Protein: GLP1R
Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R)

Gene: GLP1R
Organism: Homo sapiens
Interactions: 120
UniProt ID: P43220

Gene Ontology (top 5):
GO:0004888 - transmembrane signaling receptor activity
GO:0004967 - glucagon receptor activity
GO:0005886 - plasma membrane
GO:0007166 - cell surface receptor signaling pathway
GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

377278

GLUC
Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide

2

1

Small-scale

0.738

High

846058

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

9

Small-scale

0.621

High

846050

CD81
CD81 antigen

2

14

Small-scale

0.619

High

846061

IFM3
Interferon-induced transmembrane protein 3

2

1

Small-scale

0.619

High

846082

S15A4
Solute carrier family 15 member 4

2

4

Small-scale

0.619

High

846075

NT2NA
Notch homolog 2 N-terminal-like protein A

2

3

High-throughput

0.578

High

846045

RAB5C
Ras-related protein Rab-5C

1

1

Small-scale

0.561

High

846056

RAB5B
Ras-related protein Rab-5B

1

2

Small-scale

0.561

High

846062

CAV1
Caveolin-1

1

2

Small-scale

0.561

High

685814

KRA59
Keratin-associated protein 5-9

2

8

High-throughput

0.553

High

846063

KRA11
Keratin-associated protein 1-1

2

7

High-throughput

0.553

High

846077

KRA13
Keratin-associated protein 1-3

2

7

High-throughput

0.553

High

186893

GPR37
Prosaposin receptor GPR37

1

8

Small-scale

0.552

High

226473

SNG3
Synaptogyrin-3

1

6

Small-scale

0.552

High

292578

RENR
Renin receptor

1

1

Small-scale

0.552

High

425243

CFAI
Complement factor I

1

6

Small-scale

0.552

High

437639

HEPS
Serine protease hepsin

1

5

Small-scale

0.552

High

789870

FDFT
Squalene synthase

1

2

Small-scale

0.552

High

846046

APLP1
Amyloid beta precursor like protein 1

1

3

Small-scale

0.552

High

846071

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

9

Small-scale

0.552

High

846072

MFSD5
Molybdate-anion transporter

1

6

Small-scale

0.552

High

846088

APH1A
Gamma-secretase subunit APH-1A

1

1

Small-scale

0.552

High

846093

ELOV1
Very long chain fatty acid elongase 1

1

6

Small-scale

0.552

High

846098

AT131
Endoplasmic reticulum transmembrane helix translocase

1

10

Small-scale

0.552

High

846108

STML2
Stomatin-like protein 2, mitochondrial

1

1

Small-scale

0.552

High

130025

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.537

High

190549

COPT2
Protein SLC31A2

1

0

Small-scale

0.529

High

296855

GABR2
Gamma-aminobutyric acid type B receptor subunit 2

1

0

Small-scale

0.529

High

349349

TSN13
Tetraspanin-13

1

0

Small-scale

0.529

High

716167

ERP29
Endoplasmic reticulum resident protein 29

1

0

Small-scale

0.529

High

846055

MYL6
Myosin light polypeptide 6

1

0

Small-scale

0.529

High

846073

PAQR6
Membrane progestin receptor delta

1

0

Small-scale

0.529

High

846078

CEND
Cell cycle exit and neuronal differentiation protein 1

1

0

Small-scale

0.529

High

846089

AP2M1
AP-2 complex subunit mu

1

0

Small-scale

0.529

High

846090

VATO
V-type proton ATPase 21 kDa proteolipid subunit c''

1

0

Small-scale

0.529

High

846092

TM147
BOS complex subunit TMEM147

1

0

Small-scale

0.529

High

846096

CYTM1
Cysteine-rich and transmembrane domain-containing protein 1

1

0

Small-scale

0.529

High

846052

KR107
Keratin-associated protein 10-7

1

7

High-throughput

0.523

High

846053

KR108
Keratin-associated protein 10-8

1

7

High-throughput

0.523

High

846054

KR109
Keratin-associated protein 10-9

1

7

High-throughput

0.523

High

680263

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

4

High-throughput

0.515

High

273171

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

3

Small-scale

0.504

High

846069

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

1

3

Small-scale

0.504

High

846081

SVOP
Synaptic vesicle 2-related protein

1

6

Small-scale

0.504

High

846104

P4HTM
Transmembrane prolyl 4-hydroxylase

1

1

Small-scale

0.504

High

846105

STMN3
Stathmin-3

1

1

Small-scale

0.504

High

229219

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

2

Small-scale

0.481

High

328871

RTN3
Reticulon-3

1

1

Small-scale

0.481

High

332904

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

Small-scale

0.481

High

455956

ASGR2
Asialoglycoprotein receptor 2

1

4

Small-scale

0.481

High

477409

CD63
CD63 antigen

1

14

Small-scale

0.481

High

599559

STMN1
Stathmin

1

1

Small-scale

0.481

High

846048

BI1
Bax inhibitor 1

1

4

Small-scale

0.481

High

846049

GP2
Pancreatic secretory granule membrane major glycoprotein GP2

1

1

Small-scale

0.481

High

846057

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

1

Small-scale

0.481

High

846065

ARFRP
ADP-ribosylation factor-related protein 1

1

1

Small-scale

0.481

High

846076

LFG1
Protein lifeguard 1

1

4

Small-scale

0.481

High

846091

RNF5
E3 ubiquitin-protein ligase RNF5

1

2

Small-scale

0.481

High

846099

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

1

Small-scale

0.481

High

846100

GP108
Protein GPR108

1

4

Small-scale

0.481

High

846101

RTN4
Reticulon-4

1

1

Small-scale

0.481

High

846102

AIG1
Androgen-induced gene 1 protein

1

2

Small-scale

0.481

High

846111

DHRS7
Dehydrogenase/reductase SDR family member 7

1

4

Small-scale

0.481

High

846112

MTCH2
Mitochondrial carrier homolog 2

1

5

Small-scale

0.481

High

846039

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

2

Small-scale

0.479

High

846043

ARRB1
Beta-arrestin-1

1

2

Small-scale

0.479

High

516975

NT2NC
Notch homolog 2 N-terminal-like protein C

1

3

High-throughput

0.470

High

337867

CLD7
Claudin-7

1

0

Small-scale

0.460

High

391197

FRIL
Ferritin light chain

1

0

Small-scale

0.460

High

515876

SAA1
Serum amyloid A-1 protein

1

0

Small-scale

0.460

High

618180

AMD
Peptidyl-glycine alpha-amidating monooxygenase

1

0

Small-scale

0.460

High

642207

COMT
Catechol O-methyltransferase

1

0

Small-scale

0.460

High

656063

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

0

Small-scale

0.460

High

846038

IEX1
Radiation-inducible immediate-early gene IEX-1

1

0

Small-scale

0.460

High

846041

T4S4
Transmembrane 4 L6 family member 4

1

0

Small-scale

0.460

High

846047

EMP2
Epithelial membrane protein 2

1

0

Small-scale

0.460

High

846074

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

1

0

Small-scale

0.460

High

846107

CC167
Coiled-coil domain-containing protein 167

1

0

Small-scale

0.460

High

846113

SELK
Selenoprotein K

1

0

Small-scale

0.460

High

846059

SUMO1
Small ubiquitin-related modifier 1

1

0

Small-scale

0.458

High

490

NBPFJ
NBPF family member NBPF19

1

2

High-throughput

0.439

High

252940

UD19
UDP-glucuronosyltransferase 1A9

1

1

Small-scale

0.439

High

337921

SNG4
Synaptogyrin-4

1

6

Small-scale

0.439

High

458007

TRY2
Trypsin-2

1

5

Small-scale

0.439

High

464681

CXB1
Gap junction beta-1 protein

1

4

Small-scale

0.439

High

476528

CEL3B
Chymotrypsin-like elastase family member 3B

1

6

Small-scale

0.439

High

846040

AT5G3
ATP synthase F(0) complex subunit C3, mitochondrial

1

2

Small-scale

0.439

High

846051

KR103
Keratin-associated protein 10-3

1

7

High-throughput

0.439

High

846067

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

2

Small-scale

0.439

High

846109

POMT2
Protein O-mannosyl-transferase 2

1

1

Small-scale

0.439

High

70136

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

846095

KR171
Keratin-associated protein 17-1

2

0

High-throughput

0.316

High

846083

CR032
UPF0729 protein C18orf32

1

0

Small-scale

0.288

High

846097

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

Small-scale

0.288

High

846103

RM22
Large ribosomal subunit protein uL22m

1

0

Small-scale

0.288

High

846110

RTRAF
RNA transcription, translation and transport factor protein

1

0

Small-scale

0.288

High

846114

SERP1
Stress-associated endoplasmic reticulum protein 1

1

0

Small-scale

0.288

High

71783

ZNF99
Zinc finger protein 99

1

0

Small-scale

0.251

Low

286524

SG2A1
Mammaglobin-B

1

0

Small-scale

0.251

Low

367175

ATP6
ATP synthase F(0) complex subunit a

1

0

Small-scale

0.251

Low

369325

A1AT
Alpha-1-antitrypsin

1

0

Small-scale

0.251

Low

397659

NU4LM
NADH-ubiquinone oxidoreductase chain 4L

1

0

Small-scale

0.251

Low

403249

COL
Colipase

1

0

Small-scale

0.251

Low

505140

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

Small-scale

0.251

Low

638835

AGT1
Alanine--glyoxylate aminotransferase

1

0

Small-scale

0.251

Low

846042

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

Small-scale

0.251

Low

846044

KHK
Ketohexokinase

1

0

Small-scale

0.251

Low

846060

HEPC
Hepcidin

1

0

Small-scale

0.251

Low

846064

FGL1
Fibrinogen-like protein 1

1

0

Small-scale

0.251

Low

846066

LAP4A
Lysosomal-associated transmembrane protein 4A

1

0

Small-scale

0.251

Low

846068

T176B
Transmembrane protein 176B

1

0

Small-scale

0.251

Low

846070

OCAD2
OCIA domain-containing protein 2

1

0

Small-scale

0.251

Low

846079

SYS1
Protein SYS1 homolog

1

0

Small-scale

0.251

Low

846080

CLIP4
CAP-Gly domain-containing linker protein 4

1

0

Small-scale

0.251

Low

846084

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

1

0

Small-scale

0.251

Low

846085

NEUG
Neurogranin

1

0

Small-scale

0.251

Low

846086

SPTSA
Serine palmitoyltransferase small subunit A

1

0

Small-scale

0.251

Low

846087

TOM6
Mitochondrial import receptor subunit TOM6 homolog

1

0

Small-scale

0.251

Low

846094

SC11C
Signal peptidase complex catalytic subunit SEC11C

1

0

Small-scale

0.251

Low

846106

CNIH4
Protein cornichon homolog 4

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025