Protein: SAHH3
Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.13.2.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2)

Gene: SAHH3, AHCYL2
Organism: Homo sapiens
Interactions: 145
UniProt ID: Q96HN2

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0006730 - one-carbon metabolic process
GO:0016787 - hydrolase activity
GO:0033353 - S-adenosylmethionine cycle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

230088

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

4

10

High-throughput

0.895

High

1346716

JOS2
Josephin-2

4

4

High-throughput

0.694

High

659819

SAHH
Adenosylhomocysteinase

1

10

High-throughput

0.691

High

1128083

DHX8
ATP-dependent RNA helicase DHX8

3

1

High-throughput

0.667

High

1214359

SYT6
Synaptotagmin-6

3

3

High-throughput

0.667

High

1353321

DOK4
Docking protein 4

3

1

High-throughput

0.667

High

871998

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

3

6

High-throughput

0.662

High

1393326

CEP72
Centrosomal protein of 72 kDa

3

2

High-throughput

0.662

High

1393333

FBW1B
F-box/WD repeat-containing protein 11

3

3

High-throughput

0.662

High

324267

FA13A
Protein FAM13A

3

6

High-throughput

0.650

High

1393317

UNKL
Putative E3 ubiquitin-protein ligase UNKL

3

0

High-throughput

0.638

High

714942

EF1D
Elongation factor 1-delta

2

2

High-throughput

0.628

High

724701

MK04
Mitogen-activated protein kinase 4

2

3

High-throughput

0.628

High

732672

ARRB2
Beta-arrestin-2

2

1

High-throughput

0.628

High

1006162

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

2

6

High-throughput

0.628

High

1349211

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

2

6

High-throughput

0.628

High

1393305

HEXI2
Protein HEXIM2

2

4

High-throughput

0.628

High

1393309

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

2

6

High-throughput

0.628

High

1335368

CAMKV
CaM kinase-like vesicle-associated protein

3

1

High-throughput

0.616

High

705510

GRN
Progranulin

2

1

High-throughput

0.611

High

725156

HXC9
Homeobox protein Hox-C9

3

7

High-throughput

0.609

High

946028

VSX2
Visual system homeobox 2

3

6

High-throughput

0.609

High

1287686

RBM23
Probable RNA-binding protein 23

3

4

High-throughput

0.609

High

1313118

ZC3H3
Zinc finger CCCH domain-containing protein 3

3

3

High-throughput

0.609

High

1322342

ZN444
Zinc finger protein 444

3

4

High-throughput

0.609

High

1337103

FA13C
Protein FAM13C

3

4

High-throughput

0.609

High

1393308

PITX2
Pituitary homeobox 2

3

4

High-throughput

0.609

High

1294883

KI18B
Kinesin-like protein KIF18B

2

0

High-throughput

0.602

High

582921

EZRI
Ezrin

2

3

High-throughput

0.584

High

978224

RHOB
Rho-related GTP-binding protein RhoB

2

9

High-throughput

0.584

High

171915

ZN263
Zinc finger protein 263

2

1

High-throughput

0.574

High

275994

DUS11
RNA/RNP complex-1-interacting phosphatase

2

7

High-throughput

0.574

High

604849

HXB9
Homeobox protein Hox-B9

2

7

High-throughput

0.574

High

605020

HXB6
Homeobox protein Hox-B6

2

6

High-throughput

0.574

High

889792

CLK3
Dual specificity protein kinase CLK3

2

7

High-throughput

0.574

High

1017467

FOXK1
Forkhead box protein K1

2

9

High-throughput

0.574

High

1029728

FOXK2
Forkhead box protein K2

2

9

High-throughput

0.574

High

1091196

FOXD4
Forkhead box protein D4

2

9

High-throughput

0.574

High

1279014

TAFA3
Chemokine-like protein TAFA-3

2

1

High-throughput

0.574

High

1307239

TF2LY
Homeobox protein TGIF2LY

2

1

High-throughput

0.574

High

1325071

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

2

1

High-throughput

0.574

High

1332008

BANP
Protein BANP

2

1

High-throughput

0.574

High

1393304

ZN414
Zinc finger protein 414

2

1

High-throughput

0.574

High

1393307

RSLAB
Ras-like protein family member 10B

2

3

High-throughput

0.574

High

1393310

SOST
Sclerostin

2

1

High-throughput

0.574

High

1393313

NUAK2
NUAK family SNF1-like kinase 2

2

3

High-throughput

0.574

High

1393327

IKBL1
NF-kappa-B inhibitor-like protein 1

2

1

High-throughput

0.574

High

1393330

ABCF2
ATP-binding cassette sub-family F member 2

2

1

High-throughput

0.574

High

1331836

SYT2
Synaptotagmin-2

2

3

High-throughput

0.549

High

1370564

FGF11
Fibroblast growth factor 11

2

3

High-throughput

0.549

High

254408

CC14B
Dual specificity protein phosphatase CDC14B

1

9

High-throughput

0.536

High

885869

KC1E
Casein kinase I isoform epsilon

1

2

High-throughput

0.536

High

1029535

SRSF2
Serine/arginine-rich splicing factor 2

1

1

High-throughput

0.536

High

1228207

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

6

High-throughput

0.536

High

1347137

WDR48
WD repeat-containing protein 48

1

6

High-throughput

0.536

High

1364518

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.536

High

1393306

ZN641
Zinc finger protein 641

1

3

High-throughput

0.536

High

1393321

CAN10
Calpain-10

1

1

High-throughput

0.536

High

1393322

PAK6
Serine/threonine-protein kinase PAK 6

1

3

High-throughput

0.536

High

1393323

PKHJ1
Pleckstrin homology domain-containing family J member 1

1

4

High-throughput

0.536

High

1393334

FBW1A
F-box/WD repeat-containing protein 1A

1

3

High-throughput

0.536

High

1393335

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

2

High-throughput

0.536

High

106459

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

1393325

DACT1
Dapper homolog 1

1

0

High-throughput

0.513

High

1393336

CAB39
Calcium-binding protein 39

1

0

High-throughput

0.513

High

340771

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

1

3

High-throughput

0.489

High

430236

JUN
Transcription factor Jun

1

9

High-throughput

0.489

High

634869

HXA5
Homeobox protein Hox-A5

1

5

High-throughput

0.489

High

871177

TFPI2
Tissue factor pathway inhibitor 2

1

2

High-throughput

0.489

High

889482

CLK1
Dual specificity protein kinase CLK1

1

7

High-throughput

0.489

High

961206

FGF12
Fibroblast growth factor 12

1

3

High-throughput

0.489

High

1005631

PITX1
Pituitary homeobox 1

1

4

High-throughput

0.489

High

1052899

HME1
Homeobox protein engrailed-1

1

3

High-throughput

0.489

High

1091075

FOXF2
Forkhead box protein F2

1

9

High-throughput

0.489

High

1260715

KNDC1
Kinase non-catalytic C-lobe domain-containing protein 1

1

1

High-throughput

0.489

High

1315240

CA174
UPF0688 protein C1orf174

1

1

High-throughput

0.489

High

1324479

AN36B
Ankyrin repeat domain-containing protein 36B

1

2

High-throughput

0.489

High

1340899

MB3L2
Methyl-CpG-binding domain protein 3-like 2

1

1

High-throughput

0.489

High

1393312

WDR33
pre-mRNA 3' end processing protein WDR33

1

2

High-throughput

0.489

High

1393315

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

2

High-throughput

0.489

High

1393318

CLK4
Dual specificity protein kinase CLK4

1

7

High-throughput

0.489

High

1393319

PKHA2
Pleckstrin homology domain-containing family A member 2

1

1

High-throughput

0.489

High

1393329

DKK2
Dickkopf-related protein 2

1

1

High-throughput

0.489

High

173225

XPO1
Exportin-1

1

2

High-throughput

0.479

High

213481

CTIF
CBP80/20-dependent translation initiation factor

1

1

High-throughput

0.479

High

242581

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

363709

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.479

High

375835

RASK
GTPase KRas

1

4

High-throughput

0.479

High

541638

FGFR1
Fibroblast growth factor receptor 1

1

10

High-throughput

0.479

High

611288

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

3

High-throughput

0.479

High

715720

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

790085

ZEB1
Zinc finger E-box-binding homeobox 1

1

1

Small-scale

0.479

High

955473

CDC42
Cell division control protein 42 homolog

1

10

High-throughput

0.479

High

962806

RND3
Rho-related GTP-binding protein RhoE

1

11

High-throughput

0.479

High

988607

RAC1
Ras-related C3 botulinum toxin substrate 1

1

8

High-throughput

0.479

High

1041227

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1138510

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1145056

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.479

High

1146454

KS6A2
Ribosomal protein S6 kinase alpha-2

1

2

High-throughput

0.479

High

1270945

RHOU
Rho-related GTP-binding protein RhoU

1

10

High-throughput

0.479

High

1370293

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.479

High

1393320

RHOF
Rho-related GTP-binding protein RhoF

1

11

High-throughput

0.479

High

1393337

TRAF6
TNF receptor-associated factor 6

1

3

High-throughput

0.479

High

951352

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

953035

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.458

High

720302

UFO
Tyrosine-protein kinase receptor UFO

1

8

High-throughput

0.457

High

530223

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

1393339

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

8

High-throughput

0.445

High

218625

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.437

High

325049

HEXI1
Protein HEXIM1

1

4

High-throughput

0.437

High

693055

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.437

High

932114

EPHA4
Ephrin type-A receptor 4

1

6

High-throughput

0.437

High

1157029

NTRK3
NT-3 growth factor receptor

1

7

High-throughput

0.437

High

1163750

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

8

High-throughput

0.437

High

1235314

STYK1
Tyrosine-protein kinase STYK1

1

8

High-throughput

0.437

High

1255063

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1324041

RHG24
Rho GTPase-activating protein 24

1

4

High-throughput

0.437

High

1335946

ZBT44
Zinc finger and BTB domain-containing protein 44

1

2

High-throughput

0.437

High

1381933

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

420034

B3A2
Anion exchange protein 2

1

8

High-throughput

0.407

High

516117

CT456
Cancer/testis antigen family 45 member A6

1

1

High-throughput

0.407

High

877615

B3A3
Anion exchange protein 3

1

8

High-throughput

0.407

High

877708

SL9A3
Sodium/hydrogen exchanger 3

1

3

High-throughput

0.407

High

1133799

SL9A5
Sodium/hydrogen exchanger 5

1

3

High-throughput

0.407

High

1281729

Q7Z7N5
Josephin-2

1

4

High-throughput

0.407

High

1314360

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.407

High

1331421

MB213
Protein mab-21-like 3

1

1

High-throughput

0.407

High

1393328

S53A1
Solute carrier family 53 member 1

1

1

High-throughput

0.407

High

1393331

EGFL7
Epidermal growth factor-like protein 7

1

1

High-throughput

0.407

High

1393332

CCNL1
Cyclin-L1

1

1

High-throughput

0.407

High

1393338

S4A7
Sodium bicarbonate cotransporter 3

1

8

High-throughput

0.407

High

1228909

MSL1
Male-specific lethal 1 homolog

3

0

High-throughput

0.347

High

336231

ZIC2
Zinc finger protein ZIC 2

2

0

High-throughput

0.328

High

1165377

ODAPH
Odontogenesis associated phosphoprotein

2

0

High-throughput

0.328

High

1204469

ARSI
Arylsulfatase I

2

0

High-throughput

0.328

High

1279499

SNX20
Sorting nexin-20

2

0

High-throughput

0.328

High

1393311

PDD2L
Programmed cell death protein 2-like

2

0

High-throughput

0.328

High

1393324

BCD1
Box C/D snoRNA protein 1

2

0

High-throughput

0.328

High

49944

LNP1
Leukemia NUP98 fusion partner 1

1

0

High-throughput

0.279

Low

271173

COBL
Protein cordon-bleu

1

0

High-throughput

0.279

Low

1128668

ZN460
Zinc finger protein 460

1

0

High-throughput

0.279

Low

1393314

IKZF4
Zinc finger protein Eos

1

0

High-throughput

0.279

Low

1393316

GREM2
Gremlin-2

1

0

High-throughput

0.279

Low

1322943

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

653506

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025