Protein: PBPA
Penicillin-binding protein 1A (PBP-1a) (PBP1a) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.99.28) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)]

Gene: PBPA, mrcA
Organism: Escherichia coli K-12
Interactions: 81
UniProt ID: P02918

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0006508 - proteolysis
GO:0008360 - regulation of cell shape
GO:0008658 - penicillin binding
GO:0008955 - peptidoglycan glycosyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

367383

MRDA
Peptidoglycan D,D-transpeptidase MrdA

2

16

Small-scale

0.786

High

367404

LPOA
Penicillin-binding protein activator LpoA

2

0

Small-scale

0.576

High

367342

PBPB
Penicillin-binding protein 1B

1

17

Small-scale

0.575

High

367376

FTSH
ATP-dependent zinc metalloprotease FtsH

1

0

High-throughput

0.513

High

367386

ELAB
Protein ElaB

1

2

High-throughput

0.479

High

367413

YQJD
Uncharacterized protein YqjD

1

2

High-throughput

0.479

High

367364

RS4
Small ribosomal subunit protein uS4

1

0

High-throughput

0.458

High

367396

EFTU1
Elongation factor Tu 1

1

0

High-throughput

0.458

High

367400

FTSN
Cell division protein FtsN

1

3

Small-scale

0.445

High

367343

PFLB
Formate acetyltransferase 1

1

1

High-throughput

0.437

High

367351

IHFA
Integration host factor subunit alpha

1

2

High-throughput

0.437

High

367367

TALB
Transaldolase B

1

1

High-throughput

0.437

High

367379

DBHA
DNA-binding protein HU-alpha

1

2

High-throughput

0.437

High

367399

SYD
Aspartate--tRNA ligase

1

1

High-throughput

0.437

High

367402

DHAM
PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM

1

1

High-throughput

0.437

High

367408

RL2
Large ribosomal subunit protein uL2

1

1

High-throughput

0.437

High

367412

CLPB
Chaperone protein ClpB

1

1

High-throughput

0.437

High

367414

GRCA
Autonomous glycyl radical cofactor

1

1

High-throughput

0.437

High

343752

SYA
Alanine--tRNA ligase

1

0

High-throughput

0.279

Low

367373

GATD
Galactitol 1-phosphate 5-dehydrogenase

1

0

High-throughput

0.279

Low

367381

YECA
Uncharacterized protein YecA

1

0

High-throughput

0.279

Low

367407

ABPB
Anti-bacteriophage protein B

1

0

High-throughput

0.279

Low

334327

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

0

High-throughput

0.249

Low

341620

ASPG2
L-asparaginase 2

1

0

High-throughput

0.249

Low

343452

MANA
Mannose-6-phosphate isomerase

1

0

High-throughput

0.249

Low

358343

RL15
Large ribosomal subunit protein uL15

1

0

High-throughput

0.249

Low

367344

CH10
Co-chaperonin GroES

1

0

High-throughput

0.249

Low

367345

DEOB
Phosphopentomutase

1

0

High-throughput

0.249

Low

367346

EFG
Elongation factor G

1

0

High-throughput

0.249

Low

367347

EFP
Elongation factor P

1

0

High-throughput

0.249

Low

367348

EFTS
Elongation factor Ts

1

0

High-throughput

0.249

Low

367349

ENO
Enolase

1

0

High-throughput

0.249

Low

367350

GREA
Transcription elongation factor GreA

1

0

High-throughput

0.249

Low

367352

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.249

Low

367353

RL10
Large ribosomal subunit protein uL10

1

0

High-throughput

0.249

Low

367354

RL11
Large ribosomal subunit protein uL11

1

0

High-throughput

0.249

Low

367355

RL19
Large ribosomal subunit protein bL19

1

0

High-throughput

0.249

Low

367356

RL1
Large ribosomal subunit protein uL1

1

0

High-throughput

0.249

Low

367357

RL29
Large ribosomal subunit protein uL29

1

0

High-throughput

0.249

Low

367358

RL9
Large ribosomal subunit protein bL9

1

0

High-throughput

0.249

Low

367359

RS10
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

367360

RS11
Small ribosomal subunit protein uS11

1

0

High-throughput

0.249

Low

367361

RS13
Small ribosomal subunit protein uS13

1

0

High-throughput

0.249

Low

367362

RS16
Small ribosomal subunit protein bS16

1

0

High-throughput

0.249

Low

367363

RS19
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

367365

GLYA
Serine hydroxymethyltransferase

1

0

High-throughput

0.249

Low

367366

TIG
Trigger factor

1

0

High-throughput

0.249

Low

367368

YBAB
Nucleoid-associated protein YbaB

1

0

High-throughput

0.249

Low

367369

NQOR
NAD(P)H dehydrogenase

1

0

High-throughput

0.249

Low

367370

SYK2
Lysine--tRNA ligase, heat inducible

1

0

High-throughput

0.249

Low

367371

FUR
Ferric uptake regulation protein

1

0

High-throughput

0.249

Low

367372

G3P1
Glyceraldehyde-3-phosphate dehydrogenase A

1

0

High-throughput

0.249

Low

367374

CSPC
Cold shock-like protein CspC

1

0

High-throughput

0.249

Low

367375

USPD
Universal stress protein D

1

0

High-throughput

0.249

Low

367377

YCCJ
Uncharacterized protein YccJ

1

0

High-throughput

0.249

Low

367378

DPS
DNA protection during starvation protein

1

0

High-throughput

0.249

Low

367380

HNS
DNA-binding protein H-NS

1

0

High-throughput

0.249

Low

367382

YFCZ
UPF0381 protein YfcZ

1

0

High-throughput

0.249

Low

367384

RL16
Large ribosomal subunit protein uL16

1

0

High-throughput

0.249

Low

367385

AHPC
Alkyl hydroperoxide reductase C

1

0

High-throughput

0.249

Low

367387

FABG
3-oxoacyl-[acyl-carrier-protein] reductase FabG

1

0

High-throughput

0.249

Low

367388

HDEB
Acid stress chaperone HdeB

1

0

High-throughput

0.249

Low

367389

RISA
Riboflavin synthase

1

0

High-throughput

0.249

Low

367390

RS14
Small ribosomal subunit protein uS14

1

0

High-throughput

0.249

Low

367391

RS1
Small ribosomal subunit protein bS1

1

0

High-throughput

0.249

Low

367392

UGPB
sn-glycerol-3-phosphate-binding periplasmic protein UgpB

1

0

High-throughput

0.249

Low

367393

PSTS
Phosphate-binding protein PstS

1

0

High-throughput

0.249

Low

367394

RL18
Large ribosomal subunit protein uL18

1

0

High-throughput

0.249

Low

367395

OSMC
Peroxiredoxin OsmC

1

0

High-throughput

0.249

Low

367397

KATG
Catalase-peroxidase

1

0

High-throughput

0.249

Low

367398

GLMS
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.249

Low

367401

PGM
Phosphoglucomutase

1

0

High-throughput

0.249

Low

367403

RMLB1
dTDP-glucose 4,6-dehydratase 1

1

0

High-throughput

0.249

Low

367405

FKBA
FKBP-type peptidyl-prolyl cis-trans isomerase FkpA

1

0

High-throughput

0.249

Low

367406

LUXS
S-ribosylhomocysteine lyase

1

0

High-throughput

0.249

Low

367409

RL24
Large ribosomal subunit protein uL24

1

0

High-throughput

0.249

Low

367410

MDH
Malate dehydrogenase

1

0

High-throughput

0.249

Low

367411

RL5
Large ribosomal subunit protein uL5

1

0

High-throughput

0.249

Low

367415

RL25
Large ribosomal subunit protein bL25

1

0

High-throughput

0.249

Low

367416

KAD
Adenylate kinase

1

0

High-throughput

0.249

Low

367417

DCEB
Glutamate decarboxylase beta

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024