Protein: CDN2B
Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)

Gene: CDN2B, CDKN2B
Organism: Homo sapiens
Interactions: 77
UniProt ID: P42772

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001889 - liver development
GO:0004861 - cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

515364

CDK4
Cyclin-dependent kinase 4

18

16

Small-scale

0.991

High

790922

CDK6
Cyclin-dependent kinase 6

11

16

Small-scale

0.985

High

790923

CDK17
Cyclin-dependent kinase 17

2

1

High-throughput

0.783

High

790915

CDN2C
Cyclin-dependent kinase 4 inhibitor C

2

15

High-throughput

0.768

High

790944

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.742

High

200164

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

14

High-throughput

0.698

High

790921

ISL1
Insulin gene enhancer protein ISL-1

1

3

High-throughput

0.698

High

790927

TRAF1
TNF receptor-associated factor 1

3

1

High-throughput

0.678

High

790916

MAGAB
Melanoma-associated antigen 11

3

8

High-throughput

0.667

High

790937

P5CR3
Pyrroline-5-carboxylate reductase 3

3

1

Small-scale

0.653

High

373839

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

11

High-throughput

0.647

High

383675

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

19

High-throughput

0.647

High

386259

P53
Cellular tumor antigen p53

1

10

High-throughput

0.647

High

435574

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.647

High

557061

PGFRA
Platelet-derived growth factor receptor alpha

1

20

High-throughput

0.647

High

681717

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

High-throughput

0.647

High

790914

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

14

High-throughput

0.647

High

790917

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

19

High-throughput

0.647

High

790918

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

20

High-throughput

0.647

High

790934

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.647

High

790949

LATS2
Serine/threonine-protein kinase LATS2

1

10

High-throughput

0.647

High

658831

MK01
Mitogen-activated protein kinase 1

1

11

High-throughput

0.618

High

790920

CDN2D
Cyclin-dependent kinase 4 inhibitor D

1

15

High-throughput

0.618

High

624407

CCNC
Cyclin-C

2

5

High-throughput

0.606

High

790926

INCA1
Protein INCA1

2

3

High-throughput

0.606

High

790939

CNKR3
Connector enhancer of kinase suppressor of ras 3

2

3

High-throughput

0.606

High

790948

PICK1
PRKCA-binding protein

2

3

High-throughput

0.606

High

790701

CDN2A
Cyclin-dependent kinase inhibitor 2A

2

17

High-throughput

0.595

High

790951

SPG21
Maspardin

2

0

High-throughput

0.580

High

790954

VATH
V-type proton ATPase subunit H

2

0

High-throughput

0.580

High

607909

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.579

High

665164

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.579

High

790928

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

20

High-throughput

0.579

High

790947

NIF3L
NIF3-like protein 1

1

2

High-throughput

0.573

High

169045

ARPC3
Actin-related protein 2/3 complex subunit 3

1

1

High-throughput

0.541

High

305740

ELP1
Elongator complex protein 1

1

0

High-throughput

0.518

High

790952

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.518

High

154005

TERT
Telomerase reverse transcriptase

1

1

High-throughput

0.501

High

169253

MDM4
Protein Mdm4

1

6

High-throughput

0.501

High

346157

MYC
Myc proto-oncogene protein

1

13

High-throughput

0.501

High

394280

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

441463

MET
Hepatocyte growth factor receptor

1

15

High-throughput

0.501

High

488608

ARAF
Serine/threonine-protein kinase A-Raf

1

11

High-throughput

0.501

High

536126

HGF
Hepatocyte growth factor

1

6

High-throughput

0.501

High

555098

CD44
CD44 antigen

1

4

High-throughput

0.501

High

624559

CCNE1
G1/S-specific cyclin-E1

1

2

High-throughput

0.501

High

649060

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

6

High-throughput

0.501

High

673035

CCND2
G1/S-specific cyclin-D2

1

8

High-throughput

0.501

High

719403

MERL
Merlin

1

20

High-throughput

0.501

High

790929

GRM1
Metabotropic glutamate receptor 1

1

3

High-throughput

0.501

High

790932

BECN1
Beclin-1

1

3

High-throughput

0.501

High

790933

TEAD2
Transcriptional enhancer factor TEF-4

1

1

High-throughput

0.501

High

790936

HIF1A
Hypoxia-inducible factor 1-alpha

1

6

High-throughput

0.501

High

790941

TSC1
Hamartin

1

15

High-throughput

0.501

High

790942

KAT2A
Histone acetyltransferase KAT2A

1

12

High-throughput

0.501

High

790945

GLIS2
Zinc finger protein GLIS2

1

4

High-throughput

0.501

High

790950

RASF1
Ras association domain-containing protein 1

1

2

High-throughput

0.501

High

790956

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.501

High

790946

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.494

High

204121

KLF4
Krueppel-like factor 4

1

6

Small-scale

0.479

High

206813

FOXO3
Forkhead box protein O3

1

7

Small-scale

0.479

High

773055

PBX1
Pre-B-cell leukemia transcription factor 1

1

4

Small-scale

0.479

High

790919

KAD2
Adenylate kinase 2, mitochondrial

1

4

High-throughput

0.479

High

790925

EP300
Histone acetyltransferase p300

1

12

High-throughput

0.479

High

790930

SMAD4
Mothers against decapentaplegic homolog 4

1

4

Small-scale

0.479

High

790935

CDC37
Hsp90 co-chaperone Cdc37

1

5

High-throughput

0.479

High

790938

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

7

Small-scale

0.479

High

790953

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

790931

KLF5
Krueppel-like factor 5

1

5

Small-scale

0.470

High

584340

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

3

High-throughput

0.457

High

708206

ERD22
ER lumen protein-retaining receptor 2

1

1

High-throughput

0.457

High

790943

TTYH2
Protein tweety homolog 2

1

1

High-throughput

0.457

High

790955

CBLC
E3 ubiquitin-protein ligase CBL-C

1

1

High-throughput

0.457

High

790924

MDM2
E3 ubiquitin-protein ligase Mdm2

1

6

Small-scale

0.445

High

64422

RTL8C
Retrotransposon Gag-like protein 8C

2

0

High-throughput

0.316

High

790940

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024