput

0.479

High

607311

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.479

High

607317

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.479

High

607320

ARP4
Actin-related protein 4

1

5

Small-scale

0.479

High

607321

HPC2
Histone promoter control protein 2

1

6

Small-scale

0.479

High

607327

ABF2
ARS-binding factor 2, mitochondrial

1

9

Small-scale

0.479

High

607329

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.479

High

607358

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

607360

RAD59
DNA repair protein RAD59

1

4

Small-scale

0.479

High

607361

SMC4
Structural maintenance of chromosomes protein 4

1

4

Small-scale

0.479

High

607366

EAF3
Chromatin modification-related protein EAF3

1

2

Small-scale

0.479

High

607368

RUVB2
RuvB-like protein 2

1

3

Small-scale

0.479

High

607369

PSF1
DNA replication complex GINS protein PSF1

1

1

Small-scale

0.479

High

607372

H2AZ
Histone H2A.Z

1

5

Small-scale

0.479

High

607347

CORO
Coronin-like protein

1

4

High-throughput

0.470

High

602467

OPI1
Transcriptional repressor OPI1

1

0

Small-scale

0.460

High

607206

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

Small-scale

0.460

High

607252

CENPC
Inner kinetochore subunit MIF2

1

0

Small-scale

0.460

High

607264

ECM21
Protein ECM21

1

0

Small-scale

0.460

High

607293

MAF1
Repressor of RNA polymerase III transcription MAF1

1

0

Small-scale

0.460

High

607299

MHP1
MAP-homologous protein 1

1

0

Small-scale

0.460

High

607303

DPOD3
DNA polymerase delta subunit 3

1

0

Small-scale

0.460

High

607304

MOG1
Nuclear import protein MOG1

1

0

Small-scale

0.460

High

607337

APC4
Anaphase-promoting complex subunit 4

1

0

Small-scale

0.460

High

607356

MED2
Mediator of RNA polymerase II transcription subunit 2

1

0

Small-scale

0.460

High

607367

PAA1
Polyamine N-acetyltransferase 1

1

0

Small-scale

0.460

High

607370

LDB19
Protein LDB19

1

0

Small-scale

0.460

High

419451

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

486129

ADH4
Alcohol dehydrogenase 4

1

0

Small-scale

0.458

High

557880

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

607204

DPB2
DNA polymerase epsilon subunit B

1

0

Small-scale

0.458

High

607213

SGF29
SAGA-associated factor 29

1

0

Small-scale

0.458

High

607238

MG101
Mitochondrial genome maintenance protein MGM101

1

0

Small-scale

0.458

High

607241

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

Small-scale

0.458

High

607256

MUD2
Splicing factor MUD2

1

0

Small-scale

0.458

High

607265

YBY7
UPF0303 protein YBR137W

1

0

Small-scale

0.458

High

607284

PSF2
DNA replication complex GINS protein PSF2

1

0

Small-scale

0.458

High

607289

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

607295

IES1
Ino eighty subunit 1

1

0

Small-scale

0.458

High

607300

SUM1
Suppressor of mar1-1 protein

1

0

Small-scale

0.458

High

607305

BIR1
Protein BIR1

1

0

Small-scale

0.458

High

607312

RT102
Regulator of Ty1 transposition protein 102

1

0

Small-scale

0.458

High

607313

MSO1
Protein MSO1

1

0

High-throughput

0.458

High

607316

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

Small-scale

0.458

High

607332

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

607342

BUR2
Protein BUR2

1

0

Small-scale

0.458

High

607345

EAF1
Chromatin modification-related protein EAF1

1

0

Small-scale

0.458

High

607346

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

607348

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

Small-scale

0.458

High

607355

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

607365

IES3
Ino eighty subunit 3

1

0

Small-scale

0.458

High

607373

CENPX
Inner kinetochore subunit MHF2

1

0

High-throughput

0.458

High

477912

HSP77
Import motor subunit, mitochondrial

1

6

High-throughput

0.445

High

490366

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

493224

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

510289

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.445

High

514148

NHP6A
Non-histone chromosomal protein 6A

1

8

High-throughput

0.445

High

587935

HSP60
Heat shock protein 60, mitochondrial

1

4

High-throughput

0.445

High

607207

ROX1
Repressor ROX1

1

4

High-throughput

0.445

High

607212

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

607225

HS104
Heat shock protein 104

1

3

High-throughput

0.445

High

607231

ZUO1
Zuotin

1

9

High-throughput

0.445

High

607233

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

607243

DOM34
Protein DOM34

1

1

High-throughput

0.445

High

607244

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

607245

MSN2
Zinc finger protein MSN2

1

4

High-throughput

0.445

High

607269

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.445

High

607275

CAJ1
Protein CAJ1

1

8

High-throughput

0.445

High

607288

DJP1
DnaJ-like protein 1

1

7

High-throughput

0.445

High

607294

TCPH
T-complex protein 1 subunit eta

1

5

High-throughput

0.445

High

607301

JJJ2
J protein JJJ2

1

6

High-throughput

0.445

High

607341

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

7

High-throughput

0.445

High

580803

GAP1
General amino-acid permease GAP1

1

1

Small-scale

0.439

High

607255

SRPB
Signal recognition particle receptor subunit beta

1

11

Small-scale

0.439

High

607306

IML1
Vacuolar membrane-associated protein IML1

1

5

Small-scale

0.439

High

607290

LYS14
Lysine biosynthesis regulatory protein LYS14

1

0

High-throughput

0.438

High

607325

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.438

High

607326

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

7

Small-scale

0.437

High

607263

SEA4
SEH-associated protein 4

1

0

High-throughput

0.426

High

607363

SMT3
Ubiquitin-like protein SMT3

1

1

Small-scale

0.408

High

607274

TCPD
T-complex protein 1 subunit delta

1

7

High-throughput

0.407

High

607283

JEM1
DnaJ-like chaperone JEM1

1

5

High-throughput

0.407

High

607285

TCPE
T-complex protein 1 subunit epsilon

1

6

High-throughput

0.407

High

607298

ERJ5
ER-localized J domain-containing protein 5

1

5

High-throughput

0.407

High

607291

MMM1
Maintenance of mitochondrial morphology protein 1

1

0

Small-scale

0.279

Low

607296

IOC3
ISWI one complex protein 3

1

0

High-throughput

0.279

Low

607266

MCFS2
Medium-chain fatty acid ethyl ester synthase/esterase 2

1

0

Small-scale

0.251

Low

607272

AXL2
Axial budding pattern protein 2

1

0

Small-scale

0.251

Low

607292

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

Small-scale

0.251

Low

607315

YN9A
Uncharacterized isomerase YNR071C

1

0

Small-scale

0.251

Low

607351

ALR1
Magnesium transporter ALR1

1

0

Small-scale

0.251

Low

607362

YD180
Uncharacterized membrane protein YDL180W

1

0

Small-scale

0.251

Low

607219

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

607328

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024