Protein: IF4E
Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)

Gene: IF4E, CDC33
Organism: Saccharomyces cerevisiae S288C
Interactions: 186
UniProt ID: P07260

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000340 - RNA 7-methylguanosine cap binding
GO:0003743 - translation initiation factor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

424869

IF4F1
Eukaryotic initiation factor 4F subunit p150

24

18

Small-scale

0.993

High

424870

IF4F2
Eukaryotic initiation factor 4F subunit p130

8

18

Small-scale

0.971

High

424806

CAF20
Cap-associated protein CAF20

17

0

Small-scale

0.935

High

424851

EAP1
Protein EAP1

9

0

Small-scale

0.920

High

376583

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

8

2

Small-scale

0.745

High

415856

DED1
ATP-dependent RNA helicase DED1

3

2

Small-scale

0.680

High

424842

NCBP1
Nuclear cap-binding protein complex subunit 1

3

1

High-throughput

0.667

High

424800

IF4A
ATP-dependent RNA helicase eIF4A

3

6

Small-scale

0.662

High

424933

SLF1
Protein SLF1

3

3

Small-scale

0.650

High

424813

XRN1
5'-3' exoribonuclease 1

3

0

Small-scale

0.634

High

424801

HSP71
Heat shock protein SSA1

3

2

High-throughput

0.633

High

424803

SSB1
Ribosome-associated molecular chaperone SSB1

3

2

High-throughput

0.633

High

424799

SSBP1
Single-stranded nucleic acid-binding protein

2

5

High-throughput

0.628

High

424840

LHP1
La protein homolog

2

2

High-throughput

0.628

High

424856

HEK2
Heterogeneous nuclear rnp K-like protein 2

2

1

High-throughput

0.621

High

406656

RS3
Small ribosomal subunit protein uS3

3

0

Small-scale

0.613

High

424822

GBP2
Serine/arginine

2

5

Small-scale

0.611

High

365578

HSP82
ATP-dependent molecular chaperone HSP82

3

0

High-throughput

0.606

High

424835

TOR2
Serine/threonine-protein kinase TOR2

2

2

Small-scale

0.602

High

424812

DPOE
DNA polymerase epsilon catalytic subunit A

2

0

High-throughput

0.602

High

424926

LUC7
Protein LUC7

2

0

High-throughput

0.595

High

424896

LSM7
U6 snRNA-associated Sm-like protein LSm7

2

3

High-throughput

0.588

High

424852

GBLP
Small ribosomal subunit protein RACK1

2

4

Small-scale

0.584

High

424865

DHH1
ATP-dependent RNA helicase DHH1

2

7

Small-scale

0.584

High

424930

NCBP2
Nuclear cap-binding protein subunit 2

2

1

Small-scale

0.584

High

424845

UTP20
U3 small nucleolar RNA-associated protein 20

2

0

High-throughput

0.576

High

424887

PSP2
Protein PSP2

2

0

Small-scale

0.576

High

424889

ROM2
RHO1 GDP-GTP exchange protein 2

2

0

High-throughput

0.576

High

424793

HSP77
Import motor subunit, mitochondrial

2

1

High-throughput

0.571

High

424838

SMY2
Protein SMY2

2

0

Small-scale

0.559

High

424834

HSP7F
Heat shock protein homolog SSE1

2

3

High-throughput

0.552

High

424873

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.552

High

424795

RS4A
Small ribosomal subunit protein eS4A

2

0

Small-scale

0.547

High

424805

AAKG
5'-AMP-activated protein kinase subunit gamma

1

2

High-throughput

0.536

High

424810

YPK2
Serine/threonine-protein kinase YPK2/YKR2

1

1

High-throughput

0.536

High

424854

TAF5
Transcription initiation factor TFIID subunit 5

1

1

High-throughput

0.536

High

424864

DUN1
DNA damage response protein kinase DUN1

1

1

High-throughput

0.536

High

424885

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

1

High-throughput

0.536

High

424886

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.536

High

424893

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

424895

CBK1
Serine/threonine-protein kinase CBK1

1

4

High-throughput

0.536

High

424901

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

424908

GCN5
Histone acetyltransferase GCN5

2

0

High-throughput

0.528

High

342447

TRPE
Anthranilate synthase component 1

1

0

High-throughput

0.513

High

419283

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.513

High

424788

CYAA
Adenylate cyclase

1

0

High-throughput

0.513

High

424811

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

0

High-throughput

0.513

High

424839

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.513

High

424868

RV167
Reduced viability upon starvation protein 167

1

0

High-throughput

0.513

High

424871

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

0

High-throughput

0.513

High

424874

RAD26
DNA repair and recombination protein RAD26

1

0

High-throughput

0.513

High

424879

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.513

High

424883

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.513

High

424913

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.513

High

424919

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.513

High

424921

MAG2
E3 ubiquitin-protein ligase MAG2

1

0

High-throughput

0.513

High

424938

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.513

High

424843

HSL1
Probable serine/threonine-protein kinase HSL1

1

1

High-throughput

0.501

High

424844

TOR1
Serine/threonine-protein kinase TOR1

1

2

Small-scale

0.501

High

424880

SCD6
Protein SCD6

1

2

Small-scale

0.501

High

424910

STE20
Serine/threonine-protein kinase STE20

1

1

High-throughput

0.501

High

334404

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

High-throughput

0.500

High

424789

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.500

High

424809

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.500

High

424914

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.493

High

424850

YPT53
GTP-binding protein YPT53

1

2

High-throughput

0.489

High

424912

WDR59
Maintenance of telomere capping protein 5

1

4

High-throughput

0.489

High

424934

RTK1
Probable serine/threonine-protein kinase RTK1

1

3

High-throughput

0.489

High

424940

RS22B
Small ribosomal subunit protein uS8B

1

1

High-throughput

0.489

High

424818

KC12
Casein kinase I homolog 2

1

0

High-throughput

0.480

High

424904

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

0

High-throughput

0.480

High

381404

GAL1
Galactokinase

1

0

High-throughput

0.479

High

410852

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.479

High

419760

SNF1
Carbon catabolite-derepressing protein kinase

1

0

High-throughput

0.479

High

424787

GAL7
Galactose-1-phosphate uridylyltransferase

1

0

High-throughput

0.479

High

424828

URA7
CTP synthase 1

1

0

High-throughput

0.479

High

339341

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.479

High

410047

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

2

Small-scale

0.479

High

410251

SC160
Protein SCP160

1

1

High-throughput

0.479

High

424786

LTE1
Guanine nucleotide exchange factor LTE1

1

1

High-throughput

0.479

High

424814

DBF2
Cell cycle protein kinase DBF2

1

2

High-throughput

0.479

High

424819

SSD1
Protein SSD1

1

2

High-throughput

0.479

High

424823

SRO9
RNA-binding protein SRO9

1

3

Small-scale

0.479

High

424832

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

Small-scale

0.479

High

424837

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

424849

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

424857

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

1

Small-scale

0.479

High

424859

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

424861

HRB1
Serine/arginine

1

4

Small-scale

0.479

High

424882

LSM1
Sm-like protein LSm1

1

3

Small-scale

0.479

High

424892

CDH1
APC/C activator protein CDH1

1

3

Small-scale

0.479

High

424898

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

2

Small-scale

0.479

High

424900

NAM8
Protein NAM8

1

2

High-throughput

0.479

High

424906

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.479

High

424920

RGA2
Rho-type GTPase-activating protein 2

1

2

High-throughput

0.479

High

424939

CMR1
DNA damage-binding protein CMR1

1

3

High-throughput

0.479

High

424890

MLC1
Myosin light chain 1

1

1

High-throughput

0.470

High

424877

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.460

High

356170

H4
Histone H4

1

0

High-throughput

0.458

High

407622

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

408214

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

424784

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.458

High

424790

TBA1
Tubulin alpha-1 chain

1

0

Small-scale

0.458

High

424797

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

424808

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

424816

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

424820

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

424821

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

424826

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.458

High

424829

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

424830

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

424833

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.458

High

424836

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.458

High

424846

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

424847

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

424848

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

424858

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

424860

SDO1L
Restriction of telomere capping protein 3

1

0

Small-scale

0.458

High

424872

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

0

Small-scale

0.458

High

424875

TM108
Protein TMA108

1

0

High-throughput

0.458

High

424878

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

424884

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

424891

PNC1
Nicotinamidase

1

0

High-throughput

0.458

High

424894

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.458

High

424899

H3
Histone H3

1

0

High-throughput

0.458

High

424902

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

424909

EBS1
Nonsense-mediated mRNA decay factor EBS1

1

0

Small-scale

0.458

High

424911

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

424917

PAL1
Protein PAL1

1

0

High-throughput

0.458

High

424918

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

424922

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.458

High

424929

VTS1
RNA-binding protein VTS1

1

0

Small-scale

0.458

High

424932

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

424936

BBP
Branchpoint-bridging protein

1

0

Small-scale

0.458

High

424937

CSN10
COP9 signalosome complex subunit 10

1

0

Small-scale

0.458

High

424941

SUS1
Transcription and mRNA export factor SUS1

1

0

Small-scale

0.458

High

424907

PKH3
Serine/threonine-protein kinase PKH3

1

2

High-throughput

0.457

High

334862

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

1

High-throughput

0.457

High

378257

LEU3
3-isopropylmalate dehydrogenase

1

1

High-throughput

0.457

High

424876

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.457

High

367616

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

424802

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

424815

TRX1
Thioredoxin-1

1

1

Small-scale

0.445

High

424817

TRX2
Thioredoxin-2

1

1

Small-scale

0.445

High

424825

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.445

High

424853

CDC27
Anaphase-promoting complex subunit CDC27

1

1

High-throughput

0.445

High

424791

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

424824

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.437

High

424862

HAL5
Serine/threonine-protein kinase HAL5

1

1

High-throughput

0.437

High

424905

YMZ2
WD repeat-containing protein YMR102C

1

3

High-throughput

0.437

High

404448

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.426

High

424272

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

424804

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

Small-scale

0.426

High

424831

FKBP2
Peptidyl-prolyl cis-trans isomerase FPR2

1

0

High-throughput

0.426

High

424866

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

424888

SPT20
Transcription factor SPT20

1

0

High-throughput

0.426

High

424903

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.426

High

424925

BRE1
E3 ubiquitin-protein ligase BRE1

1

0

High-throughput

0.426

High

424935

CHS5
Chitin biosynthesis protein CHS5

1

0

High-throughput

0.426

High

424881

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.407

High

424796

RS8A
Small ribosomal subunit protein eS8A

2

0

High-throughput

0.305

High

407441

RS9B
Small ribosomal subunit protein uS4B

1

0

High-throughput

0.279

Low

424863

TEM1
Protein TEM1

1

0

High-throughput

0.279

Low

424915

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

424916

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.279

Low

424927

NOP6
Nucleolar protein 6

1

0

High-throughput

0.279

Low

424807

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.269

Low

424924

BSP1
Protein BSP1

1

0

High-throughput

0.269

Low

381669

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

382856

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

405330

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

413206

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

424785

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

424792

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

424794

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

424798

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.249

Low

424827

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

424841

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

424855

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

424867

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

424897

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

424923

GPN3
GPN-loop GTPase 3

1

0

Small-scale

0.249

Low

424928

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

424931

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

399210

FUR4
Uracil permease

1

0

High-throughput

0.232

Low

404942

RL6B
Large ribosomal subunit protein eL6B

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024