Protein: FBX21
F-box only protein 21

Gene: FBX21, FBXO21
Organism: Homo sapiens
Interactions: 75
UniProt ID: O94952

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003677 - DNA binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

322599

CUL1
Cullin-1

6

1

Small-scale

0.945

High

322595

SKP1
S-phase kinase-associated protein 1

6

0

Small-scale

0.894

High

322594

RBX1
E3 ubiquitin-protein ligase RBX1

3

0

Small-scale

0.638

High

322585

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

3

0

High-throughput

0.622

High

322600

CUL3
Cullin-3

1

1

High-throughput

0.618

High

322574

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.614

High

322579

IDS
Iduronate 2-sulfatase

3

6

High-throughput

0.609

High

322578

KPCA
Protein kinase C alpha type

2

0

High-throughput

0.602

High

322568

CRYAB
Alpha-crystallin B chain

2

0

High-throughput

0.585

High

322582

PRTN3
Myeloblastin

2

0

High-throughput

0.576

High

322618

VWCE
von Willebrand factor C and EGF domain-containing protein

2

2

High-throughput

0.574

High

322619

ARSG
Arylsulfatase G

2

6

High-throughput

0.574

High

322584

GALNS
N-acetylgalactosamine-6-sulfatase

2

6

High-throughput

0.549

High

322588

SPHM
N-sulphoglucosamine sulphohydrolase

2

6

High-throughput

0.549

High

322598

NOTC2
Neurogenic locus notch homolog protein 2

1

0

High-throughput

0.546

High

322602

NEDD8
Ubiquitin-like protein NEDD8

1

0

High-throughput

0.546

High

322583

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

Small-scale

0.537

High

322576

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

155987

SOCS6
Suppressor of cytokine signaling 6

1

1

High-throughput

0.515

High

322581

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.513

High

322610

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.513

High

322617

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

322577

ARSA
Arylsulfatase A

1

6

High-throughput

0.489

High

322589

ARSL
Arylsulfatase L

1

6

High-throughput

0.489

High

322596

FBLN2
Fibulin-2

1

1

High-throughput

0.489

High

322603

ARSI
Arylsulfatase I

1

6

High-throughput

0.489

High

322591

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.479

High

156796

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

222598

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

322569

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

322570

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

322572

K1C16
Keratin, type I cytoskeletal 16

1

0

Small-scale

0.458

High

322586

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.458

High

322587

CCN3
CCN family member 3

1

0

High-throughput

0.458

High

322592

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

322593

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

322597

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

322606

CDC73
Parafibromin

1

0

High-throughput

0.458

High

322624

COL11
Collectin-11

1

0

High-throughput

0.458

High

322627

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

0

Small-scale

0.458

High

322629

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

322631

ARI1
E3 ubiquitin-protein ligase ARIH1

1

0

High-throughput

0.458

High

322601

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.437

High

322565

TNF6B
Tumor necrosis factor receptor superfamily member 6B

1

0

High-throughput

0.426

High

322567

CEP43
Centrosomal protein 43

1

0

Small-scale

0.426

High

322575

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

322590

NUP98
Nuclear pore complex protein Nup98-Nup96

1

0

Small-scale

0.426

High

322622

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

322628

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

Small-scale

0.426

High

322633

EID1
EP300-interacting inhibitor of differentiation 1

4

0

Small-scale

0.373

High

262170

KERA
Keratocan

3

0

High-throughput

0.345

High

322571

MDR1
ATP-dependent translocase ABCB1

1

0

Small-scale

0.292

High

322607

CF015
Uncharacterized protein C6orf15

1

0

High-throughput

0.279

Low

322630

TINAG
Tubulointerstitial nephritis antigen

1

0

High-throughput

0.279

Low

322625

CNTP4
Contactin-associated protein-like 4

1

0

Small-scale

0.265

Low

322573

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

322604

TENS2
Tensin-2

1

0

High-throughput

0.249

Low

322608

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

322609

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

322613

ZBT46
Zinc finger and BTB domain-containing protein 46

1

0

High-throughput

0.249

Low

322614

F219A
Protein FAM219A

1

0

High-throughput

0.249

Low

322616

EID2
EP300-interacting inhibitor of differentiation 2

1

0

Small-scale

0.249

Low

190294

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.232

Low

231029

VEGFD
Vascular endothelial growth factor D

1

0

High-throughput

0.232

Low

322566

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.232

Low

322580

IBP4
Insulin-like growth factor-binding protein 4

1

0

High-throughput

0.232

Low

322605

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

0

Small-scale

0.232

Low

322611

S46A3
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3

1

0

High-throughput

0.232

Low

322612

SL9B2
Sodium/hydrogen exchanger 9B2

1

0

High-throughput

0.232

Low

322615

S22AO
Steroid transmembrane transporter SLC22A24

1

0

High-throughput

0.232

Low

322620

HIPL1
HHIP-like protein 1

1

0

High-throughput

0.232

Low

322621

MCEE
Methylmalonyl-CoA epimerase, mitochondrial

1

0

High-throughput

0.232

Low

322623

TR61B
tRNA

1

0

High-throughput

0.232

Low

322626

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.232

Low

322632

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025