Protein: ACHA4
Neuronal acetylcholine receptor subunit alpha-4

Gene: ACHA4, CHRNA4
Organism: Homo sapiens
Interactions: 181
UniProt ID: P43681

Gene Ontology (top 5):
GO:0001508 - action potential
GO:0001666 - response to hypoxia
GO:0005886 - plasma membrane
GO:0005892 - acetylcholine-gated channel complex
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

607912

ACHB2
Neuronal acetylcholine receptor subunit beta-2

3

17

Small-scale

0.831

High

703430

GBRB3
Gamma-aminobutyric acid receptor subunit beta-3

2

18

High-throughput

0.776

High

851103

GLRB
Glycine receptor subunit beta

2

18

High-throughput

0.776

High

333448

MPZL1
Myelin protein zero-like protein 1

2

0

High-throughput

0.736

High

247505

FZD6
Frizzled-6

2

3

High-throughput

0.601

High

277002

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

2

4

High-throughput

0.601

High

851108

EREP3
Protein ENTREP3

2

3

High-throughput

0.601

High

851115

TUSC3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3

2

4

High-throughput

0.601

High

851122

SGCB
Beta-sarcoglycan

2

2

High-throughput

0.601

High

851126

IPIL2
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2

2

1

High-throughput

0.601

High

851129

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

2

2

High-throughput

0.601

High

851135

WLS
Protein wntless homolog

2

1

High-throughput

0.601

High

851140

LRC8E
Volume-regulated anion channel subunit LRRC8E

2

2

High-throughput

0.601

High

851141

GOLM2
Protein GOLM2

2

4

High-throughput

0.601

High

851150

ILDR2
Immunoglobulin-like domain-containing receptor 2

2

4

High-throughput

0.601

High

851160

LSR
Lipolysis-stimulated lipoprotein receptor

2

4

High-throughput

0.601

High

851165

LRC8A
Volume-regulated anion channel subunit LRRC8A

2

2

High-throughput

0.601

High

851166

K2013
Uncharacterized protein KIAA2013

2

1

High-throughput

0.601

High

851169

CISD2
CDGSH iron-sulfur domain-containing protein 2

2

3

High-throughput

0.601

High

851175

GOLM1
Golgi membrane protein 1

2

4

High-throughput

0.601

High

851177

LEMD2
LEM domain-containing protein 2

2

5

High-throughput

0.601

High

851191

PIGB
GPI alpha-1,2-mannosyltransferase 3

2

6

High-throughput

0.601

High

851197

ASTRA
Protein Aster-A

2

5

High-throughput

0.601

High

851210

TM39B
Transmembrane protein 39B

2

6

High-throughput

0.601

High

851216

GL8D2
Glycosyltransferase 8 domain-containing protein 2

2

2

High-throughput

0.601

High

603875

CXA1
Gap junction alpha-1 protein

2

0

High-throughput

0.576

High

851172

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

2

0

High-throughput

0.576

High

851215

LMA2L
VIP36-like protein

2

0

High-throughput

0.576

High

539695

ACHB
Acetylcholine receptor subunit beta

1

18

High-throughput

0.575

High

516630

LYNX1
Ly-6/neurotoxin-like protein 1

2

6

Small-scale

0.552

High

270001

XYLK
Glycosaminoglycan xylosylkinase

2

1

High-throughput

0.549

High

814762

CUX1
Homeobox protein cut-like 1

2

2

High-throughput

0.549

High

851130

MANEA
Glycoprotein endo-alpha-1,2-mannosidase

2

1

High-throughput

0.549

High

851134

DIK1A
Divergent protein kinase domain 1A

2

2

High-throughput

0.549

High

851174

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

2

2

High-throughput

0.549

High

851181

DIK2A
Divergent protein kinase domain 2A

2

3

High-throughput

0.549

High

851208

SC11C
Signal peptidase complex catalytic subunit SEC11C

2

3

High-throughput

0.549

High

851239

POMT2
Protein O-mannosyl-transferase 2

2

4

High-throughput

0.549

High

154526

PLPP1
Phospholipid phosphatase 1

1

2

High-throughput

0.536

High

213311

ADCY6
Adenylate cyclase type 6

1

4

High-throughput

0.536

High

230766

EXTL3
Exostosin-like 3

1

5

High-throughput

0.536

High

327851

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

High-throughput

0.536

High

336531

PIGN
GPI ethanolamine phosphate transferase 1

1

2

High-throughput

0.536

High

343841

SEM4F
Semaphorin-4F

1

2

High-throughput

0.536

High

560958

GP1BB
Platelet glycoprotein Ib beta chain

1

2

High-throughput

0.536

High

851113

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

7

High-throughput

0.536

High

851119

ICAM4
Intercellular adhesion molecule 4

1

2

High-throughput

0.536

High

851120

NOMO1
BOS complex subunit NOMO1

1

1

High-throughput

0.536

High

851125

ASTRB
Protein Aster-B

1

5

High-throughput

0.536

High

851131

TM63B
Mechanosensitive cation channel TMEM63B

1

1

High-throughput

0.536

High

851132

MRP7
ATP-binding cassette sub-family C member 10

1

2

High-throughput

0.536

High

851133

TMTC4
Protein O-mannosyl-transferase TMTC4

1

5

High-throughput

0.536

High

851143

PLPR3
Phospholipid phosphatase-related protein type 3

1

2

High-throughput

0.536

High

851148

TMPPE
Transmembrane protein with metallophosphoesterase domain

1

2

High-throughput

0.536

High

851149

TMTC3
Protein O-mannosyl-transferase TMTC3

1

5

High-throughput

0.536

High

851153

LRC8D
Volume-regulated anion channel subunit LRRC8D

1

2

High-throughput

0.536

High

851154

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

1

High-throughput

0.536

High

851161

TM219
Insulin-like growth factor-binding protein 3 receptor

1

1

High-throughput

0.536

High

851163

ZDH21
Palmitoyltransferase ZDHHC21

1

4

High-throughput

0.536

High

851168

GHDC
GH3 domain-containing protein

1

2

High-throughput

0.536

High

851176

SIDT2
SID1 transmembrane family member 2

1

4

High-throughput

0.536

High

851179

CTL5
Choline transporter-like protein 5

1

2

High-throughput

0.536

High

851183

SPPL3
Signal peptide peptidase-like 3

1

6

High-throughput

0.536

High

851184

SPP2B
Signal peptide peptidase-like 2B

1

6

High-throughput

0.536

High

851186

PIGO
GPI ethanolamine phosphate transferase 3, catalytic subunit

1

2

High-throughput

0.536

High

851189

CTL1
Choline transporter-like protein 1

1

2

High-throughput

0.536

High

851190

PIEZ1
Piezo-type mechanosensitive ion channel component 1

1

1

High-throughput

0.536

High

851192

TM131
Transmembrane protein 131

1

5

High-throughput

0.536

High

851195

EDA
Ectodysplasin-A

1

3

High-throughput

0.536

High

851201

SMO
Protein smoothened

1

3

High-throughput

0.536

High

851202

LMF2
Lipase maturation factor 2

1

4

High-throughput

0.536

High

851203

ABHEA
Protein ABHD14A

1

2

High-throughput

0.536

High

851204

ALG12
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

1

6

High-throughput

0.536

High

851206

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

1

High-throughput

0.536

High

851207

CA043
Protein C1orf43

1

2

High-throughput

0.536

High

851209

FUT8
Alpha-(1,6)-fucosyltransferase

1

2

High-throughput

0.536

High

851214

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

High-throughput

0.536

High

851219

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

6

High-throughput

0.536

High

851220

RN167
E3 ubiquitin-protein ligase RNF167

1

6

High-throughput

0.536

High

851221

PACC1
Proton-activated chloride channel

1

1

High-throughput

0.536

High

851223

S38AA
Solute carrier family 38 member 10

1

1

High-throughput

0.536

High

851225

FZD3
Frizzled-3

1

3

High-throughput

0.536

High

851226

CHSTC
Carbohydrate sulfotransferase 12

1

2

High-throughput

0.536

High

851234

B4GT7
Beta-1,4-galactosyltransferase 7

1

2

High-throughput

0.536

High

851237

NB5R1
NADH-cytochrome b5 reductase 1

1

2

High-throughput

0.536

High

851238

NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

1

2

High-throughput

0.536

High

851240

CCPG1
Cell cycle progression protein 1

1

3

High-throughput

0.536

High

851241

SIA10
Type 2 lactosamine alpha-2,3-sialyltransferase

1

7

High-throughput

0.536

High

851242

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

4

High-throughput

0.536

High

851248

POMT1
Protein O-mannosyl-transferase 1

1

4

High-throughput

0.536

High

421677

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.515

High

851194

SORL
Sortilin-related receptor

1

1

High-throughput

0.515

High

851231

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

1

High-throughput

0.515

High

62102

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

0

High-throughput

0.513

High

160245

GOSR2
Golgi SNAP receptor complex member 2

1

0

High-throughput

0.513

High

327188

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.513

High

851110

B4GN1
Beta-1,4 N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.513

High

851112

TMM62
Transmembrane protein 62

1

0

High-throughput

0.513

High

851121

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

0

High-throughput

0.513

High

851123

OCLN
Occludin

1

0

High-throughput

0.513

High

851138

STEA3
Metalloreductase STEAP3

1

0

High-throughput

0.513

High

851144

LMBRL
Protein LMBR1L

1

0

High-throughput

0.513

High

851147

CERS6
Ceramide synthase 6

1

0

High-throughput

0.513

High

851158

T179B
Transmembrane protein 179B

1

0

High-throughput

0.513

High

851170

PAR16
Protein mono-ADP-ribosyltransferase PARP16

1

0

High-throughput

0.513

High

851171

S15A4
Solute carrier family 15 member 4

1

0

High-throughput

0.513

High

851188

NAT14
Probable N-acetyltransferase 14

1

0

High-throughput

0.513

High

851224

NRN1
Neuritin

1

0

High-throughput

0.513

High

851228

GPR27
Probable G-protein coupled receptor 27

1

0

High-throughput

0.513

High

851235

LPAR3
Lysophosphatidic acid receptor 3

1

0

High-throughput

0.513

High

851243

SL9A8
Sodium/hydrogen exchanger 8

1

0

High-throughput

0.513

High

627610

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.493

High

49442

TM223
Transmembrane protein 223

1

1

High-throughput

0.489

High

253820

TPST2
Protein-tyrosine sulfotransferase 2

1

3

High-throughput

0.489

High

299867

C1QRF
C1q-related factor

1

5

High-throughput

0.489

High

700776

DMB
HLA class II histocompatibility antigen, DM beta chain

1

2

High-throughput

0.489

High

851127

UD3A2
UDP-glucuronosyltransferase 3A2

1

2

High-throughput

0.489

High

851136

MANEL
Glycoprotein endo-alpha-1,2-mannosidase-like protein

1

1

High-throughput

0.489

High

851137

MARC1
Mitochondrial amidoxime-reducing component 1

1

1

High-throughput

0.489

High

851151

PGAP1
GPI inositol-deacylase

1

1

High-throughput

0.489

High

851155

D19L4
Probable C-mannosyltransferase DPY19L4

1

5

High-throughput

0.489

High

851167

PLD6
Mitochondrial cardiolipin hydrolase

1

2

High-throughput

0.489

High

851178

NETO2
Neuropilin and tolloid-like protein 2

1

4

High-throughput

0.489

High

851180

SIA7C
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

1

7

High-throughput

0.489

High

851185

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.489

High

851193

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

3

High-throughput

0.489

High

851198

C1GLC
C1GALT1-specific chaperone 1

1

1

High-throughput

0.489

High

851199

BSCL2
Seipin

1

1

High-throughput

0.489

High

851200

FACR2
Fatty acyl-CoA reductase 2

1

2

High-throughput

0.489

High

851218

SIA7D
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase

1

7

High-throughput

0.489

High

851222

DJC18
DnaJ homolog subfamily C member 18

1

7

High-throughput

0.489

High

851229

TM39A
Transmembrane protein 39A

1

6

High-throughput

0.489

High

851245

TMX2
Thioredoxin-related transmembrane protein 2

1

1

High-throughput

0.489

High

851247

ZDHC9
Palmitoyltransferase ZDHHC9

1

3

High-throughput

0.489

High

851107

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

791159

SYUA
Alpha-synuclein

1

3

High-throughput

0.481

High

851117

RAPSN
43 kDa receptor-associated protein of the synapse

1

8

Small-scale

0.481

High

851152

RHOU
Rho-related GTP-binding protein RhoU

1

0

High-throughput

0.480

High

402549

ALDOA
Fructose-bisphosphate aldolase A

1

1

High-throughput

0.479

High

851232

P2RX2
P2X purinoceptor 2

1

4

Small-scale

0.479

High

851146

ATL4
ADAMTS-like protein 4

1

1

High-throughput

0.470

High

851145

CREL2
Protein disulfide isomerase CRELD2

1

3

Small-scale

0.462

High

851111

1433F
14-3-3 protein eta

1

0

Small-scale

0.460

High

222254

PSCA
Prostate stem cell antigen

1

0

Small-scale

0.458

High

241001

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

851116

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

High-throughput

0.458

High

379937

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.445

High

851114

DNJC3
DnaJ homolog subfamily C member 3

1

5

High-throughput

0.445

High

851118

MFS10
Major facilitator superfamily domain-containing protein 10

1

1

High-throughput

0.445

High

851159

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

6

High-throughput

0.445

High

851162

LYPD6
Ly6/PLAUR domain-containing protein 6

1

6

Small-scale

0.445

High

851236

SEC63
Translocation protein SEC63 homolog

1

7

High-throughput

0.445

High

489081

ALDOC
Fructose-bisphosphate aldolase C

1

1

High-throughput

0.437

High

851182

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.426

High

851227

VPS45
Vacuolar protein sorting-associated protein 45

1

0

High-throughput

0.426

High

851105

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.407

High

851106

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

3

High-throughput

0.407

High

851124

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

1

2

High-throughput

0.407

High

851128

KLH22
Kelch-like protein 22

1

1

High-throughput

0.407

High

851230

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.407

High

851233

EXTL2
Exostosin-like 2

1

5

High-throughput

0.407

High

851244

DJC16
DnaJ homolog subfamily C member 16

1

2

High-throughput

0.407

High

851217

TMX4
Thioredoxin-related transmembrane protein 4

2

0

High-throughput

0.313

High

63818

PEDS1
Plasmanylethanolamine desaturase 1

1

0

High-throughput

0.279

Low

65418

NEMP2
Nuclear envelope integral membrane protein 2

1

0

High-throughput

0.279

Low

270133

FKTN
Ribitol-5-phosphate transferase FKTN

1

0

High-throughput

0.279

Low

851104

NMU
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

1

0

High-throughput

0.279

Low

851139

MYORG
Myogenesis-regulating glycosidase

1

0

High-throughput

0.279

Low

851142

OFUT3
GDP-fucose protein O-fucosyltransferase 3

1

0

High-throughput

0.279

Low

851156

CF120
UPF0669 protein C6orf120

1

0

High-throughput

0.279

Low

851157

TMED4
Transmembrane emp24 domain-containing protein 4

1

0

High-throughput

0.279

Low

851164

F219A
Protein FAM219A

1

0

High-throughput

0.279

Low

851173

COX18
Cytochrome c oxidase assembly protein COX18, mitochondrial

1

0

High-throughput

0.279

Low

851205

ALG8
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

0

High-throughput

0.279

Low

851212

COA1
Cytochrome c oxidase assembly factor 1 homolog

1

0

High-throughput

0.279

Low

851213

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.279

Low

851109

CBX1
Chromobox protein homolog 1

1

0

High-throughput

0.268

Low

851187

THEM6
Protein THEM6

1

0

High-throughput

0.232

Low

851196

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.232

Low

851211

CHST6
Carbohydrate sulfotransferase 6

1

0

High-throughput

0.232

Low

851246

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025