Protein: MCM2
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2)

Gene: MCM2
Organism: Saccharomyces cerevisiae S288C
Interactions: 169
UniProt ID: P29469

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

667549

MCM4
DNA replication licensing factor MCM4

22

20

Small-scale

0.990

High

667640

CDC45
Cell division control protein 45

22

15

Small-scale

0.990

High

622145

MCM3
DNA replication licensing factor MCM3

15

20

Small-scale

0.983

High

667606

MCM6
DNA replication licensing factor MCM6

13

20

Small-scale

0.980

High

667546

MCM5
Minichromosome maintenance protein 5

14

20

Small-scale

0.979

High

667599

CDT1
Cell division cycle protein CDT1

10

3

Small-scale

0.976

High

667627

SLD5
DNA replication complex GINS protein SLD5

11

15

Small-scale

0.970

High

667656

PSF1
DNA replication complex GINS protein PSF1

9

11

Small-scale

0.964

High

667573

MCM7
DNA replication licensing factor MCM7

8

20

Small-scale

0.961

High

667592

PSF2
DNA replication complex GINS protein PSF2

7

8

Small-scale

0.954

High

667617

H3
Histone H3

5

20

Small-scale

0.930

High

356302

H4
Histone H4

5

8

Small-scale

0.906

High

667602

ORC5
Origin recognition complex subunit 5

4

5

Small-scale

0.901

High

667647

PSF3
DNA replication complex GINS protein PSF3

4

9

Small-scale

0.882

High

355382

H2B1
Histone H2B.1

3

20

Small-scale

0.853

High

392333

H2A2
Histone H2A.2

3

20

Small-scale

0.817

High

667545

MCM2
DNA replication licensing factor MCM2

2

20

Small-scale

0.800

High

667580

ORC6
Origin recognition complex subunit 6

2

0

Small-scale

0.776

High

412529

CDC7
Cell division control protein 7

14

20

Small-scale

0.762

High

667551

MCM10
Minichromosome maintenance protein 10

10

13

Small-scale

0.760

High

392073

H2A1
Histone H2A.1

2

20

Small-scale

0.754

High

667550

DBF4
DDK kinase regulatory subunit DBF4

7

3

Small-scale

0.749

High

667615

ORC4
Origin recognition complex subunit 4

1

19

Small-scale

0.734

High

667607

SLD3
DNA replication regulator SLD3

6

3

Small-scale

0.728

High

355815

H2B2
Histone H2B.2

1

20

Small-scale

0.724

High

447785

CDC6
Cell division control protein 6

5

19

Small-scale

0.722

High

667631

POB3
FACT complex subunit POB3

4

7

Small-scale

0.689

High

634861

MRC1
Mediator of replication checkpoint protein 1

4

3

Small-scale

0.686

High

667641

DIA2
Protein DIA2

3

3

Small-scale

0.679

High

667620

CTF4
DNA polymerase alpha-binding protein

4

6

Small-scale

0.676

High

607222

RFA1
Replication factor A protein 1

4

7

Small-scale

0.676

High

667555

SPT16
FACT complex subunit SPT16

4

5

Small-scale

0.676

High

667632

CSM3
Chromosome segregation in meiosis protein 3

4

3

Small-scale

0.676

High

667561

SLD2
DNA replication regulator SLD2

3

3

Small-scale

0.670

High

602321

DPOE
DNA polymerase epsilon catalytic subunit A

3

10

Small-scale

0.656

High

526827

DPOLA
DNA polymerase alpha catalytic subunit A

3

10

Small-scale

0.646

High

667609

TOF1
Topoisomerase 1-associated factor 1

3

8

Small-scale

0.640

High

667613

ORC1
Origin recognition complex subunit 1

2

20

Small-scale

0.633

High

667558

ORC2
Origin recognition complex subunit 2

2

8

Small-scale

0.629

High

667597

DPB11
DNA replication regulator DPB11

2

3

Small-scale

0.624

High

667566

CENPA
Histone H3-like centromeric protein CSE4

1

20

High-throughput

0.618

High

667614

ORC3
Origin recognition complex subunit 3

2

0

Small-scale

0.602

High

667619

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

2

0

High-throughput

0.595

High

667552

ASF1
Histone chaperone ASF1

1

9

High-throughput

0.575

High

667659

H2AZ
Histone H2A.Z

1

20

High-throughput

0.575

High

457000

SWI6
Regulatory protein SWI6

2

8

High-throughput

0.571

High

493389

HSP72
Heat shock protein SSA2

2

15

High-throughput

0.571

High

510520

SSB1
Ribosome-associated molecular chaperone SSB1

2

16

High-throughput

0.571

High

667591

ATAD2
ATPase histone chaperone YTA7

2

5

High-throughput

0.571

High

667588

SSB2
Ribosome-associated molecular chaperone SSB2

2

16

High-throughput

0.552

High

667598

DPOD3
DNA polymerase delta subunit 3

1

0

Small-scale

0.537

High

490560

HSP71
Heat shock protein SSA1

1

15

High-throughput

0.536

High

667548

CGS5
S-phase entry cyclin-5

1

6

High-throughput

0.536

High

667595

ECO1
N-acetyltransferase ECO1

1

6

Small-scale

0.527

High

667652

SMT3
Ubiquitin-like protein SMT3

1

7

Small-scale

0.515

High

667654

HAT1
Histone acetyltransferase type B catalytic subunit

1

1

High-throughput

0.515

High

526129

KIN1
Serine/threonine protein kinase KIN1

1

4

High-throughput

0.508

High

526196

KIN2
Serine/threonine-protein kinase KIN2

1

4

High-throughput

0.508

High

667589

PSA6
Proteasome subunit alpha type-6

1

3

High-throughput

0.508

High

539320

KSS1
Mitogen-activated protein kinase KSS1

1

11

High-throughput

0.501

High

562691

FUS3
Mitogen-activated protein kinase FUS3

1

11

High-throughput

0.501

High

565489

PHO85
Cyclin-dependent protein kinase PHO85

1

10

High-throughput

0.501

High

602636

MCK1
Protein kinase MCK1

1

7

High-throughput

0.501

High

667556

IME2
Meiosis induction protein kinase IME2/SME1

1

14

Small-scale

0.501

High

667648

YP150
Putative serine/threonine-protein kinase YPL150W

1

3

High-throughput

0.501

High

667625

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

1

0

High-throughput

0.486

High

667651

POC4
Proteasome chaperone 4

1

0

High-throughput

0.486

High

667582

RT107
Regulator of Ty1 transposition protein 107

1

2

Small-scale

0.481

High

333718

ADH1
Alcohol dehydrogenase 1

1

2

High-throughput

0.479

High

340057

KPYK1
Pyruvate kinase 1

1

5

High-throughput

0.479

High

406858

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

410938

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.479

High

413358

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

488484

PRI1
DNA primase small subunit

1

1

Small-scale

0.479

High

522678

AAKG
5'-AMP-activated protein kinase subunit gamma

1

5

High-throughput

0.479

High

534531

GCY1
Glycerol 2-dehydrogenase

1

1

High-throughput

0.479

High

560919

EF3A
Elongation factor 3A

1

6

High-throughput

0.479

High

562338

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

3

High-throughput

0.479

High

606239

VPS15
Serine/threonine-protein kinase VPS15

1

4

High-throughput

0.479

High

614569

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.479

High

619123

SPT6
Transcription elongation factor SPT6

1

1

Small-scale

0.479

High

645306

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

650241

SPT5
Transcription elongation factor SPT5

1

1

Small-scale

0.479

High

661541

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

667562

BMH2
Protein BMH2

1

2

Small-scale

0.479

High

667565

DEF1
RNA polymerase II degradation factor 1

1

4

High-throughput

0.479

High

667570

OMA1
Mitochondrial metalloendopeptidase OMA1

1

1

High-throughput

0.479

High

667572

DPOA2
DNA polymerase alpha subunit B

1

2

Small-scale

0.479

High

667576

RGD1
RHO GTPase-activating protein RGD1

1

5

High-throughput

0.479

High

667579

TRA1
Transcription-associated protein 1

1

8

Small-scale

0.479

High

667596

CTK2
CTD kinase subunit beta

1

7

High-throughput

0.479

High

667601

CTF18
Chromosome transmission fidelity protein 18

1

1

Small-scale

0.479

High

667604

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.479

High

667605

UFD1
Ubiquitin fusion degradation protein 1

1

3

Small-scale

0.479

High

667608

HST2
NAD-dependent protein deacetylase HST2

1

12

High-throughput

0.479

High

667610

IPI3
Pre-rRNA-processing protein IPI3

1

3

Small-scale

0.479

High

667630

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

667635

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

3

High-throughput

0.479

High

667638

NOC3
Nucleolar complex-associated protein 3

1

1

Small-scale

0.479

High

667643

PMG2
Phosphoglycerate mutase 2

1

2

High-throughput

0.479

High

667650

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

667655

YPR1
Putative reductase 1

1

1

High-throughput

0.479

High

667658

GLT1
Glutamate synthase [NADH]

1

3

High-throughput

0.470

High

667554

EI2BB
Translation initiation factor eIF2B subunit beta

1

2

High-throughput

0.464

High

498642

RT01
Small ribosomal subunit protein mS43

1

0

High-throughput

0.458

High

608738

CHL1
ATP-dependent DNA helicase CHL1

1

0

Small-scale

0.458

High

625797

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.458

High

631649

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.458

High

657784

MGLL
Monoglyceride lipase

1

0

High-throughput

0.458

High

667547

RIF1
Telomere length regulator protein RIF1

1

0

High-throughput

0.458

High

667563

THI80
Thiamine pyrophosphokinase

1

0

High-throughput

0.458

High

667568

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.458

High

667571

TBS1
Uncharacterized transcriptional regulatory protein TBS1

1

0

High-throughput

0.458

High

667574

TRM7
tRNA

1

0

High-throughput

0.458

High

667575

CENPU
Inner kinetochore subunit AME1

1

0

High-throughput

0.458

High

667577

NCB5R
NADH-cytochrome b5 reductase 1

1

0

High-throughput

0.458

High

667578

GIC1
GTPase-interacting component 1

1

0

High-throughput

0.458

High

667587

PHM8
Phosphate metabolism protein 8

1

0

High-throughput

0.458

High

667590

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.458

High

667594

SERB
Phosphoserine phosphatase

1

0

High-throughput

0.458

High

667600

BUL1
Ubiquitin ligase-binding protein BUL1

1

0

High-throughput

0.458

High

667616

DOS2
Protein DOS2

1

0

High-throughput

0.458

High

667618

RAGAB
GTP-binding protein GTR1

1

0

High-throughput

0.458

High

667623

TFB3
RNA polymerase II transcription factor B subunit 3

1

0

High-throughput

0.458

High

667626

DIG2
Down-regulator of invasive growth 2

1

0

High-throughput

0.458

High

667634

NEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.458

High

667636

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

667644

TGS1
Trimethylguanosine synthase

1

0

High-throughput

0.458

High

667645

TSR3
18S rRNA aminocarboxypropyltransferase

1

0

High-throughput

0.458

High

667646

CMR3
Zinc finger protein CRM3

1

0

High-throughput

0.458

High

365929

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.445

High

419313

HAP2
Transcriptional activator HAP2

1

2

High-throughput

0.445

High

516279

RAP1
DNA-binding protein RAP1

1

2

High-throughput

0.445

High

605211

AFT1
Iron-regulated transcriptional activator AFT1

1

2

High-throughput

0.445

High

628842

SWI4
Regulatory protein SWI4

1

7

High-throughput

0.445

High

633007

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

667557

HSP7F
Heat shock protein homolog SSE1

1

19

High-throughput

0.445

High

667560

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

667564

SPT10
Protein SPT10

1

3

High-throughput

0.445

High

667567

LHS1
Heat shock protein 70 homolog LHS1

1

16

High-throughput

0.445

High

667569

SET3
SET domain-containing protein 3

1

7

High-throughput

0.445

High

667581

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

9

High-throughput

0.445

High

667584

TCPG
T-complex protein 1 subunit gamma

1

5

High-throughput

0.445

High

667585

MBP1
Transcription factor MBP1

1

9

High-throughput

0.445

High

667611

PFD4
Prefoldin subunit 4

1

1

High-throughput

0.445

High

667621

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

15

High-throughput

0.445

High

667624

GCN5
Histone acetyltransferase GCN5

1

17

High-throughput

0.445

High

667628

GIS1
Transcriptional activator/repressor GIS1

1

6

High-throughput

0.445

High

667633

SWR1
Helicase SWR1

1

4

High-throughput

0.445

High

667639

RSC58
Chromatin structure-remodeling complex protein RSC58

1

2

High-throughput

0.445

High

667657

RLF2
Chromatin assembly factor 1 subunit p90

1

6

High-throughput

0.445

High

667559

LIPA
Lipoyl synthase, mitochondrial

1

0

High-throughput

0.438

High

342881

ENO2
Enolase 2

1

5

High-throughput

0.437

High

357936

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

383000

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

667612

MTQ1
Mitochondrial MRF1 N(5)-glutamine methyltransferase MTQ1

1

1

High-throughput

0.437

High

667653

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

549653

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.249

Low

667553

ATP11
Protein ATP11, mitochondrial

1

0

High-throughput

0.249

Low

667583

AIM46
Altered inheritance of mitochondria protein 46, mitochondrial

1

0

High-throughput

0.249

Low

667586

FIR1
Factor interacting with REF2

1

0

High-throughput

0.249

Low

667593

BNI1
Protein BNI1

1

0

High-throughput

0.249

Low

667603

RL4P
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.249

Low

667622

YD090
Uncharacterized membrane protein YDR090C

1

0

High-throughput

0.249

Low

667629

RT24
Small ribosomal subunit protein mS35

1

0

High-throughput

0.249

Low

667637

FMP45
SUR7 family protein FMP45

1

0

High-throughput

0.249

Low

667642

PGC1
Phosphatidylglycerol phospholipase C

1

0

High-throughput

0.249

Low

667649

RFM1
Repression factor of MSEs protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024