Protein: DPOLA
DNA polymerase alpha catalytic subunit A (EC 2.7.7.7) (DNA polymerase I subunit A) (DNA polymerase alpha:primase complex p180 subunit) (DNA polymerase-primase complex p180 subunit) (Pol alpha-primase complex p180 subunit)

Gene: DPOLA, POL1
Organism: Saccharomyces cerevisiae S288C
Interactions: 69
UniProt ID: P13382

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000731 - DNA synthesis involved in DNA repair
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

526840

DPOA2
DNA polymerase alpha subunit B

11

5

Small-scale

0.976

High

526816

PRI2
DNA primase large subunit

5

3

Small-scale

0.916

High

526817

DPOE
DNA polymerase epsilon catalytic subunit A

3

2

Small-scale

0.857

High

526858

CTF4
DNA polymerase alpha-binding protein

14

7

Small-scale

0.765

High

488477

PRI1
DNA primase small subunit

9

4

Small-scale

0.753

High

526829

MCM4
DNA replication licensing factor MCM4

9

12

Small-scale

0.751

High

526867

CDC45
Cell division control protein 45

5

4

Small-scale

0.714

High

526861

SLD5
DNA replication complex GINS protein SLD5

10

7

Small-scale

0.686

High

526853

DPOD3
DNA polymerase delta subunit 3

3

2

Small-scale

0.668

High

526822

MCM3
DNA replication licensing factor MCM3

3

10

Small-scale

0.656

High

526865

POB3
FACT complex subunit POB3

5

3

Small-scale

0.647

High

526827

MCM2
DNA replication licensing factor MCM2

3

10

Small-scale

0.646

High

526831

MCM10
Minichromosome maintenance protein 10

3

2

Small-scale

0.646

High

526825

SPT5
Transcription elongation factor SPT5

3

1

Small-scale

0.642

High

526832

SPT16
FACT complex subunit SPT16

4

1

Small-scale

0.634

High

526869

PSF1
DNA replication complex GINS protein PSF1

4

2

Small-scale

0.633

High

526851

DPOD2
DNA polymerase delta small subunit

1

6

Small-scale

0.618

High

526828

MCM5
Minichromosome maintenance protein 5

2

10

Small-scale

0.611

High

526856

H3
Histone H3

3

7

Small-scale

0.606

High

526843

POP2
Poly(A) ribonuclease POP2

2

0

High-throughput

0.595

High

526841

MCM7
DNA replication licensing factor MCM7

2

7

Small-scale

0.595

High

526815

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

High-throughput

0.584

High

526818

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.582

High

356210

H4
Histone H4

2

2

Small-scale

0.570

High

526823

DPB2
DNA polymerase epsilon subunit B

1

4

Small-scale

0.553

High

493064

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.536

High

355319

H2B1
Histone H2B.1

2

6

Small-scale

0.533

High

334420

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.515

High

339396

CDK1
Cyclin-dependent kinase 1

1

5

High-throughput

0.512

High

526863

CTK1
CTD kinase subunit alpha

1

5

Small-scale

0.512

High

526848

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.504

High

510090

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.489

High

526834

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.489

High

501307

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

Small-scale

0.479

High

526819

RFA1
Replication factor A protein 1

1

2

High-throughput

0.479

High

526826

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

526830

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

526854

TOF1
Topoisomerase 1-associated factor 1

1

2

Small-scale

0.479

High

526857

SEN1
Helicase SEN1

1

2

Small-scale

0.479

High

526864

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

526868

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

526837

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

355758

H2B2
Histone H2B.2

1

6

Small-scale

0.437

High

392036

H2A1
Histone H2A.1

1

1

Small-scale

0.437

High

410066

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.437

High

526838

CENPA
Histone H3-like centromeric protein CSE4

1

7

High-throughput

0.437

High

526842

TRA1
Transcription-associated protein 1

1

2

Small-scale

0.437

High

526847

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

526849

PSF2
DNA replication complex GINS protein PSF2

1

1

Small-scale

0.437

High

526850

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

526844

MET30
F-box protein MET30

1

1

High-throughput

0.417

High

490177

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.407

High

526824

SIS1
Protein SIS1

1

5

High-throughput

0.407

High

526835

HSP79
Heat shock protein homolog SSE2

1

13

High-throughput

0.407

High

526845

TCPB
T-complex protein 1 subunit beta

1

3

High-throughput

0.407

High

526846

CAJ1
Protein CAJ1

1

4

High-throughput

0.407

High

526836

CDC13
Cell division control protein 13

5

0

Small-scale

0.376

High

526839

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

4

0

Small-scale

0.358

High

516836

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.261

Low

526833

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

0

Small-scale

0.261

Low

526855

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

0

Small-scale

0.261

Low

524122

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

526820

CHL1
ATP-dependent DNA helicase CHL1

1

0

Small-scale

0.249

Low

526860

RL6A
Large ribosomal subunit protein eL6A

1

0

High-throughput

0.249

Low

526862

LIP1
Ceramide synthase subunit LIP1

1

0

High-throughput

0.249

Low

526866

CSM3
Chromosome segregation in meiosis protein 3

1

0

Small-scale

0.249

Low

526859

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.238

Low

526821

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.232

Low

526852

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024